Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1801 |
ADA-UCB-dc2b944c-11
|
|
c1ccc2c(c1)c(cnc2Br)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.08
± 0.10
|
5.16
± 0.07
|
1802 |
EN300-2007627_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(CC(C5)CO)CO |
−7.1
± 0.3
|
5.2
± 0.2
|
1803 |
EN300-194172_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)CC(=O)N |
−7.1
± 0.2
|
5.2
± 0.2
|
1804 |
EN300-26953_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C(=O)N)C(=O)N |
−7.1
± 0.3
|
5.2
± 0.2
|
1805 |
EN300-6489476_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCNC(=O)C6 |
−7.1
± 0.2
|
5.2
± 0.2
|
1806 |
EN300-29520_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn6c5nccc6 |
−7.1
± 0.2
|
5.2
± 0.2
|
1807 |
EN300-123489_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(CO)(F)F |
−7.1
± 0.3
|
5.2
± 0.2
|
1808 |
EN300-59733_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCNC(=O)C5 |
−7.1
± 0.2
|
5.2
± 0.1
|
1809 |
EN300-30687_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc(c5)OCC(=O)N |
−7.1
± 0.3
|
5.2
± 0.2
|
1810 |
EN300-1452069_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(CC5CCOCC5)O |
−7.1
± 0.3
|
5.2
± 0.2
|
1811 |
EN300-120920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCC(=O)NC5=O |
−7.1
± 0.1
|
5.2
± 0.1
|
1812 |
EN300-7542483_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5COCCOC5 |
−7.1
± 0.2
|
5.1
± 0.2
|
1813 |
EN300-04614_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccc(=O)[nH]n5 |
−7.1
± 0.2
|
5.1
± 0.2
|
1814 |
EN300-41863_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c[nH]nc5 |
−7.1
± 0.2
|
5.1
± 0.2
|
1815 |
EN300-10729_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)N |
−7.1
± 0.3
|
5.1
± 0.2
|
1816 |
EN300-93574_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCS(=O)C5 |
−7.1
± 0.2
|
5.1
± 0.1
|
1817 |
EN300-1700760_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC6(C5)CC(=O)N6 |
−7.1
± 0.3
|
5.1
± 0.2
|
1818 |
EN300-233678_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C(C5)CO)O |
−7.1
± 0.3
|
5.1
± 0.2
|
1819 |
EN300-198633_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCCCNC5=O |
−7.1
± 0.3
|
5.1
± 0.2
|
1820 |
EN300-80001_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5cc(cn5)C#N |
−7.1
± 0.2
|
5.1
± 0.2
|
1821 |
EN300-36845_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)C5CCCC5 |
−7.1
± 0.3
|
5.1
± 0.2
|
1822 |
EN300-1242134_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C56CCC6 |
−7.1
± 0.3
|
5.1
± 0.2
|
1823 |
EN300-99391_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CCOC5 |
−7.1
± 0.2
|
5.1
± 0.1
|
1824 |
EN300-7353971_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H](CO)F |
−7.1
± 0.3
|
5.1
± 0.2
|
1825 |
EN300-396372_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CC(CNC6=O)O |
−7.1
± 0.3
|
5.1
± 0.2
|
1826 |
EN300-170720_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5OCCCO5 |
−7.1
± 0.3
|
5.1
± 0.2
|
1827 |
EN300-47606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC5CCS(=O)(=O)C5 |
−7.1
± 0.2
|
5.1
± 0.2
|
1828 |
EN300-44993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cnc5)C(=O)N |
−7.1
± 0.2
|
5.1
± 0.2
|
1829 |
EN300-59487_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC(=O)NC5 |
−7.1
± 0.2
|
5.1
± 0.1
|
1830 |
EN300-1709745_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cn(nn5)C6COC6 |
−7.1
± 0.3
|
5.1
± 0.2
|
1831 |
EN300-6732376_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCCC5CO |
−7.1
± 0.3
|
5.1
± 0.2
|
1832 |
EN300-761209_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn(c5)CCO |
−7.1
± 0.2
|
5.1
± 0.2
|
1833 |
EN300-395654_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C6(C5)COC6)CO |
−7.1
± 0.3
|
5.1
± 0.2
|
1834 |
EN300-1067786_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C56CC6 |
−7.1
± 0.3
|
5.1
± 0.2
|
1835 |
EN300-1717166_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC56CC(C6)O |
−7.1
± 0.2
|
5.1
± 0.1
|
1836 |
EN300-108305_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCOCC(=O)N |
−7.1
± 0.3
|
5.1
± 0.2
|
1837 |
DAR-DIA-0d514e7d-17
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cc(cc(c5)F)F |
−7.1
± 0.2
|
5.1
± 0.2
|
1838 |
EN300-181688_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCO6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1839 |
EN300-6504697_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CC6(CC6)S(=O)(=O)N5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1840 |
EN300-37077_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccn[nH]5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1841 |
EN300-135238_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnn6c5[nH]cc6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1842 |
EN300-58821_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C(=O)CO |
−7.0
± 0.3
|
5.1
± 0.2
|
1843 |
EN300-359750_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCC(=O)O5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1844 |
EN300-133058_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)n[nH]n6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1845 |
EN300-36622_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5ccccc5=O |
−7.0
± 0.3
|
5.1
± 0.2
|
1846 |
EN300-43206_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCS5(=O)=O |
−7.0
± 0.3
|
5.1
± 0.2
|
1847 |
EN300-2908043_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5c6[nH]nnn6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1848 |
EN300-46832_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC5CCOC5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1849 |
EN300-105267_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)Nc5cnccn5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1850 |
EN300-120480_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)S(=O)(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1851 |
DAR-DIA-0d514e7d-9
