Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3101 |
EN300-59478_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCC(=O)N |
−5.7
± 0.3
|
4.2
± 0.2
|
3102 |
EN300-321597_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CC[C@H](C5)O |
−5.7
± 0.2
|
4.2
± 0.2
|
3103 |
EN300-62449_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)C5CCC5 |
−5.7
± 0.3
|
4.2
± 0.2
|
3104 |
EN300-66518_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)n6cncn6 |
−5.7
± 0.2
|
4.2
± 0.2
|
3105 |
EN300-6730275_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCNS(=O)(=O)C5CC5 |
−5.7
± 0.3
|
4.2
± 0.2
|
3106 |
EN300-36522_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)C5CC5 |
−5.7
± 0.2
|
4.2
± 0.2
|
3107 |
EN300-117839_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCS(=O)(=O)CC5 |
−5.7
± 0.3
|
4.2
± 0.2
|
3108 |
EN300-1277662_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@H]5CO |
−5.7
± 0.3
|
4.2
± 0.2
|
3109 |
EN300-1110375_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5cnn(c5)C6CCNC6=O |
−5.7
± 0.2
|
4.2
± 0.1
|
3110 |
EN300-195743_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H](CCO)CO |
−5.7
± 0.3
|
4.2
± 0.2
|
3111 |
DAR-DIA-6a508060-9
|
|
c1ccc2c(c1)cncc2NC(=O)C3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−5.7
± 0.2
|
4.2
± 0.2
|
3112 |
EN300-6478040_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC56CC(C5)(C6)CO |
−5.7
± 0.2
|
4.2
± 0.2
|
3113 |
EN300-6497444_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5OCC(C6)O |
−5.7
± 0.2
|
4.2
± 0.1
|
3114 |
EN300-106781_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccc(=O)[nH]c5=O |
−5.7
± 0.3
|
4.2
± 0.2
|
3115 |
EN300-134855_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(c5cccnc5)O |
−5.7
± 0.2
|
4.2
± 0.1
|
3116 |
EN300-103031_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c6c([nH]n5)CCOC6 |
−5.7
± 0.3
|
4.2
± 0.2
|
3117 |
EN300-226334_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCN(C5)CCCO |
−5.7
± 0.3
|
4.2
± 0.2
|
3118 |
EN300-706065_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5(CCOCC5)O)(F)F |
−5.7
± 0.2
|
4.2
± 0.1
|
3119 |
MAK-UNK-83e0a0b4-1
|
|
CCCCc1ccc2c(c1)C(CCO2)C(=O)N(CCNC3CNC3)c4cncc5c4ccc(c5)CN6CCNCC6 |
−5.7
± 0.5
|
4.2
± 0.4
|
3120 |
EN300-316216_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCn5cncn5 |
−5.7
± 0.2
|
4.2
± 0.2
|
3121 |
EN300-62166_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCCC5CNC(=O)N |
−5.7
± 0.2
|
4.2
± 0.2
|
3122 |
EN300-88819_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c(on5)CCOC6 |
−5.7
± 0.3
|
4.2
± 0.2
|
3123 |
EN300-53423_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCOC5 |
−5.7
± 0.2
|
4.2
± 0.2
|
3124 |
EN300-13287_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccc(=O)[nH]c5=O |
−5.7
± 0.2
|
4.2
± 0.2
|
3125 |
EN300-2690393_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(cnc5)n6cnnn6 |
−5.7
± 0.2
|
4.2
± 0.2
|
3126 |
EN300-217107_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCC5C(=O)N |
−5.7
± 0.2
|
4.2
± 0.1
|
3127 |
EN300-109535_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CC(=O)OC5 |
−5.7
± 0.2
|
4.2
± 0.2
|
3128 |
EN300-109060_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(CC5)C(=O)CC#N |
−5.7
± 0.3
|
4.2
± 0.2
|
3129 |
EN300-188377_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc6c5[nH]nn6 |
−5.7
± 0.2
|
4.2
± 0.2
|
3130 |
EN300-88819_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c6c(on5)CCOC6 |
−5.7
± 0.3
|
4.2
± 0.2
|
3131 |
EN300-122656_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCSC5)O |
−5.7
± 0.4
|
4.2
± 0.3
|
3132 |
EN300-21200_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(nccn5)C(=O)N |
−5.7
± 0.2
|
4.2
± 0.2
|
3133 |
EN300-99064_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)N(C5)c6c[nH]nc6 |
−5.7
± 0.2
|
4.2
± 0.1
|
3134 |
EN300-16248_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cc5)S(=O)(=O)N |
−5.7
± 0.2
|
4.2
± 0.2
|
3135 |
