Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
101 |
EN300-6238494_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)C5COCCO5 |
−9.7
± 0.2
|
7.1
± 0.2
|
102 |
EN300-102853_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6nnnn6c5 |
−9.7
± 0.2
|
7.1
± 0.2
|
103 |
EN300-138676_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)CC(F)(F)F |
−9.7
± 0.3
|
7.1
± 0.2
|
104 |
EN300-149013_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c([nH]nn5)Cl |
−9.7
± 0.2
|
7.1
± 0.1
|
105 |
EN300-104395_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCO5 |
−9.7
± 0.2
|
7.1
± 0.2
|
106 |
EN300-1253178_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CC5 |
−9.7
± 0.1
|
7.05
± 0.10
|
107 |
EN300-54588_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCn6c5ncn6 |
−9.7
± 0.2
|
7.1
± 0.2
|
108 |
EN300-269453_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nnnn6C5 |
−9.7
± 0.2
|
7.0
± 0.1
|
109 |
EN300-701244_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6CS(=O)(=O)C[C@]6(C5)C#N |
−9.7
± 0.3
|
7.0
± 0.2
|
110 |
EN300-146491_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCC(=O)N5 |
−9.7
± 0.2
|
7.0
± 0.2
|
111 |
EN300-192893_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(c5)ncn6 |
−9.7
± 0.2
|
7.0
± 0.1
|
112 |
EN300-201551_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COCCN5CC(F)(F)F |
−9.7
± 0.3
|
7.0
± 0.2
|
113 |
EN300-7549839_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn[nH]c5n6cnnn6 |
−9.7
± 0.2
|
7.0
± 0.2
|
114 |
EN300-225786_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5nnnn5C6CC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
115 |
EN300-6482296_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COC6C5COC6 |
−9.6
± 0.1
|
7.03
± 0.10
|
116 |
EN300-301925_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCOC5)C#N |
−9.6
± 0.2
|
7.0
± 0.1
|
117 |
EN300-97055_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]ccn5 |
−9.6
± 0.2
|
7.0
± 0.1
|
118 |
EN300-333468_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5Cl)CCO |
−9.6
± 0.2
|
7.0
± 0.2
|
119 |
EN300-783124_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CCOC5)F |
−9.6
± 0.2
|
7.0
± 0.1
|
120 |
EN300-322100_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6n5ncc6 |
−9.6
± 0.2
|
7.0
± 0.2
|
121 |
EN300-31998_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]nn5 |
−9.6
± 0.2
|
7.0
± 0.1
|
122 |
EN300-1178005_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C#N |
−9.6
± 0.2
|
7.0
± 0.1
|
123 |
EN300-248618_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)C5CC5 |
−9.6
± 0.2
|
7.0
± 0.2
|
124 |
EN300-7459768_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(C6(CCC6)O)O |
−9.6
± 0.3
|
7.0
± 0.2
|
125 |
EN300-1697480_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6c(cnn6c5)C#N |
−9.6
± 0.3
|
7.0
± 0.2
|
126 |
EN300-3710141_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCO5)C#N |
−9.6
± 0.2
|
7.0
± 0.1
|
127 |
EN300-13489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCN(CC5)C(=O)N |
−9.6
± 0.3
|
7.0
± 0.2
|
128 |
EN300-1273016_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCc6n5ncn6 |
−9.6
± 0.2
|
7.0
± 0.2
|
129 |
EDJ-MED-28ec730d-5
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5c[nH]nc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
130 |
VLA-UCB-551c2366-1
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.1
|
131 |
EN300-73967_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCS(=O)(=O)CC5)C#N |
−9.6
± 0.3
|
7.0
± 0.2
|
132 |
EN300-217416_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCn6c5nnn6 |
−9.6
± 0.2
|
7.0
± 0.1
|
133 |
EN300-7538678_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)n6c5COCC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
