Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2101 |
EN300-70815_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn(n5)CCO |
−6.8
± 0.2
|
4.9
± 0.2
|
2102 |
EN300-305567_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)nnn6 |
−6.8
± 0.3
|
4.9
± 0.2
|
2103 |
EN300-131690_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)c6ncon6 |
−6.8
± 0.2
|
4.9
± 0.1
|
2104 |
EN300-373584_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CC(=O)N)C5CCOCC5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2105 |
EN300-246178_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn(c5)CC(CO)O |
−6.8
± 0.3
|
4.9
± 0.2
|
2106 |
EN300-75875_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnnc5 |
−6.8
± 0.2
|
4.9
± 0.2
|
2107 |
EN300-36845_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)C5CCCC5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2108 |
EN300-393056_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCS(=O)(=O)CC5CCO |
−6.8
± 0.3
|
4.9
± 0.2
|
2109 |
EN300-68747_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)C(=O)N |
−6.8
± 0.2
|
4.9
± 0.2
|
2110 |
EN300-111863_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnc(n5)C#N |
−6.8
± 0.2
|
4.9
± 0.2
|
2111 |
EN300-1071940_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCCOC5)O |
−6.8
± 0.2
|
4.9
± 0.2
|
2112 |
EN300-08063_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCC(CC5)C(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2113 |
DAR-DIA-6a508060-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C#N |
−6.77
± 0.09
|
4.94
± 0.06
|
2114 |
EN300-59757_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCCNC5=O |
−6.8
± 0.3
|
4.9
± 0.2
|
2115 |
EN300-1605043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CC5)C(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2116 |
EN300-205143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCCS(=O)(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2117 |
EN300-60862_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)C(=O)N |
−6.8
± 0.2
|
4.9
± 0.1
|
2118 |
EN300-818709_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)Cc6[nH]nnn6 |
−6.8
± 0.2
|
4.9
± 0.2
|
2119 |
EN300-7550655_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nnc(s5)CO |
−6.8
± 0.2
|
4.9
± 0.2
|
2120 |
EN300-221122_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(c6cnn[nH]6)O |
−6.8
± 0.3
|
4.9
± 0.2
|
2121 |
EDJ-MED-e4b030d8-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3c(c(cc4)Cl)Cl |
−6.77
± 0.09
|
4.93
± 0.07
|
2122 |
EN300-33513_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CSCC(=O)N |
−6.8
± 0.2
|
4.9
± 0.2
|
2123 |
EN300-189563_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCC5CS(=O)(=O)C5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2124 |
EN300-90068_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5ccc(nc5)C(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2125 |
EN300-384557_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(c5cnc[nH]5)O |
−6.8
± 0.2
|
4.9
± 0.2
|
2126 |
EN300-1608992_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(C#N)C(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2127 |
EN300-23942_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5cccn5 |
−6.8
± 0.2
|
4.9
± 0.2
|
2128 |
EN300-157502_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5OCCCO5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2129 |
EN300-107493_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCNC(=O)C5 |
−6.8
± 0.2
|
4.9
± 0.1
|
2130 |
EN300-98429_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5c[nH]nn5 |
−6.8
± 0.2
|
4.9
± 0.1
|
2131 |
EN300-316258_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COCc5cc[nH]c(=O)c5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2132 |
EN300-22884_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCNC(=O)C5 |
−6.8
± 0.2
|
4.9
± 0.2
|
2133 |
EN300-62449_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)C5CCC5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2134 |
EN300-26953_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(C(=O)N)C(=O)N |
−6.8
± 0.3
|
4.9
± 0.2
|
2135 |
EN300-239219_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5nc(no5)c6cnccn6 |
−6.8
± 0.2
|
4.9
± 0.2
|
2136 |
EN300-107700_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCC(O5)C(=O)N |
−6.8
± 0.1
|
4.92
± 0.09
|
2137 |
EN300-98143_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(cn[nH]5)F |
−6.8
± 0.2
|
4.9
± 0.2
|
2138 |
EN300-1273202_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCNC(=O)C(C5)(F)F |
−6.8
± 0.3
|
4.9
± 0.2
|
2139 |
EN300-80001_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cc(cn5)C#N |
−6.8
± 0.3
|
4.9
± 0.2
|
2140 |
EN300-114593_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5cccn6 |
−6.8
± 0.2
|
4.9
± 0.1
|
2141 |
EN300-13287_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccc(=O)[nH]c5=O |
−6.8
± 0.2
|
4.9
± 0.2
|
2142 |
EN300-817870_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(COC5)CCO |
−6.8
± 0.2
|
4.9
± 0.2
|
2143 |
EN300-19242_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CO |
−6.8
± 0.2
|
4.9
± 0.1
|
2144 |
EN300-366852_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)c6[nH]nnn6 |
−6.8
± 0.2
|
4.9
± 0.2
|
2145 |
EN300-39785_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccn[nH]5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2146 |
EN300-315238_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−6.7
± 0.2
|
4.9
± 0.2
|
2147 |
EN300-185729_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCc6c(nn[nH]6)C5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2148 |
EN300-128715_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC(=O)NCC(F)(F)F |
−6.7
± 0.3
|
4.9
± 0.2
|
2149 |
EN300-20980_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnnn5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2150 |
EN300-28340_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC(=O)N5CCCC5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2151 |
