Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1 |
EDJ-MED-9f4ac58c-3_1
|
|
CS(=O)(=O)Nc1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−12.3
± 0.6
|
2 |
EDJ-MED-9f4ac58c-3_1
|
|
CS(=O)(=O)Nc1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−12.3
± 0.6
|
3 |
EDJ-MED-6b23330e-6_2
|
|
CC(C)(CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl)F |
−12.2
± 0.3
|
4 |
MAT-POS-e75f6e44-9_4
|
|
C[C@H](C1CC1)NC(=O)C[N@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−11.9
± 0.3
|
5 |
EDJ-MED-6b23330e-5_2
|
|
CC1(CC1)CNC(=O)C[N@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−11.9
± 0.2
|
6 |
PET-UNK-c6bcc80b-5_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.8
± 0.3
|
7 |
PET-UNK-c6bcc80b-5_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.8
± 0.3
|
8 |
EDJ-MED-7d88f880-2_1
|
|
CNC(=O)C1(CC1)N2C[C@]3(CCN(C3=O)c4cncc5c4ccc(c5)[S@](=N)(=O)C)c6cc(ccc6C2=O)Cl |
−11.7
± 0.4
|
9 |
EDJ-MED-7d88f880-2_1
|
|
CNC(=O)C1(CC1)N2C[C@]3(CCN(C3=O)c4c[nH+]cc5c4ccc(c5)[S@](=N)(=O)C)c6cc(ccc6C2=O)Cl |
−11.7
± 0.4
|
10 |
VLA-UNK-e334495f-3_2
|
|
c1ccc2c(c1)cncc2N3CC[C@]4(C3=O)c5cc(ccc5C[N@@]([C@@H]4C(F)(F)F)S(=O)(=O)CC6(CC6)C#N)Cl |
−11.5
± 0.3
|
11 |
VLA-UNK-e334495f-3_2
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@]4(C3=O)c5cc(ccc5C[N@@]([C@@H]4C(F)(F)F)S(=O)(=O)CC6(CC6)C#N)Cl |
−11.5
± 0.3
|
12 |
EDJ-MED-7d88f880-3_2
|
|
C[S@](=N)(=O)c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−11.5
± 0.6
|
13 |
EDJ-MED-7d88f880-3_2
|
|
C[S@](=N)(=O)c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−11.5
± 0.6
|
14 |
MAT-POS-e75f6e44-11_2
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@H+](Cc5c4cc(cc5)Cl)CC(=O)NCC6(CC6)C#N |
−11.5
± 0.3
|
15 |
MAT-POS-e75f6e44-16_1
|
|
C[NH+]1CC(C1)CNC(=O)C[N@@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−11.4
± 0.6
|
16 |
MAT-POS-e75f6e44-16_1
|
|
C[NH+]1CC(C1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−11.4
± 0.6
|
17 |
MAT-POS-e75f6e44-16_1
|
|
C[NH+]1CC(C1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5c[nH+]cc6c5cccc6)Cl |
−11.4
± 0.6
|
18 |
MAT-POS-e75f6e44-16_1
|
|
CN1CC(C1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−11.4
± 0.6
|
19 |
PET-UNK-c6bcc80b-13_1
|
|
CNC(=O)CN1C[C@]2(CCN(C2=O)c3cncc4c3cc(c(c4)NS(=O)(=O)C)F)c5cc(ccc5C1=O)Cl |
−11.4
± 0.4
|
20 |
PET-UNK-c6bcc80b-13_1
|
|
CNC(=O)CN1C[C@]2(CCN(C2=O)c3c[nH+]cc4c3cc(c(c4)NS(=O)(=O)C)F)c5cc(ccc5C1=O)Cl |
−11.4
± 0.4
|
21 |
PET-UNK-77d5678a-1_2
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)C[N@H+](Cc5c4cc(cc5)Cl)Cc6n[nH+]cs6 |
−11.4
± 0.5
|
22 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.4
± 0.6
|
23 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.4
± 0.6
|
24 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.4
± 0.6
|
25 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCCN(C)C)Cl |
−11.4
± 0.6
|
26 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.4
± 0.6
|
27 |
MAT-POS-38eb6498-3_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCCN(C)C)Cl |
−11.4
± 0.6
|
28 |
EDJ-MED-0d144977-5_1
|
|
Cn1cc[nH+]c1CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−11.3
± 0.3
|
29 |
EDJ-MED-0d144977-5_1
|
|
Cn1cc[nH+]c1CN2C[C@]3(CCN(C3=O)c4c[nH+]cc5c4cccc5)c6cc(ccc6C2=O)Cl |
−11.3
± 0.3
|
30 |
EDJ-MED-0d144977-5_1
|
|
Cn1ccnc1CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−11.3
± 0.3
|
31 |
PET-UNK-c6bcc80b-12_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.2
± 0.3
|
32 |
PET-UNK-c6bcc80b-12_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.2
± 0.3
|
33 |
PET-UNK-c6bcc80b-5_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.1
± 0.7
|
34 |
PET-UNK-c6bcc80b-5_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.1
± 0.7
|
35 |
PET-UNK-c6bcc80b-5_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.1
