Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3701 |
EN300-6729730_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCNS(=O)(=O)C5CC5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3702 |
EN300-262409_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cn5)n6cnnn6 |
−4.8
± 0.2
|
3.5
± 0.1
|
3703 |
EN300-250120_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CCS(=O)(=O)CC5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3704 |
JOH-UNI-f51e3bbc-2
|
|
COc1c2ccccc2c(cn1)NC(=O)C3CCOc4c3cc(cc4)Cl |
−4.8
± 0.1
|
3.50
± 0.08
|
3705 |
EN300-310398_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)S(=O)(=O)N |
−4.8
± 0.3
|
3.5
± 0.2
|
3706 |
EN300-307190_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnc6n5CCOC6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3707 |
EN300-1265946_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)C(=O)N |
−4.8
± 0.2
|
3.5
± 0.1
|
3708 |
EN300-1587757_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCNS5(=O)=O |
−4.8
± 0.1
|
3.49
± 0.10
|
3709 |
EN300-1722016_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CC5)n6nccn6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3710 |
EN300-35843_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5[nH]c(=O)[nH]n5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3711 |
EN300-37077_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn[nH]5 |
−4.8
± 0.2
|
3.5
± 0.2
|
3712 |
EN300-60862_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)C(=O)N |
−4.8
± 0.2
|
3.5
± 0.2
|
3713 |
EN300-378760_2
|
|
CS(=O)(=O)[C@H]1C[C@@H](C1)NC(=O)CC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3714 |
EN300-98313_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCSC5)O |
−4.8
± 0.2
|
3.5
± 0.1
|
3715 |
JOH-SUS-a69c159d-4
|
|
c1ccc2c(c1)c(cnc2C(F)(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−4.79
± 0.10
|
3.49
± 0.07
|
3716 |
EN300-13489_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCN(CC5)C(=O)N |
−4.8
± 0.3
|
3.5
± 0.2
|
3717 |
EN300-189901_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc6c5[nH]c(=O)[nH]6 |
−4.8
± 0.2
|
3.5
± 0.2
|
3718 |
EN300-7429986_2
|
|
CS(=O)(=O)C[C@H]1C[C@@H](C1)NC(=O)CC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−4.8
± 0.4
|
3.5
± 0.3
|
3719 |
EN300-61636_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)C(=O)NC6CC6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3720 |
ALP-POS-d3acb8cc-2
|
|
C[C@@H]1C[C@@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−4.8
± 0.1
|
3.5
± 0.1
|
3721 |
EN300-190253_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cc(=O)o5)O |
−4.8
± 0.3
|
3.5
± 0.2
|
3722 |
EN300-127843_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(=O)NCC5CC5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3723 |
EN300-6486793_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCCC5)S(=O)(=O)N |
−4.8
± 0.3
|
3.5
± 0.2
|
3724 |
EN300-96159_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5[nH]cnn5 |
−4.8
± 0.2
|
3.5
± 0.2
|
3725 |
EN300-313366_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C56CCN(C5)CC6 |
−4.8
± 0.2
|
3.5
± 0.2
|
3726 |
EN300-247026_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CCOCC5=O |
−4.8
± 0.3
|
3.5
± 0.2
|
3727 |
EN300-59733_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCNC(=O)C5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3728 |
EN300-246440_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)n6cncn6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3729 |
EN300-245318_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(C5)C(=O)C6CC6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3730 |
EN300-115760_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC(C5)c6[nH]nnn6 |
−4.8
± 0.3
|
3.5
± 0.2
|
3731 |
EN300-133915_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5csc(=O)[nH]5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3732 |
EN300-384280_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5ccc(=O)[nH]c5=O |
