Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
901 |
EN300-1644723_1_7 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@H]6[C@H]5COCC6 |
−11.4
± 0.3
|
902 |
EN300-315963_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnoc5 |
−11.4
± 0.3
|
903 |
EN300-332601_3_2 |
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.4
± 0.3
|
904 |
EN300-103638_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCOC5=O |
−11.4
± 0.3
|
905 |
EN300-99983_1_1 |
|
CNC(=O)Cc1nc(on1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
906 |
EN300-1723214_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(c5)c(=O)[nH]c(=O)[nH]6 |
−11.4
± 0.4
|
907 |
EN300-304135_3_2 |
|
CC[C@]1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
908 |
EN300-10747_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CSCC5=O |
−11.4
± 0.3
|
909 |
EN300-188341_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cn5)O |
−11.4
± 0.3
|
910 |
EN300-107493_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCNC(=O)C5 |
−11.4
± 0.3
|
911 |
EN300-1273362_2_2 |
|
C[C@]1(CN(C1=O)C)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
912 |
EN300-225053_1_1 |
|
COc1cnc(nc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
913 |
EN300-68747_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)C(=O)N |
−11.4
± 0.3
|
914 |
EN300-1212400_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C[C@@H]5CO)CO |
−11.4
± 0.3
|
915 |
EN300-7355981_1_1 |
|
Cn1c2c(c(n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)nc[nH]c2=O |
−11.4
± 0.3
|
916 |
EN300-21303_3_1 |
|
CCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.2
|
917 |
EN300-30397_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.4
± 0.3
|
918 |
EN300-30397_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.4
± 0.3
|
919 |
EN300-42269_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnns5 |
−11.4
± 0.2
|
920 |
EN300-120920_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H]5CCC(=O)NC5=O |
−11.4
± 0.3
|
921 |
EN300-310398_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)S(=O)(=O)N |
−11.4
± 0.3
|
922 |
EN300-370967_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−11.4
± 0.2
|
923 |
EN300-370967_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−11.4
± 0.2
|
924 |
EN300-29520_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5nccc6 |
−11.4
± 0.2
|
925 |
EN300-333468_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5Cl)CCO |
−11.4
± 0.3
|
926 |
EN300-201346_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5COC(=O)N5 |
−11.4
± 0.3
|
927 |
EN300-122656_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@]5(CCSC5)O |
−11.4
± 0.4
|
928 |
EN300-254883_3_1 |
|
Cc1c(non1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
929 |
EN300-173006_3_1 |
|
C[C@@H](c1nnnn1C)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
930 |
EN300-783124_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]([C@@H]5CCOC5)F |
−11.4
± 0.2
|
931 |
EN300-266736_1_1 |
|
Cc1c(nc[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
932 |
EN300-6277108_1_3 |
|
CO[C@@H]([C@H]1CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
933 |
EN300-7435545_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5C(=O)N |
−11.4
± 0.4
|
934 |
EN300-28571_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5n6cncn6 |
−11.4
± 0.3
|
935 |
EN300-1072972_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCOC5=O |
−11.4
± 0.3
|
936 |
EN300-304135_3_1 |
|
CC[C@@]1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
937 |
EN300-1273362_2_1 |
|
C[C@@]1(CN(C1=O)C)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
938 |
EN300-82616_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCNC5=O |
−11.4
± 0.3
|
939 |
EN300-197715_1_1 |
|
Cc1nnnn1CCCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
940 |
EN300-14628_1_2 |
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)[C@H]5CCS(=O)(=O)C5 |
−11.4
± 0.5
|
941 |
EN300-761220_3_1 |
|
CC(=O)N1CSC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
942 |
EN300-6729572_3_7 |
|
C[C@@H]([C@H]1C[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.4
± 0.3
|
943 |
EN300-24297_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5csnn5 |
−11.4
± 0.3
|
944 |
EN300-103031_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c([nH]n5)CCOC6 |
−11.4
± 0.3
|
945 |
EN300-248352_1_1 |
|
Cn1c(cc(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
946 |
EN300-7461023_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N(=O)=O |
−11.4
± 0.2
|
947 |
EN300-260816_3_1 |
|
CN1CC[C@@H](C1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
948 |
EN300-6743783_1_1 |
|
COC[C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
949 |
EN300-12929_1_1 |
|
Cc1cc(no1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
950 |
EN300-65050_3_1 |
|
CC(C)(CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.3
|
951 |
