Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2401 |
EN300-130656_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccc(n5)C(=O)N |
−6.5
± 0.2
|
4.7
± 0.2
|
2402 |
EN300-6487134_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC56CC(C5)C(=O)NC6 |
−6.5
± 0.3
|
4.7
± 0.2
|
2403 |
EN300-61021_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5cccn6 |
−6.5
± 0.3
|
4.7
± 0.2
|
2404 |
EN300-123291_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CS(=O)(=O)C5 |
−6.5
± 0.2
|
4.7
± 0.2
|
2405 |
EN300-151461_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cn(nn5)C6CCOC6 |
−6.5
± 0.3
|
4.7
± 0.2
|
2406 |
EN300-7499295_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CCCO)CO |
−6.5
± 0.2
|
4.7
± 0.1
|
2407 |
EN300-6731821_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)nc[nH]5 |
−6.5
± 0.2
|
4.7
± 0.2
|
2408 |
EN300-107892_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5cc(nn5)C6CC6 |
−6.5
± 0.3
|
4.7
± 0.2
|
2409 |
EN300-7500507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(COCCOC5)F |
−6.5
± 0.4
|
4.7
± 0.3
|
2410 |
EN300-36111_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCCCC5=O |
−6.5
± 0.2
|
4.7
± 0.2
|
2411 |
EN300-254105_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CO)C5CCCOC5 |
−6.5
± 0.3
|
4.7
± 0.2
|
2412 |
EN300-386232_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CC5CCCO5)CO |
−6.5
± 0.2
|
4.7
± 0.1
|
2413 |
EN300-1179690_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C(=O)N)(F)F |
−6.5
± 0.3
|
4.7
± 0.2
|
2414 |
EN300-175300_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5nnc6n5CCC6 |
−6.5
± 0.4
|
4.7
± 0.3
|
2415 |
EN300-396535_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCC5)S(=O)(=O)N |
−6.5
± 0.3
|
4.7
± 0.2
|
2416 |
EN300-6474341_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCn6cnnc6C5 |
−6.5
± 0.2
|
4.7
± 0.2
|
2417 |
EN300-1722017_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)n6nccn6 |
−6.5
± 0.2
|
4.7
± 0.2
|
2418 |
EN300-3044054_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(=O)N5C6CC6 |
−6.5
± 0.3
|
4.7
± 0.2
|
2419 |
EN300-203853_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNS(=O)(=O)C5CC5 |
−6.5
± 0.3
|
4.7
± 0.2
|
2420 |
EN300-6779469_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C6C5CS(=O)(=O)C6 |
−6.5
± 0.2
|
4.7
± 0.2
|
2421 |
EN300-1723511_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCC5)CO |
−6.5
± 0.2
|
4.7
± 0.2
|
2422 |
EN300-264301_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC[C@@H]5CCC(=O)N5 |
−6.5
± 0.3
|
4.7
± 0.2
|
2423 |
EN300-123400_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C5CCOC5)C(=O)N |
−6.5
± 0.1
|
4.70
± 0.10
|
2424 |
EN300-7463171_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCS(=O)(=O)CCO |
−6.5
± 0.4
|
4.7
± 0.3
|
2425 |
EN300-378373_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC5CC5 |
−6.5
± 0.2
|
4.7
± 0.2
|
2426 |
EN300-7426781_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6cccn6ncn5 |
−6.5
± 0.2
|
4.7
± 0.2
|
2427 |
EN300-124374_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cn5)S(=O)(=O)N |
−6.5
± 0.2
|
4.7
± 0.2
|
2428 |
EN300-80855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(C5CCOC5)O |
−6.5
± 0.2
|
4.7
± 0.2
|
2429 |
EN300-7427798_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6CS(=O)(=O)CC6C5 |
−6.5
± 0.2
|
4.7
± 0.1
|
2430 |
EN300-102071_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccnc(c5)C(=O)N |
−6.5
± 0.3
|
4.7
± 0.2
|
2431 |
EN300-1270299_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccc(cn5)CO |
−6.5
± 0.2
|
4.7
± 0.2
|
2432 |
EN300-343103_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]c(=O)c6c(n5)CCOC6 |
−6.5
± 0.2
|
4.7
± 0.2
|
2433 |
NAU-LAT-0543f7f2-10
|
|
CC(=O)NCCOc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−6.4
± 0.3
|
4.7
± 0.2
|
2434 |
EN300-139167_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5COCCO5 |
−6.4
± 0.1
|
4.70
± 0.09
|
2435 |
