Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1901 |
EN300-52645_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5cnn(c5)CCO |
−7.0
± 0.2
|
5.1
± 0.1
|
1902 |
EN300-1428805_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5Cc6cncn6C(=O)N5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1903 |
EN300-100467_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccnn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1904 |
EN300-7550655_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc(s5)CO |
−7.0
± 0.2
|
5.1
± 0.2
|
1905 |
EN300-1707980_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)c6[nH]cnn6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1906 |
EN300-7549247_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5nnc(s5)CO |
−7.0
± 0.3
|
5.1
± 0.2
|
1907 |
EN300-321053_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCOCC5O |
−7.0
± 0.2
|
5.1
± 0.1
|
1908 |
EN300-255990_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5ncc(c6)C#N |
−7.0
± 0.2
|
5.1
± 0.2
|
1909 |
EN300-52210_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CC(=O)N6 |
−7.0
± 0.2
|
5.1
± 0.1
|
1910 |
EN300-251752_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(Cn5ccnn5)O |
−7.0
± 0.2
|
5.1
± 0.2
|
1911 |
EN300-19926_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC#N |
−7.0
± 0.2
|
5.1
± 0.1
|
1912 |
EN300-80481_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C5CCOCC5)O |
−7.0
± 0.3
|
5.1
± 0.2
|
1913 |
EN300-82616_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCNC5=O |
−7.0
± 0.2
|
5.1
± 0.1
|
1914 |
EN300-26031_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5CCC6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1915 |
EN300-303519_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn6c5OCC6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1916 |
EN300-235010_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(c(=O)[nH]c5=O)C#N |
−7.0
± 0.3
|
5.1
± 0.2
|
1917 |
EN300-97300_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC5F |
−7.0
± 0.1
|
5.08
± 0.09
|
1918 |
EN300-7473032_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C5C(=O)N |
−7.0
± 0.2
|
5.1
± 0.1
|
1919 |
EN300-261056_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(cn5)c6ncccn6 |
−7.0
± 0.2
|
5.1
± 0.1
|
1920 |
EN300-360157_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCOC5)O |
−7.0
± 0.2
|
5.1
± 0.2
|
1921 |
EN300-5340532_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(nc5)N6CCOCC6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1922 |
EN300-223198_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCCS(=O)(=O)N |
−7.0
± 0.4
|
5.1
± 0.3
|
1923 |
EN300-31998_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c[nH]nn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1924 |
EN300-260760_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cc(=O)[nH][nH]5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1925 |
EN300-98690_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6n5cccn6 |
−7.0
± 0.2
|
5.1
± 0.1
|
1926 |
EN300-69553_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cncn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1927 |
EN300-6491316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6cnnn6c5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1928 |
EN300-34636_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccc(=O)[nH]5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1929 |
EN300-307198_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(COC5)CO |
−7.0
± 0.4
|
5.1
± 0.3
|
1930 |
EN300-344753_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)C(=O)NCCO |
−7.0
± 0.3
|
5.1
± 0.2
|
1931 |
EN300-215607_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCn5cc(nn5)CO |
−7.0
± 0.3
|
5.1
± 0.2
|
1932 |
EN300-1233032_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(Cn5cccn5)O |
−7.0
± 0.2
|
5.1
± 0.2
|
1933 |
EN300-43972_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]cnn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1934 |
EN300-370967_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCN5CCOC5=O |
−7.0
± 0.2
|
5.1
± 0.1
|
1935 |
EN300-30039_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(=O)[nH]c(=O)[nH]5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1936 |
EN300-07752_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(CC5C(=O)N)O |
−7.0
± 0.2
|
5.1
± 0.1
|
1937 |
EN300-1272295_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCCS6(=O)=O |
−7.0
± 0.2
|
5.1
± 0.1
|
1938 |
EN300-246501_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C6CS(=O)(=O)C6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1939 |
EN300-373446_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCO[C@@H](C5)[C@H](CO)O |
−7.0
± 0.4
|
5.1
± 0.3
|
1940 |
EN300-6472952_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)NC(=O)CO6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1941 |
EN300-251851_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5[nH]nnn5 |
−6.9
± 0.3
|
5.1
± 0.2
|
1942 |
EN300-31147_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)C5CC5 |
−6.9
± 0.3
|
5.1
± 0.2
|
1943 |
EN300-10397_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)N |
−6.9
± 0.2
|
5.1
± 0.2
|
1944 |
EN300-19507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(F)F |
−6.9
± 0.2
|
5.1
± 0.1
|
1945 |
EN300-94856_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC(C5)O |
−6.9
± 0.2
|
5.1
± 0.2
|
1946 |
EN300-246178_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn(c5)CC(CO)O |
−6.9
± 0.2
|
5.1
± 0.2
|
1947 |
EN300-783124_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCOC5)F |
−6.9
± 0.1
|
5.1
± 0.1
|
1948 |
EN300-255498_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CS(=O)(=O)C6 |
−6.9
± 0.3
|
5.1
± 0.2
|
1949 |
EN300-82181_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)NCCO |
−6.9
± 0.3
|
5.1
± 0.2
|
1950 |
EN300-318344_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ncco5 |
−6.9
± 0.1
|
5.1
± 0.1
|
1951 |
