Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1301 |
MAT-POS-e9e99895-1_2
|
|
C[C@](c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)[NH3+] |
−7.6
± 0.4
|
1302 |
MAK-UNK-b7886382-1_1
|
|
C[C@@H](C[NH2+]CCCO)N(Cc1ccsc1)C(=O)Cc2cncc3c2cccc3 |
−7.6
± 0.3
|
1303 |
RAL-THA-8416115c-1_4
|
|
c1ccc(cc1)CN2CC[C@H](c3c2ccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.56
± 0.10
|
1304 |
BEN-DND-c852c98b-6_2
|
|
c1cc2cncc(c2cc1OC(F)F)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−7.6
± 0.3
|
1305 |
DAR-DIA-6a508060-10_1
|
|
C[C@@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.6
± 0.4
|
1306 |
EDG-MED-ba1ac7b9-23_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5C[N@]6CC(F)F |
−7.55
± 0.08
|
1307 |
DAR-DIA-0f2f46c9-1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CC[N@@](c4c3cc(cc4)Cl)S(=O)(=O)N |
−7.6
± 0.2
|
1308 |
MIC-UNK-cdc2493e-10_3
|
|
CC(=O)N[C@@H]1CC[C@H](C1)N(c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.6
± 0.3
|
1309 |
BEN-DND-34fc7f90-8_1
|
|
C[N@@H+]1Cc2cc(c(cc2[C@@H](C1)C(=O)Nc3cncc4c3cccc4)Cl)Cl |
−7.6
± 0.1
|
1310 |
VLA-UNK-5b0345c3-3_2
|
|
c1ccc(cc1)COS(=O)(=O)[N@]2Cc3ccc(cc3[C@@H](C2)C(=O)Nc4cncc5c4cccc5)Cl |
−7.5
± 0.5
|
1311 |
MIC-UNK-6ab519a7-1_1
|
|
CC(=O)N1CC[NH+](CC1)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.4
|
1312 |
MIC-UNK-0a05c952-4_1
|
|
c1ccc2c(c1)cncc2N3[C@@H](CC[C@@H](C3=O)c4ccc(c(c4)Cl)Cl)[C@@H]5CO5 |
−7.5
± 0.2
|
1313 |
ED_-GRI-5b13fbe2-12_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[N@H+](CCO)CCOCCO |
−7.5
± 0.2
|
1314 |
MAT-POS-4223bc15-36_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CN(Cc4c3cc(cc4)Cl)C(=O)c5cnco5 |
−7.55
± 0.10
|
1315 |
ALP-POS-3b848b35-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](CCC3CCCCC3)c4cccc(c4)Cl |
−7.5
± 0.3
|
1316 |
EDJ-MED-37aac4bd-4_2
|
|
CO[C@]1(CCOc2c1cc(cc2F)F)C(=O)Nc3cncc4c3cccc4 |
−7.55
± 0.09
|
1317 |
MAK-UNK-8be7dca9-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3C[C@@H](Oc4c3cc(cc4)Cl)C(=O)[O-] |
−7.5
± 0.3
|
1318 |
MAT-POS-fce787c2-10_2
|
|
CN(C)CC[NH2+][C@H](c1ccc(c(c1)Cl)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.5
± 0.3
|
1319 |
KAD-UNI-80f122c8-2_2
|
|
CC(=O)N1C[C@H]2C[C@@H]1CN2C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.54
± 0.10
|
1320 |
EDJ-MED-28ec730d-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−7.5
± 0.4
|
1321 |
RAL-THA-8416115c-9_3
|
|
CN(C)C(=O)CN1CC[C@H](c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.54
± 0.10
|
1322 |
DAR-DIA-9e4459de-15_3
|
|
c1cc2c(c(c1)NC(=O)CCC(=O)Nc3ccc4c(c3)cncc4NC(=O)[C@@H]5CCOc6c5cc(cc6)Cl)c(n(c2O)[C@@H]7CCC(=O)NC7=O)O |
−7.5
± 0.2
|
1323 |
ED_-GRI-5b13fbe2-3_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](c5n[n-]nn5)[NH3+] |
−7.5
± 0.2
|
1324 |
EDJ-MED-1981ceba-3_4
|
|
COC1CN(C1)S(=O)(=O)[N@]2Cc3ccc(cc3[C@H](C2)C(=O)Nc4cncc5c4cccc5)Cl |
−7.5
± 0.2
|
1325 |
MAT-POS-fb82b63d-2_1
