Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
101 |
PET-UNK-77d5678a-4
|
|
c1ccc2c(c1)cncc2N3C(=O)CC4(C3=O)CN(Cc5c4cc(cc5)Cl)Cc6nncs6 |
−9.7
± 0.3
|
7.1
± 0.2
|
102 |
MAT-POS-e75f6e44-9
|
|
C[C@H](C1CC1)NC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.7
± 0.2
|
7.1
± 0.1
|
103 |
EDJ-MED-6b23330e-6
|
|
CC(C)(CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl)F |
−9.7
± 0.2
|
7.1
± 0.2
|
104 |
MAT-POS-50a80394-6
|
|
CC(C)C1CN(C(=O)C12CN(Cc3c2cc(cc3)Cl)CC(=O)NC)c4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
105 |
EDJ-MED-0d144977-1
|
|
Cc1[nH]cc(n1)CN2CC3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−9.6
± 0.3
|
7.0
± 0.2
|
106 |
MAT-POS-69786b79-2
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NC6CC6 |
−9.6
± 0.4
|
7.0
± 0.3
|
107 |
EDJ-MED-6b23330e-2
|
|
CC(C)(C)CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl |
−9.6
± 0.4
|
7.0
± 0.3
|
108 |
EDJ-MED-4cb9dd84-2
|
|
c1cc2cncc(c2cc1Cl)N3CCC4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−9.6
± 0.2
|
7.0
± 0.2
|
109 |
EDJ-MED-5cd3920d-4
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4cc(cc5)C(F)F)c6cc(ccc6C2=O)Cl |
−9.6
± 0.4
|
7.0
± 0.3
|
110 |
ALP-POS-ecbed2ba-14
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC#N |
−9.6
± 0.3
|
7.0
± 0.2
|
111 |
PET-UNK-94036022-2
|
|
C#CC1(CC1)CS(=O)(=O)N2Cc3ccc(cc3[C@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.5
± 0.7
|
6.9
± 0.5
|
112 |
VLA-UNK-5d8210f0-1
|
|
CNC(=O)CN1Cc2c(cc(cc2F)Cl)C3(C1)CCN(C3=O)c4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
113 |
EDJ-MED-59d5ca70-2
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)C6(CC6)C(=O)NCC7CC7 |
−9.5
± 0.7
|
6.9
± 0.5
|
114 |
EDJ-MED-7d88f880-1
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3ccc(c4)S(=N)(=O)C)c5cc(ccc5C1=O)Cl |
−9.5
± 0.4
|
6.9
± 0.3
|
115 |
EDJ-MED-9f4ac58c-6
|
|
COC1(CC1)CS(=O)(=O)N2CC3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−9.5
± 0.7
|
6.9
± 0.5
|
116 |
VLA-UNK-5d8210f0-2
|
|
CNC(=O)CN1Cc2cc(c(cc2C3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl)F |
−9.5
± 0.3
|
6.9
± 0.2
|
117 |
MAT-POS-566864e2-1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−9.5
± 0.2
|
6.9
± 0.2
|
118 |
MAT-POS-1a788f51-3
|
|
CC(C)NCCOc1ccc2cncc(c2c1)N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.5
± 0.8
|
6.9
± 0.6
|
119 |
MIK-ENA-60569a44-1
|
|
COc1ccc2cncc(c2c1)N3CC[C@@]4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.5
± 0.8
|
6.9
± 0.6
|
120 |
EDJ-MED-b6c6ee2b-5
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cc(cc4)OCCN(C)C)c5cc(ccc5C1=O)Cl |
−9.5
± 0.6
|
6.9
± 0.4
|
121 |
EDJ-MED-d4864bdc-4
|
|
CN(C)CCOc1ccc2cncc(c2c1)N3CCC4(C3=O)CCS(=O)(=O)c5c4cc(cc5)Cl |
−9.4
± 0.6
|
6.9
± 0.4
|
122 |
MAT-POS-b4d6b7fc-5
|
|
CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4cc(cc5)F)Cl |
−9.4
± 0.3
|
6.9
± 0.2
|
123 |
MAT-POS-e75f6e44-7
|
|
CN(C)C1(CC1)CNC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.4
± 0.6
|
6.9
± 0.5
|
124 |
MIK-ENA-623fe2a6-1
|
|
C[C@@H]1CN(C(=O)[C@]12CN(Cc3c2cc(cc3)Cl)S(=O)(=O)CC4(CC4)C#N)c5cncc6c5cccc6 |
−9.4
± 0.8
|
6.8
± 0.6
|
125 |
MAT-POS-e75f6e44-15
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6(CCC6)F |
