Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
901 |
MAT-POS-8a69d52e-4
|
|
CC1COc2ccc(cc2C1C(=O)Nc3cncc4c3cccc4)Cl |
−8.01
± 0.08
|
5.84
± 0.06
|
902 |
EN300-227055_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CC(=O)NC5=O |
−8.0
± 0.2
|
5.8
± 0.1
|
903 |
EN300-309235_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)CO |
−8.0
± 0.2
|
5.8
± 0.2
|
904 |
EN300-233951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC(C5)O |
−8.0
± 0.2
|
5.8
± 0.1
|
905 |
EN300-49777_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)N6CCNC6=O |
−8.0
± 0.3
|
5.8
± 0.2
|
906 |
EN300-101443_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(COC5)O |
−8.0
± 0.2
|
5.8
± 0.2
|
907 |
EN300-1212400_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(CC5CO)CO |
−8.0
± 0.2
|
5.8
± 0.1
|
908 |
EN300-1707774_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)OC(=O)N |
−8.0
± 0.2
|
5.8
± 0.2
|
909 |
EN300-70815_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ccn(n5)CCO |
−8.0
± 0.2
|
5.8
± 0.2
|
910 |
EN300-58864_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)C(=O)N |
−8.0
± 0.2
|
5.8
± 0.2
|
911 |
EN300-144970_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)CO |
−8.0
± 0.2
|
5.8
± 0.1
|
912 |
EN300-61636_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)C(=O)NC6CC6 |
−8.0
± 0.2
|
5.8
± 0.2
|
913 |
EN300-172179_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCOC5=O |
−8.0
± 0.2
|
5.8
± 0.2
|
914 |
EN300-75875_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccnnc5 |
−8.0
± 0.2
|
5.8
± 0.2
|
915 |
EN300-80083_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCCC(=O)N5 |
−8.0
± 0.3
|
5.8
± 0.2
|
916 |
EN300-261210_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOC5)C#N |
−8.0
± 0.2
|
5.8
± 0.1
|
917 |
EN300-1722016_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)n6nccn6 |
−8.0
± 0.2
|
5.8
± 0.2
|
918 |
EN300-1387104_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCS5(=O)=O |
−8.0
± 0.2
|
5.8
± 0.1
|
919 |
EN300-7354033_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CC(C5)S(=O)(=O)C6 |
−8.0
± 0.2
|
5.8
± 0.2
|
920 |
JAG-UCB-706446eb-7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCOC5 |
−8.0
± 0.2
|
5.8
± 0.1
|
921 |
EN300-52193_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CCO |
−8.0
± 0.3
|
5.8
± 0.2
|
922 |
EN300-142412_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCCC(=O)N |
−8.0
± 0.3
|
5.8
± 0.2
|
923 |
EN300-68747_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)C(=O)N |
−8.0
± 0.3
|
5.8
± 0.2
|
924 |
EN300-1091489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@@H]5CC(C6)C(=O)N |
−8.0
± 0.3
|
5.8
± 0.2
|
925 |
EN300-1719432_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5nc(nn5)C6CC6 |
−8.0
± 0.2
|
5.8
± 0.2
|
926 |
EN300-1706036_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5C(=O)NCCO5 |
−8.0
± 0.2
|
5.8
± 0.1
|
927 |
EN300-141254_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCSCC5c6[nH]nnn6 |
−8.0
± 0.2
|
5.8
± 0.2
|
928 |
EN300-704039_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C56CCOCC6)O |
−8.0
± 0.3
|
5.8
± 0.2
|
929 |
EN300-19507_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(F)F |
−8.0
± 0.2
|
5.8
± 0.1
|
930 |
EN300-65383_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cc[nH]c(=O)c5=O |
−8.0
± 0.4
|
5.8
± 0.3
|
931 |
EN300-25702_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)O |
−8.0
± 0.2
|
5.8
± 0.1
|
932 |
MAK-UNK-8be7dca9-1
|
|
c1cc2c(cc1CN3CCNCC3)cncc2NC(=O)C4CCOc5c4cc(cc5)Cl |
−8.0
± 0.1
|
5.81
± 0.10
|
933 |
EN300-364612_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC6C5C(=O)NCCO6 |
−8.0
± 0.2
|
5.8
± 0.2
|
934 |
EN300-7493255_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(OCC56CC6)CO |
