Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
201 |
EN300-144606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn[nH]c5S(=O)(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
202 |
EN300-10747_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CSCC5=O |
−9.3
± 0.2
|
6.8
± 0.2
|
203 |
EN300-1704428_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnnn5c6cccnc6 |
−9.3
± 0.2
|
6.8
± 0.2
|
204 |
MAK-UNK-8be7dca9-5
|
|
c1cc2c(cc1CN)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.3
± 0.1
|
6.78
± 0.08
|
205 |
EN300-1696962_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCn5cnnn5 |
−9.3
± 0.3
|
6.8
± 0.2
|
206 |
EN300-251396_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)(CO)O |
−9.3
± 0.3
|
6.8
± 0.2
|
207 |
EN300-20363_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nccnn5 |
−9.3
± 0.2
|
6.8
± 0.1
|
208 |
EN300-219330_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOCC5=O |
−9.3
± 0.3
|
6.8
± 0.2
|
209 |
EN300-122340_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCSCC5)O |
−9.3
± 0.3
|
6.8
± 0.2
|
210 |
EN300-6472771_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5[C@H](CCC[C@H]5CO)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
211 |
EN300-148421_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)O |
−9.3
± 0.2
|
6.8
± 0.1
|
212 |
EN300-872798_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(nnn5)C6CC6 |
−9.3
± 0.3
|
6.8
± 0.2
|
213 |
EN300-114082_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C#N |
−9.3
± 0.2
|
6.8
± 0.2
|
214 |
EN300-7456948_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cccnn5 |
−9.3
± 0.2
|
6.8
± 0.2
|
215 |
EN300-342082_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ncncn5 |
−9.3
± 0.2
|
6.8
± 0.1
|
216 |
EN300-254908_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)n6cnnn6 |
−9.3
± 0.3
|
6.8
± 0.2
|
217 |
VLA-UCB-34f3ed0c-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc[nH]n5 |
−9.3
± 0.2
|
6.8
± 0.2
|
218 |
EN300-219496_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCN(C5)S(=O)(=O)N |
−9.3
± 0.6
|
6.8
± 0.4
|
219 |
EN300-25446_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnco5 |
−9.3
± 0.2
|
6.8
± 0.1
|
220 |
EN300-640698_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc([nH]c5=O)C#N |
−9.3
± 0.3
|
6.8
± 0.2
|
221 |
EN300-151756_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(cn5)nc[nH]c6=O |
−9.3
± 0.2
|
6.7
± 0.1
|
222 |
EN300-1723214_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(c5)c(=O)[nH]c(=O)[nH]6 |
−9.3
± 0.3
|
6.7
± 0.2
|
223 |
EN300-1600363_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@H]5C#N |
−9.3
± 0.2
|
6.7
± 0.2
|
224 |
VLA-UCB-50c39ae8-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC(=O)N5)Cl |
−9.3
± 0.1
|
6.7
± 0.1
|
225 |
EN300-244947_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5c[nH]nn5 |
−9.3
± 0.2
|
6.7
± 0.1
|
226 |
EN300-124652_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5CC(=O)N |
−9.3
± 0.2
|
6.7
± 0.2
|
227 |
EN300-141457_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCCO)CCCO |
−9.3
± 0.3
|
6.7
± 0.2
|
228 |
EN300-208959_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CNC(=O)CC5C(F)(F)F |
−9.3
± 0.1
|
6.7
± 0.1
|
229 |
EN300-624143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC56CC(C6)O |
−9.2
± 0.3
|
6.7
± 0.2
|
230 |
EN300-317555_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5=NCCO5 |
−9.2
± 0.2
|
6.7
± 0.1
|
231 |
EN300-176023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6n(nn5)CCNC6=O |
−9.2
± 0.2
|
6.7
± 0.2
|
232 |
EN300-47500_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCCCn5cccn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
233 |
EN300-1592151_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6ncnn6c5 |
−9.2
± 0.2
|
6.7