EN300-219330_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCOCC5=O |
−6.7
± 0.3
|
4.9
± 0.2
|
2152 |
MAT-POS-f7918075-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−6.74
± 0.08
|
4.91
± 0.06
|
2153 |
EN300-1704047_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5Cc6c(cn[nH]6)C5C(=O)N |
−6.7
± 0.4
|
4.9
± 0.3
|
2154 |
EN300-107990_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)c5cccnc5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2155 |
EN300-100741_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5[nH]cnn5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2156 |
EN300-69312_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@@H](C5)O |
−6.7
± 0.2
|
4.9
± 0.2
|
2157 |
EN300-200699_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOC5)O |
−6.7
± 0.1
|
4.9
± 0.1
|
2158 |
EN300-154942_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5OCCO5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2159 |
EN300-50845_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(CO)O |
−6.7
± 0.3
|
4.9
± 0.2
|
2160 |
EN300-203402_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)[nH]c(=O)[nH]6 |
−6.7
± 0.2
|
4.9
± 0.2
|
2161 |
EN300-124258_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCOC5)C(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2162 |
EN300-46832_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCC5CCOC5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2163 |
EN300-77438_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(C5=O)C6CC6 |
−6.7
± 0.2
|
4.9
± 0.1
|
2164 |
EN300-210084_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCCC(=O)N5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2165 |
EN300-252018_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c6c(nc[nH]6)ncn5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2166 |
EN300-365965_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(C5)CS(=O)(=O)C6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2167 |
EN300-25446_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnco5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2168 |
EN300-36850_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCNC(=O)C5CC5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2169 |
EN300-3451857_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCC(=O)NC5=O |
−6.7
± 0.3
|
4.9
± 0.2
|
2170 |
EN300-333078_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H](Cc5cnc[nH]5)CO |
−6.7
± 0.3
|
4.9
± 0.2
|
2171 |
EN300-82476_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cnc[nH]5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2172 |
EN300-315836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5[nH]ccn5 |
−6.7
± 0.1
|
4.9
± 0.1
|
2173 |
EN300-223198_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCCS(=O)(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2174 |
EN300-1265434_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(C5CC5)C(=O)N |
−6.7
± 0.3
|
4.9
± 0.2
|
2175 |
EN300-256513_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)CC(=O)N |
−6.7
± 0.2
|
4.9
± 0.2
|
2176 |
EN300-378836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCCS5(=O)=O |
−6.7
± 0.3
|
4.9
± 0.2
|
2177 |
EN300-252113_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)C6C5CCOC6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2178 |
EN300-2726690_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)OCC(=O)N6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2179 |
EN300-657153_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6(C5)CS(=O)(=O)C6 |
−6.7
± 0.2
|
4.9
± 0.2
|
2180 |
EN300-176023_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6n(nn5)CCNC6=O |
−6.7
± 0.2
|
4.9
± 0.2
|
2181 |
EN300-6734454_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC56CC(C5)(OC6)CO |
−6.7
± 0.3
|
4.9
± 0.2
|
2182 |
EN300-113507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)N |
−6.7
± 0.2
|
4.9
± 0.1
|
2183 |
EN300-74450_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]ccn5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2184 |
EN300-749499_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5(CCOCC5)O)O |
−6.7
± 0.3
|
4.9
± 0.2
|
2185 |
EN300-6746631_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nnc6n5CCCC6 |
−6.7
± 0.2
|
4.9
± 0.2
|
2186 |
EN300-152337_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)NCC5 |
−6.7
± 0.2
|
4.9
± 0.1
|
2187 |
DAR-DIA-6a508060-4
|
|
COc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−6.7
± 0.1
|
4.88
± 0.08
|
2188 |
EN300-7541885_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)c(=O)n6c(n5)CCC6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2189 |
EN300-7355978_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(c(=O)[nH]cn6)[nH]n5 |
−6.7
± 0.2
|
4.9
± 0.2
|
2190 |
EN300-215968_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6CCOCC6 |
−6.7
± 0.3
|
4.9
± 0.2
|
2191 |
EN300-6473108_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6cccnn6n5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2192 |
EN300-219496_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCN(C5)S(=O)(=O)N |
−6.7
± 0.5
|
4.9
± 0.4
|
2193 |
EN300-226314_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)C5CCS(=O)(=O)C5 |
−6.7
± 0.3
|
4.9
± 0.2
|
2194 |
EN300-98313_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCSC5)O |
−6.7
± 0.2
|
4.9
± 0.2
|
2195 |
EN300-257573_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCC[C@@H]5C(=O)N |
−6.7
± 0.2
|
4.9
± 0.2
|
2196 |
EN300-73967_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCS(=O)(=O)CC5)C#N |
−6.7
± 0.2
|
4.9
± 0.2
|
2197 |
EN300-128715_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC(=O)NCC(F)(F)F |
−6.7
± 0.3
|
4.9
± 0.2
|
2198 |
EN300-6478631_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCc6n5cnn6 |
−6.7
± 0.2
|
4.9
± 0.2
|
2199 |
EN300-6746733_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6nccn6CC(C5)CO |
−6.7
± 0.2
|
4.9
± 0.1
|
2200 |
EN300-1600613_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC(CO)CO |
−6.7
± 0.3
|
4.9
± 0.2
|