−8.0
± 0.3
|
5.8
± 0.2
|
935 |
EN300-203118_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(CO)F |
−8.0
± 0.2
|
5.8
± 0.1
|
936 |
EN300-75875_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnnc5 |
−8.0
± 0.2
|
5.8
± 0.1
|
937 |
EN300-28262_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6n5ncn6 |
−8.0
± 0.2
|
5.8
± 0.2
|
938 |
EN300-1265948_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N5CCS(=O)(=O)CC5 |
−8.0
± 0.3
|
5.8
± 0.2
|
939 |
EN300-1719432_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5nc(nn5)C6CC6 |
−8.0
± 0.2
|
5.8
± 0.2
|
940 |
EN300-97758_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCF |
−8.0
± 0.2
|
5.8
± 0.1
|
941 |
EN300-148421_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOC5)O |
−8.0
± 0.2
|
5.8
± 0.1
|
942 |
EN300-7457159_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5cc(on5)C6(COC6)O |
−8.0
± 0.3
|
5.8
± 0.2
|
943 |
EN300-24297_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5csnn5 |
−8.0
± 0.2
|
5.8
± 0.2
|
944 |
EN300-861925_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC(CO)F |
−8.0
± 0.2
|
5.8
± 0.1
|
945 |
EN300-35789_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cccnc5=O |
−8.0
± 0.3
|
5.8
± 0.2
|
946 |
EN300-205616_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6[nH]cnn6 |
−8.0
± 0.2
|
5.8
± 0.1
|
947 |
EN300-310888_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nnc6n5CCOCC6 |
−8.0
± 0.3
|
5.8
± 0.3
|
948 |
EN300-82179_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC(=O)N |
−8.0
± 0.2
|
5.8
± 0.2
|
949 |
EN300-150212_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc(n[nH]5)F |
−8.0
± 0.2
|
5.8
± 0.2
|
950 |
EN300-7457160_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5=NOC(C5)CC6(COC6)O |
−8.0
± 0.2
|
5.8
± 0.2
|
951 |
EN300-134204_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCc5[nH]nnn5 |
−7.9
± 0.3
|
5.8
± 0.2
|
952 |
EN300-212795_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5CNC(=O)N |
−7.9
± 0.2
|
5.8
± 0.2
|
953 |
EN300-41549_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)CNC(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
954 |
EN300-1267093_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6C[C@@]6(C5)O |
−7.9
± 0.3
|
5.8
± 0.2
|
955 |
EN300-88131_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)CO |
−7.9
± 0.2
|
5.8
± 0.2
|
956 |
EN300-657320_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CSCC(=O)N5 |
−7.9
± 0.2
|
5.8
± 0.2
|
957 |
EN300-262604_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
958 |
EN300-178515_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCC(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
959 |
EN300-6474220_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(CCn5ccnn5)(F)F |
−7.9
± 0.3
|
5.8
± 0.2
|
960 |
EN300-6762327_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(Cc5ccccn5)O |
−7.9
± 0.2
|
5.8
± 0.2
|
961 |
EN300-212381_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCCN(C5)C(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
962 |
EN300-7500524_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@@H](C5)COC(=O)N6 |
−7.9
± 0.3
|
5.8
± 0.2
|
963 |
EN300-1387104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS5(=O)=O |
−7.9
± 0.2
|
5.8
± 0.2
|
964 |
EN300-59386_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(s5)S(=O)(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
965 |
EN300-47500_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCCn5cccn5 |
−7.9
± 0.3
|
5.8
± 0.2
|
966 |
EN300-2011576_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5Cc6c(nccn6)C5 |
−7.9
± 0.3
|
5.8
± 0.2
|
967 |
EN300-42154_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)C5CCCC5 |
