Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
2001 |
ALP-UNI-44c99a80-3
|
|
c1ccc2c(c1)cncc2N(Cc3cnco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−6.9
± 0.2
|
5.0
± 0.2
|
2002 |
EN300-130656_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)C(=O)N |
−6.9
± 0.2
|
5.0
± 0.2
|
2003 |
EN300-246992_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCC(=O)NC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
2004 |
EN300-1074262_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccn6c5cnn6 |
−6.9
± 0.3
|
5.0
± 0.2
|
2005 |
EN300-146051_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(nc5)CO |
−6.9
± 0.3
|
5.0
± 0.2
|
2006 |
EN300-6488240_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5nncs5 |
−6.9
± 0.2
|
5.0
± 0.2
|
2007 |
EN300-6740040_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCNS(=O)(=O)N |
−6.9
± 0.6
|
5.0
± 0.4
|
2008 |
EN300-383904_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)CO |
−6.9
± 0.3
|
5.0
± 0.2
|
2009 |
EN300-210933_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCN(C5)C(=O)N |
−6.9
± 0.2
|
5.0
± 0.1
|
2010 |
EN300-1260794_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCSC5)CO |
−6.9
± 0.3
|
5.0
± 0.2
|
2011 |
EN300-269863_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5CC(=O)N6 |
−6.9
± 0.2
|
5.0
± 0.2
|
2012 |
EN300-1440100_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6(C5)CC(=O)NC6 |
−6.9
± 0.3
|
5.0
± 0.2
|
2013 |
EN300-7426383_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c(ccn5)[nH]nn6 |
−6.9
± 0.3
|
5.0
± 0.2
|
2014 |
EN300-103219_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CC(=O)N5 |
−6.9
± 0.2
|
5.0
± 0.2
|
2015 |
EN300-195173_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5c6[nH]nnn6 |
−6.9
± 0.3
|
5.0
± 0.2
|
2016 |
EN300-1968342_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(CF)O |
−6.9
± 0.1
|
5.01
± 0.09
|
2017 |
EN300-6746326_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCC(=O)NC5 |
−6.9
± 0.1
|
5.01
± 0.10
|
2018 |
EN300-1273172_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(cn5)C(=O)N |
−6.9
± 0.2
|
5.0
± 0.1
|
2019 |
EN300-1071940_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CCCOC5)O |
−6.9
± 0.2
|
5.0
± 0.2
|
2020 |
EN300-7493768_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC56CC(C5)S(=O)(=O)C6 |
−6.9
± 0.2
|
5.0
± 0.2
|
2021 |
EN300-175608_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CCF)CO |
−6.9
± 0.2
|
5.0
± 0.2
|
2022 |
EN300-378373_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
2023 |
EN300-124301_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCn5ccnn5 |
−6.9
± 0.3
|
5.0
± 0.2
|
2024 |
EN300-6503811_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H](Cc5cnc[nH]5)O |
−6.9
± 0.3
|
5.0
± 0.2
|
2025 |
EN300-28340_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC(=O)N5CCCC5 |
−6.9
± 0.3
|
5.0
± 0.2
|
2026 |
EN300-141942_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOCC5)O |
−6.9
± 0.2
|
5.0
± 0.1
|
2027 |
EN300-157541_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCS(=O)(=O)CC5CO |
−6.9
± 0.4
|
5.0
± 0.3
|
2028 |
EN300-60330_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN6C(C5)CCC6=O |
−6.9
± 0.2
|
5.0
± 0.2
|
2029 |
EN300-321459_1
|
|
CN(C(=O)C[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@H](C5)C(=O)N |
−6.9
± 0.3
|
5.0
± 0.2
|
2030 |
EN300-225012_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c6nccn6ccn5 |
−6.9
± 0.2
|
5.0
± 0.1
|
2031 |
EN300-261056_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(cn5)c6ncccn6 |
−6.9
± 0.2
|
5.0
± 0.2
|
2032 |
EN300-6733595_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC56CC(C5)(CO6)C(=O)N |
−6.9
± 0.3
|
5.0
± 0.2
|
2033 |
MAK-UNK-3875bbc8-1
|
|
Cc1ccc2c(c1)C(CCO2)C(=O)N(C)c3cncc4c3cccc4 |
−6.9
± 0.1
|
4.99
± 0.09
|
2034 |
EN300-219609_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cnccc5=O |
−6.9
± 0.3
|
5.0
± 0.2
|
2035 |
EN300-1653482_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6c(nnn6)C5 |
−6.9
± 0.2
|
5.0
± 0.1
|
2036 |
EN300-72946_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5c(=O)n6ccccc6n5 |
−6.9
± 0.3
|
5.0
± 0.2
|
2037 |
EN300-85043_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccnc5OCCO |
−6.9
± 0.3
|
5.0
± 0.2
|
2038 |
EN300-344563_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6[nH]nnn6)O |
−6.9
± 0.2
|
5.0
± 0.2
|
2039 |
EN300-1627945_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CCCOC5 |
−6.9
± 0.2
|
5.0
± 0.1
|
2040 |
EN300-1644723_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C6C5COCC6 |
−6.9
± 0.1
|
4.99
± 0.08
|
2041 |
EN300-204507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(CO)F |
−6.8
± 0.2
|
5.0
± 0.1
|
2042 |
EN300-1609249_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CS(=O)(=O)C6 |
−6.8
± 0.3
|
5.0
± 0.2
|
2043 |
EN300-83280_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)c5ccccn5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2044 |
EN300-7438185_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6nncn6nc5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2045 |
EN300-256759_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCC(=O)NCC5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2046 |
EN300-315238_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
2047 |
EN300-6763991_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nnc6n5CCOC6 |
−6.8
± 0.2
|
5.0
± 0.1
|
2048 |
EN300-250112_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5csc(n5)CO |
−6.8
± 0.3
|
5.0
± 0.2
|
2049 |
MAT-POS-8a69d52e-7
|
|
C[C@@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−6.84
± 0.05
|
4.98
± 0.04
|
2050 |
EN300-1589101_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5c[nH]nc5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2051 |
EN300-6744029_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccsc5n6cnnn6 |
−6.8
± 0.3
|
5.0
± 0.2
|
2052 |
