| Rank | Compound | SMILES | ΔG / kcal M-1 | pIC50 | 
  
  
    | 401 | EN300-35789_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccnc5=O | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 402 | EN300-6474220_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CCn5ccnn5)(F)F | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 403 | EN300-132613_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(scn5)S(=O)(=O)N | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 404 | EN300-87536_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCN5C(=O)N | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 405 | EN300-342226_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnc[nH]5 | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 406 | EN300-42195_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)CNC(=O)N | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 407 | EN300-122590_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnc(s5)CCO | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 408 | EN300-188356_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)F | −8.8
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 409 | JAG-UCB-706446eb-6 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn[nH]5 | −8.8
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 410 | EN300-51736_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5cccc(c5)C(=O)N | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 411 | EN300-315963_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnoc5 | −8.8
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 412 | EN300-20496_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC5CCOC5=O | −8.8
         ± 0.1 | 6.4
         ± 0.1 | 
  
  
    | 413 | EN300-05512_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CCS(=O)(=O)C5 | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 414 | EN300-154942_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5OCCO5 | −8.8
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 415 | EN300-244909_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)CO | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 416 | EN300-159634_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(=O)[nH]nc5 | −8.8
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 417 | EN300-183231_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCc5[nH]nnn5 | −8.8
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 418 | EN300-7426781_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6cccn6ncn5 | −8.7
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 419 | EN300-156995_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCc5c[nH]nn5 | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 420 | EN300-6488240_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5nncs5 | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 421 | EN300-748981_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCn6c5nnc6 | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 422 | EN300-6478631_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCc6n5cnn6 | −8.7
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 423 | EN300-13499_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCNC(=O)N | −8.7
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 424 | EN300-1600517_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(CO)F | −8.7
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 425 | EN300-94945_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCNC5=O | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 426 | EN300-223187_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c6c(nn5)CCCC6 | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 427 | EN300-6759972_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(CC5)NC(=O)N | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 428 | EN300-95094_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CSC5 | −8.7
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 429 | EN300-364679_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cnnn5 | −8.7
         ± 0.2 | 6.4
         ± 0.1 | 
  
  
    | 430 | EN300-149975_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)CO | −8.7
         ± 0.2 | 6.4
         ± 0.2 | 
  
  
    | 431 | EN300-1428769_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@@H]5[C@H](CO)O | −8.7
         ± 0.4 | 6.4
         ± 0.3 | 
  
  
    | 432 | EN300-6486793_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCC5)S(=O)(=O)N | −8.7
         ± 0.3 | 6.4
         ± 0.2 | 
  
  
    | 433 | EN300-396748_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)CO | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 434 | EN300-1968342_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CF)O | −8.7
         ± 0.1 | 6.35
         ± 0.09 | 
  
  
    | 435 | EN300-59478_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCC(=O)N | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 436 | EN300-246248_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCNC5=O | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 437 | EN300-19926_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC#N | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 438 | EN300-54837_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5C(=O)CCCC5=O | −8.7
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 439 | EN300-658865_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc([nH]n5)CO | −8.7
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 440 | EN300-5253939_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COC(=O)O5 | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 441 | EN300-7459540_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5C(CO)O | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 442 | EN300-34542_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCCC5C(=O)N | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 443 | EN300-7439985_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(CC5C6)CO | −8.7
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 444 | EN300-13890_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CSC5CCS(=O)(=O)C5 | −8.7
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 445 | EN300-53918_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCN5CCOC5=O | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 446 | EN300-133915_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(=O)[nH]5 | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 447 | EN300-223284_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c[nH][nH]c5=O | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 448 | EN300-7385389_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C(F)(F)F | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 449 | EN300-108236_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)CO | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 450 | EN300-131572_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5cncc6 | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 451 | EN300-1267109_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c(cn[nH]5)C#N | −8.7
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 452 | EN300-82179_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)N | −8.7
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 453 | EN300-370792_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5cnccn5 | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 454 | EN300-251851_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5[nH]nnn5 | −8.7
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 455 | EN300-151298_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cnc5)n6ccnn6 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 456 | EN300-11714_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccccc5=O | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 457 | EN300-4698402_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@H]5F | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 458 | EN300-18249_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 459 | EN300-123712_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)n6cncn6 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 460 | EN300-1608992_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(C#N)C(=O)N | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 461 | EN300-1715993_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 462 | EN300-69070_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C(=O)N | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 463 | EN300-211422_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC5 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 464 | EN300-2910941_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)C(F)(F)F | −8.6
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 465 | EN300-186943_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5=O | −8.6
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 466 | EN300-154942_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5OCCO5 | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 467 | EN300-1932780_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C(F)F)O | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 468 | EN300-65063_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCN(CC5)C(=O)N | −8.6
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 469 | EN300-85760_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCO5 | −8.6
         ± 0.1 | 6.3
         ± 0.1 | 
  
  
    | 470 | EN300-7463171_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCS(=O)(=O)CCO | −8.6
         ± 0.4 | 6.3
         ± 0.3 | 
  
  
    | 471 | EN300-310888_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc6n5CCOCC6 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 472 | EN300-1717166_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC56CC(C6)O | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 473 | EN300-146051_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)CO | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 474 | EN300-06030_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cc5)n6cnnn6 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 475 | EN300-1726277_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(n5cccn5)F | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 476 | EN300-91314_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)Cc6cccnc6 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 477 | EN300-139167_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5COCCO5 | −8.60
         ± 0.10 | 6.26
         ± 0.07 | 
  
  
    | 478 | EN300-1590388_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(cn5)C#N | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 479 | EN300-246747_4 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC(=O)NC5 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 480 | EN300-6489145_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNS(=O)(=O)CC5 | −8.6
         ± 0.3 | 6.3
         ± 0.2 | 
  
  
    | 481 | EN300-100467_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnn5 | −8.6
         ± 0.2 | 6.3
         ± 0.2 | 
  
  
    | 482 | EN300-83527_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6ncccn6n5 | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 483 | EN300-151461_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CCOC6 | −8.6
         ± 0.2 | 6.3
         ± 0.1 | 
  
  
    | 484 | EN300-1704404_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CNC(=O)CC56CCC6 | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 485 | EN300-139268_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC(F)(F)F | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 486 | EN300-3044054_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)N5C6CC6 | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 487 | EN300-2910941_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C(F)(F)F | −8.6
         ± 0.2 | 6.2
         ± 0.2 | 
  
  
    | 488 | EN300-185729_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCc6c(nn[nH]6)C5 | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 489 | EN300-217416_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCn6c5nnn6 | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 490 | EN300-10334_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCC(=O)N5CCS6 | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 491 | EN300-205486_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnccc5O | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 492 | EN300-97758_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCF | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 493 | EN300-23792_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(sc5)S(=O)(=O)N | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 494 | EN300-360157_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOC5)O | −8.6
         ± 0.2 | 6.2
         ± 0.2 | 
  
  
    | 495 | EN300-156995_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCc5c[nH]nn5 | −8.6
         ± 0.3 | 6.2
         ± 0.2 | 
  
  
    | 496 | EN300-140582_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COCCN5CC(F)F | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 497 | EN300-120586_2 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC(F)F | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 498 | EN300-22245_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccon5 | −8.6
         ± 0.2 | 6.2
         ± 0.1 | 
  
  
    | 499 | EN300-26147_1 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cncn5 | −8.6
         ± 0.2 | 6.2
         ± 0.2 | 
  
  
    | 500 | EN300-6255179_3 |   | c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 | −8.6
         ± 0.2 | 6.2
         ± 0.1 |