−7.9
± 0.3
|
5.8
± 0.2
|
968 |
EN300-88656_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCS5(=O)=O |
−7.9
± 0.2
|
5.8
± 0.1
|
969 |
EN300-316171_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C(=O)N)O |
−7.9
± 0.2
|
5.8
± 0.2
|
970 |
EN300-6498856_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCC5C(=O)NC(=O)N5 |
−7.9
± 0.2
|
5.8
± 0.1
|
971 |
EN300-196962_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]5CO |
−7.9
± 0.2
|
5.8
± 0.2
|
972 |
EN300-39826_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nc6ncccn6n5 |
−7.9
± 0.3
|
5.8
± 0.2
|
973 |
EN300-123489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CO)(F)F |
−7.9
± 0.3
|
5.8
± 0.2
|
974 |
EN300-6743781_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCNS(=O)(=O)CC5 |
−7.9
± 0.3
|
5.8
± 0.2
|
975 |
EN300-270710_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)N |
−7.9
± 0.2
|
5.8
± 0.2
|
976 |
EN300-366687_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCc6nncn6CC5 |
−7.9
± 0.3
|
5.8
± 0.2
|
977 |
EN300-6764893_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)OCCO |
−7.9
± 0.2
|
5.8
± 0.2
|
978 |
EN300-127156_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(no5)C(=O)N |
−7.9
± 0.2
|
5.8
± 0.1
|
979 |
EN300-80245_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c(cnn5CCO)C(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
980 |
EN300-1609922_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(c6ccn[nH]6)O |
−7.9
± 0.2
|
5.8
± 0.1
|
981 |
EN300-29228_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(cnn6)C5 |
−7.9
± 0.3
|
5.8
± 0.2
|
982 |
EN300-80522_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COCC5CCOC5 |
−7.9
± 0.2
|
5.8
± 0.1
|
983 |
EN300-103979_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(nc5)OCC(=O)N6 |
−7.9
± 0.2
|
5.8
± 0.2
|
984 |
EN300-246423_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCC5)O |
−7.9
± 0.3
|
5.8
± 0.2
|
985 |
EN300-321597_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@H](C5)O |
−7.9
± 0.2
|
5.8
± 0.2
|
986 |
EN300-148421_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOC5)O |
−7.9
± 0.2
|
5.8
± 0.1
|
987 |
EN300-18249_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N |
−7.9
± 0.1
|
5.8
± 0.1
|
988 |
EN300-1644703_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)O |
−7.9
± 0.2
|
5.8
± 0.2
|
989 |
EN300-344121_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5CCC[C@H]5O |
−7.9
± 0.3
|
5.8
± 0.2
|
990 |
EN300-25791_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)C(=O)N |
−7.9
± 0.3
|
5.8
± 0.2
|
991 |
EN300-303908_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@]6(C[C@H]6C5)O |
−7.9
± 0.3
|
5.8
± 0.2
|
992 |
VLA-UCB-05e51b3f-12
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4OC5CC(=O)N5)Cl)CCC6CCCCC6 |
−7.9
± 0.2
|
5.7
± 0.2
|
993 |
EN300-107267_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC5CCCNC5=O |
−7.9
± 0.3
|
5.7
± 0.2
|
994 |
EN300-108022_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnnn5 |
−7.9
± 0.2
|
5.7
± 0.2
|
995 |
EN300-1588617_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]5C#N |
−7.9
± 0.2
|
5.7
± 0.2
|
996 |
EN300-6504498_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC(C5)n6cncn6 |
−7.9
± 0.3
|
5.7
± 0.2
|
997 |
EN300-6474220_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(CCn5ccnn5)(F)F |
−7.9
± 0.3
|
5.7
± 0.2
|
998 |
EN300-69312_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)O |
−7.9
± 0.2
|
5.7
± 0.2
|
999 |
EN300-306097_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOCC5)n6cnnn6 |
−7.9
± 0.2
|
5.7
± 0.2
|
1000 |
EN300-246747_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC(=O)NC5 |
−7.9
± 0.2
|
5.7
± 0.1
|