|
|
C[C@@]1(c2cc(ccc2CC[NH2+]1)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.2
|
1326 |
PET-UNK-acd70dee-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5=NCCO5 |
−7.53
± 0.09
|
1327 |
EDJ-MED-ee07cf00-18_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)CN4CCN(C4=O)C5CC5 |
−7.53
± 0.09
|
1328 |
ALP-UNI-3496895b-2_5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@@H]5CCC[N@H+]6CCO |
−7.5
± 0.3
|
1329 |
EDJ-MED-fa7708b3-2_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3C[N@H+](Cc4c3cc(cc4)Cl)Cc5[nH]ncn5 |
−7.5
± 0.2
|
1330 |
MIC-UNK-b9827f26-4_1
|
|
COc1ccc(cc1N2CCN(CC2=O)C(=O)c3cncc4c3cccc4)Cl |
−7.5
± 0.1
|
1331 |
JAG-UCB-f37eaa14-8_1
|
|
c1ccc2c(c1)cncc2N3CC[C@@]4(C3=O)C[N@@](c5c4cc(cc5)Cl)CCn6ccnc6 |
−7.5
± 0.2
|
1332 |
MAT-POS-4223bc15-28_4
|
|
COCC[N@H+]1Cc2ccc(cc2[C@H](C1)C(=O)Nc3cncc4c3cccc4)Cl |
−7.53
± 0.09
|
1333 |
ALP-UNI-ba800595-1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCNc4c3cc(cc4Cl)Cl |
−7.5
± 0.1
|
1334 |
EDJ-MED-4f704dc9-1_1
|
|
CO[C@@]1(CCNc2c1cc(c(c2)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.2
|
1335 |
KAD-UNI-cb0f2bbc-10_2
|
|
CC(C)(C)OC(=O)N[C@H](CCO)C[NH2+]C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.1
|
1336 |
EDG-MED-90036822-39_2
|
|
C[C@H](CO)NCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F |
−7.5
± 0.3
|
1337 |
ED_-GRI-5b13fbe2-30_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[NH2+]CCO |
−7.5
± 0.4
|
1338 |
RAL-THA-8416115c-10_3
|
|
CNC(=O)CN1CC[C@H](c2c1ccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.2
|
1339 |
ALF-EVA-b701bd13-5_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCCNc4c3cc(c(c4)Cl)Cl |
−7.5
± 0.4
|
1340 |
MAT-POS-24589f88-14_4
|
|
C[N@H+]1CCN(C(=O)[C@H]1c2cccc(c2)Cl)c3cncc4c3cccc4 |
−7.52
± 0.09
|
1341 |
KAD-UNI-8a629cb0-38_2
|
|
C[N@]1[C@@H](CCS1(=O)=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.5
± 0.4
|
1342 |
MAT-POS-1f3f1a6f-3_2
|
|
CC(=O)N[C@H](c1ccc(c(c1)Cl)Cl)C(=O)Nc2cncc3c2cccc3 |
−7.52
± 0.10
|
1343 |
MIC-UNK-bcd487e9-6_1
|
|
c1ccc2c(c1)cncc2NC(=O)N(C[C@@H]3CCCS3(=O)=O)c4cccc(c4)Cl |
−7.5
± 0.4
|
1344 |
MAK-UNK-c749d764-26_8
|
|
c1ccc2c(c1)cncc2NC(=O)C[C@H]3CCCC[C@H]([C@H]3O)Cl |
−7.5
± 0.4
|
1345 |
MIC-UNK-0a05c952-4_2
|
|
c1ccc2c(c1)cncc2N3[C@H](CC[C@@H](C3=O)c4ccc(c(c4)Cl)Cl)[C@@H]5CO5 |
−7.5
± 0.2
|
1346 |
DAR-DIA-56cf811e-5_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)/C=C/C(F)(F)F |
−7.5
± 0.2
|
1347 |
ED_-GRI-5b13fbe2-23_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[N@H+]5CCn6c(c(cn6)C[NH3+])C5 |
−7.5
± 0.3
|
1348 |
JOH-UNI-a38a7bdd-5_4
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)[C@H]4C[C@H]4F |
−7.5
± 0.5
|
1349 |
ALP-POS-869ac754-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3ccc(c4Cl)Cl |
−7.51
± 0.10
|
1350 |
MAK-UNK-c749d764-15_15
|
|
C[C@@H](N(c1cncc2c1cccc2)C(=O)C[C@H]3CCC[C@H]([C@H]3O)C(F)F)OCC4CCCCC4 |
−7.5
± 0.3
