| Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
| 301 |
EN300-103722_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCCC6 |
−9.0
± 0.2
|
6.6
± 0.2
|
| 302 |
EN300-315963_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnoc5 |
−9.0
± 0.2
|
6.6
± 0.2
|
| 303 |
EN300-1241327_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCOCC5 |
−9.0
± 0.1
|
6.57
± 0.10
|
| 304 |
EN300-379219_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CNC(=O)O6 |
−9.0
± 0.2
|
6.6
± 0.1
|
| 305 |
EN300-04520_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)S(=O)(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
| 306 |
EN300-58433_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)n6cncn6 |
−9.0
± 0.2
|
6.6
± 0.2
|
| 307 |
EN300-1700760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6(C5)CC(=O)N6 |
−9.0
± 0.2
|
6.6
± 0.1
|
| 308 |
EN300-6474740_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)c6[nH]cnn6 |
−9.0
± 0.3
|
6.6
± 0.2
|
| 309 |
EN300-100741_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]cnn5 |
−9.0
± 0.2
|
6.6
± 0.1
|
| 310 |
EN300-52193_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCO |
−9.0
± 0.2
|
6.6
± 0.1
|
| 311 |
EN300-364679_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cnnn5 |
−9.0
± 0.2
|
6.6
± 0.2
|
| 312 |
EN300-183231_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCc5[nH]nnn5 |
−9.0
± 0.2
|
6.6
± 0.2
|
| 313 |
EN300-1719432_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5nc(nn5)C6CC6 |
−9.0
± 0.3
|
6.6
± 0.2
|
| 314 |
EN300-307333_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCNC5=O |
−9.0
± 0.2
|
6.5
± 0.1
|
| 315 |
EN300-107892_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C6CC6 |
−9.0
± 0.2
|
6.5
± 0.2
|
| 316 |
EN300-134855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5cccnc5)O |
−9.0
± 0.2
|
6.5
± 0.1
|
| 317 |
EN300-6497444_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCC(C6)O |
−9.0
± 0.2
|
6.5
± 0.1
|
| 318 |
DAR-DIA-0d514e7d-4
|
|
C[C@H]1COc2c(cc(cc2OC3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
| 319 |
EN300-28571_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5n6cncn6 |
−9.0
± 0.2
|
6.5
± 0.2
|
| 320 |
EN300-1425677_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCO5)CO |
−9.0
± 0.2
|
6.5
± 0.2
|
| 321 |
EN300-244947_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5c[nH]nn5 |
−9.0
± 0.3
|
6.5
± 0.2
|
| 322 |
EN300-373584_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)C5CCOCC5 |
−9.0
± 0.4
|
6.5
± 0.3
|
| 323 |
EN300-64297_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncnc5 |
−9.0
± 0.2
|
6.5
± 0.1
|
| 324 |
EN300-18928_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CSCN5C(=O)C6CC6 |
−9.0
± 0.2
|
6.5
± 0.2
|
| 325 |
EN300-239825_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6[nH]nnn6 |
−9.0
± 0.3
|
6.5
± 0.2
|
| 326 |
EN300-102071_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)C(=O)N |
−9.0
± 0.2
|
6.5
± 0.2
|
| 327 |
EN300-264301_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCC(=O)N5 |
−9.0
± 0.3
|
6.5
± 0.2
|
| 328 |
EN300-220676_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCS(=O)(=O)C5 |
−9.0
± 0.3
|
6.5
± 0.2
|
| 329 |
EN300-6491117_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnco5 |
−9.0
± 0.2
|
6.5
± 0.1
|
| 330 |
EN300-73772_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)[nH]n5 |
−9.0
± 0.2
|
6.5
± 0.1
|
| 331 |
EN300-321597_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H](C5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
| 332 |
EN300-3710141_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCO5)C#N |
−8.9
± 0.2
|
6.5
± 0.2
|
| 333 |
EN300-36522_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)C5CC5 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 334 |
EN300-107435_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCS5(=O)=O |
−8.9
± 0.3
|
6.5
± 0.2
|
| 335 |
EN300-237561_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)cccn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
| 336 |
EN300-317082_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5COC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 337 |
EN300-115760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)c6[nH]nnn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
| 338 |
EDJ-MED-e4b030d8-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5COC5)Cl |
−8.9
± 0.2
|
6.5
± 0.2
|
| 339 |
EN300-343474_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCNC5=O |
−8.9
± 0.2
|
6.5
± 0.1
|
| 340 |
EN300-1590388_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(cn5)C#N |
−8.9
± 0.3
|
6.5
± 0.2
|
| 341 |
EN300-25986_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cccn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 342 |
EN300-251851_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]nnn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
| 343 |
EN300-70489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)C#N |
−8.9
± 0.2
|
6.5
± 0.2
|
| 344 |
EN300-191904_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cnnn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 345 |
EN300-1600517_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CO)F |
−8.9
± 0.2
|
6.5
± 0.2
|
| 346 |
EN300-54417_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cccc(c5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
| 347 |
EN300-246248_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CCNC5=O |
−8.9
± 0.2
|
6.5
± 0.1
|
| 348 |
EN300-85760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCO5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 349 |
EN300-1726277_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(n5cccn5)F |
−8.9
± 0.1
|
6.5
± 0.1
|
| 350 |
EN300-189901_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5[nH]c(=O)[nH]6 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 351 |
