Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2001 |
EDJ-MED-d203f206-15
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5[C@H](CO)O |
−5.7
± 0.4
|
4.1
± 0.3
|
2002 |
DAR-DIA-0cde14eb-59
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cccc(c3)C4(CC4)C#N |
−5.7
± 0.2
|
4.1
± 0.2
|
2003 |
VLA-UNK-3a43cd95-1
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@@]4(CCOc5c4cc(c(c5)F)Cl)NC3=O |
−5.7
± 0.2
|
4.1
± 0.2
|
2004 |
ED_-GRI-5b13fbe2-61
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)C6CCNC6 |
−5.7
± 0.4
|
4.1
± 0.3
|
2005 |
EDG-MED-90036822-97
|
|
CN1CCC(CC1)[C@H](CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−5.7
± 0.4
|
4.1
± 0.3
|
2006 |
EDJ-MED-015fb6b4-2
|
|
CNC(=O)CN1CC(c2cc(ccc2C1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.7
± 0.2
|
4.1
± 0.2
|
2007 |
EDJ-MED-b7309adf-1
|
|
c1cc2c(cc1F)cncc2NC(=O)C3CCS(=O)(=O)c4c3cc(cc4)Cl |
−5.7
± 0.3
|
4.1
± 0.2
|
2008 |
MAT-POS-8a69d52e-6
|
|
C[C@@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−5.65
± 0.10
|
4.12
± 0.07
|
2009 |
MAT-POS-9db1e783-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)O |
−5.65
± 0.06
|
4.12
± 0.05
|
2010 |
CHO-MSK-5891c1ff-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(F)F |
−5.7
± 0.3
|
4.1
± 0.3
|
2011 |
KAD-UNI-80f122c8-4
|
|
CCN1CCN(CC1)C2CN(C2)C(=O)CC3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.6
± 0.4
|
4.1
± 0.3
|
2012 |
EDJ-MED-6864a934-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnn5CC#N |
−5.6
± 0.4
|
4.1
± 0.3
|
2013 |
MAT-POS-4223bc15-32
|
|
c1ccc2c(c1)cncc2NC(=O)C3CN(Cc4c3cc(cc4)Cl)c5[nH]ccn5 |
−5.6
± 0.2
|
4.1
± 0.1
|
2014 |
KAD-UNI-8a629cb0-42
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5CN6C(=O)N |
−5.6
± 0.3
|
4.1
± 0.3
|
2015 |
PET-UNK-bcc8fd08-6
|
|
[2H]C([2H])([2H])O[C@]1(CN(Cc2c1cc(cc2)Cl)S(=O)(=O)C)C(=O)Nc3cncc4c3ccc(c4)F |
−5.6
± 0.2
|
4.1
± 0.2
|
2016 |
RAL-THA-e002e396-3
|
|
c1ccc(cc1)S(=O)(=O)CC2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.6
± 0.1
|
4.11
± 0.09
|
2017 |
ALP-POS-64a710fa-2
|
|
CN(C)CCCN(Cc1cccs1)C(=O)Cc2cncc3c2cccc3 |
−5.64
± 0.10
|
4.11
± 0.07
|
2018 |
PET-UNK-bcc8fd08-4
|
|
[2H]C([2H])([2H])O[C@]1(CN(Cc2c1cc(cc2)Cl)S(=O)(=O)C)C(=O)Nc3cncc4c3cccc4 |
−5.6
± 0.3
|
4.1
± 0.2
|
2019 |
RAL-THA-58fba2bc-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CCO |
−5.6
± 0.2
|
4.1
± 0.1
|
2020 |
ED_-GRI-5b13fbe2-64
