Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
401 |
EN300-35789_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccnc5=O |
−8.8
± 0.2
|
6.4
± 0.2
|
402 |
EN300-6474220_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CCn5ccnn5)(F)F |
−8.8
± 0.2
|
6.4
± 0.2
|
403 |
EN300-132613_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(scn5)S(=O)(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|
404 |
EN300-87536_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCN5C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
405 |
EN300-342226_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnc[nH]5 |
−8.8
± 0.2
|
6.4
± 0.2
|
406 |
EN300-42195_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)CNC(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
407 |
EN300-122590_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnc(s5)CCO |
−8.8
± 0.2
|
6.4
± 0.2
|
408 |
EN300-188356_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)F |
−8.8
± 0.2
|
6.4
± 0.1
|
409 |
JAG-UCB-706446eb-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn[nH]5 |
−8.8
± 0.2
|
6.4
± 0.1
|
410 |
EN300-51736_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5cccc(c5)C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
411 |
EN300-315963_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnoc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
412 |
EN300-20496_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC5CCOC5=O |
−8.8
± 0.1
|
6.4
± 0.1
|
413 |
EN300-05512_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CCS(=O)(=O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
414 |
EN300-154942_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5OCCO5 |
−8.8
± 0.2
|
6.4
± 0.1
|
415 |
EN300-244909_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
416 |
EN300-159634_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(=O)[nH]nc5 |
−8.8
± 0.2
|
6.4
± 0.1
|
417 |
EN300-183231_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCc5[nH]nnn5 |
−8.8
± 0.3
|
6.4
± 0.2
|
418 |
EN300-7426781_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6cccn6ncn5 |
−8.7
± 0.2
|
6.4
± 0.1
|
419 |
EN300-156995_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCc5c[nH]nn5 |
−8.7
± 0.2
|
6.4
± 0.2
|
420 |
EN300-6488240_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5nncs5 |
−8.7
± 0.2
|
6.4
± 0.2
|
421 |
EN300-748981_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCn6c5nnc6 |
−8.7
± 0.2
|
6.4
± 0.2
|
422 |
EN300-6478631_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCc6n5cnn6 |
−8.7
± 0.3
|
6.4
± 0.2
|
423 |
EN300-13499_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCNC(=O)N |
−8.7
± 0.3
|
6.4
± 0.2
|
424 |
EN300-1600517_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(CO)F |
−8.7
± 0.2
|
6.4
± 0.1
|
425 |
EN300-94945_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCNC5=O |
−8.7
± 0.2
|
6.4
± 0.2
|
426 |
EN300-223187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c6c(nn5)CCCC6 |
−8.7
± 0.2
|
6.4
± 0.2
|
427 |
EN300-6759972_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(CC5)NC(=O)N |
−8.7
± 0.2
|
6.4
± 0.2
|
428 |
EN300-95094_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CSC5 |
−8.7
± 0.2
|
6.4
± 0.1
|
429 |
EN300-364679_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cnnn5 |
−8.7
± 0.2
|
6.4
± 0.1
|
430 |
EN300-149975_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)CO |
−8.7
± 0.2
|
6.4
± 0.2
|
431 |
EN300-1428769_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@@H]5[C@H](CO)O |
−8.7
± 0.4
|
6.4
± 0.3
|
432 |
EN300-6486793_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCC5)S(=O)(=O)N |
−8.7
± 0.3
|
6.4
± 0.2
|
433 |
EN300-396748_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)CO |
−8.7
± 0.2
|
6.3
± 0.1
|
434 |
EN300-1968342_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CF)O |
−8.7
± 0.1
|
6.35
± 0.09
|
435 |
EN300-59478_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCC(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
436 |
EN300-246248_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCNC5=O |
−8.7
± 0.2
|
6.3
± 0.1
|
437 |
EN300-19926_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC#N |
−8.7
± 0.2
|
6.3
± 0.1
|
438 |
EN300-54837_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5C(=O)CCCC5=O |
−8.7
± 0.2
|
6.3
± 0.2
|
439 |
EN300-658865_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc([nH]n5)CO |
−8.7
± 0.2
|
6.3
± 0.2
|
440 |
EN300-5253939_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COC(=O)O5 |
−8.7
± 0.2
|
6.3
± 0.1
|
441 |
EN300-7459540_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5C(CO)O |
−8.7
± 0.3
|
6.3
± 0.2
|
442 |
EN300-34542_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCC5C(=O)N |
−8.7
± 0.2
|
6.3
± 0.1
|
443 |
EN300-7439985_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(CC5C6)CO |
−8.7
± 0.2
|
6.3
± 0.2
|
444 |
EN300-13890_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CSC5CCS(=O)(=O)C5 |
−8.7
± 0.2
|
6.3
± 0.2
|
445 |
EN300-53918_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCN5CCOC5=O |
−8.7
± 0.3
|
6.3
± 0.2
|
446 |
EN300-133915_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(=O)[nH]5 |
−8.7
± 0.2
|
6.3
± 0.1
|
447 |
EN300-223284_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c[nH][nH]c5=O |
−8.7
± 0.2
|
6.3
± 0.1
|
448 |
EN300-7385389_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C(F)(F)F |
−8.7
± 0.3
|
6.3
± 0.2
|
449 |
EN300-108236_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)CO |
−8.7
± 0.3
|