EN300-53423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCOC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 352 |
EN300-107048_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
| 353 |
EN300-399072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]5CO |
−8.9
± 0.2
|
6.5
± 0.2
|
| 354 |
EN300-141457_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCCO)CCCO |
−8.9
± 0.3
|
6.5
± 0.2
|
| 355 |
EN300-46832_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC5CCOC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 356 |
EN300-66461_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CNC(=O)N5 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 357 |
EN300-171766_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5n[nH]c(=O)s5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 358 |
EN300-384234_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6cnn[nH]6)O |
−8.9
± 0.2
|
6.5
± 0.2
|
| 359 |
EN300-318344_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncco5 |
−8.9
± 0.1
|
6.46
± 0.10
|
| 360 |
EN300-69588_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)CC5 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 361 |
EN300-103720_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCCO6 |
−8.9
± 0.2
|
6.5
± 0.2
|
| 362 |
EN300-244403_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CNC(=O)O5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 363 |
EN300-69368_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
| 364 |
EN300-42269_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnns5 |
−8.9
± 0.2
|
6.5
± 0.1
|
| 365 |
EN300-4726186_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CN5CCCNS5(=O)=O |
−8.9
± 0.3
|
6.5
± 0.2
|
| 366 |
EN300-1600363_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5C#N |
−8.9
± 0.2
|
6.4
± 0.1
|
| 367 |
EN300-95507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)CO |
−8.9
± 0.2
|
6.4
± 0.1
|
| 368 |
EN300-128464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NC5CC5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 369 |
EN300-343562_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]([C@H]5CO)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
| 370 |
EN300-7443878_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CCOCC5)O |
−8.8
± 0.2
|
6.4
± 0.2
|
| 371 |
EN300-1267109_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)C#N |
−8.8
± 0.2
|
6.4
± 0.1
|
| 372 |
EN300-210110_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CC6 |
−8.8
± 0.2
|
6.4
± 0.1
|
| 373 |
EN300-321703_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCOC5COC5 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 374 |
EN300-7349829_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NCC56CCC6 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 375 |
EN300-14767_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCN(C5)C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
| 376 |
EN300-70133_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c(cnn5CCO)C#N |
−8.8
± 0.2
|
6.4
± 0.2
|
| 377 |
EN300-761618_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5cccnn5 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 378 |
EN300-22879_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCCC5C(=O)N |
−8.8
± 0.2
|
6.4
± 0.1
|
| 379 |
EN300-7434209_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5[nH]c(=O)[nH]6 |
−8.8
± 0.2
|
6.4
± 0.1
|
| 380 |
EN300-6499531_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCCS5(=O)=O |
−8.8
± 0.2
|
6.4
± 0.2
|
| 381 |
EN300-51350_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nncn6C5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 382 |
DAR-DIA-6a508060-5
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4CC5CC(=O)N5)Cl |
−8.8
± 0.1
|
6.4
± 0.1
|
| 383 |
EN300-307567_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)Cn6ccnn6 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 384 |
EN300-169955_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C(CC(=O)N5)C(F)(F)F |
−8.8
± 0.2
|
6.4
± 0.1
|
| 385 |
EN300-6491316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6cnnn6c5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 386 |
EN300-54891_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CO |
−8.8
± 0.2
|
6.4
± 0.2
|
| 387 |
EN300-77092_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5OCCO5 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 388 |
EN300-149975_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)CO |
−8.8
± 0.2
|
6.4
± 0.2
|
| 389 |
EN300-225165_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CC(=O)NC(=O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
| 390 |
EN300-122656_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCSC5)O |
−8.8
± 0.4
|
6.4
± 0.3
|
| 391 |
EN300-45182_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCN5CCOC5=O |
−8.8
± 0.3
|
6.4
± 0.2
|
| 392 |
EN300-1604607_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CC(C5)OC6 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 393 |
EN300-31015_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCSCC(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|
| 394 |
EN300-359750_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)O5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 395 |
EN300-270710_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
| 396 |
EN300-245265_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cnc(n5)C#N |
−8.8
± 0.3
|
6.4
± 0.2
|
| 397 |
EN300-306316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]cnn5 |
−8.8
± 0.2
|
6.4
± 0.1
|
| 398 |
EN300-1715993_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5ccnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 399 |
EN300-1696962_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCn5cnnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
| 400 |
EN300-315238_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|