|
1351 |
MAT-POS-e9e99895-12_1
|
|
C[C@@](c1ccc(c(c1)Cl)Cl)(C(=O)Nc2cncc3c2cccc3)NC(=O)CC[NH+](C)C |
−7.5
± 0.6
|
1352 |
MIC-UNK-5a93dd5f-11_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[NH+]4CCC(CC4)[NH+]5CCCCC5 |
−7.5
± 0.3
|
1353 |
EDG-MED-4c68219f-14_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@H]5C[C@H]([NH2+]C5)CO |
−7.5
± 0.4
|
1354 |
EDJ-MED-15e90dfc-1_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)C[NH2+]Cc5ccn[nH]5 |
−7.5
± 0.2
|
1355 |
MAK-UNK-c749d764-24_8
|
|
CCN(c1cncc2c1cccc2)C(=O)C[C@H]3CCC[C@H]([C@H]3O)C(F)F |
−7.5
± 0.3
|
1356 |
FRA-DIA-b66f7109-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3COc4c3cc(cc4Cl)O[C@H]5CC(=O)N5 |
−7.5
± 0.4
|
1357 |
MAT-POS-4223bc15-11_1
|
|
C[C@@H]1CC[N@@](C1)S(=O)(=O)[N@@]2Cc3ccc(cc3[C@@H](C2)C(=O)Nc4cncc5c4cccc5)Cl |
−7.51
± 0.09
|
1358 |
MAK-UNK-8be7dca9-10_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3C[C@@H](Oc4c3cc(cc4)Cl)C(=O)[O-] |
−7.5
± 0.4
|
1359 |
EDJ-MED-f893e2a1-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC[C@]5(CCOC5)C#N |
−7.5
± 0.1
|
1360 |
FRA-DIA-b66f7109-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CNc4c3cc(cc4Cl)O[C@@H]5CC(=O)N5 |
−7.5
± 0.3
|
1361 |
ALP-UNI-44c99a80-2_1
|
|
c1ccc2c(c1)cncc2N(Cc3cnc[nH]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−7.5
± 0.3
|
1362 |
BEN-DND-c852c98b-6_1
|
|
c1cc2cncc(c2cc1OC(F)F)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.5
± 0.3
|
1363 |
ROB-UNI-7b37d95b-1_1
|
|
C[C@H]1CNc2cc(c(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)F)F |
−7.50
± 0.06
|
1364 |
MAK-UNK-c749d764-10_4
|
|
CSN(c1cncc2c1cccc2)C(=O)C[C@H]3CCC[C@H]([C@@H]3O)C(F)F |
−7.50
± 0.08
|
1365 |
ALP-POS-9c80c481-1_1
|
|
CNC(=O)COC[C@@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.50
± 0.09
|
1366 |
ALP-POS-347519b5-3_58
|
|
CS(=O)(=O)[N@]1C[C@@H]2[C@@H]3CC[C@H]([C@H]2[C@H](C1)C(=O)Nc4cncc5c4cccc5)O3 |
−7.5
± 0.3
|
1367 |
PET-UNK-7a31b064-1_1
|
|
CN1C[C@H](C(=O)N(C1=O)c2cncc3c2cccc3)c4cccc(c4)Cl |
−7.5
± 0.1
|
1368 |
ED_-GRI-5b13fbe2-6_1
|
|
C[NH+](C)CC(=O)NC[C@H](CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−7.5
± 0.2
|
1369 |
DAR-DIA-0587064e-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OCCC(F)(F)F |
−7.5
± 0.2
|
1370 |
MAT-POS-61f37a1a-11_1
|
|
COC(=O)CCc1c(con1)C[NH2+]C[C@@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−7.49
± 0.09
|
1371 |
MAK-UNK-ffc90da7-4_8
|
|
C[C@H](C[NH2+]C[C@H]1CCCO1)[C@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.2
|
1372 |
JOH-UNI-a38a7bdd-6_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)[C@@H]4C[C@@H]4C(F)(F)F |
−7.5
± 0.3
|
1373 |
ROB-UNI-611831f5-2_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCNc4c3cc(cn4)Cl |
−7.5
± 0.2
|
1374 |
EDG-MED-90036822-61_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[NH+]5CCC5 |
−7.5
± 0.3
|
1375 |
DAR-DIA-6a508060-11_4
|
|
c1ccc2c(c1)cncc2NC(=O)C3CC(C3)[C@H]4C[C@H]4Cl |