EN300-52009_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCC5)O |
−6.9
± 0.2
|
5.1
± 0.2
|
1952 |
EN300-1702911_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)NC(=O)N |
−6.9
± 0.3
|
5.1
± 0.2
|
1953 |
EN300-05277_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCC(=O)N5CCOCC5 |
−6.9
± 0.3
|
5.1
± 0.2
|
1954 |
EN300-154156_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC5 |
−6.9
± 0.2
|
5.1
± 0.1
|
1955 |
EN300-7542483_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5COCCOC5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1956 |
EN300-7500408_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCCOC5)CO |
−6.9
± 0.2
|
5.0
± 0.2
|
1957 |
DAR-DIA-6a508060-10
|
|
CC1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−6.93
± 0.10
|
5.05
± 0.07
|
1958 |
EN300-267219_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@@H](O5)C(=O)N6CCCC6 |
−6.9
± 0.3
|
5.0
± 0.2
|
1959 |
EN300-1222454_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cn(nn5)C6CCOC6 |
−6.9
± 0.2
|
5.0
± 0.2
|
1960 |
EN300-6503694_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCNS(=O)(=O)C(F)F |
−6.9
± 0.4
|
5.0
± 0.3
|
1961 |
EN300-183736_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCOC5)CCO |
−6.9
± 0.3
|
5.0
± 0.2
|
1962 |
MAK-UNK-8be7dca9-7
|
|
c1cc2cncc(c2cc1C(=O)O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−6.9
± 0.1
|
5.04
± 0.08
|
1963 |
EN300-67573_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NC5CCOCC5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1964 |
EN300-92635_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nc6ncc(cn6n5)CCO |
−6.9
± 0.2
|
5.0
± 0.2
|
1965 |
EN300-1073320_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5(CCC5)O)O |
−6.9
± 0.2
|
5.0
± 0.1
|
1966 |
EN300-6498726_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H](CO)CF |
−6.9
± 0.3
|
5.0
± 0.2
|
1967 |
EN300-746646_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn6cc[nH]c(=O)c6n5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1968 |
DAR-DIA-23e5a6a0-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CCC6(N5)CCC6)Cl |
−6.9
± 0.3
|
5.0
± 0.2
|
1969 |
EN300-49064_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5COC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1970 |
EN300-1718675_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnnn5C6CC6 |
−6.9
± 0.3
|
5.0
± 0.2
|
1971 |
EN300-2010267_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CCC(=O)N6 |
−6.9
± 0.3
|
5.0
± 0.2
|
1972 |
EN300-123291_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CS(=O)(=O)C5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1973 |
EN300-7549555_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5coc(n5)CO |
−6.9
± 0.3
|
5.0
± 0.2
|
1974 |
EN300-80522_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COCC5CCOC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1975 |
EN300-6482296_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COC6C5COC6 |
−6.9
± 0.1
|
5.04
± 0.09
|
1976 |
EN300-77778_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCS(=O)(=O)C5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1977 |
EN300-1720496_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(C(C(=O)N)(F)F)O |
−6.9
± 0.2
|
5.0
± 0.2
|
1978 |
EN300-151461_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6CCOC6 |
−6.9
± 0.2
|
5.0
± 0.2
|
1979 |
EN300-1215738_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCC5CCC(=O)NC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1980 |
EN300-36158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COCCO5 |
−6.9
± 0.1
|
5.0
± 0.1
|
1981 |
EN300-151756_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c(cn5)nc[nH]c6=O |
−6.9
± 0.3
|
5.0
± 0.2
|
1982 |
EN300-1265948_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCS(=O)(=O)CC5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1983 |
EN300-23792_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(sc5)S(=O)(=O)N |
−6.9
± 0.3
|
5.0
± 0.2
|
1984 |
EN300-7438227_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)CCS(=O)(=O)N |
−6.9
± 0.5
|
5.0
± 0.3
|
1985 |
EN300-262136_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCC6 |
−6.9
± 0.2
|
5.0
± 0.2
|
1986 |
EN300-120586_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCC(F)F |
−6.9
± 0.2
|
5.0
± 0.2
|
1987 |
EN300-74200_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCCO)CCO |
−6.9
± 0.3
|
5.0
± 0.2
|
1988 |
EN300-81528_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCN5CCNC(=O)C5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1989 |
EN300-14006_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCS(=O)(=O)C5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1990 |
EN300-1726277_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(n5cccn5)F |
−6.9
± 0.2
|
5.0
± 0.2
|
1991 |
EN300-64297_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cncnc5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1992 |
EN300-7537194_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6cnnc6c5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1993 |
EN300-7427115_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCc6c([nH]c(=O)[nH]c6=O)C5 |
−6.9
± 0.3
|
5.0
± 0.2
|
1994 |
EN300-93074_2
|
|
CN(C(=O)CC[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@@H](C5)O |
−6.9
± 0.3
|
5.0
± 0.2
|
1995 |
EN300-298582_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CC(=O)NC5 |
−6.9
± 0.2
|
5.0
± 0.2
|
1996 |
BEN-BAS-5c03e89e-1
|
|
CC(C)(C1COc2ccc(cc2C1C(=O)Nc3cncc4c3cccc4)Cl)O |
−6.9
± 0.1
|
5.03
± 0.08
|
1997 |
EN300-6746631_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5nnc6n5CCCC6 |
−6.9
± 0.3
|
5.0
± 0.2
|
1998 |
EN300-151423_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCOCC5)O |
−6.9
± 0.3
|
5.0
± 0.2
|
1999 |
EN300-82616_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCNC5=O |
−6.9
± 0.2
|
5.0
± 0.1
|
2000 |
EN300-7534935_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCC(=O)O6 |
−6.9
± 0.2
|
5.0
± 0.2
|