± 0.1
|
234 |
EN300-82037_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccon5 |
−9.2
± 0.2
|
6.7
± 0.2
|
235 |
EN300-20980_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnnn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
236 |
EN300-246440_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6cncn6 |
−9.2
± 0.2
|
6.7
± 0.2
|
237 |
EN300-331993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5[nH]ccn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
238 |
EN300-06654_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cncn5 |
−9.2
± 0.1
|
6.7
± 0.1
|
239 |
EN300-146174_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)CO |
−9.2
± 0.2
|
6.7
± 0.1
|
240 |
EN300-146174_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)CO |
−9.2
± 0.2
|
6.7
± 0.2
|
241 |
EN300-152337_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(=O)NCC5 |
−9.2
± 0.2
|
6.7
± 0.1
|
242 |
EN300-1448674_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6c(ncn6)C5 |
−9.2
± 0.2
|
6.7
± 0.1
|
243 |
EN300-203293_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CNC(=O)O5 |
−9.2
± 0.2
|
6.7
± 0.2
|
244 |
EN300-23942_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccn5 |
−9.2
± 0.2
|
6.7
± 0.2
|
245 |
EN300-1718675_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnnn5C6CC6 |
−9.2
± 0.2
|
6.7
± 0.2
|
246 |
EN300-4726186_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCNS5(=O)=O |
−9.2
± 0.3
|
6.7
± 0.2
|
247 |
EN300-316258_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCc5cc[nH]c(=O)c5 |
−9.2
± 0.3
|
6.7
± 0.2
|
248 |
EN300-74089_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)C#N |
−9.2
± 0.3
|
6.7
± 0.2
|
249 |
EN300-706065_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5(CCOCC5)O)(F)F |
−9.2
± 0.3
|
6.7
± 0.2
|
250 |
EN300-135530_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5C(=O)N |
−9.2
± 0.2
|
6.7
± 0.2
|
251 |
EN300-113218_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CSC5CCOC5=O |
−9.2
± 0.2
|
6.7
± 0.1
|
252 |
EN300-7438185_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6nncn6nc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
253 |
EN300-38979_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccnc5 |
−9.2
± 0.2
|
6.7
± 0.1
|
254 |
EN300-111006_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccncn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
255 |
EN300-96159_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]cnn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
256 |
EN300-2011083_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(=O)OCC5 |
−9.2
± 0.2
|
6.7
± 0.1
|
257 |
EN300-131051_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(ccn5)C(=O)N |
−9.2
± 0.2
|
6.7
± 0.1
|
258 |
EN300-107267_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC5CCCNC5=O |
−9.2
± 0.2
|
6.7
± 0.1
|
259 |
EN300-6472316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5c(cnc6n5ncn6)C#N |
−9.2
± 0.2
|
6.7
± 0.2
|
260 |
EN300-60033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCC5CCCO5 |
−9.2
± 0.2
|
6.7
± 0.1
|
261 |
EN300-181558_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCC(CC5)O)O |
−9.2
± 0.3
|
6.7
± 0.2
|
262 |
EN300-7433864_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c(=O)n(c5=O)C6CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
263 |
EN300-20980_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnnn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
264 |
EN300-144606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn[nH]c5S(=O)(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
265 |
EN300-252018_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(nc[nH]6)ncn5 |
−9.1
± 0.2
|
6.7
± 0.1
|
266 |
EN300-203940_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5[nH]ccc6=O |