EN300-1242134_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)C56CCC6 |
−6.8
± 0.4
|
5.0
± 0.3
|
2053 |
EN300-332606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCC(=O)O5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2054 |
EN300-233786_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCS(=O)(=O)C5)O |
−6.8
± 0.3
|
5.0
± 0.2
|
2055 |
EN300-250836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5c[nH]nc5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2056 |
EN300-203853_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNS(=O)(=O)C5CC5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2057 |
EN300-6474341_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCn6cnnc6C5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2058 |
EN300-05512_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC5CCS(=O)(=O)C5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2059 |
EN300-99064_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)N(C5)c6c[nH]nc6 |
−6.8
± 0.2
|
5.0
± 0.1
|
2060 |
EN300-6526669_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5C(=O)NCC6 |
−6.8
± 0.3
|
5.0
± 0.2
|
2061 |
EN300-761618_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)Nc5cccnn5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2062 |
EN300-1689158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc([nH]n5)C(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
2063 |
EN300-1718675_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnnn5C6CC6 |
−6.8
± 0.3
|
5.0
± 0.2
|
2064 |
EN300-246486_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5coc(=O)[nH]5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2065 |
EN300-77520_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CCOCC5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2066 |
EN300-28611_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCc6c(cn(n6)CCO)C5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2067 |
EN300-25446_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnco5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2068 |
EN300-1448603_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CCS(=O)(=O)C5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2069 |
EN300-1253178_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NC5CC5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2070 |
ADA-UCB-dc2b944c-10
|
|
Cc1c(c2ccccc2cn1)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−6.8
± 0.1
|
4.97
± 0.08
|
2071 |
EN300-19926_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC#N |
−6.8
± 0.2
|
5.0
± 0.1
|
2072 |
EN300-378044_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC=CCO5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2073 |
EN300-210110_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cn(nn5)C6CC6 |
−6.8
± 0.2
|
5.0
± 0.2
|
2074 |
EN300-378652_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CC5)S(=O)(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
2075 |
EN300-7540875_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnc6ncnn6c5 |
−6.8
± 0.3
|
5.0
± 0.2
|
2076 |
EN300-266460_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nc(co5)C(=O)N |
−6.8
± 0.2
|
5.0
± 0.2
|
2077 |
EN300-25446_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnco5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2078 |
EN300-6491117_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5cnco5 |
−6.8
± 0.2
|
5.0
± 0.2
|
2079 |
EN300-105693_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(COC5)CO |
−6.8
± 0.2
|
5.0
± 0.2
|
2080 |
EN300-312662_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]c(nn5)CO |
−6.8
± 0.4
|
5.0
± 0.3
|
2081 |
EN300-1692858_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cnn(c5)CCO |
−6.8
± 0.2
|
5.0
± 0.1
|
2082 |
EN300-396329_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@@H]5CO |
−6.8
± 0.2
|
5.0
± 0.2
|
2083 |
EN300-31015_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCSCC(=O)N |
−6.8
± 0.3
|
5.0
± 0.2
|
2084 |
EN300-6762327_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(Cc5ccccn5)O |
−6.8
± 0.3
|
5.0
± 0.2
|
2085 |
EN300-149224_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc(cn5)C#N |
−6.8
± 0.2
|
5.0
± 0.2
|
2086 |
EN300-21009_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCO5 |
−6.8
± 0.2
|
5.0
± 0.1
|
2087 |
EN300-188341_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5ccc(cn5)O |
−6.8
± 0.3
|
4.9
± 0.2
|
2088 |
EN300-124258_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCOC5)C(=O)N |
−6.8
± 0.2
|
4.9
± 0.1
|
2089 |
EN300-7430909_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CN(C5)C6COC6 |
−6.8
± 0.3
|
4.9
± 0.2
|
2090 |
EN300-1704404_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CNC(=O)CC56CCC6 |
−6.8
± 0.2
|
4.9
± 0.2
|
2091 |
EN300-31147_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)C5CC5 |
−6.8
± 0.3
|
4.9
± 0.2
|
2092 |
EN300-6255179_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCn5cncn5 |
−6.8
± 0.2
|
4.9
± 0.1
|
2093 |
EN300-657410_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)c5[nH]ccn5 |
−6.8
± 0.4
|
4.9
± 0.3
|
2094 |
EN300-210907_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CCS(=O)(=O)CC5)O |
−6.8
± 0.3
|
4.9
± 0.2
|
2095 |
EN300-321703_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCOC5COC5 |
−6.8
± 0.2
|
4.9
± 0.2
|
2096 |
EN300-157541_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)CC5CO |
−6.8
± 0.2
|
4.9
± 0.2
|
2097 |
EN300-7549555_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5coc(n5)CO |
−6.8
± 0.2
|
4.9
± 0.2
|
2098 |
EN300-6497444_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn6c5OCC(C6)O |
−6.8
± 0.2
|
4.9
± 0.1
|
2099 |
EN300-1657635_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5F |
−6.8
± 0.2
|
4.9
± 0.2
|
2100 |
EN300-1720923_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(C(C(=O)N)(F)F)O |
−6.8
± 0.3
|
4.9
± 0.2
|