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)[C@H]6CC[C@H](C6)N |
−5.6
± 0.4
|
4.1
± 0.3
|
2021 |
DAR-DIA-0d514e7d-29
|
|
C[C@@H]1COc2ccc(cc2[C@]1(C)C(=O)Nc3cncc4c3cccc4)Cl |
−5.6
± 0.3
|
4.1
± 0.2
|
2022 |
ALP-UNI-0676e700-28
|
|
Cn1cc(c(=O)n(c1=O)C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.6
± 0.4
|
4.1
± 0.3
|
2023 |
EDJ-MED-fcba3f31-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)[nH]n5 |
−5.6
± 0.3
|
4.1
± 0.2
|
2024 |
ALP-UNI-dbbfd3db-12
|
|
Cc1c(c(=O)ccn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−5.6
± 0.4
|
4.1
± 0.3
|
2025 |
EDG-MED-90036822-72
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(n[nH]5)F |
−5.6
± 0.5
|
4.1
± 0.3
|
2026 |
EDJ-MED-d203f206-20
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ncncn5 |
−5.6
± 0.3
|
4.1
± 0.2
|
2027 |
DAR-DIA-0587064e-6
|
|
c1ccc(cc1)CCOc2cc(cc(c2)Cl)CC(=O)Nc3cncc4c3cccc4 |
−5.63
± 0.10
|
4.10
± 0.07
|
2028 |
MIC-UNK-d854bf4c-3
|
|
CC(=O)N1CCC2(CC1)CCN(C(=O)C2c3cccc(c3)Cl)c4cncc5c4cccc5 |
−5.63
± 0.07
|
4.10
± 0.05
|
2029 |
PET-UNK-4b4f2bb7-5
|
|
CO[C@]1(CCS(=O)(=O)c2c1cc(cc2)Cl)C(=O)Nc3cncc4c3ccc(c4)F |
−5.6
± 0.3
|
4.1
± 0.2
|
2030 |
JIN-POS-6dc588a4-24
|
|
c1ccc2c(c1)c(cnc2C#N)NC(=O)Cc3cccc(c3)Cl |
−5.62
± 0.10
|
4.10
± 0.07
|
2031 |
PET-UNK-b566c0b0-1
|
|
CO[C@]1(CS(=O)(=O)Cc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3ccc(c4)F |
−5.6
± 0.2
|
4.1
± 0.2
|
2032 |
ALP-POS-25b4df59-2
|
|
Cc1ccc(cc1)N(Cc2c[nH]cn2)C(=O)Cc3cncc4c3cccc4 |
−5.6
± 0.3
|
4.1
± 0.2
|
2033 |
DAR-DIA-0587064e-19
|
|
c1ccc(cc1)COc2cc(cc3c2OCCC3C(=O)Nc4cncc5c4cccc5)Cl |
−5.62
± 0.09
|
4.09
± 0.06
|
2034 |
RAL-THA-1d44ff04-9
|
|
CS(=O)(=O)NCc1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2cccc3 |
−5.6
± 0.3
|
4.1
± 0.2
|
2035 |
PET-UNK-1320d94d-28
|
|
CN([C@@H](c1cccc(c1)Cl)C(=O)Nc2cncc3c2cccc3)C(=O)[C@@H]4C[C@@H](O4)C(=O)N5CCCC5 |
−5.6
± 0.2
|
4.1
± 0.2
|
2036 |
ALP-POS-a0a4abd7-8
|
|
Cn1cc(c(=O)[nH]c1=O)CCN(c2cncc3c2cccc3)C(=O)C4CCOc5c4ccc(c5)Cl |
−5.6
± 0.2
|
4.1
± 0.1
|
2037 |
MIC-UNK-ddc6ad53-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)OCCC(F)(F)F |
−5.6
± 0.3
|
4.1
± 0.2
|
2038 |
EDG-MED-90036822-92
|
|
CN(CCC#N)CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F |
−5.6
± 0.5
|
4.1
± 0.3
|
2039 |
EDJ-MED-fa7708b3-3
|
|
Cc1nc([nH]n1)CN2Cc3ccc(cc3C(C2)C(=O)Nc4cncc5c4cccc5)Cl |
−5.6
± 0.2
|
4.1
± 0.1
|
2040 |
PET-UNK-cf04cb02-1