± 0.7
|
36 |
PET-UNK-c6bcc80b-5_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(c(c5)NS(=O)(=O)C)F)Cl |
−11.1
± 0.7
|
37 |
LUO-POS-868e8996-12_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl |
−11.1
± 0.3
|
38 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.1
± 0.5
|
39 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.1
± 0.5
|
40 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.1
± 0.5
|
41 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCCN(C)C)Cl |
−11.1
± 0.5
|
42 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(cc5)OCC[NH+](C)C)Cl |
−11.1
± 0.5
|
43 |
EDJ-MED-b6c6ee2b-1_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OCCN(C)C)Cl |
−11.1
± 0.5
|
44 |
ALP-POS-ecbed2ba-14_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@H+](Cc5c4cc(cc5)Cl)CC(=O)NCC#N |
−11.0
± 0.4
|
45 |
ALP-POS-ecbed2ba-14_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC#N |
−11.0
± 0.4
|
46 |
ALP-POS-ecbed2ba-14_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC#N |
−11.0
± 0.4
|
47 |
VLA-UNK-e334495f-4_2
|
|
c1ccc2c(c1)cncc2N3CC[C@]4(C3=O)c5cc(ccc5C[N@@]([C@@H]4C(F)F)S(=O)(=O)CC6(CC6)C#N)Cl |
−11.0
± 0.4
|
48 |
VLA-UNK-e334495f-4_2
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@]4(C3=O)c5cc(ccc5C[N@@]([C@@H]4C(F)F)S(=O)(=O)CC6(CC6)C#N)Cl |
−11.0
± 0.4
|
49 |
PET-UNK-94036022-14_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)C(=O)C(=C)N(C3=O)c4cncc5c4cccc5)Cl |
−11.0
± 0.5
|
50 |
PET-UNK-94036022-14_1
|
|
CNC(=O)C[N@@]1Cc2ccc(cc2[C@]3(C1)C(=O)C(=C)N(C3=O)c4cncc5c4cccc5)Cl |
−11.0
± 0.5
|
51 |
MAT-POS-b4d6b7fc-7_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4ccc(c5)NS(=O)(=O)C)Cl |
−11.0
± 0.2
|
52 |
MAT-POS-b4d6b7fc-7_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4ccc(c5)NS(=O)(=O)C)Cl |
−11.0
± 0.2
|
53 |
MAT-POS-b4d6b7fc-7_1
|
|
CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4ccc(c5)NS(=O)(=O)C)Cl |
−11.0
± 0.2
|
54 |
MAT-POS-b4d6b7fc-7_1
|
|
CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4ccc(c5)NS(=O)(=O)C)Cl |
−11.0
± 0.2
|
55 |
EDJ-MED-6b23330e-6_1
|
|
CC(C)(CNC(=O)C[N@@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl)F |
−10.9
± 0.5
|
56 |
EDJ-MED-6b23330e-6_1
|
|
CC(C)(CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl)F |
−10.9
± 0.5
|
57 |
EDJ-MED-6b23330e-6_1
|
|
CC(C)(CNC(=O)C[N@]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cccc5)Cl)F |
−10.9
± 0.5
|
58 |
MAT-POS-566864e2-2_2
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@H+](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.9
± 0.3
|
59 |
MAT-POS-566864e2-1_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@H+](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.9
± 0.6
|
60 |
MAT-POS-566864e2-1_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.9
± 0.6
|
61 |
MAT-POS-566864e2-1_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.9
± 0.6
|
62 |
PET-UNK-aa57768f-1_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)Cc6n[nH+]co6 |
−10.9
± 0.2
|
63 |
PET-UNK-aa57768f-1_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)Cc6n[nH+]co6 |
−10.9
± 0.2
|
64 |
EDJ-MED-0d144977-4_1
|
|
Cn1c(nc[nH+]1)CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.9
± 0.3
|
65 |
EDJ-MED-0d144977-4_1
|
|
Cn1c(nc[nH+]1)CN2C[C@]3(CCN(C3=O)c4c[nH+]cc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.9
± 0.3
|
66 |
EDJ-MED-b6c6ee2b-2_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OC)Cl |
−10.9
± 0.3
|
67 |
EDJ-MED-b6c6ee2b-2_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4c[nH+]cc5c4cc(cc5)OC)Cl |
−10.9
± 0.3
|
68 |
MAT-POS-b4d6b7fc-5_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)F)Cl |
−10.8
± 0.3
|
69 |
MAT-POS-50a80394-6_2
|
|
CC(C)[C@H]1CN(C(=O)[C@@]12C[N@@](Cc3c2cc(cc3)Cl)CC(=O)NC)c4cncc5c4cccc5 |