134 |
EN300-97661_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc[nH]c(=O)c5 |
−9.6
± 0.2
|
7.0
± 0.2
|
135 |
EN300-74089_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)C#N |
−9.6
± 0.2
|
7.0
± 0.2
|
136 |
EN300-6743433_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(c5)cnn6 |
−9.5
± 0.2
|
7.0
± 0.1
|
137 |
EN300-6488157_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc6n5cnn6 |
−9.5
± 0.2
|
7.0
± 0.1
|
138 |
EN300-315836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ccn5 |
−9.5
± 0.1
|
6.95
± 0.10
|
139 |
EN300-7426383_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(ccn5)[nH]nn6 |
−9.5
± 0.2
|
6.9
± 0.1
|
140 |
EN300-217107_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC5C(=O)N |
−9.5
± 0.2
|
6.9
± 0.1
|
141 |
EN300-731622_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5COCCO5 |
−9.5
± 0.2
|
6.9
± 0.2
|
142 |
EN300-42131_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c(=O)[nH]c6=O)nc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
143 |
EN300-383824_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c([nH]c5=O)CCOC6 |
−9.5
± 0.3
|
6.9
± 0.2
|
144 |
EN300-21009_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCO5 |
−9.5
± 0.2
|
6.9
± 0.1
|
145 |
EN300-133058_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)n[nH]n6 |
−9.5
± 0.2
|
6.9
± 0.1
|
146 |
EN300-53591_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(CC5)NC(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
147 |
EN300-120820_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cn[nH]c5=O |
−9.5
± 0.2
|
6.9
± 0.1
|
148 |
EN300-6474341_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6cnnc6C5 |
−9.5
± 0.2
|
6.9
± 0.2
|
149 |
EN300-4293814_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CCO |
−9.5
± 0.4
|
6.9
± 0.3
|
150 |
EN300-366687_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nncn6CC5 |
−9.5
± 0.2
|
6.9
± 0.1
|
151 |
EN300-1248250_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C(=O)N |
−9.5
± 0.2
|
6.9
± 0.1
|
152 |
EN300-1588617_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]5C#N |
−9.5
± 0.2
|
6.9
± 0.1
|
153 |
EN300-105693_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(COC5)CO |
−9.5
± 0.3
|
6.9
± 0.2
|
154 |
EN300-78135_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NC5CC5 |
−9.5
± 0.2
|
6.9
± 0.1
|
155 |
EN300-52380_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC(=O)N |
−9.5
± 0.2
|
6.9
± 0.2
|
156 |
EN300-77778_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCS(=O)(=O)C5 |
−9.5
± 0.2
|
6.9
± 0.2
|
157 |
EN300-246423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCC5)O |
−9.5
± 0.2
|
6.9
± 0.2
|
158 |
EN300-746311_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c6c5c(=O)[nH]cn6 |
−9.5
± 0.2
|
6.9
± 0.1
|
159 |
EN300-263456_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(=O)n(n5)CCF |
−9.5
± 0.2
|
6.9
± 0.2
|
160 |
EN300-103638_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCOC5=O |
−9.4
± 0.2
|
6.9
± 0.2
|
161 |
EN300-399606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCCC6O |
−9.4
± 0.2
|
6.9
± 0.1
|
162 |
EN300-300519_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5csnn5 |
−9.4
± 0.2
|
6.9
± 0.2
|
163 |
EN300-220527_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]ccn5 |
−9.4
± 0.2
|
6.9
± 0.1
|
164 |
EN300-173216_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC5CC5 |
−9.4
± 0.2
|
6.9
± 0.1
|
165 |
EN300-1722017_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6nccn6 |
−9.4
± 0.2
|
6.9
± 0.2
|
166 |
EN300-370753_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H](C5)C(=O)N |
−9.4
± 0.3
|
6.9
± 0.2
|
167 |
