Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
1301 |
EN300-1699332_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)C(CO)O |
−7.6
± 0.4
|
5.5
± 0.3
|
1302 |
EN300-370753_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CC[C@H](C5)C(=O)N |
−7.6
± 0.3
|
5.5
± 0.2
|
1303 |
EN300-36096_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCNC5=O |
−7.6
± 0.3
|
5.5
± 0.2
|
1304 |
EN300-259251_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)CO)C5 |
−7.6
± 0.2
|
5.5
± 0.2
|
1305 |
EN300-10895_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCCC#N |
−7.6
± 0.3
|
5.5
± 0.2
|
1306 |
EN300-1911992_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(C5CCOC5)O |
−7.6
± 0.2
|
5.5
± 0.2
|
1307 |
EN300-82179_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC(=O)N |
−7.6
± 0.2
|
5.5
± 0.1
|
1308 |
EN300-1911992_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(C5CCOC5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1309 |
EN300-312450_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(n5)N6CCOCC6 |
−7.5
± 0.2
|
5.5
± 0.2
|
1310 |
EN300-146491_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCCC(=O)N5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1311 |
EN300-396748_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccnc(c5)CO |
−7.5
± 0.3
|
5.5
± 0.2
|
1312 |
EN300-1179673_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cccc(c5)C(=O)N |
−7.5
± 0.3
|
5.5
± 0.2
|
1313 |
EN300-6503811_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H](Cc5cnc[nH]5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1314 |
EN300-7456317_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](C56CCOCC6)O)O |
−7.5
± 0.4
|
5.5
± 0.3
|
1315 |
EN300-341337_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CCOC5CCOC6 |
−7.5
± 0.3
|
5.5
± 0.2
|
1316 |
EN300-62192_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)NC(=O)C5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1317 |
EN300-122340_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCSCC5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1318 |
EN300-210089_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5C6C5COC6 |
−7.5
± 0.1
|
5.5
± 0.1
|
1319 |
EN300-1700760_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC6(C5)CC(=O)N6 |
−7.5
± 0.2
|
5.5
± 0.2
|
1320 |
MAK-UNK-3875bbc8-2
|
|
CN(c1cncc2c1cccc2)C(=O)C3CCOc4c3cc(cc4)Cl |
−7.54
± 0.09
|
5.49
± 0.06
|
1321 |
EN300-6238494_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)C5COCCO5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1322 |
EN300-1588753_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(c6cnn[nH]6)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1323 |
EN300-7439043_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(n[nH]5)CO |
−7.5
± 0.2
|
5.5
± 0.2
|
1324 |
EN300-6472573_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC6(C5)CC6 |
−7.5
± 0.2
|
5.5
± 0.2
|
1325 |
EN300-84186_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)CO |
−7.5
± 0.3
|
5.5
± 0.3
|
1326 |
EN300-1704404_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CNC(=O)CC56CCC6 |
−7.5
± 0.3
|
5.5
± 0.2
|
1327 |
EDJ-MED-e4b030d8-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C5COC5)Cl |
−7.5
± 0.2
|
5.5
± 0.1
|
1328 |
EN300-62448_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)C5CCC5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1329 |
EN300-7355835_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(cn6)O)C5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1330 |
EN300-253571_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCc6nnnn6CC5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1331 |
EN300-331993_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)Nc5[nH]ccn5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1332 |
EN300-222620_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cc(cnc5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1333 |
EN300-195756_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCC(=O)N5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1334 |
DAR-DIA-0d514e7d-15
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cc(ccc5F)F |
−7.5
± 0.2
|
5.5
± 0.2
|
1335 |
EN300-170985_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5OCCCO5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1336 |
EN300-72896_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC(=O)N5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1337 |
EN300-365993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6CS(=O)(=O)CC6C5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1338 |
EN300-1605566_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN6CCN5CC6 |
−7.5
± 0.2
|
5.5
± 0.2
|
1339 |
EN300-79180_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCOCC5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1340 |
EN300-7427921_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)n6cnnc6 |
−7.5
± 0.2
|
5.5
± 0.2
|
1341 |
EN300-10397_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)N |
−7.5
± 0.2
|
5.5
± 0.2
|
1342 |
EN300-309106_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn6cnnc6cn5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1343 |
EN300-120586_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC(F)F |
−7.5
± 0.2
|
5.5
± 0.2
|
1344 |
EN300-222120_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)(c6cnn[nH]6)O |
−7.5
± 0.2
|
5.5
± 0.2
|
1345 |
EN300-212381_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCCN(C5)C(=O)N |
−7.5
± 0.2
|
5.5
± 0.2
|
1346 |
EN300-7432415_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C6(CCC6)OC(=O)N5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1347 |
EN300-254121_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(c5cnc[nH]5)O |
−7.5
± 0.2
|
5.5
± 0.2
|
1348 |
EN300-67533_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(C5CC5)O |
−7.5
± 0.2
|
5.5
± 0.1
|
1349 |
EN300-27314_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC(=O)N5CCOCC5 |
−7.5
± 0.4
|
5.5