EN300-6481333_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)NC(=O)C(F)(F)F |
−5.7
± 0.3
|
4.2
± 0.2
|
3136 |
EN300-6472771_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@H](CCC[C@H]5CO)CO |
−5.7
± 0.3
|
4.2
± 0.2
|
3137 |
EN300-31244_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCS(=O)(=O)C5 |
−5.7
± 0.1
|
4.2
± 0.1
|
3138 |
EN300-69049_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C6CCCC6O |
−5.7
± 0.3
|
4.2
± 0.2
|
3139 |
EN300-1212491_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC5CCS(=O)(=O)C5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3140 |
EN300-261916_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)N6CCOCC6 |
−5.7
± 0.4
|
4.1
± 0.3
|
3141 |
ADA-UCB-dc2b944c-7
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)F |
−5.69
± 0.08
|
4.15
± 0.06
|
3142 |
EN300-134855_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(c5cccnc5)O |
−5.7
± 0.2
|
4.1
± 0.1
|
3143 |
EN300-1067786_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)C56CC6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3144 |
EN300-318305_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC6(C5)CS(=O)(=O)C6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3145 |
EN300-187253_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)N(C5)CC6CC6 |
−5.7
± 0.2
|
4.1
± 0.2
|
3146 |
EN300-64686_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5[nH]ccc(=O)n5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3147 |
EN300-68735_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)N6CCOCC6 |
−5.7
± 0.2
|
4.1
± 0.1
|
3148 |
EN300-22473_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5ccnc5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3149 |
EN300-1654606_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5F |
−5.7
± 0.2
|
4.1
± 0.1
|
3150 |
EN300-1587757_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCNS5(=O)=O |
−5.7
± 0.2
|
4.1
± 0.1
|
3151 |
EN300-7537194_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn6cnnc6c5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3152 |
EN300-363154_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc([nH]c5=O)CC6CC6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3153 |
EN300-245231_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)CC5C6CC6 |
−5.7
± 0.4
|
4.1
± 0.3
|
3154 |
EN300-97746_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C5CCOCC5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3155 |
EN300-1448674_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCn6c(ncn6)C5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3156 |
EN300-6739235_3
|
|
CN([C@H]1C[C@@H](C1)C(=O)NCC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)C |
−5.7
± 0.3
|
4.1
± 0.2
|
3157 |
EN300-1722713_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CC(=O)NC6 |
−5.7
± 0.4
|
4.1
± 0.3
|
3158 |
EN300-315963_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5cnoc5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3159 |
EN300-102007_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)CCO |
−5.7
± 0.2
|
4.1
± 0.2
|
3160 |
EN300-7459805_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC56CC(C5)(CCO6)CO |
−5.7
± 0.3
|
4.1
± 0.2
|
3161 |
EN300-175160_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C(F)F)O |
−5.7
± 0.2
|
4.1
± 0.2
|
3162 |
EN300-72556_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)c6[nH]nnn6 |
−5.7
± 0.2
|
4.1
± 0.2
|
3163 |
EN300-86205_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5c(=O)[nH]cnc5O |
−5.7
± 0.3
|
4.1
± 0.2
|
3164 |
EN300-253681_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCNC5=O |
−5.7
± 0.3
|
4.1
± 0.2
|
3165 |
EN300-31147_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)C5CC5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3166 |
EN300-31553_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCS(=O)(=O)N |
−5.7
± 0.3
|
4.1
± 0.2
|
3167 |
EN300-155447_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nnc6n5CCOC6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3168 |