−4.8
± 0.3
|
3.5
± 0.2
|
3733 |
EN300-129820_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CCNC(=O)C5 |
−4.8
± 0.4
|
3.5
± 0.3
|
3734 |
EN300-818709_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)Cc6[nH]nnn6 |
−4.8
± 0.4
|
3.5
± 0.3
|
3735 |
EN300-173216_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(=O)NCC5CC5 |
−4.8
± 0.3
|
3.5
± 0.2
|
3736 |
EN300-1179745_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCOC5CCS(=O)(=O)CC5 |
−4.7
± 0.5
|
3.5
± 0.4
|
3737 |
EN300-7425555_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)C6COC6 |
−4.7
± 0.4
|
3.5
± 0.3
|
3738 |
EN300-300044_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCS(=O)(=O)C(F)(F)F |
−4.7
± 0.5
|
3.5
± 0.3
|
3739 |
EN300-188650_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5[nH]ccn5 |
−4.7
± 0.3
|
3.5
± 0.2
|
3740 |
EN300-7183657_4
|
|
C[C@]1(C[C@@H](C1)C(=O)NCCC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−4.7
± 0.3
|
3.5
± 0.2
|
3741 |
EN300-69553_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5cncn5 |
−4.7
± 0.2
|
3.5
± 0.2
|
3742 |
EN300-250593_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CC(=O)N5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3743 |
VLA-UCB-05e51b3f-10
|
|
C=CC(=O)N(c1cncc2c1cccc2)C(=O)[C@H]3CCOc4c3cc(cc4)Cl |
−4.7
± 0.2
|
3.4
± 0.1
|
3744 |
EN300-7465386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCS(=O)(=O)C5)CO |
−4.7
± 0.3
|
3.4
± 0.2
|
3745 |
EN300-103031_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c6c([nH]n5)CCOC6 |
−4.7
± 0.3
|
3.4
± 0.2
|
3746 |
EN300-73738_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCC(CC5)CO |
−4.7
± 0.3
|
3.4
± 0.2
|
3747 |
EN300-191323_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCNC(=O)C5CCC5 |
−4.7
± 0.2
|
3.4
± 0.2
|
3748 |
EN300-191323_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCNC(=O)C5CCC5 |
−4.7
± 0.2
|
3.4
± 0.2
|
3749 |
EN300-1609231_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC(C5)CO)C(=O)N |
−4.7
± 0.3
|
3.4
± 0.2
|
3750 |
VLA-UCB-50c39ae8-4
|
|
CC(=O)N1CCN(CC1)CC(=O)N(c2cncc3c2cccc3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−4.7
± 0.5
|
3.4
± 0.4
|
3751 |
EN300-227044_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(CO)C#N |
−4.7
± 0.3
|
3.4
± 0.2
|
3752 |
EN300-65115_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)O |
−4.7
± 0.2
|
3.4
± 0.2
|
3753 |
EN300-41518_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCOCC5 |
−4.7
± 0.4
|
3.4
± 0.3
|
3754 |
EN300-244100_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5Cc6cncn6C5 |
−4.7
± 0.2
|
3.4
± 0.2
|
3755 |
EN300-187348_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)N(C5)C6CC6 |
−4.7
± 0.2
|
3.4
± 0.2
|
3756 |
EN300-51459_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C(F)(F)F)O |
−4.7
± 0.3
|
3.4
± 0.2
|
3757 |
EN300-84783_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CC=CC5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3758 |
EN300-59879_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCC(CC5)CO |
−4.7
± 0.3
|
3.4
± 0.2
|
3759 |
EN300-41518_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOCC5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3760 |
EN300-67478_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)NC(=O)N |
−4.7
± 0.4
|
3.4
± 0.3
|
3761 |
EN300-261236_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)Cc6[nH]cnn6 |
−4.7
± 0.3
|
3.4
± 0.2
|
3762 |
EN300-186943_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCOCC5=O |
−4.7
± 0.3
|
3.4
± 0.2
|
3763 |
EN300-93878_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCN5CC[C@H](C5)O |
−4.7
± 0.3
|
3.4
± 0.2
|
3764 |
EN300-7429986_1
|
|
CS(=O)(=O)C[C@H]1C[C@@H](C1)NC(=O)C[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−4.7
± 0.4
|
3.4
± 0.3
|
3765 |
EN300-6746727_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5Cc6c([nH]c(=O)[nH]c6=O)C5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3766 |