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(cc(c3)Cl)OC4CCN4 |
−5.6
± 0.2
|
4.1
± 0.2
|
2041 |
RAL-THA-2d450e86-24
|
|
c1ccc2c(c1)cncc2NC(=O)Cc3cc(ccc3Cl)Cl |
−5.6
± 0.4
|
4.1
± 0.3
|
2042 |
LAU-MED-88a3970a-18
|
|
CNC(=O)CCc1cc(cc2c1OCC[C@@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−5.6
± 0.1
|
4.08
± 0.10
|
2043 |
DAR-DIA-076fb6ea-9
|
|
c1ccc2c(c1)cncc2N(C#CC3CCCN3)C(=O)Cc4cccc(c4)Cl |
−5.6
± 0.2
|
4.1
± 0.2
|
2044 |
RAL-THA-05e671eb-31
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3c(c(cc4)Cl)C#N |
−5.6
± 0.5
|
4.1
± 0.4
|
2045 |
EDJ-MED-d203f206-26
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H](C5)O |
−5.6
± 0.3
|
4.1
± 0.2
|
2046 |
MAT-POS-8a69d52e-5
|
|
C[C@H]1COc2ccc(cc2[C@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−5.59
± 0.10
|
4.08
± 0.07
|
2047 |
EDG-MED-90036822-26
|
|
Cn1cncc1C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−5.6
± 0.3
|
4.1
± 0.2
|
2048 |
ED_-GRI-5b13fbe2-56
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5[nH]nnn5 |
−5.6
± 0.7
|
4.1
± 0.5
|
2049 |
EDJ-MED-92e193ae-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCNc4c3cc(cc4)Cl |
−5.59
± 0.10
|
4.07
± 0.07
|
2050 |
EDJ-MED-d203f206-22
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5C(=O)N |
−5.6
± 0.4
|
4.1
± 0.3
|
2051 |
EDJ-MED-670ad2ee-3
|
|
CO[C@]1(CN(Cc2c1cc(cc2)Cl)S(=O)(=O)C)C(=O)Nc3cncc4c3cc(cc4)F |
−5.6
± 0.3
|
4.1
± 0.2
|
2052 |
MAT-POS-c7771779-2
|
|
COC1(CC(=O)Nc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.6
± 0.5
|
4.1
± 0.3
|
2053 |
ALP-UNI-76695c4f-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6CS(=O)(=O)CC6C5 |
−5.6
± 0.3
|
4.1
± 0.2
|
2054 |
ALP-UNI-76695c4f-3
|
|
Cn1c(=O)c2c(cn1)CN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.6
± 0.5
|
4.1
± 0.4
|
2055 |
DAR-DIA-4987d2cd-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3c4cc(ccc4CN3c5c(c(=O)c5=O)N)Cl |
−5.6
± 0.1
|
4.07
± 0.09
|
2056 |
ALP-UNI-dbbfd3db-17
|
|
Cc1c(c(=O)n2c(n1)cc[nH]2)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.6
± 0.2
|
4.1
± 0.2
|
2057 |
MAT-POS-a3f7f96a-8
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CNCc5cc6c(nc5)OCC(=O)N6 |
−5.6
± 0.2
|
4.1
± 0.1
|
2058 |
EDG-MED-90036822-109
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCN5CCC(C5)F |
−5.6
± 0.5
|
4.1
± 0.3
|
2059 |
CHE-UNK-1fcbaeee-3
|
|
C=CC(=O)c1ccc(cc1)N(c2cncc3c2cccc3)C(=O)C4CCOc5c4cccc5 |
−5.6
± 0.2
|
4.1
± 0.1