−9.4
± 0.3
|
6.8
± 0.2
|
126 |
EDG-MED-b1ef7fe3-2
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cc(cc4)F)c5cc(ccc5C1=O)Cl |
−9.4
± 0.4
|
6.8
± 0.3
|
127 |
LUO-POS-868e8996-8
|
|
CNC(=O)CN1C[C@]2(CC(=O)N(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl |
−9.3
± 0.1
|
6.80
± 0.09
|
128 |
MIK-ENA-bb7b6957-1
|
|
COc1ccc2cncc(c2c1)N3CC[C@]4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.3
± 0.9
|
6.8
± 0.6
|
129 |
MAT-POS-1bed62cf-1
|
|
c1ccc2c(c1)cncc2N3C(=O)CC4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.3
± 0.1
|
6.77
± 0.10
|
130 |
MAT-POS-e75f6e44-4
|
|
CC1(CC1)CNC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.3
± 0.2
|
6.7
± 0.2
|
131 |
MAT-POS-e75f6e44-5
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6(CC6)N |
−9.2
± 0.3
|
6.7
± 0.2
|
132 |
EDG-MED-b1ef7fe3-1
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cc(cc4)Cl)c5cc(ccc5C1=O)Cl |
−9.2
± 0.1
|
6.74
± 0.09
|
133 |
EDJ-MED-a12e3a20-1
|
|
c1ccc2c(c1)cncc2N3CC(=O)C4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.2
± 0.8
|
6.7
± 0.6
|
134 |
MAT-POS-566864e2-2
|
|
c1ccc2c(c1)cncc2N3CC[C@]4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
135 |
VLA-UNK-f2612802-1
|
|
CNC(=O)CN1C([C@]2(CCN(C2=O)c3cncc4c3cccc4)c5cc(ccc5S1(=O)=O)Cl)C(F)(F)F |
−9.2
± 0.4
|
6.7
± 0.3
|
136 |
MAT-POS-853c0ffa-22
|
|
CC1(CC1)CS(=O)(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5ccc(c6)S(=O)(=O)C)Cl |
−9.2
± 0.1
|
6.72
± 0.10
|
137 |
EDJ-MED-33064c06-7
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4ccc(c5)S(=O)(=O)C)c6cc(ccc6C2=O)Cl |
−9.2
± 0.1
|
6.70
± 0.10
|
138 |
LUO-POS-e1dab717-4
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4cc(cc5)Cl)c6cc(ccc6C2=O)Cl |
−9.2
± 0.3
|
6.7
± 0.2
|
139 |
EDJ-MED-976a33d5-2
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4ccc(c5)S(=O)(=O)C)c6cc(ccc6C2=O)Cl |
−9.2
± 0.1
|
6.68
± 0.10
|
140 |
LUO-POS-ed2cfb03-1
|
|
CN1CCN(CC1)S(=O)(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.1
± 0.9
|
6.7
± 0.7
|
141 |
LUO-POS-e1dab717-10
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4ccc(c5)S(=O)(=O)C)c6cc(ccc6C2=O)Cl |
−9.1
± 0.1
|
6.65
± 0.09
|
142 |
MAT-POS-e75f6e44-8
|
|
C[C@@H](C1CC1)NC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.1
± 0.3
|
6.6
± 0.3
|
143 |
PET-UNK-77d5678a-3
|
|
COC(=O)CN1C[C@]2(CC(=O)N(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl |
−9.1
± 0.3
|
6.6
± 0.2
|
144 |
EDJ-MED-b6c6ee2b-2
|
|
CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4cc(cc5)OC)Cl |
−9.1
± 0.2
|
6.6
± 0.2
|
145 |
MAT-POS-853c0ffa-20
|
|
CC1(CC1)CS(=O)(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cc(cc6)C(C)(C)O)Cl |
−9.1
± 0.9
|
6.6
± 0.6
|
146 |
ALP-POS-afe0272e-2
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cccc4)c5cc(c(cc5C1=O)Cl)Cl |
−9.1
± 0.4
|
6.6
± 0.3
|
147 |
MAT-POS-be048f2c-5
|
|
CCn1c(ccn1)C(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−9.1
± 0.2
|
6.6
± 0.2
|
148 |
LUO-POS-868e8996-9
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−9.1
± 0.8
|
6.6
± 0.6
|
149 |
EDJ-MED-33064c06-9
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CC(=O)NCC6COC6 |
−9.0
± 0.2
|
6.6
± 0.2
|
150 |
LUO-POS-868e8996-11