EN300-62191_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCC(=O)NC5 |
−4.7
± 0.2
|
3.4
± 0.1
|
3767 |
EN300-317210_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CC(C6)O |
−4.7
± 0.3
|
3.4
± 0.2
|
3768 |
EN300-7444122_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCN(CC5)CC(CO)O |
−4.7
± 0.5
|
3.4
± 0.3
|
3769 |
EN300-124365_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)N6CCOCC6 |
−4.7
± 0.3
|
3.4
± 0.3
|
3770 |
EN300-124394_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(CC5)C6COC6 |
−4.7
± 0.4
|
3.4
± 0.3
|
3771 |
EN300-1709213_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)c6[nH]cnn6 |
−4.7
± 0.3
|
3.4
± 0.2
|
3772 |
EN300-107048_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CC5)CO |
−4.7
± 0.2
|
3.4
± 0.2
|
3773 |
EN300-61371_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(COCC5CC5)O |
−4.7
± 0.3
|
3.4
± 0.2
|
3774 |
EN300-39033_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCNC(=O)c5ccncc5 |
−4.7
± 0.4
|
3.4
± 0.3
|
3775 |
EN300-6731820_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)N6CC(C6)F |
−4.7
± 0.4
|
3.4
± 0.3
|
3776 |
EN300-124213_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CS(=O)(=O)CCO5 |
−4.7
± 0.2
|
3.4
± 0.2
|
3777 |
EN300-139268_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(=O)NCC(F)(F)F |
−4.7
± 0.2
|
3.4
± 0.2
|
3778 |
EN300-149975_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCC5)CO |
−4.7
± 0.2
|
3.4
± 0.2
|
3779 |
EN300-2965876_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CCC(C5)CO |
−4.7
± 0.2
|
3.4
± 0.1
|
3780 |
EN300-6758891_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6COCCN6C(=O)C5 |
−4.7
± 0.2
|
3.4
± 0.2
|
3781 |
EN300-360157_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCOC5)O |
−4.7
± 0.2
|
3.4
± 0.2
|
3782 |
EN300-78368_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCCC5)NC(=O)N |
−4.7
± 0.2
|
3.4
± 0.2
|
3783 |
EN300-110325_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5cnncn5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3784 |
EN300-112454_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ccc(nn5)C(=O)N |
−4.7
± 0.2
|
3.4
± 0.2
|
3785 |
EN300-127612_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCNC(=O)c5ccn[nH]5 |
−4.7
± 0.3
|
3.4
± 0.2
|
3786 |
EN300-342668_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC56CCN(C5)CC6 |
−4.7
± 0.2
|
3.4
± 0.2
|
3787 |
EN300-71022_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)CCO |
−4.7
± 0.4
|
3.4
± 0.3
|
3788 |
EN300-10747_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CSCC5=O |
−4.7
± 0.3
|
3.4
± 0.2
|
3789 |
EN300-90372_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5c[nH]c(=O)[nH]c5=O |
−4.7
± 0.2
|
3.4
± 0.2
|
3790 |
EN300-6482801_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)C6(CC6)O |
−4.6
± 0.2
|
3.4
± 0.2
|
3791 |
EN300-365077_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCNC(=O)c5cnccn5 |
−4.6
± 0.2
|
3.4
± 0.1
|
3792 |
EN300-6498726_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)CF |
−4.6
± 0.3
|
3.4
± 0.2
|
3793 |
EN300-2965876_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCC(C5)CO |
−4.6
± 0.2
|
3.4
± 0.1
|
3794 |
EN300-1697735_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(CNC(=O)N)O |
−4.6
± 0.3
|
3.4
± 0.2
|
3795 |
EN300-321213_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CC[C@H](C5)O |
−4.6
± 0.3
|
3.4
± 0.2
|
3796 |
EN300-749499_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5(CCOCC5)O)O |
−4.6
± 0.2
|
3.4
± 0.2
|
3797 |
EN300-61337_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(CC5)CCCO |
−4.6
± 0.4
|
3.4
± 0.3
|
3798 |
EN300-13890_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CSC5CCS(=O)(=O)C5 |
−4.6
± 0.3
|
3.4
± 0.2
|
3799 |
EN300-701259_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cnc6n5CCOC6 |
−4.6
± 0.3
|
3.4
± 0.2
|
3800 |
EN300-7355978_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c(c(=O)[nH]cn6)[nH]n5 |
−4.6
± 0.3
|
3.4
± 0.2
|