|
2060 |
ALP-POS-ddb41b15-6
|
|
c1ccc2c(c1)cncc2NC(=O)Oc3cccc(c3)Cl |
−5.6
± 0.1
|
4.1
± 0.1
|
2061 |
EDG-MED-4c68219f-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N |
−5.6
± 0.5
|
4.1
± 0.4
|
2062 |
PET-UNK-acd70dee-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nncs5 |
−5.6
± 0.3
|
4.1
± 0.2
|
2063 |
JOH-UNI-3fc3434e-3
|
|
c1cc(cc(c1)Cl)CC(=O)Nc2cncc3c2c(ccc3)CC(F)(F)F |
−5.6
± 0.4
|
4.1
± 0.3
|
2064 |
ED_-GRI-5b13fbe2-37
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cn(nn5)C[C@@H]6CCCN6 |
−5.6
± 0.4
|
4.1
± 0.3
|
2065 |
MIC-UNK-ea4eb352-12
|
|
COC1(CCSc2c1cc(c(c2)F)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.6
± 0.2
|
4.1
± 0.1
|
2066 |
EDJ-MED-d203f206-42
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]([C@H]5CO)CO |
−5.6
± 0.4
|
4.0
± 0.3
|
2067 |
MAT-POS-ec6d90b7-2
|
|
c1ccc2c(c1)cncc2N3C(=O)[C@]4(CCOc5c4cc(cc5)Cl)OC3=O |
−5.56
± 0.10
|
4.05
± 0.07
|
2068 |
MIC-UNK-c5a20098-1
|
|
c1ccc2c(c1)cncc2C(=O)C3CCN(CC3)c4cccc(c4)Cl |
−5.6
± 0.3
|
4.0
± 0.2
|
2069 |
PET-UNK-9b23ef84-4
|
|
CO[C@]1(CN(Cc2c1cc(cc2)Cl)c3nnco3)C(=O)Nc4cncc5c4cccc5 |
−5.6
± 0.2
|
4.0
± 0.2
|
2070 |
ALP-UNI-3496895b-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)CCCO |
−5.6
± 0.4
|
4.0
± 0.3
|
2071 |
MAT-POS-c74bc7b3-2
|
|
C[C@@]1(CCNc2c1cc(c(c2)Cl)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.55
± 0.10
|
4.04
± 0.07
|
2072 |
RAL-THA-e002e396-12
|
|
CCOCC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.5
± 0.5
|
4.0
± 0.4
|
2073 |
EDG-MED-90036822-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](CN)F |
−5.5
± 0.4
|
4.0
± 0.3
|
2074 |
MAT-POS-2bb0cf2b-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CN |
−5.55
± 0.10
|
4.04
± 0.07
|
2075 |
ED_-GRI-5b13fbe2-43
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H](CF)N |
−5.5
± 0.3
|
4.0
± 0.2
|
2076 |
ALP-UNI-0676e700-23
|
|
Cn1cc(nn1)c2cc(no2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−5.5
± 0.3
|
4.0
± 0.2
|
2077 |
ALP-POS-c3a96089-2
|
|
Cc1ccc(nc1)N(Cc2cscn2)C(=O)Cc3cncc4c3cccc4 |
−5.54
± 0.10
|
4.04
± 0.07
|
2078 |
EDJ-MED-670ad2ee-9
|
|
CNS(=O)(=O)N1Cc2ccc(cc2[C@@H](C1)C(=O)Nc3cncc4c3cc(cc4)F)Cl |
−5.5
± 0.3
|
4.0
± 0.2
|
2079 |
ALP-POS-a0a4abd7-4
|
|
Cn1cc(c(=O)[nH]c1=O)NCC2(CCOc3c2ccc(c3)Cl)C(=O)Nc4cncc5c4cccc5 |
−5.5
± 0.2
|
4.0
± 0.1
|
2080 |
RAL-THA-05e671eb-6
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C(F)(F)F |