|
|
CNC(=O)CN1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cccc5)Cl |
−9.0
± 0.3
|
6.6
± 0.2
|
151 |
EDJ-MED-a12e3a20-2
|
|
CNC(=O)CN1CC2(c3cc(ccc3C1=O)Cl)C(=O)CN(C2=O)c4cncc5c4cccc5 |
−9.0
± 0.4
|
6.5
± 0.3
|
152 |
EDJ-MED-5cd3920d-3
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4cc(cc5)OC(F)F)c6cc(ccc6C2=O)Cl |
−9.0
± 0.5
|
6.5
± 0.3
|
153 |
MAT-POS-1bed62cf-2
|
|
CNC(=O)CN1CC2(CC(=O)N(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl |
−9.0
± 0.1
|
6.52
± 0.09
|
154 |
LUO-POS-b4dec3be-2
|
|
CNC(=O)CN1Cc2ccc(cc2[C@]3(C1)CCN(C3=O)c4cncc5c4cc(cc5)F)Cl |
−9.0
± 0.2
|
6.5
± 0.2
|
155 |
EDJ-MED-7e491f08-2
|
|
CNC(=O)C1(CC1)N2C[C@]3(c4cc(ccc4C2=O)Cl)C(=O)N(CC3(F)F)c5cncc6c5cccc6 |
−8.9
± 0.4
|
6.5
± 0.3
|
156 |
EDJ-MED-9f4ac58c-5
|
|
COC1(CC1)CS(=O)(=O)N2CC3(CCN(C3=O)c4cncc5c4ccc(c5)Cl)c6cc(ccc6C2=O)Cl |
−8.9
± 0.8
|
6.5
± 0.6
|
157 |
MAT-POS-e75f6e44-12
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6(CC6)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
158 |
EDJ-MED-94fddcec-7
|
|
CS(=O)(=O)Nc1ccc2c(c1)cncc2N3CCC4(C3=O)CCS(=O)(=O)c5c4cc(cc5)Cl |
−8.8
± 0.5
|
6.4
± 0.4
|
159 |
EDJ-MED-accc2c4d-2
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)[C@@]6C[C@@]6C#N |
−8.8
± 1.0
|
6.4
± 0.7
|
160 |
LUO-POS-e1dab717-9
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5ccc(c6)S(=O)(=O)C)Cl |
−8.8
± 0.4
|
6.4
± 0.3
|
161 |
MAT-POS-e75f6e44-3
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NC6(CC6)CN |
−8.8
± 0.4
|
6.4
± 0.3
|
162 |
PET-UNK-77d5678a-1
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)CN(Cc5c4cc(cc5)Cl)Cc6nncs6 |
−8.8
± 0.2
|
6.4
± 0.2
|
163 |
EDJ-MED-33064c06-12
|
|
CC(C)(CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl)O |
−8.8
± 0.4
|
6.4
± 0.3
|
164 |
ALP-POS-ecbed2ba-4
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−8.8
± 1.0
|
6.4
± 0.7
|
165 |
LUO-POS-8c3e556a-1
|
|
CNC(=O)CN1C[C@]2(CCN(C2=O)c3cncc4c3cc(cc4)Cl)c5cc(ccc5C1=O)Cl |
−8.8
± 0.3
|
6.4
± 0.2
|
166 |
VLA-UCB-50c39ae8-2
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)CCOc5c4cc(cc5)Cl |
−8.8
± 0.1
|
6.39
± 0.09
|
167 |
MAT-POS-e75f6e44-21
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6CC(C6)(F)F |
−8.7
± 0.6
|
6.4
± 0.4
|
168 |
EDJ-MED-accc2c4d-4
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)C6(CC6)C#N |
−8.7
± 0.8
|
6.4
± 0.6
|
169 |
EDJ-MED-cc48ee33-4
|
|
Cc1cnn(c1C(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl)C |
−8.7
± 0.3
|
6.4
± 0.2
|
170 |
MAT-POS-b4d6b7fc-7
|
|
CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4ccc(c5)NS(=O)(=O)C)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
171 |
EDJ-MED-cc48ee33-2
|
|
Cn1c(ccn1)C(=O)N2CC3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−8.7
± 0.3
|
6.3
± 0.2
|
172 |
EDJ-MED-98c0a822-3
|
|
CNC(=O)C1(CCC1)N2CC3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−8.7
± 0.6
|
6.3
± 0.5
|
173 |
EDJ-MED-dfa1d800-3
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4cc(cc5)OCCN6CCS(=O)(=O)CC6)c7cc(ccc7C2=O)Cl |
−8.7
± 0.7
|
6.3
± 0.5
|
174 |
EDG-MED-b1ef7fe3-3
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3ccc(c4)F)c5cc(ccc5C1=O)Cl |
−8.7
± 0.1
|
6.31
± 0.09
|
175 |