EN300-96013_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5[nH]c(nn5)CO |
−9.4
± 0.2
|
6.9
± 0.1
|
168 |
EN300-11934_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCC5=O |
−9.4
± 0.2
|
6.9
± 0.2
|
169 |
EN300-122849_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6ncon6 |
−9.4
± 0.3
|
6.9
± 0.2
|
170 |
EN300-7549839_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cn[nH]c5n6cnnn6 |
−9.4
± 0.3
|
6.9
± 0.2
|
171 |
VLA-UCB-34f3ed0c-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCc5cc[nH]n5 |
−9.4
± 0.2
|
6.9
± 0.2
|
172 |
EN300-6478631_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCc6n5cnn6 |
−9.4
± 0.2
|
6.9
± 0.2
|
173 |
EN300-263085_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6cnnn6 |
−9.4
± 0.3
|
6.9
± 0.2
|
174 |
EN300-341337_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCOC5CCOC6 |
−9.4
± 0.2
|
6.8
± 0.1
|
175 |
EN300-88819_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(on5)CCOC6 |
−9.4
± 0.2
|
6.8
± 0.1
|
176 |
EN300-6499719_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6ccnc6n5 |
−9.4
± 0.2
|
6.8
± 0.2
|
177 |
EN300-749499_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5(CCOCC5)O)O |
−9.4
± 0.2
|
6.8
± 0.2
|
178 |
EN300-102347_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5(COC5)CO |
−9.4
± 0.2
|
6.8
± 0.2
|
179 |
EN300-191904_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cnnn5 |
−9.4
± 0.2
|
6.8
± 0.2
|
180 |
EN300-18928_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CSCN5C(=O)C6CC6 |
−9.4
± 0.3
|
6.8
± 0.2
|
181 |
EN300-110325_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5cnncn5 |
−9.4
± 0.3
|
6.8
± 0.2
|
182 |
EN300-317555_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5=NCCO5 |
−9.4
± 0.2
|
6.8
± 0.1
|
183 |
EN300-20496_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCOC5=O |
−9.4
± 0.2
|
6.8
± 0.2
|
184 |
EN300-150212_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(n[nH]5)F |
−9.4
± 0.2
|
6.8
± 0.1
|
185 |
EN300-6494158_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC(CO5)CO |
−9.4
± 0.2
|
6.8
± 0.1
|
186 |
EN300-171766_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5n[nH]c(=O)s5 |
−9.4
± 0.2
|
6.8
± 0.1
|
187 |
EN300-7540875_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6ncnn6c5 |
−9.4
± 0.2
|
6.8
± 0.1
|
188 |
EN300-100916_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5nccn5 |
−9.4
± 0.2
|
6.8
± 0.1
|
189 |
EN300-11195_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC5 |
−9.4
± 0.2
|
6.8
± 0.1
|
190 |
EN300-143449_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCN(=O)=O |
−9.3
± 0.2
|
6.8
± 0.2
|
191 |
EN300-72211_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CC5)O |
−9.3
± 0.2
|
6.8
± 0.1
|
192 |
EN300-83529_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nc6ncccn6n5 |
−9.3
± 0.2
|
6.8
± 0.1
|
193 |
EN300-09325_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccccc5n6cnnn6 |
−9.3
± 0.3
|
6.8
± 0.2
|
194 |
EN300-22880_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCCC(C5)C(=O)N |
−9.3
± 0.2
|
6.8
± 0.2
|
195 |
EN300-246440_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6cncn6 |
−9.3
± 0.2
|
6.8
± 0.2
|
196 |
EN300-102347_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(COC5)CO |
−9.3
± 0.2
|
6.8
± 0.2
|
197 |
EN300-6736413_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCNC5=O |
−9.3
± 0.1
|
6.80
± 0.09
|
198 |
EN300-35781_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6ccccn6c5=O |
−9.3
± 0.3
|
6.8
± 0.2
|
199 |
EN300-294602_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccsc5S(=O)(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
200 |
EN300-761209_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5)CCO |
−9.3
± 0.2
|
6.8
± 0.1
|