EN300-25986_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cccn5 |
−11.4
± 0.3
|
952 |
EN300-246248_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCNC5=O |
−11.4
± 0.3
|
953 |
EN300-05798_1_1 |
|
Cn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
954 |
EN300-98018_3_2 |
|
CC(=O)N1CC[C@](C1)(C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
955 |
EN300-59487_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC(=O)NC5 |
−11.4
± 0.2
|
956 |
EN300-6737762_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCCNC5=O |
−11.4
± 0.2
|
957 |
EN300-1600363_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5C#N |
−11.4
± 0.2
|
958 |
EN300-6734171_3_2 |
|
C[C@]1(CCC(=O)N(C1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
959 |
EN300-1932780_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C(F)F)O |
−11.4
± 0.2
|
960 |
EN300-755161_1_1 |
|
Cn1ncc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
961 |
EN300-360157_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@]5(CCOC5)O |
−11.4
± 0.2
|
962 |
EN300-6255179_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 |
−11.4
± 0.3
|
963 |
EN300-6255179_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 |
−11.4
± 0.3
|
964 |
EN300-152913_1_1 |
|
CN(C)c1nc(on1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
965 |
EN300-264744_3_2 |
|
CC(C)([C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)F)O |
−11.4
± 0.3
|
966 |
EN300-6729572_1_1 |
|
C[C@@H]([C@@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.4
± 0.3
|
967 |
EN300-98018_1_1 |
|
CC(=O)N1CC[C@@](C1)(C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
968 |
EN300-137191_1_1 |
|
Cc1cc(n(c(=O)n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.4
± 0.3
|
969 |
EN300-219531_1_1 |
|
CCC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.4
± 0.3
|
970 |
EN300-206646_1_1 |
|
CS(=O)(=O)c1cncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
971 |
EN300-211779_3_1 |
|
CC(=O)N1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
972 |
EN300-103638_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCOC5=O |
−11.4
± 0.3
|
973 |
EN300-252961_1_2 |
|
COC[C@H]1C[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.4
± 0.3
|
974 |
EN300-52193_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCO |
−11.4
± 0.3
|
975 |
EN300-181938_1_1 |
|
C[C@@](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−11.4
± 0.2
|
976 |
EN300-4293814_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CCO |
−11.4
± 0.5
|
977 |
EN300-100689_3_1 |
|
CC(=O)N1CCO[C@@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
978 |
EN300-60033_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COC[C@H]5CCCO5 |
−11.4
± 0.4
|
979 |
EN300-6734171_1_1 |
|
C[C@@]1(CCC(=O)N(C1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
980 |
EN300-72730_3_1 |
|
C[C@@H](C#N)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.2
|
981 |
EN300-1705754_3_1 |
|
CC1(CS(=O)(=O)C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
982 |
EN300-128715_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NCC(F)(F)F |
−11.4
± 0.3
|
983 |
EN300-1258964_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−11.4
± 0.4
|
984 |
EN300-331828_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO[C@@H]5COC[C@H]5O |
−11.4
± 0.3
|
985 |
EN300-1697480_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6c(cnn6c5)C#N |
−11.4
± 0.3
|
986 |
EN300-138676_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)CC(F)(F)F |
−11.4
± 0.3
|
987 |
EN300-7457159_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cc(on5)C6(COC6)O |
−11.4
± 0.3
|
988 |
EN300-1715993_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 |
−11.3
± 0.2
|
989 |
EN300-364992_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[C@H]5CC[C@H](O5)C(=O)N |
−11.3
± 0.3
|
990 |
EN300-365017_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C6(COC6)O |
−11.3
± 0.3
|
991 |
EN300-7435400_1_1 |
|
C[C@@H]1C[C@@H](CC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
992 |
EN300-1724086_1_4 |
|
C[C@H]1C[C@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−11.3
± 0.3
|
993 |
EN300-107048_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−11.3
± 0.2
|
994 |
EN300-1655797_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)O)F |
−11.3
± 0.3
|
995 |
EN300-95639_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)O)CO |
−11.3
± 0.4
|
996 |
EN300-303908_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@]6(C[C@H]6C5)O |
−11.3
± 0.2
|
997 |
EN300-83558_1_1 |
|
Cc1ccnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
998 |
EN300-233678_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)CO)O |
−11.3
± 0.3
|
999 |
EN300-85853_1_1 |
|
Cc1cc(=O)c(c[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
1000 |
EN300-210552_3_1 |
|
CC(=O)N1CCC[C@@](C1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.3
± 0.4
|