MAT-POS-50a80394-4
|
|
CC1CN(C(=O)C12CN(Cc3c2cc(cc3)Cl)CC(=O)NC)c4cncc5c4cccc5 |
−8.6
± 0.3
|
6.3
± 0.2
|
176 |
EDJ-MED-33064c06-1
|
|
CC(C)(CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl)N |
−8.6
± 0.5
|
6.3
± 0.4
|
177 |
EDJ-MED-33064c06-16
|
|
COC1(CC1)CNC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.6
± 0.5
|
6.3
± 0.3
|
178 |
MAT-POS-853c0ffa-8
|
|
COC1(CC1)CS(=O)(=O)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5c(cc(c6)F)Cl)Cl |
−8.6
± 0.8
|
6.3
± 0.6
|
179 |
JOH-MSK-51c67e7d-2
|
|
CN1Cc2ccc(cc2[C@]3(C1)CC(=O)N(C3=O)c4cncc5c4cccc5)Cl |
−8.6
± 0.2
|
6.3
± 0.2
|
180 |
PET-UNK-94036022-5
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)Cl |
−8.6
± 0.8
|
6.3
± 0.6
|
181 |
EDG-MED-b1ef7fe3-4
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3ccc(c4)Cl)c5cc(ccc5C1=O)Cl |
−8.6
± 0.1
|
6.26
± 0.09
|
182 |
MAT-POS-38eb6498-5
|
|
CNC(=O)CN1Cc2ccc(cc2C3(C1)CCN(C3=O)c4cncc5c4cc(cc5)C(=O)NC)Cl |
−8.6
± 0.1
|
6.25
± 0.08
|
183 |
LUO-POS-9931618f-1
|
|
CNC(=O)CN1C[C@]2(CCN(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl |
−8.6
± 0.4
|
6.2
± 0.3
|
184 |
VLA-UNK-8e615992-4
|
|
CNC(=O)CN1C(C2(CCN(C2=O)c3cncc4c3cccc4)c5cc(ccc5C1=O)Cl)C(F)(F)F |
−8.6
± 0.3
|
6.2
± 0.2
|
185 |
LUO-POS-e1dab717-3
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cc(cc6)Cl)Cl |
−8.6
± 0.2
|
6.2
± 0.2
|
186 |
LUO-POS-e1dab717-1
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.6
± 0.3
|
6.2
± 0.2
|
187 |
MIK-ENA-5d9157e9-2
|
|
c1ccc2c(c1)cncc2N3CC[C@]4(C3=O)CN(Cc5c4cc(cc5)Cl)S(=O)(=O)CC6(CC6)C#N |
−8.6
± 0.8
|
6.2
± 0.6
|
188 |
MAT-POS-e75f6e44-10
|
|
COC1(CC1)CNC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.5
± 0.3
|
6.2
± 0.3
|
189 |
LUO-POS-8c3e556a-2
|
|
CNC(=O)CN1C[C@@]2(CCN(C2=O)c3cncc4c3cc(cc4)Cl)c5cc(ccc5C1=O)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
190 |
MAT-POS-566864e2-4
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3[C@@]4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.5
± 0.4
|
6.2
± 0.3
|
191 |
EDJ-MED-976a33d5-1
|
|
CNC(=O)C1(CC1)N2CC3(CCN(C3=O)c4cncc5c4cccc5)c6cc(ccc6C2=O)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
192 |
ALP-POS-ecbed2ba-7
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
193 |
EDJ-MED-b6c6ee2b-6
|
|
CNC(=O)CN1CC2(CCN(C2=O)c3cncc4c3cc(cc4)F)c5cc(ccc5C1=O)Cl |
−8.5
± 0.4
|
6.2
± 0.3
|
194 |
MAT-POS-e75f6e44-1
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(Cc5c4cc(cc5)Cl)CC(=O)NCC6(CC6)O |
−8.5
± 0.2
|
6.2
± 0.2
|
195 |
ALP-POS-c3a90b22-11
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CC(=O)NCC6CCC6 |
−8.5
± 0.3
|
6.2
± 0.2
|
196 |
EDJ-MED-6b23330e-5
|
|
CC1(CC1)CNC(=O)CN2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.5
± 0.2
|
6.2
± 0.1
|
197 |
MAT-POS-69786b79-1
|
|
CNC(=O)C1(CC1)N2Cc3ccc(cc3C4(C2)CCN(C4=O)c5cncc6c5cccc6)Cl |
−8.5
± 0.3
|
6.2
± 0.2
|
198 |
PET-UNK-37c7074c-3
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)Cc6ccno6 |
−8.5
± 0.2
|
6.2
± 0.1
|
199 |
MAT-POS-94643566-1
|
|
c1ccc2c(c1)cncc2N3C(=O)CC4(C3=O)CCOc5c4cc(cc5)Cl |
−8.4
± 0.1
|
6.15
± 0.08
|
200 |
EDJ-MED-33064c06-18
|
|
c1ccc2c(c1)cncc2N3CCC4(C3=O)CN(C(=O)c5c4cc(cc5)Cl)CC(=O)NC6CC6 |
−8.4
± 0.3
|
6.2
± 0.2
|