EN300-135530_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5C(=O)N |
−6.4
± 0.3
|
4.7
± 0.2
|
2436 |
EN300-154332_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC5CO |
−6.4
± 0.2
|
4.7
± 0.2
|
2437 |
EN300-244278_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCOC6 |
−6.4
± 0.2
|
4.7
± 0.2
|
2438 |
EN300-36622_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCn5ccccc5=O |
−6.4
± 0.3
|
4.7
± 0.2
|
2439 |
EN300-322603_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)(CO)CO |
−6.4
± 0.2
|
4.7
± 0.2
|
2440 |
EN300-343103_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]c(=O)c6c(n5)CCOC6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2441 |
EN300-384559_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(COCCO)O |
−6.4
± 0.5
|
4.7
± 0.3
|
2442 |
EN300-61371_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(COCC5CC5)O |
−6.4
± 0.3
|
4.7
± 0.2
|
2443 |
EN300-88131_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@@H](C5)CO |
−6.4
± 0.2
|
4.7
± 0.2
|
2444 |
EN300-258081_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)OCCO |
−6.4
± 0.2
|
4.7
± 0.2
|
2445 |
EN300-155447_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5CCOC6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2446 |
EN300-108506_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(cn5)n6cccn6 |
−6.4
± 0.2
|
4.7
± 0.1
|
2447 |
EN300-142412_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCCC(=O)N |
−6.4
± 0.3
|
4.7
± 0.2
|
2448 |
EN300-1081256_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)OCC(=O)N |
−6.4
± 0.3
|
4.7
± 0.2
|
2449 |
EN300-321703_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCOC5COC5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2450 |
EN300-102071_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc(c5)C(=O)N |
−6.4
± 0.2
|
4.7
± 0.2
|
2451 |
EN300-396329_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@@H]5CO |
−6.4
± 0.2
|
4.7
± 0.2
|
2452 |
EN300-37102_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCO)C5CC5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2453 |
EN300-210907_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCS(=O)(=O)CC5)O |
−6.4
± 0.2
|
4.7
± 0.2
|
2454 |
EN300-2913619_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5Cc6nccn6C5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2455 |
EN300-222145_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CNC(=O)N5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2456 |
EN300-135123_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cc5)C(=O)N |
−6.4
± 0.2
|
4.7
± 0.2
|
2457 |
EN300-148421_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCOC5)O |
−6.4
± 0.2
|
4.7
± 0.2
|
2458 |
EN300-141464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)NCC5(CC5)C#N |
−6.4
± 0.3
|
4.7
± 0.2
|
2459 |
EN300-150212_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(n[nH]5)F |
−6.4
± 0.2
|
4.7
± 0.2
|
2460 |
EN300-250120_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCS(=O)(=O)CC5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2461 |
EN300-214552_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c([nH]c(=O)[nH]6)nc5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2462 |
EN300-7355477_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC(C(CC6C5)O)O |
−6.4
± 0.2
|
4.7
± 0.2
|
2463 |
EN300-1425963_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCC5N6CCOCC6 |
−6.4
± 0.2
|
4.7
± 0.2
|
2464 |
EN300-113234_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)OC5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2465 |
EN300-7470991_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C[C@H]5CO)CO |
−6.4
± 0.3
|
4.7
± 0.2
|
2466 |
EN300-6763991_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5nnc6n5CCOC6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2467 |
EN300-66461_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CNC(=O)N5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2468 |
