Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
301 |
EN300-103722_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCCC6 |
−9.0
± 0.2
|
6.6
± 0.2
|
302 |
EN300-315963_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnoc5 |
−9.0
± 0.2
|
6.6
± 0.2
|
303 |
EN300-1241327_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCOCC5 |
−9.0
± 0.1
|
6.57
± 0.10
|
304 |
EN300-379219_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CNC(=O)O6 |
−9.0
± 0.2
|
6.6
± 0.1
|
305 |
EN300-04520_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(c5)S(=O)(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
306 |
EN300-58433_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)n6cncn6 |
−9.0
± 0.2
|
6.6
± 0.2
|
307 |
EN300-1700760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6(C5)CC(=O)N6 |
−9.0
± 0.2
|
6.6
± 0.1
|
308 |
EN300-6474740_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)c6[nH]cnn6 |
−9.0
± 0.3
|
6.6
± 0.2
|
309 |
EN300-100741_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]cnn5 |
−9.0
± 0.2
|
6.6
± 0.1
|
310 |
EN300-52193_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCO |
−9.0
± 0.2
|
6.6
± 0.1
|
311 |
EN300-364679_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cnnn5 |
−9.0
± 0.2
|
6.6
± 0.2
|
312 |
EN300-183231_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCc5[nH]nnn5 |
−9.0
± 0.2
|
6.6
± 0.2
|
313 |
EN300-1719432_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5nc(nn5)C6CC6 |
−9.0
± 0.3
|
6.6
± 0.2
|
314 |
EN300-307333_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCNC5=O |
−9.0
± 0.2
|
6.5
± 0.1
|
315 |
EN300-107892_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C6CC6 |
−9.0
± 0.2
|
6.5
± 0.2
|
316 |
EN300-134855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5cccnc5)O |
−9.0
± 0.2
|
6.5
± 0.1
|
317 |
EN300-6497444_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCC(C6)O |
−9.0
± 0.2
|
6.5
± 0.1
|
318 |
DAR-DIA-0d514e7d-4
|
|
C[C@H]1COc2c(cc(cc2OC3CCCC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
319 |
EN300-28571_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5n6cncn6 |
−9.0
± 0.2
|
6.5
± 0.2
|
320 |
EN300-1425677_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCO5)CO |
−9.0
± 0.2
|
6.5
± 0.2
|
321 |
EN300-244947_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5c[nH]nn5 |
−9.0
± 0.3
|
6.5
± 0.2
|
322 |
EN300-373584_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)C5CCOCC5 |
−9.0
± 0.4
|
6.5
± 0.3
|
323 |
EN300-64297_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncnc5 |
−9.0
± 0.2
|
6.5
± 0.1
|
324 |
EN300-18928_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CSCN5C(=O)C6CC6 |
−9.0
± 0.2
|
6.5
± 0.2
|
325 |
EN300-239825_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6[nH]nnn6 |
−9.0
± 0.3
|
6.5
± 0.2
|
326 |
EN300-102071_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)C(=O)N |
−9.0
± 0.2
|
6.5
± 0.2
|
327 |
EN300-264301_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCC(=O)N5 |
−9.0
± 0.3
|
6.5
± 0.2
|
328 |
EN300-220676_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCS(=O)(=O)C5 |
−9.0
± 0.3
|
6.5
± 0.2
|
329 |
EN300-6491117_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnco5 |
−9.0
± 0.2
|
6.5
± 0.1
|
330 |
EN300-73772_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)[nH]n5 |
−9.0
± 0.2
|
6.5
± 0.1
|
331 |
EN300-321597_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H](C5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
332 |
EN300-3710141_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCCO5)C#N |
−8.9
± 0.2
|
6.5
± 0.2
|
333 |
EN300-36522_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)C5CC5 |
−8.9
± 0.2
|
6.5
± 0.2
|
334 |
EN300-107435_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCS5(=O)=O |
−8.9
± 0.3
|
6.5
± 0.2
|
335 |
EN300-237561_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)cccn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
336 |
EN300-317082_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5COC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
337 |
EN300-115760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)c6[nH]nnn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
338 |
EDJ-MED-e4b030d8-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5COC5)Cl |
−8.9
± 0.2
|
6.5
± 0.2
|
339 |
EN300-343474_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCNC5=O |
−8.9
± 0.2
|
6.5
± 0.1
|
340 |
EN300-1590388_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(cn5)C#N |
−8.9
± 0.3
|
6.5
± 0.2
|
341 |
EN300-25986_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cccn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
342 |
EN300-251851_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]nnn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
343 |
EN300-70489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)C#N |
−8.9
± 0.2
|
6.5
± 0.2
|
344 |
EN300-191904_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cnnn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
345 |
EN300-1600517_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(CO)F |
−8.9
± 0.2
|
6.5
± 0.2
|
346 |
EN300-54417_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cccc(c5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
347 |
EN300-246248_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CCNC5=O |
−8.9
± 0.2
|
6.5
± 0.1
|
348 |
EN300-85760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCO5 |
−8.9
± 0.2
|
6.5
± 0.1
|
349 |
EN300-1726277_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(n5cccn5)F |
−8.9
± 0.1
|
6.5
± 0.1
|
350 |