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccccc5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1852 |
EN300-187385_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5ccc(=O)[nH]c5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1853 |
EN300-6491697_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5cccc(=O)[nH]5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1854 |
EN300-6731820_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CC(C6)F |
−7.0
± 0.3
|
5.1
± 0.2
|
1855 |
EN300-6732376_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCCC5CO |
−7.0
± 0.2
|
5.1
± 0.2
|
1856 |
EN300-172481_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(C(=O)N)O |
−7.0
± 0.2
|
5.1
± 0.2
|
1857 |
EN300-74856_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCS(=O)(=O)C5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1858 |
EN300-266460_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nc(co5)C(=O)N |
−7.0
± 0.2
|
5.1
± 0.2
|
1859 |
EN300-95094_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CSC5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1860 |
EN300-67050_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)CC5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1861 |
EN300-7435545_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5C(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1862 |
EN300-225165_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CC(=O)NC(=O)C5 |
−7.0
± 0.3
|
5.1
± 0.2
|
1863 |
EN300-1696043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6COC6 |
−7.0
± 0.3
|
5.1
± 0.2
|
1864 |
EN300-306316_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5[nH]cnn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1865 |
EN300-6478040_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC56CC(C5)(C6)CO |
−7.0
± 0.2
|
5.1
± 0.1
|
1866 |
EN300-1696143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CCCN6C(=O)C5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1867 |
EN300-332714_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C(c5ccccn5)O |
−7.0
± 0.3
|
5.1
± 0.2
|
1868 |
EN300-1425677_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCO5)CO |
−7.0
± 0.2
|
5.1
± 0.1
|
1869 |
EN300-75402_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(C5)C(=O)N |
−7.0
± 0.2
|
5.1
± 0.2
|
1870 |
EN300-62192_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)NC(=O)C5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1871 |
EN300-263456_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccc(=O)n(n5)CCF |
−7.0
± 0.3
|
5.1
± 0.2
|
1872 |
EN300-321558_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)CC(=O)N |
−7.0
± 0.2
|
5.1
± 0.1
|
1873 |
EN300-260152_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnns5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1874 |
EN300-103219_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CC(=O)N5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1875 |
EN300-149013_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c([nH]nn5)Cl |
−7.0
± 0.2
|
5.1
± 0.2
|
1876 |
EN300-6970573_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(COC5)CF |
−7.0
± 0.3
|
5.1
± 0.2
|
1877 |
EN300-1265434_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C5CC5)C(=O)N |
−7.0
± 0.2
|
5.1
± 0.1
|
1878 |
EN300-188650_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5[nH]ccn5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1879 |
EN300-149296_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ncc(cn5)F |
−7.0
± 0.2
|
5.1
± 0.2
|
1880 |
EN300-69313_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)O |
−7.0
± 0.2
|
5.1
± 0.1
|
1881 |
EN300-1448674_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCn6c(ncn6)C5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1882 |
EN300-204239_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(=O)[nH]c(n5)C6CC6 |
−7.0
± 0.2
|
5.1
± 0.2
|
1883 |
EN300-86732_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)C5CCCO5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1884 |
EN300-21200_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c(nccn5)C(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1885 |
EN300-126127_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C6CC6)O |
−7.0
± 0.2
|
5.1
± 0.2
|
1886 |
EN300-7562761_1
|
|
CS(=O)(=O)[C@H]1C[C@@H](C1)CNC(=O)C[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−7.0
± 0.2
|
5.1
± 0.2
|
1887 |
EN300-1440321_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)S(=O)(=O)N |
−7.0
± 0.3
|
5.1
± 0.2
|
1888 |
EN300-196612_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)NCCF |
−7.0
± 0.3
|
5.1
± 0.2
|
1889 |
EN300-62191_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCC(=O)NC5 |
−7.0
± 0.1
|
5.10
± 0.09
|
1890 |
EN300-79606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCCNC(=O)N |
−7.0
± 0.2
|
5.1
± 0.2
|
1891 |
EN300-105829_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOC5)CCO |
−7.0
± 0.2
|
5.1
± 0.1
|
1892 |
MAK-UNK-83e0a0b4-2
|
|
c1cc2c(cc1CN3CCNCC3)cncc2N(CCNC4CNC4)C(=O)C5CCOc6c5cc(cc6)Cl |
−7.0
± 0.4
|
5.1
± 0.3
|
1893 |
EN300-182579_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CN(C5)CC(F)F |
−7.0
± 0.3
|
5.1
± 0.2
|
1894 |
EN300-108236_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5cc(nn5)CO |
−7.0
± 0.3
|
5.1
± 0.2
|
1895 |
EN300-142130_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H](CO)C(F)(F)F |
−7.0
± 0.3
|
5.1
± 0.2
|
1896 |
EN300-210104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnc(n5)C#N |
−7.0
± 0.3
|
5.1
± 0.2
|
1897 |
EN300-817811_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cc(=O)[nH]cn5 |
−7.0
± 0.2
|
5.1
± 0.1
|
1898 |
JAG-UCB-706446eb-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(F)(F)F |
−7.0
± 0.2
|
5.1
± 0.2
|
1899 |
EN300-179091_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC(F)F |
−7.0
± 0.2
|
5.1
± 0.2
|
1900 |
EN300-3451857_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCC(=O)NC5=O |
−7.0
± 0.2
|
5.1
± 0.2
|