−10.8
± 0.5
|
70 |
MAT-POS-50a80394-6_2
|
|
CC(C)[C@H]1CN(C(=O)[C@@]12C[N@@H+](Cc3c2cc(cc3)Cl)CC(=O)NC)c4cncc5c4cccc5 |
−10.8
± 0.5
|
71 |
MAT-POS-50a80394-6_2
|
|
CC(C)[C@H]1CN(C(=O)[C@@]12C[N@](Cc3c2cc(cc3)Cl)CC(=O)NC)c4c[nH+]cc5c4cccc5 |
−10.8
± 0.5
|
72 |
EDJ-MED-9f4ac58c-1_1
|
|
c1cc2c(cc1Cl)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−10.8
± 0.4
|
73 |
PET-UNK-aa57768f-7_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)Cc6n[nH+]co6 |
−10.7
± 0.2
|
74 |
PET-UNK-aa57768f-7_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)Cc6n[nH+]co6 |
−10.7
± 0.2
|
75 |
MAT-POS-e75f6e44-9_1
|
|
C[C@@H](C1CC1)NC(=O)C[N@@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.7
± 0.6
|
76 |
MAT-POS-e75f6e44-9_1
|
|
C[C@@H](C1CC1)NC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.7
± 0.6
|
77 |
MAT-POS-e75f6e44-9_1
|
|
C[C@@H](C1CC1)NC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5c[nH+]cc6c5cccc6)Cl |
−10.7
± 0.6
|
78 |
EDJ-MED-6b23330e-1_2
|
|
CC(C)CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl |
−10.7
± 0.2
|
79 |
MAT-POS-c7726e07-6_2
|
|
CNC(=O)C[N@H+]1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl |
−10.6
± 0.3
|
80 |
EDJ-MED-0d144977-1_1
|
|
CC1=NC(=C[NH2+]1)CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.6
± 0.4
|
81 |
EDJ-MED-0d144977-1_1
|
|
Cc1[nH]cc([nH+]1)CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.6
± 0.4
|
82 |
EDJ-MED-0d144977-2_1
|
|
Cn1c[nH+]cc1CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.6
± 0.3
|
83 |
EDJ-MED-0d144977-2_1
|
|
Cn1c[nH+]cc1CN2C[C@]3(CCN(C3=O)c4c[nH+]cc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.6
± 0.3
|
84 |
MAT-POS-e75f6e44-7_1
|
|
C[NH+](C)C1(CC1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.6
± 0.2
|
85 |
MAT-POS-e75f6e44-7_1
|
|
C[NH+](C)C1(CC1)CNC(=O)C[N@@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.6
± 0.2
|
86 |
MAT-POS-e75f6e44-7_1
|
|
C[NH+](C)C1(CC1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5c[nH+]cc6c5cccc6)Cl |
−10.6
± 0.2
|
87 |
MAT-POS-e75f6e44-7_1
|
|
CN(C)C1(CC1)CNC(=O)C[N@]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.6
± 0.2
|
88 |
MAT-POS-96396902-1_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@H+](Cc5c4cc(cc5)Cl)Cc6n[nH+]cs6 |
−10.6
± 0.7
|
89 |
MAT-POS-96396902-1_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@](Cc5c4cc(cc5)Cl)Cc6n[nH+]cs6 |
−10.6
± 0.7
|
90 |
MAT-POS-96396902-1_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)C[N@@](Cc5c4cc(cc5)Cl)Cc6n[nH+]cs6 |
−10.6
± 0.7
|
91 |
EDJ-MED-a12e3a20-1_1
|
|
c1ccc2c(c1)cncc2N3CC(=O)[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−10.5
± 0.9
|
92 |
ALP-POS-c3a90b22-10_2
|
|
CNC(=O)C1(CCOCC1)[N@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.5
± 0.2
|
93 |
MAT-POS-e75f6e44-16_2
|
|
C[NH+]1CC(C1)CNC(=O)C[N@H+]2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−10.5
± 0.3
|
94 |
ALP-POS-c3a90b22-8_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CS(=O)(=O)CC6(CC6)C#N |
−10.5
± 0.4
|
95 |
ALP-POS-c3a90b22-8_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CS(=O)(=O)CC6(CC6)C#N |
−10.5
± 0.4
|
96 |
ALP-POS-ecbed2ba-12_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@H+](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.4
± 0.3
|
97 |
ALP-POS-ecbed2ba-12_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.4
± 0.3
|
98 |
ALP-POS-ecbed2ba-12_1
|
|
c1ccc2c(c1)c[nH+]cc2N3CC[C@@]4(C3=O)C[N@](Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−10.4
± 0.3
|
99 |
EDJ-MED-cc48ee33-7_1
|
|
Cn1c(cc[nH+]1)CN2C[C@]3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.4
± 0.3
|
100 |
EDJ-MED-cc48ee33-7_1
|
|
Cn1c(cc[nH+]1)CN2C[C@]3(CCN(C3=O)c4c[nH+]cc5c4cccc5)c6cc(ccc6C2=O)Cl |
−10.4
± 0.3
|