Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3001 |
EN300-1222960_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C6CCOC6=O |
−5.9
± 0.2
|
4.3
± 0.2
|
3002 |
EN300-704039_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C56CCOCC6)O |
−5.9
± 0.2
|
4.3
± 0.2
|
3003 |
EN300-253187_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5COCO5 |
−5.9
± 0.3
|
4.3
± 0.2
|
3004 |
EN300-59386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(s5)S(=O)(=O)N |
−5.9
± 0.3
|
4.3
± 0.2
|
3005 |
EN300-6480251_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CN(C5)C(=O)C6CC6 |
−5.9
± 0.3
|
4.3
± 0.2
|
3006 |
EN300-220228_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6ccnn6c5O |
−5.9
± 0.3
|
4.3
± 0.2
|
3007 |
EN300-155176_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCCS5(=O)=O |
−5.9
± 0.4
|
4.3
± 0.3
|
3008 |
EN300-11714_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccccc5=O |
−5.8
± 0.3
|
4.3
± 0.2
|
3009 |
EN300-1664105_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)n6cc(nn6)CO |
−5.8
± 0.3
|
4.3
± 0.2
|
3010 |
EN300-247026_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCOCC5=O |
−5.8
± 0.3
|
4.3
± 0.2
|
3011 |
EN300-254272_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)cc[nH]5 |
−5.8
± 0.3
|
4.3
± 0.2
|
3012 |
EN300-109119_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5cc([nH]n5)C(=O)N |
−5.8
± 0.2
|
4.3
± 0.2
|
3013 |
EN300-315792_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COCC(F)F |
−5.8
± 0.2
|
4.3
± 0.2
|
3014 |
EN300-79180_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5CCOCC5)O |
−5.8
± 0.2
|
4.3
± 0.1
|
3015 |
EN300-310254_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5C(=O)NCC56CCOCC6 |
−5.8
± 0.2
|
4.3
± 0.2
|
3016 |
EN300-207092_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC5(CCOCC5)O |
−5.8
± 0.3
|
4.3
± 0.2
|
3017 |
EN300-313366_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CCN(C5)CC6 |
−5.8
± 0.3
|
4.3
± 0.2
|
3018 |
EN300-2011083_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(=O)OCC5 |
−5.8
± 0.2
|
4.3
± 0.1
|
3019 |
EN300-26031_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nnc6n5CCC6 |
−5.8
± 0.2
|
4.3
± 0.2
|
3020 |
EN300-314088_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)CO)CO |
−5.8
± 0.3
|
4.3
± 0.2
|
3021 |
EN300-189672_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5ccc(=O)[nH]c5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3022 |
EN300-124365_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)N6CCOCC6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3023 |
EN300-42269_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnns5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3024 |
EN300-19625_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCN5CCOCC5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3025 |
EN300-7443518_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6cncn6c(=O)[nH]5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3026 |
EN300-7443835_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H]([C@H]([C@H]5O)O)CO |
−5.8
± 0.3
|
4.2
± 0.2
|
3027 |
EN300-7385389_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnc(n5)C(F)(F)F |
−5.8
± 0.3
|
4.2
± 0.2
|
3028 |
EN300-7430909_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CN(C5)C6COC6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3029 |
EN300-08033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCS(=O)(=O)C5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3030 |
EN300-103031_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c([nH]n5)CCOC6 |
−5.8
± 0.2
|
4.2
± 0.2
|
3031 |
EN300-6478948_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CCC(=O)NC5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3032 |
EN300-258326_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnccc5=O |
−5.8
± 0.3
|
4.2
± 0.2
|
3033 |
EN300-1719432_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5nc(nn5)C6CC6 |
−5.8
± 0.2
|
4.2
± 0.2
|
3034 |
EN300-343434_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCC5)c6[nH]nnn6 |
−5.8
± 0.4
|
4.2
± 0.3
|
3035 |
EN300-102871_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CN(C5)c6ccncn6 |
−5.8
± 0.2
|
4.2
± 0.2
|
3036 |
EN300-6763045_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CCCNC6=O |
−5.8
± 0.3
|
4.2
± 0.2
|
3037 |
EN300-07127_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC5C(=O)N |
−5.8
± 0.2
|
4.2
± 0.1
|
3038 |
EN300-7459805_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC56CC(C5)(CCO6)CO |
−5.8
± 0.3
|
4.2
± 0.2
|
3039 |
EN300-7385329_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5Cc6nccn6C5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3040 |
EN300-702756_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CS(=O)(=O)CC(=O)N5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3041 |
EN300-226776_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(CO)O |
−5.8
± 0.3
|
4.2
± 0.2
|
3042 |
EN300-1717443_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC56CS(=O)(=O)C6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3043 |
EN300-107700_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCC(O5)C(=O)N |
−5.8
± 0.2
|
4.2
± 0.1
|
3044 |
EN300-379570_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)COCCO6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3045 |
EN300-124383_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC5C(=O)N |
−5.8
± 0.3
|
4.2
± 0.2
|
3046 |
EN300-61898_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nn5)n6ccnc6 |
−5.8
± 0.2
|
4.2
± 0.1
|
3047 |
EN300-1293808_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCSC5)OCCO |
−5.8
± 0.3
|
4.2
± 0.2
|
3048 |
EN300-181558_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CCC(CC5)O)O |
−5.8
± 0.3
|
4.2
± 0.2
|
3049 |
EN300-260475_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)N5CCCO5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3050 |
