Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2201 |
EN300-141809_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC56CCS(=O)(=O)CC6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2202 |
EN300-226949_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnnc5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2203 |
EN300-393334_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)CC(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2204 |
EN300-173903_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC[C@H]5CO |
−6.7
± 0.3
|
4.9
± 0.2
|
2205 |
EN300-203118_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(CO)F |
−6.7
± 0.3
|
4.9
± 0.2
|
2206 |
EN300-195464_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)NCC(F)F |
−6.7
± 0.2
|
4.9
± 0.2
|
2207 |
EN300-6491117_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnco5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2208 |
EN300-250593_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CC(=O)N5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2209 |
EN300-1664603_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5ccn[nH]5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2210 |
EN300-01527_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC5CCCO5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2211 |
EN300-70656_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCC5)O |
−6.7
± 0.5
|
4.9
± 0.3
|
2212 |
EN300-5638430_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CS(=O)(=O)C5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2213 |
EN300-104592_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCC5CCC(=O)N5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2214 |
EN300-66779_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)c6[nH]nnn6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2215 |
EN300-6480951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)C6CC(=O)NC6 |
−6.7
± 0.2
|
4.9
± 0.1
|
2216 |
EN300-225920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(c5ccccn5)C(=O)N |
−6.7
± 0.2
|
4.9
± 0.2
|
2217 |
EN300-98214_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCCC5=O |
−6.7
± 0.3
|
4.9
± 0.2
|
2218 |
EN300-94202_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(C(=O)C5)CCO |
−6.7
± 0.3
|
4.9
± 0.2
|
2219 |
EN300-7445396_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5Cc6c[nH]cc6S5(=O)=O |
−6.7
± 0.2
|
4.9
± 0.2
|
2220 |
EN300-50194_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cccn5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2221 |
EN300-1605043_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)C(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2222 |
EN300-85760_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCO5 |
−6.7
± 0.1
|
4.9
± 0.1
|
2223 |
EN300-1600887_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5COCCO5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2224 |
EN300-82037_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5ccon5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2225 |
EN300-188356_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCOC5)F |
−6.7
± 0.2
|
4.9
± 0.1
|
2226 |
EN300-1087098_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCC(C(=O)N5)(F)F |
−6.7
± 0.3
|
4.9
± 0.2
|
2227 |
EN300-247428_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CC6CC6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2228 |
EN300-226425_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccc(=O)[nH]n5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2229 |
EN300-1448674_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6c(ncn6)C5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2230 |
EN300-6491682_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCc6c(nn[nH]6)C5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2231 |
EN300-76707_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCCC5)C(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2232 |
EN300-62808_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc[nH]5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2233 |
EN300-60837_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6nncn6c5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2234 |
EN300-24297_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5csnn5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2235 |
EN300-74089_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOCC5)C#N |
−6.7
± 0.2
|
4.9
± 0.2
|
2236 |
EN300-702542_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC56CC(C5)(CO6)CO |
−6.7
± 0.3
|
4.9
± 0.2
|
2237 |
EN300-1722017_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)n6nccn6 |
−6.7
± 0.2
|
4.9
± 0.2
|
2238 |
EN300-67533_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C5CC5)O |
−6.7
± 0.3
|
4.9
± 0.2
|
2239 |
EN300-207873_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CC5)O |
−6.7
± 0.2
|
4.9
± 0.1
|
2240 |
EN300-178515_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCC(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2241 |
EN300-36845_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)C5CCCC5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2242 |
EN300-365993_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC6CS(=O)(=O)CC6C5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2243 |
EN300-113507_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(=O)N |
−6.7
± 0.2
|
4.9
± 0.1
|
2244 |
EN300-226949_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5cnnc5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2245 |
EN300-225786_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5nnnn5C6CC6 |
−6.7
± 0.3
|
4.8
± 0.2
|
2246 |
EN300-1266316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCS(=O)(=O)N5 |
−6.7
± 0.3
|
4.8
± 0.2
|
2247 |
EN300-261859_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(=O)[nH]sn5 |
−6.7
± 0.2
|
4.8
± 0.2
|
2248 |
EN300-135182_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(=O)n6c([nH]5)ncn6 |
−6.7
± 0.2
|
4.8
± 0.2
|
2249 |