−5.5
± 0.3
|
4.0
± 0.2
|
2081 |
ED_-GRI-5b13fbe2-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(CN)c5[nH]nnn5 |
−5.5
± 0.2
|
4.0
± 0.2
|
2082 |
MAT-POS-4223bc15-20
|
|
CCOC(=O)N1Cc2ccc(cc2C(C1)C(=O)Nc3cncc4c3cccc4)Cl |
−5.5
± 0.2
|
4.0
± 0.1
|
2083 |
PET-UNK-e8c7a26f-1
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)Cc3ccc(cc3)Cl |
−5.5
± 0.2
|
4.0
± 0.1
|
2084 |
PET-UNK-1320d94d-22
|
|
CN(C)C(=O)[C@H]1CC[C@H](O1)C(=O)N(C)[C@@H](c2cccc(c2)Cl)C(=O)Nc3cncc4c3cccc4 |
−5.5
± 0.2
|
4.0
± 0.2
|
2085 |
VLA-UNK-3a43cd95-3
|
|
c1ccc2c(c1)cncc2N3C(=O)C[C@@]4(C3=O)CCOc5c4cc(c(c5)F)Cl |
−5.5
± 0.1
|
4.02
± 0.10
|
2086 |
PET-UNK-b566c0b0-8
|
|
CN(C)S(=O)(=O)N1Cc2ccc(cc2[C@@](C1)(C(=O)Nc3cncc4c3cc(cc4)F)OC)Cl |
−5.5
± 0.3
|
4.0
± 0.2
|
2087 |
MAT-POS-64942dd0-4
|
|
CC1(CN(Cc2c1cc(c(c2)F)Cl)S(=O)(=O)C)C(=O)Nc3cncc4c3cccc4 |
−5.5
± 0.1
|
4.0
± 0.1
|
2088 |
ALP-UNI-dbbfd3db-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCN(C5=O)C6CC6 |
−5.5
± 0.2
|
4.0
± 0.1
|
2089 |
PET-UNK-ac320b15-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H](c3cccc(c3)Cl)NC(=O)[C@H]4CC[C@H](O4)C(=O)N5CCCC5 |
−5.5
± 0.2
|
4.0
± 0.1
|
2090 |
EDJ-MED-d203f206-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@@H]5c6ncon6 |
−5.5
± 0.3
|
4.0
± 0.2
|
2091 |
MAK-UNK-3875bbc8-2
|
|
CN(c1cncc2c1cccc2)C(=O)C3CCOc4c3cc(cc4)Cl |
−5.5
± 0.2
|
4.0
± 0.1
|
2092 |
EDJ-MED-4c7486ba-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5COCCN5CC(F)(F)F |
−5.5
± 0.5
|
4.0
± 0.3
|
2093 |
JIN-POS-6dc588a4-23
|
|
COc1c2ccccc2c(cn1)NC(=O)Cc3cccc(c3)Cl |
−5.51
± 0.10
|
4.01
± 0.07
|
2094 |
EDG-MED-90036822-105
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CNC5CC5)(F)F |
−5.5
± 0.4
|
4.0
± 0.3
|
2095 |
PET-UNK-9bf1291a-3
|
|
CC(=O)N1Cc2ccc(cc2[C@@](C1)(C(=O)Nc3cncc4c3cccc4)OC)Cl |
−5.5
± 0.7
|
4.0
± 0.5
|
2096 |
MAT-POS-de59a476-6
|
|
c1ccc2c(c1)cncc2NC(=O)C(c3ccc(c(c3)Cl)Cl)OCC(=O)NC4CC4 |
−5.5
± 0.2
|
4.0
± 0.2
|
2097 |
EDJ-MED-d203f206-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@](C5)(CO)O |
−5.5
± 0.3
|
4.0
± 0.2
|
2098 |
EDG-MED-90036822-78
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(C5CC5)O)F |
−5.5
± 0.2
|
4.0
± 0.2
|
2099 |
ERI-UCB-b3e6b0c2-10
|
|
c1cc2c(cc1CN)cncc2NC(=O)[C@@H]3COc4c3cc(cc4)Cl |
−5.5
± 0.2
|
4.0
± 0.1
|
2100 |
EDG-MED-90036822-87
|
|
CN(C)CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F |
−5.5
± 0.4
|
4.0
± 0.3
|