± 0.3
|
1350 |
EN300-250836_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5c[nH]nc5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1351 |
EN300-311920_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCS(=O)(=O)C5)F |
−7.5
± 0.2
|
5.5
± 0.1
|
1352 |
DAR-DIA-0d514e7d-1
|
|
C[C@H]1COc2c(cc(cc2OC)Cl)[C@@H]1C(=O)Nc3cncc4c3cccc4 |
−7.5
± 0.1
|
5.47
± 0.09
|
1353 |
EN300-257315_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCn5cnnc5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1354 |
EN300-189672_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(=O)[nH]c5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1355 |
EN300-85413_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CC(=O)N)C5CC5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1356 |
EN300-52009_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)O |
−7.5
± 0.2
|
5.5
± 0.2
|
1357 |
EN300-702062_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCOC5CCOC5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1358 |
EN300-682529_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOC5)CO |
−7.5
± 0.2
|
5.5
± 0.2
|
1359 |
EN300-189563_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCC5CS(=O)(=O)C5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1360 |
ALP-UNI-44c99a80-2
|
|
c1ccc2c(c1)cncc2N(Cc3cnc[nH]3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−7.5
± 0.2
|
5.5
± 0.1
|
1361 |
EN300-251571_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(C(=O)C5)CC(=O)N |
−7.5
± 0.3
|
5.5
± 0.2
|
1362 |
EN300-250593_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CC(=O)N5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1363 |
EN300-1697480_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6c(cnn6c5)C#N |
−7.5
± 0.3
|
5.5
± 0.2
|
1364 |
EN300-04614_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)[nH]n5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1365 |
VLA-UCB-50c39ae8-1
|
|
CC(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−7.5
± 0.2
|
5.5
± 0.1
|
1366 |
EN300-52380_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CC(=O)N |
−7.5
± 0.3
|
5.5
± 0.2
|
1367 |
EN300-55087_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)N6CCNC6=O |
−7.5
± 0.1
|
5.5
± 0.1
|
1368 |
EN300-188341_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(cn5)O |
−7.5
± 0.3
|
5.5
± 0.2
|
1369 |
EN300-183231_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5[nH]nnn5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1370 |
EN300-3710141_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCO5)C#N |
−7.5
± 0.2
|
5.5
± 0.1
|
1371 |
EN300-325737_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6ccccn6nn5 |
−7.5
± 0.2
|
5.5
± 0.1
|
1372 |
EN300-157502_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5OCCCO5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1373 |
EN300-702756_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CS(=O)(=O)CC(=O)N5 |
−7.5
± 0.3
|
5.5
± 0.2
|
1374 |
EN300-861925_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC(CO)F |
−7.5
± 0.2
|
5.5
± 0.1
|
1375 |
VLA-UCB-1dbca3b4-14
|
|
CC1(c2cc(ccc2OCC1=O)Cl)C(=O)Nc3cncc4c3cccc4 |
−7.48
± 0.10
|
5.45
± 0.07
|
1376 |
EN300-182084_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cscn5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1377 |
EN300-54541_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5 |
−7.5
± 0.2
|
5.5
± 0.2
|
1378 |
JOH-SUS-a69c159d-5
|
|
c1cc2c(cc1F)c(cnc2F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−7.48
± 0.08
|
5.45
± 0.06
|
1379 |
EN300-210110_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6CC6 |
−7.5
± 0.2
|
5.4
± 0.2
|
1380 |
EN300-1178209_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5c[nH]nn5 |
−7.5
± 0.2
|
5.4
± 0.2
|
1381 |
EN300-36089_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)c5ccncc5 |
−7.5
± 0.2
|
5.4
± 0.2
|
1382 |
EN300-114082_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)C#N |
−7.5
± 0.2
|
5.4
± 0.2
|
1383 |
EN300-2666482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc(n5)n6ccnc6 |
−7.5
± 0.2
|
5.4
± 0.2
|
1384 |
EN300-141480_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCN(C5=O)CCO |
−7.5
± 0.3
|
5.4
± 0.2
|
1385 |
EN300-321960_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn6c(n5)COCC6 |
−7.5
± 0.2
|
5.4
± 0.2
|
1386 |
EN300-253187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5COCO5 |
−7.5
± 0.2
|
5.4
± 0.1
|
1387 |
EN300-65383_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cc[nH]c(=O)c5=O |
−7.5
± 0.3
|
5.4
± 0.2
|
1388 |
EN300-175300_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCc5nnc6n5CCC6 |
−7.5
± 0.3
|
5.4
± 0.2
|
1389 |
EN300-1272704_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5c6[nH]cnn6 |
−7.5
± 0.3
|
5.4
± 0.2
|
1390 |
EN300-05620_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCNC(=O)N |
−7.5
± 0.2
|
5.4
± 0.2
|
1391 |
EN300-259849_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCCC(C5=O)O |
−7.5
± 0.3
|
5.4
± 0.2
|
1392 |
EN300-6499164_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC6C5CC6 |
−7.5
± 0.2
|
5.4
± 0.1
|
1393 |
EN300-1699871_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CCS(=O)(=O)N5 |
−7.5
± 0.2
|
5.4
± 0.2
|
1394 |
EN300-79588_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCS(=O)(=O)N |
−7.5
± 0.2
|
5.4
± 0.1
|
1395 |
EN300-1588617_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5C#N |
−7.5
± 0.2
|
5.4
± 0.2
|
1396 |
EN300-761209_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn(c5)CCO |
−7.5
± 0.2
|
5.4
± 0.2
|
1397 |
EN300-1720923_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C(C(=O)N)(F)F)O |
−7.5
± 0.3
|
5.4
± 0.2
|
1398 |
EN300-104493_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C5CCOC5 |
−7.5
± 0.3
|
5.4
± 0.2
|
1399 |
EN300-205616_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC5c6[nH]cnn6 |
−7.5
± 0.3
|
5.4
± 0.2
|
1400 |
EN300-359750_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCC(=O)O5 |
−7.5
± 0.2
|
5.4
± 0.2
|