6.3
± 0.2
|
450 |
EN300-131572_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5cncc6 |
−8.7
± 0.2
|
6.3
± 0.1
|
451 |
EN300-1267109_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c(cn[nH]5)C#N |
−8.7
± 0.2
|
6.3
± 0.2
|
452 |
EN300-82179_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)N |
−8.7
± 0.2
|
6.3
± 0.1
|
453 |
EN300-370792_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5cnccn5 |
−8.7
± 0.3
|
6.3
± 0.2
|
454 |
EN300-251851_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5[nH]nnn5 |
−8.7
± 0.3
|
6.3
± 0.2
|
455 |
EN300-151298_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cnc5)n6ccnn6 |
−8.6
± 0.2
|
6.3
± 0.2
|
456 |
EN300-11714_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccccc5=O |
−8.6
± 0.2
|
6.3
± 0.2
|
457 |
EN300-4698402_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@H]5F |
−8.6
± 0.2
|
6.3
± 0.1
|
458 |
EN300-18249_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N |
−8.6
± 0.2
|
6.3
± 0.1
|
459 |
EN300-123712_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)n6cncn6 |
−8.6
± 0.2
|
6.3
± 0.2
|
460 |
EN300-1608992_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(C#N)C(=O)N |
−8.6
± 0.2
|
6.3
± 0.2
|
461 |
EN300-1715993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 |
−8.6
± 0.2
|
6.3
± 0.2
|
462 |
EN300-69070_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C(=O)N |
−8.6
± 0.2
|
6.3
± 0.2
|
463 |
EN300-211422_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC5 |
−8.6
± 0.2
|
6.3
± 0.2
|
464 |
EN300-2910941_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)C(F)(F)F |
−8.6
± 0.3
|
6.3
± 0.2
|
465 |
EN300-186943_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5=O |
−8.6
± 0.3
|
6.3
± 0.2
|
466 |
EN300-154942_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5OCCO5 |
−8.6
± 0.2
|
6.3
± 0.1
|
467 |
EN300-1932780_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(F)F)O |
−8.6
± 0.2
|
6.3
± 0.2
|
468 |
EN300-65063_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCN(CC5)C(=O)N |
−8.6
± 0.3
|
6.3
± 0.2
|
469 |
EN300-85760_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCO5 |
−8.6
± 0.1
|
6.3
± 0.1
|
470 |
EN300-7463171_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCO |
−8.6
± 0.4
|
6.3
± 0.3
|
471 |
EN300-310888_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc6n5CCOCC6 |
−8.6
± 0.2
|
6.3
± 0.2
|
472 |
EN300-1717166_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC56CC(C6)O |
−8.6
± 0.2
|
6.3
± 0.1
|
473 |
EN300-146051_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)CO |
−8.6
± 0.2
|
6.3
± 0.2
|
474 |
EN300-06030_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cc5)n6cnnn6 |
−8.6
± 0.2
|
6.3
± 0.2
|
475 |
EN300-1726277_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(n5cccn5)F |
−8.6
± 0.2
|
6.3
± 0.1
|
476 |
EN300-91314_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)Cc6cccnc6 |
−8.6
± 0.2
|
6.3
± 0.2
|
477 |
EN300-139167_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5COCCO5 |
−8.60
± 0.10
|
6.26
± 0.07
|
478 |
EN300-1590388_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(cn5)C#N |
−8.6
± 0.2
|
6.3
± 0.2
|
479 |
EN300-246747_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC(=O)NC5 |
−8.6
± 0.2
|
6.3
± 0.2
|
480 |
EN300-6489145_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNS(=O)(=O)CC5 |
−8.6
± 0.3
|
6.3
± 0.2
|
481 |
EN300-100467_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnn5 |
−8.6
± 0.2
|
6.3
± 0.2
|
482 |
EN300-83527_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6ncccn6n5 |
−8.6
± 0.2
|
6.3
± 0.1
|
483 |
EN300-151461_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CCOC6 |
−8.6
± 0.2
|
6.3
± 0.1
|
484 |
EN300-1704404_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CNC(=O)CC56CCC6 |
−8.6
± 0.2
|
6.2
± 0.1
|
485 |
EN300-139268_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC(F)(F)F |
−8.6
± 0.2
|
6.2
± 0.1
|
486 |
EN300-3044054_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)N5C6CC6 |
−8.6
± 0.3
|
6.2
± 0.2
|
487 |
EN300-2910941_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C(F)(F)F |
−8.6
± 0.2
|
6.2
± 0.2
|
488 |
EN300-185729_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCc6c(nn[nH]6)C5 |
−8.6
± 0.3
|
6.2
± 0.2
|
489 |
EN300-217416_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCn6c5nnn6 |
−8.6
± 0.3
|
6.2
± 0.2
|
490 |
EN300-10334_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCC(=O)N5CCS6 |
−8.6
± 0.2
|
6.2
± 0.1
|
491 |
EN300-205486_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnccc5O |
−8.6
± 0.3
|
6.2
± 0.2
|
492 |
EN300-97758_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCF |
−8.6
± 0.2
|
6.2
± 0.1
|
493 |
EN300-23792_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(sc5)S(=O)(=O)N |
−8.6
± 0.3
|
6.2
± 0.2
|
494 |
EN300-360157_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOC5)O |
−8.6
± 0.2
|
6.2
± 0.2
|
495 |
EN300-156995_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCc5c[nH]nn5 |
−8.6
± 0.3
|
6.2
± 0.2
|
496 |
EN300-140582_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COCCN5CC(F)F |
−8.6
± 0.2
|
6.2
± 0.1
|
497 |
EN300-120586_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC(F)F |
−8.6
± 0.2
|
6.2
± 0.1
|
498 |
EN300-22245_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccon5 |
−8.6
± 0.2
|
6.2
± 0.1
|
499 |
EN300-26147_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cncn5 |
−8.6
± 0.2
|
6.2
± 0.2
|
500 |
EN300-6255179_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 |
−8.6
± 0.2
|
6.2
± 0.1
|