EN300-192893_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)ncn6 |
−6.7
± 0.2
|
4.8
± 0.2
|
2250 |
EN300-61636_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)C(=O)NC6CC6 |
−6.7
± 0.3
|
4.8
± 0.2
|
2251 |
EN300-7442191_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CN6CCC5CC6)O |
−6.7
± 0.2
|
4.8
± 0.2
|
2252 |
EN300-39826_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5nc6ncccn6n5 |
−6.7
± 0.3
|
4.8
± 0.2
|
2253 |
EN300-6739235_1
|
|
CN([C@H]1C[C@@H](C1)C(=O)N[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)C |
−6.7
± 0.2
|
4.8
± 0.2
|
2254 |
EN300-124555_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c(nc5)n[nH]n6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2255 |
EN300-96037_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]([C@H](C5)O)O |
−6.6
± 0.2
|
4.8
± 0.2
|
2256 |
EN300-106023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(no5)C(=O)N |
−6.6
± 0.2
|
4.8
± 0.2
|
2257 |
EN300-213215_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)N6CCC(C6)O |
−6.6
± 0.2
|
4.8
± 0.1
|
2258 |
EN300-6472558_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(nnc6CCO)C5 |
−6.6
± 0.3
|
4.8
± 0.2
|
2259 |
EN300-103720_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCCO6 |
−6.6
± 0.2
|
4.8
± 0.2
|
2260 |
EN300-10673_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCO)C5CCS(=O)(=O)C5 |
−6.6
± 0.5
|
4.8
± 0.4
|
2261 |
EN300-6763900_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCCC56COC6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2262 |
EN300-6494158_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC(CO5)CO |
−6.6
± 0.2
|
4.8
± 0.1
|
2263 |
EN300-133788_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCOC5)CO |
−6.6
± 0.2
|
4.8
± 0.2
|
2264 |
EN300-298184_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCNC5=O |
−6.6
± 0.2
|
4.8
± 0.2
|
2265 |
EN300-316386_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@H]5O |
−6.6
± 0.1
|
4.8
± 0.1
|
2266 |
EN300-7353973_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(CO)F |
−6.6
± 0.3
|
4.8
± 0.2
|
2267 |
EN300-266552_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)c6[nH]cnn6 |
−6.6
± 0.2
|
4.8
± 0.2
|
2268 |
EN300-73967_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCS(=O)(=O)CC5)C#N |
−6.6
± 0.3
|
4.8
± 0.2
|
2269 |
EN300-145616_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5cnc[nH]5 |
−6.6
± 0.2
|
4.8
± 0.2
|
2270 |
EN300-18928_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CSCN5C(=O)C6CC6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2271 |
EN300-705874_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5coc(n5)CN6CC[C@@H](C6)O |
−6.6
± 0.2
|
4.8
± 0.1
|
2272 |
EN300-29617_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)n6c(n5)CCCCC6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2273 |
EN300-141628_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccnc(c5)S(=O)(=O)N |
−6.6
± 0.4
|
4.8
± 0.3
|
2274 |
EN300-1222185_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C(=O)NC6CC6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2275 |
EN300-201781_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOCC5)OCCO |
−6.6
± 0.4
|
4.8
± 0.3
|
2276 |
EN300-151423_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CCOCC5)O |
−6.6
± 0.3
|
4.8
± 0.2
|
2277 |
EN300-6474341_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6cnnc6C5 |
−6.6
± 0.2
|
4.8
± 0.1
|
2278 |
EN300-250533_1
|
|
C[C@]1(C[C@@H](C1)NC(=O)C[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−6.6
± 0.2
|
4.8
± 0.2
|
2279 |
EN300-244403_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CNC(=O)O5 |
−6.6
± 0.2
|
4.8
± 0.1
|
2280 |
EN300-112500_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CC(=O)N)C5CC5 |
−6.6
± 0.2
|
4.8
± 0.2
|
2281 |
DAR-DIA-0d514e7d-27
|
|
C[C@@]1(c2cc(cc(c2OCC1(C)C)OC)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.6
± 0.1
|
4.8
± 0.1
|
2282 |
EN300-6494606_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(c(=O)[nH]c5=O)Cl |
−6.6
± 0.3
|
4.8
± 0.2
|
2283 |
EN300-1704047_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6c(cn[nH]6)C5C(=O)N |
−6.6
± 0.2
|
4.8
± 0.2
|
2284 |
EN300-146051_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccc(nc5)CO |
−6.6
± 0.2
|
4.8
± 0.2
|
2285 |
EN300-172179_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CN5CCOC5=O |
−6.6
± 0.2
|
4.8
± 0.2
|
2286 |
EN300-23942_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cccn5 |
−6.6
± 0.2
|
4.8
± 0.1
|
2287 |
EN300-6494859_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(OC5)Cn6cccn6 |
−6.6
± 0.2
|
4.8
± 0.1
|
2288 |
EN300-24419_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c(ccs5)S(=O)(=O)N |
−6.6
± 0.3
|
4.8
± 0.2
|
2289 |
EN300-77778_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCS(=O)(=O)C5 |
−6.6
± 0.2
|
4.8
± 0.1
|
2290 |
EN300-305984_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccn6c5nnn6 |
−6.6
± 0.3
|
4.8
± 0.2
|
2291 |
EN300-86732_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)C5CCCO5 |
−6.6
± 0.3
|
4.8
± 0.2
|
2292 |
EN300-61337_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)CCCO |
−6.6
± 0.4
|
4.8
± 0.3
|
2293 |
EN300-178829_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC(=O)NCC5CC5 |
−6.6
± 0.3
|
4.8
± 0.2
|
2294 |
EN300-1723254_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CC(C6)O |
−6.6
± 0.3
|
4.8
± 0.2
|
2295 |
EN300-10729_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)N |
−6.6
± 0.3
|
4.8
± 0.2
|
2296 |
EN300-1932013_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(CC(F)(F)F)O |
−6.6
± 0.2
|
4.8
± 0.2
|
2297 |
EN300-5638430_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CS(=O)(=O)C5 |
−6.6
± 0.3
|
4.8
± 0.2
|
2298 |
DAR-DIA-6a508060-13
|
|
CS(=O)(=O)NCCC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.6
± 0.2
|
4.8
± 0.2
|
2299 |
EN300-45182_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCN5CCOC5=O |
−6.6
± 0.3
|
4.8
± 0.2
|
2300 |
EN300-6504697_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC6(CC6)S(=O)(=O)N5 |
−6.6
± 0.3
|
4.8
± 0.2
|