−7.5
± 0.2
|
1376 |
MAT-POS-2492181e-11_1
|
|
CC(C)Cn1cc(c2ccccc2c1=O)NC(=O)NCC[NH+]3CCOCC3 |
−7.5
± 0.2
|
1377 |
ALP-POS-347519b5-1_35
|
|
CS(=O)(=O)[N@@]1C[C@H]2[C@@H]3CC[C@@H](C3)[C@@H]2[C@H](C1)C(=O)Nc4cncc5c4cccc5 |
−7.5
± 0.2
|
1378 |
ALP-UNI-8e43a71e-15_13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@H]5C[C@@H](C6)C(=O)N |
−7.5
± 0.2
|
1379 |
MIC-UNK-5a93dd5f-2_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H](c3cccc(c3)Cl)[NH+]4C[C@H]5CCCC[C@@H]5C4 |
−7.5
± 0.1
|
1380 |
EDJ-MED-f893e2a1-2_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC[C@]5(CCOC5)C#N |
−7.5
± 0.3
|
1381 |
PET-UNK-a692de38-1_1
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)NC#N |
−7.5
± 0.3
|
1382 |
DAR-DIA-0d514e7d-31_4
|
|
C[C@H]1CCO[C@H]2C=CC(=C[C@@H]2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−7.5
± 0.2
|
1383 |
WIL-UCB-7ba4ac3a-2_1
|
|
CN(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.5
± 0.2
|
1384 |
RAL-THA-05e671eb-24_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cccc4C#N |
−7.5
± 0.3
|
1385 |
MAT-POS-54c4bf04-3_1
|
|
c1ccc2c(c1)cncc2C(=O)N3CCN(CC3)c4cccc(c4)Cl |
−7.48
± 0.09
|
1386 |
MAT-POS-f39f51fd-1_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CC(=O)Nc4c3cc(cc4Cl)Cl |
−7.48
± 0.09
|
1387 |
ALP-UNI-8e43a71e-2_6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@H]5CCC[N@@H+]6CCO |
−7.48
± 0.09
|
1388 |
ALP-POS-fe871b40-3_1
|
|
CO[C@@]1(CCOc2c1cc(cc2C#N)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.2
|
1389 |
PET-UNK-5ecb6237-1_1
|
|
c1ccc2c(c1)cncc2N(C#N)C(=O)Cc3cccc(c3)Cl |
−7.5
± 0.6
|
1390 |
JOH-UNI-ea72002d-3_3
|
|
c1ccc2c(c1)cncc2[C@@H](C(=O)[C@H]3CCOc4c3cc(cc4)Cl)N5C(=O)C=CC5=O |
−7.5
± 0.5
|
1391 |
ALP-POS-ce760d3f-7_2
|
|
c1cc2cncc(c2cc1F)NC(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−7.5
± 0.3
|
1392 |
ALP-UNI-3496895b-5_2
|
|
C[C@H]1C[N@@](CC[C@@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−7.5
± 0.4
|
1393 |
DAR-DIA-0587064e-21_2
|
|
c1ccc(cc1)CCOc2cc(cc3c2NCC[C@H]3C(=O)Nc4cncc5c4cccc5)Cl |
−7.5
± 0.2
|
1394 |
JOH-UNI-a38a7bdd-6_4
|
|
c1ccc2c(c1)cncc2N(C(=O)Cc3cccc(c3)Cl)C(=O)[C@H]4C[C@H]4C(F)(F)F |
−7.5
± 0.3
|
1395 |
MIC-UNK-5a93dd5f-3_8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[N@H+]4CC[C@H]5CCCC[C@@H]5C4 |
−7.5
± 0.3
|
1396 |
ED_-GRI-5b13fbe2-25_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[NH2+]CCOCCO |
−7.5
± 0.3
|
1397 |
MIC-UNK-5a93dd5f-3_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)[N@H+]4CC[C@@H]5CCCC[C@@H]5C4 |
−7.5
± 0.2
|
1398 |
KAD-UNI-cb0f2bbc-7_1
|
|
C[C@@]1(CCS(=O)(=O)C1)n2cc(cn2)C[NH2+]C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−7.5
± 0.1
|
1399 |
DAR-DIA-0587064e-10_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OCCC(F)(F)F)Cl |
−7.46
± 0.09
|
1400 |
VLA-UCB-34f3ed0c-21_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CC[C@@H]5CC(=O)NC5 |
−7.5
± 0.3
|