EN300-268196_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)N6CCOCC6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3051 |
EN300-7434209_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cncc6c5[nH]c(=O)[nH]6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3052 |
EN300-42591_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)NC5CC5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3053 |
EN300-30536_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5c(cn[nH]5)C(=O)N |
−5.8
± 0.2
|
4.2
± 0.2
|
3054 |
EN300-103638_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCCOC5=O |
−5.8
± 0.3
|
4.2
± 0.2
|
3055 |
EN300-142333_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C6(C5)CC6)O |
−5.8
± 0.2
|
4.2
± 0.2
|
3056 |
EN300-1664603_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5ccn[nH]5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3057 |
EN300-304381_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)CC(=O)N |
−5.8
± 0.2
|
4.2
± 0.2
|
3058 |
EN300-141480_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCCN(C5=O)CCO |
−5.8
± 0.3
|
4.2
± 0.2
|
3059 |
EN300-378836_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCCCS5(=O)=O |
−5.8
± 0.4
|
4.2
± 0.3
|
3060 |
EN300-131051_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(ccn5)C(=O)N |
−5.8
± 0.2
|
4.2
± 0.2
|
3061 |
EN300-125100_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cccc(=O)[nH]5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3062 |
EN300-7439985_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(CC5C6)CO |
−5.8
± 0.3
|
4.2
± 0.2
|
3063 |
EN300-1723565_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CC5CCOC5)CO |
−5.8
± 0.2
|
4.2
± 0.2
|
3064 |
EN300-6479181_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCC6N5C(=O)CC6 |
−5.8
± 0.2
|
4.2
± 0.2
|
3065 |
EN300-81038_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)COC6 |
−5.8
± 0.2
|
4.2
± 0.2
|
3066 |
EN300-36931_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCOCC5)C(=O)N |
−5.8
± 0.3
|
4.2
± 0.2
|
3067 |
EN300-1726153_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cccn6c5nnc6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3068 |
EN300-6729730_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCNS(=O)(=O)C5CC5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3069 |
EN300-122319_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(=O)[nH]c(=O)[nH]n5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3070 |
EN300-30039_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc(=O)[nH]c(=O)[nH]5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3071 |
EN300-213724_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccccc5S(=O)(=O)N |
−5.8
± 0.3
|
4.2
± 0.2
|
3072 |
EN300-343474_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CCNC5=O |
−5.8
± 0.3
|
4.2
± 0.2
|
3073 |
EN300-43939_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)CC(F)(F)F |
−5.8
± 0.2
|
4.2
± 0.2
|
3074 |
EN300-131051_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc(ccn5)C(=O)N |
−5.8
± 0.2
|
4.2
± 0.2
|
3075 |
EN300-134204_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCc5[nH]nnn5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3076 |
EN300-1692858_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cnn(c5)CCO |
−5.8
± 0.2
|
4.2
± 0.1
|
3077 |
EN300-53918_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCN5CCOC5=O |
−5.8
± 0.3
|
4.2
± 0.2
|
3078 |
EN300-31553_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCS(=O)(=O)N |
−5.8
± 0.4
|
4.2
± 0.3
|
3079 |
EN300-1267109_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c(cn[nH]5)C#N |
−5.8
± 0.3
|
4.2
± 0.2
|
3080 |
EN300-1717166_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC56CC(C6)O |
−5.8
± 0.2
|
4.2
± 0.1
|
3081 |
EN300-109535_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CC(=O)OC5 |
−5.8
± 0.3
|
4.2
± 0.2
|
3082 |
EN300-7459768_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(C5)(C6(CCC6)O)O |
−5.8
± 0.3
|
4.2
± 0.2
|
3083 |
EN300-61898_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(nn5)n6ccnc6 |
−5.8
± 0.3
|
4.2
± 0.2
|
3084 |
EN300-244403_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CNC(=O)O5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3085 |
EN300-399072_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H]5CO |
−5.8
± 0.3
|
4.2
± 0.2
|
3086 |
EN300-43939_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)CC(F)(F)F |
−5.8
± 0.3
|
4.2
± 0.2
|
3087 |
EN300-108171_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5COCCOC5 |
−5.8
± 0.4
|
4.2
± 0.3
|
3088 |
EN300-695831_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5nnc(s5)C(=O)N |
−5.8
± 0.2
|
4.2
± 0.2
|
3089 |
EN300-207873_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CC5)O |
−5.8
± 0.2
|
4.2
± 0.2
|
3090 |
EN300-1293808_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCSC5)OCCO |
−5.8
± 0.3
|
4.2
± 0.2
|
3091 |
EN300-6478948_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC5CCC(=O)NC5 |
−5.8
± 0.2
|
4.2
± 0.2
|
3092 |
EN300-262540_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ccc(=O)n(c5)CCO |
−5.8
± 0.3
|
4.2
± 0.2
|
3093 |
EN300-6504535_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CC(CO5)CO |
−5.8
± 0.2
|
4.2
± 0.1
|
3094 |
EN300-25791_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)C(=O)N |
−5.8
± 0.3
|
4.2
± 0.2
|
3095 |
EN300-96013_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5[nH]c(nn5)CO |
−5.8
± 0.2
|
4.2
± 0.2
|
3096 |
DAR-DIA-0d514e7d-7
|
|
C[C@H]1COc2c(cc(cc2NC3CC3)Cl)[C@@H]1C(=O)Nc4cncc5c4cccc5 |
−5.8
± 0.1
|
4.19
± 0.10
|
3097 |
EN300-175608_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CCF)CO |
−5.8
± 0.3
|
4.2
± 0.2
|
3098 |
EN300-7355777_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ncc(s5)C(=O)N |
−5.8
± 0.3
|
4.2
± 0.2
|
3099 |
EN300-99391_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC5CCOC5 |
−5.7
± 0.2
|
4.2
± 0.1
|
3100 |
EN300-6499531_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCCCS5(=O)=O |
−5.7
± 0.2
|
4.2
± 0.2
|