EN300-1241327_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N5CCOCC5 |
−6.4
± 0.2
|
4.7
± 0.1
|
2469 |
EN300-1068239_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cnon5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2470 |
EN300-270328_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCn5cncn5 |
−6.4
± 0.1
|
4.7
± 0.1
|
2471 |
EN300-1697735_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(CNC(=O)N)O |
−6.4
± 0.3
|
4.7
± 0.2
|
2472 |
EN300-221418_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)CN6CCOCC6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2473 |
EN300-108305_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCOCC(=O)N |
−6.4
± 0.3
|
4.7
± 0.2
|
2474 |
EN300-7443835_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H]([C@H]([C@H]5O)O)CO |
−6.4
± 0.3
|
4.7
± 0.2
|
2475 |
EN300-59487_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)NC5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2476 |
EN300-7431651_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CN(C5)C6COC6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2477 |
EN300-82037_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5ccon5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2478 |
EN300-127156_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(no5)C(=O)N |
−6.4
± 0.2
|
4.7
± 0.2
|
2479 |
EN300-68203_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CCC(=O)N5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2480 |
EN300-30039_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(=O)[nH]c(=O)[nH]5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2481 |
EN300-35428_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)NC5CC5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2482 |
EN300-146174_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)CO |
−6.4
± 0.2
|
4.7
± 0.1
|
2483 |
EN300-101796_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc(c5)OCCO |
−6.4
± 0.3
|
4.7
± 0.2
|
2484 |
EN300-7425070_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(C(=O)C5)C6CCOC6 |
−6.4
± 0.2
|
4.7
± 0.2
|
2485 |
EN300-6739235_2
|
|
CN([C@H]1C[C@@H](C1)C(=O)NC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)C |
−6.4
± 0.3
|
4.7
± 0.2
|
2486 |
EN300-7431964_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CN(C5)C(=O)N |
−6.4
± 0.2
|
4.7
± 0.1
|
2487 |
EN300-70492_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)Cc6ncon6 |
−6.4
± 0.4
|
4.7
± 0.3
|
2488 |
EN300-26147_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCn5cncn5 |
−6.4
± 0.2
|
4.7
± 0.2
|
2489 |
EN300-7439043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cc(n[nH]5)CO |
−6.4
± 0.2
|
4.7
± 0.2
|
2490 |
EN300-6763072_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CS(=O)(=O)C56CC(C5)C6 |
−6.4
± 0.3
|
4.7
± 0.2
|
2491 |
EN300-322332_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(nc5)C(=O)N |
−6.4
± 0.2
|
4.7
± 0.2
|
2492 |
EN300-6734276_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]6[C@@]5(COC6=O)CO |
−6.4
± 0.3
|
4.7
± 0.2
|
2493 |
EN300-310398_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(CC5)S(=O)(=O)N |
−6.4
± 0.4
|
4.7
± 0.3
|
2494 |
EN300-1706036_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5C(=O)NCCO5 |
−6.4
± 0.3
|
4.7
± 0.2
|
2495 |
EN300-1590388_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cc(cn5)C#N |
−6.4
± 0.3
|
4.7
± 0.2
|
2496 |
EN300-95507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(on5)CO |
−6.4
± 0.2
|
4.6
± 0.2
|
2497 |
EN300-85043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5OCCO |
−6.4
± 0.4
|
4.6
± 0.3
|
2498 |
EN300-1265948_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCS(=O)(=O)CC5 |
−6.4
± 0.3
|
4.6
± 0.2
|
2499 |
EN300-6760278_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC6C(O5)CCO6 |
−6.38
± 0.10
|
4.65
± 0.07
|
2500 |
EN300-71405_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5ccn[nH]5 |
−6.4
± 0.2
|
4.6
± 0.2
|