EN300-189901_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5[nH]c(=O)[nH]6 |
−8.9
± 0.2
|
6.5
± 0.2
|
351 |
EN300-53423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCOC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
352 |
EN300-107048_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
353 |
EN300-399072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]5CO |
−8.9
± 0.2
|
6.5
± 0.2
|
354 |
EN300-141457_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCCO)CCCO |
−8.9
± 0.3
|
6.5
± 0.2
|
355 |
EN300-46832_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC5CCOC5 |
−8.9
± 0.2
|
6.5
± 0.1
|
356 |
EN300-66461_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CNC(=O)N5 |
−8.9
± 0.2
|
6.5
± 0.2
|
357 |
EN300-171766_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5n[nH]c(=O)s5 |
−8.9
± 0.2
|
6.5
± 0.1
|
358 |
EN300-384234_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6cnn[nH]6)O |
−8.9
± 0.2
|
6.5
± 0.2
|
359 |
EN300-318344_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncco5 |
−8.9
± 0.1
|
6.46
± 0.10
|
360 |
EN300-69588_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)CC5 |
−8.9
± 0.2
|
6.5
± 0.2
|
361 |
EN300-103720_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCCO6 |
−8.9
± 0.2
|
6.5
± 0.2
|
362 |
EN300-244403_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CNC(=O)O5 |
−8.9
± 0.2
|
6.5
± 0.1
|
363 |
EN300-69368_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)O |
−8.9
± 0.2
|
6.5
± 0.2
|
364 |
EN300-42269_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnns5 |
−8.9
± 0.2
|
6.5
± 0.1
|
365 |
EN300-4726186_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CN5CCCNS5(=O)=O |
−8.9
± 0.3
|
6.5
± 0.2
|
366 |
EN300-1600363_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5C#N |
−8.9
± 0.2
|
6.4
± 0.1
|
367 |
EN300-95507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)CO |
−8.9
± 0.2
|
6.4
± 0.1
|
368 |
EN300-128464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NC5CC5 |
−8.8
± 0.2
|
6.4
± 0.2
|
369 |
EN300-343562_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]([C@H]5CO)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
370 |
EN300-7443878_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CCOCC5)O |
−8.8
± 0.2
|
6.4
± 0.2
|
371 |
EN300-1267109_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)C#N |
−8.8
± 0.2
|
6.4
± 0.1
|
372 |
EN300-210110_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CC6 |
−8.8
± 0.2
|
6.4
± 0.1
|
373 |
EN300-321703_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCOC5COC5 |
−8.8
± 0.3
|
6.4
± 0.2
|
374 |
EN300-7349829_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NCC56CCC6 |
−8.8
± 0.3
|
6.4
± 0.2
|
375 |
EN300-14767_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCN(C5)C(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
376 |
EN300-70133_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c(cnn5CCO)C#N |
−8.8
± 0.2
|
6.4
± 0.2
|
377 |
EN300-761618_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5cccnn5 |
−8.8
± 0.3
|
6.4
± 0.2
|
378 |
EN300-22879_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCCC5C(=O)N |
−8.8
± 0.2
|
6.4
± 0.1
|
379 |
EN300-7434209_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5[nH]c(=O)[nH]6 |
−8.8
± 0.2
|
6.4
± 0.1
|
380 |
EN300-6499531_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCCS5(=O)=O |
−8.8
± 0.2
|
6.4
± 0.2
|
381 |
EN300-51350_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nncn6C5 |
−8.8
± 0.2
|
6.4
± 0.2
|
382 |
DAR-DIA-6a508060-5
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4CC5CC(=O)N5)Cl |
−8.8
± 0.1
|
6.4
± 0.1
|
383 |
EN300-307567_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)Cn6ccnn6 |
−8.8
± 0.3
|
6.4
± 0.2
|
384 |
EN300-169955_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C(CC(=O)N5)C(F)(F)F |
−8.8
± 0.2
|
6.4
± 0.1
|
385 |
EN300-6491316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6cnnn6c5 |
−8.8
± 0.2
|
6.4
± 0.2
|
386 |
EN300-54891_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CO |
−8.8
± 0.2
|
6.4
± 0.2
|
387 |
EN300-77092_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5OCCO5 |
−8.8
± 0.3
|
6.4
± 0.2
|
388 |
EN300-149975_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)CO |
−8.8
± 0.2
|
6.4
± 0.2
|
389 |
EN300-225165_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CC(=O)NC(=O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
390 |
EN300-122656_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCSC5)O |
−8.8
± 0.4
|
6.4
± 0.3
|
391 |
EN300-45182_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCN5CCOC5=O |
−8.8
± 0.3
|
6.4
± 0.2
|
392 |
EN300-1604607_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CC(C5)OC6 |
−8.8
± 0.2
|
6.4
± 0.2
|
393 |
EN300-31015_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCSCC(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|
394 |
EN300-359750_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCC(=O)O5 |
−8.8
± 0.2
|
6.4
± 0.2
|
395 |
EN300-270710_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
396 |
EN300-245265_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cnc(n5)C#N |
−8.8
± 0.3
|
6.4
± 0.2
|
397 |
EN300-306316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]cnn5 |
−8.8
± 0.2
|
6.4
± 0.1
|
398 |
EN300-1715993_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5ccnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
399 |
EN300-1696962_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCn5cnnn5 |
−8.8
± 0.2
|
6.4
± 0.2
|
400 |
EN300-315238_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−8.8
± 0.2
|
6.4
± 0.2
|