EN300-22884_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N5CCNC(=O)C5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3169 |
EN300-175474_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCc6c(c(=O)[nH]cn6)C5 |
−5.7
± 0.4
|
4.1
± 0.3
|
3170 |
EN300-54588_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCn6c5ncn6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3171 |
EN300-7431620_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC6(CC6)S(=O)(=O)N5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3172 |
EN300-6499531_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCCCS5(=O)=O |
−5.7
± 0.2
|
4.1
± 0.2
|
3173 |
EN300-41863_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c[nH]nc5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3174 |
EN300-14949_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cc5)OCC(=O)N |
−5.7
± 0.3
|
4.1
± 0.2
|
3175 |
EN300-261365_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CS(=O)(=O)C5 |
−5.7
± 0.2
|
4.1
± 0.2
|
3176 |
EN300-266565_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)C(=O)N |
−5.7
± 0.3
|
4.1
± 0.2
|
3177 |
EN300-117222_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ncon5 |
−5.7
± 0.2
|
4.1
± 0.1
|
3178 |
EN300-36096_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CN5CCCNC5=O |
−5.7
± 0.2
|
4.1
± 0.2
|
3179 |
EN300-141809_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC56CCS(=O)(=O)CC6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3180 |
EN300-6746778_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5[nH]c(=O)ccn5 |
−5.7
± 0.3
|
4.1
± 0.2
|
3181 |
EN300-7425555_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)C6COC6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3182 |
EN300-141254_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCSCC5c6[nH]nnn6 |
−5.7
± 0.3
|
4.1
± 0.2
|
3183 |
EN300-1268016_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6C5CC(C6)C(=O)N |
−5.7
± 0.1
|
4.12
± 0.09
|
3184 |
EN300-187348_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)N(C5)C6CC6 |
−5.6
± 0.2
|
4.1
± 0.2
|
3185 |
EN300-58880_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(cn5)C(=O)N |
−5.6
± 0.2
|
4.1
± 0.2
|
3186 |
VLA-UCB-05e51b3f-11
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4OC5CC(=O)N5)Cl |
−5.6
± 0.2
|
4.1
± 0.2
|
3187 |
EN300-196870_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCCS(=O)(=O)C5 |
−5.6
± 0.3
|
4.1
± 0.2
|
3188 |
EN300-05277_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCC(=O)N5CCOCC5 |
−5.6
± 0.3
|
4.1
± 0.2
|
3189 |
EN300-12440_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)N(C5)C6CC6 |
−5.6
± 0.2
|
4.1
± 0.1
|
3190 |
EN300-1627945_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC5CCCOC5 |
−5.6
± 0.2
|
4.1
± 0.1
|
3191 |
EN300-309457_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CN(C5)C6CCOC6 |
−5.6
± 0.3
|
4.1
± 0.2
|
3192 |
EN300-7434114_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)C(CCCO6)O |
−5.6
± 0.3
|
4.1
± 0.2
|
3193 |
EN300-95094_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CSC5 |
−5.6
± 0.2
|
4.1
± 0.1
|
3194 |
EN300-58821_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(CC5)C(=O)CO |
−5.6
± 0.3
|
4.1
± 0.3
|
3195 |
EN300-2666483_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cncc(n5)n6cccn6 |
−5.6
± 0.3
|
4.1
± 0.2
|
3196 |
EN300-316386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@H]5O |
−5.6
± 0.2
|
4.1
± 0.1
|
3197 |
EN300-378836_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCCS5(=O)=O |
−5.6
± 0.2
|
4.1
± 0.2
|
3198 |
EN300-262604_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5cnc(n5)C(=O)N |
−5.6
± 0.3
|
4.1
± 0.2
|
3199 |
EN300-6746326_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCC(=O)NC5 |
−5.6
± 0.2
|
4.1
± 0.1
|
3200 |
EN300-173903_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC[C@H]5CO |
−5.6
± 0.4
|
4.1
± 0.3
|