−9.1
± 0.2
|
6.7
± 0.2
|
267 |
EN300-311920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCS(=O)(=O)C5)F |
−9.1
± 0.2
|
6.7
± 0.2
|
268 |
EN300-107267_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCCNC5=O |
−9.1
± 0.2
|
6.7
± 0.1
|
269 |
EN300-59487_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)NC5 |
−9.1
± 0.2
|
6.7
± 0.1
|
270 |
EN300-303519_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5OCC6 |
−9.1
± 0.2
|
6.6
± 0.2
|
271 |
EN300-151423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCOCC5)O |
−9.1
± 0.2
|
6.6
± 0.2
|
272 |
EN300-7183657_1
|
|
C[C@]1(C[C@@H](C1)C(=O)N[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−9.1
± 0.2
|
6.6
± 0.2
|
273 |
EN300-7461023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N(=O)=O |
−9.1
± 0.2
|
6.6
± 0.1
|
274 |
EN300-80522_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCC5CCOC5 |
−9.1
± 0.2
|
6.6
± 0.1
|
275 |
EN300-149975_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)CO |
−9.1
± 0.2
|
6.6
± 0.2
|
276 |
EN300-179091_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(F)F |
−9.1
± 0.2
|
6.6
± 0.1
|
277 |
MAK-UNK-8be7dca9-6
|
|
c1cc(c2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)CN |
−9.1
± 0.1
|
6.64
± 0.09
|
278 |
EN300-1696962_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCn5cnnn5 |
−9.1
± 0.2
|
6.6
± 0.1
|
279 |
EN300-393121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(=O)[nH]ccn6n5 |
−9.1
± 0.2
|
6.6
± 0.1
|
280 |
EN300-171766_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5n[nH]c(=O)s5 |
−9.1
± 0.2
|
6.6
± 0.1
|
281 |
EN300-247428_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CC6 |
−9.1
± 0.2
|
6.6
± 0.1
|
282 |
EN300-67023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CC5CCCO5 |
−9.1
± 0.3
|
6.6
± 0.2
|
283 |
EN300-7445890_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC6(C5)C(CC6O)O |
−9.1
± 0.2
|
6.6
± 0.2
|
284 |
EN300-80083_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCCC(=O)N5 |
−9.1
± 0.2
|
6.6
± 0.2
|
285 |
EN300-373791_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccnn5CC#N |
−9.1
± 0.3
|
6.6
± 0.2
|
286 |
EN300-45049_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS(=O)(=O)N5 |
−9.1
± 0.2
|
6.6
± 0.2
|
287 |
EN300-6745581_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nncn5C6CC6 |
−9.1
± 0.2
|
6.6
± 0.2
|
288 |
EN300-239219_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nc(no5)c6cnccn6 |
−9.1
± 0.2
|
6.6
± 0.2
|
289 |
EN300-122319_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]c(=O)[nH]n5 |
−9.1
± 0.2
|
6.6
± 0.1
|
290 |
EN300-261210_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)C#N |
−9.1
± 0.2
|
6.6
± 0.1
|
291 |
EN300-6731334_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCN(CC5)S(=O)(=O)C6 |
−9.1
± 0.3
|
6.6
± 0.2
|
292 |
EN300-208236_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCc6c5nn[nH]6 |
−9.1
± 0.2
|
6.6
± 0.2
|
293 |
EN300-226314_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)C5CCS(=O)(=O)C5 |
−9.1
± 0.3
|
6.6
± 0.2
|
294 |
EN300-171481_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCC5)OCCO |
−9.1
± 0.3
|
6.6
± 0.2
|
295 |
EN300-108236_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)CO |
−9.0
± 0.2
|
6.6
± 0.2
|
296 |
EN300-83766_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC#CCO |
−9.0
± 0.2
|
6.6
± 0.1
|
297 |
EN300-107493_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCNC(=O)C5 |
−9.0
± 0.2
|
6.6
± 0.2
|
298 |
EDJ-MED-e4b030d8-6
|
|
CCC[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−9.0
± 0.1
|
6.59
± 0.08
|
299 |
EN300-7459916_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(=O)CO |
−9.0
± 0.2
|
6.6
± 0.2
|
300 |
EN300-24297_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csnn5 |
−9.0
± 0.2
|
6.6
± 0.1
|