Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
501 |
EN300-7463171_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)CCO |
−11.9
± 0.8
|
502 |
EN300-7355519_1_6 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@H]5C[C@@H]6[C@H](O5)CCO6 |
−11.9
± 0.3
|
503 |
EN300-300088_2_1 |
|
CCn1cc(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
504 |
EN300-217107_1_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H]5C(=O)N |
−11.9
± 0.2
|
505 |
EN300-126104_1_1 |
|
Cc1cccn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
506 |
EN300-188217_3_1 |
|
CC(C)(CS(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.4
|
507 |
EN300-7433864_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c(=O)n(c5=O)C6CC6 |
−11.9
± 0.4
|
508 |
EN300-6277108_1_4 |
|
CO[C@H]([C@H]1CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
509 |
EN300-192893_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(c5)ncn6 |
−11.9
± 0.2
|
510 |
EN300-188174_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)[nH]c(=O)o6 |
−11.9
± 0.3
|
511 |
EN300-97300_3_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5F |
−11.9
± 0.2
|
512 |
EN300-249899_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6ncccn6cn5 |
−11.9
± 0.2
|
513 |
EN300-298552_1_3 |
|
CO[C@@H]([C@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
514 |
EN300-2007627_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H](C[C@@H](C5)CO)CO |
−11.8
± 0.3
|
515 |
EN300-77092_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5OCCO5 |
−11.8
± 0.3
|
516 |
EN300-249421_1_4 |
|
C[C@H]([C@H]1CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
517 |
EN300-256583_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CS(=O)(=O)C5 |
−11.8
± 0.3
|
518 |
EN300-6491117_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnco5 |
−11.8
± 0.2
|
519 |
EN300-1644723_3_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5[C@H]6[C@@H]5COCC6 |
−11.8
± 0.3
|
520 |
EN300-92031_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nc(no5)c6[nH]cnn6 |
−11.8
± 0.3
|
521 |
EN300-6482967_2_1 |
|
CNS(=O)(=O)CCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
522 |
EN300-103144_4_2 |
|
CSCC[C@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.8
± 0.3
|
523 |
EN300-6745081_3_2 |
|
C[C@]1(CCCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.4
|
524 |
EN300-205622_1_1 |
|
CS(=O)(=O)c1nccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.4
|
525 |
EN300-10334_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]56CCC(=O)N5CCS6 |
−11.8
± 0.3
|
526 |
EN300-22245_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccon5 |
−11.8
± 0.2
|
527 |
EN300-52009_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)O |
−11.8
± 0.3
|
528 |
EN300-39501_1_1 |
|
COCCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
529 |
EN300-315836_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ccn5 |
−11.8
± 0.2
|
530 |
EN300-315836_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ccn5 |
−11.8
± 0.2
|
531 |
EN300-6729572_1_4 |
|
C[C@H]([C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.8
± 0.2
|
532 |
EN300-36522_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)C5CC5 |
−11.8
± 0.2
|
533 |
EN300-21009_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCO5 |
−11.8
± 0.2
|
534 |
EN300-174763_1_1 |
|
CCN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
535 |
EN300-783124_3_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]([C@H]5CCOC5)F |
−11.8
± 0.3
|
536 |
EN300-248883_3_2 |
|
COC[C@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
537 |
EN300-7456641_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(nn5)CCOC6 |
−11.8
± 0.3
|
538 |
EN300-300020_3_1 |
|
CN1CCS(=O)(=O)C[C@@H]1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
539 |
EN300-219330_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOCC5=O |
−11.8
± 0.3
|
540 |
EN300-364679_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5cnnn5 |
−11.8
± 0.3
|
541 |
EN300-125769_1_1 |
|
COCCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.2
|
542 |
EN300-3710141_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]5(CCCO5)C#N |
−11.8
± 0.2
|
543 |
EN300-298552_1_2 |
|
CO[C@H]([C@@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
544 |
EN300-77778_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCS(=O)(=O)C5 |
−11.8
± 0.3
|
545 |
EN300-157527_1_1 |
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)n6cnnc6 |
−11.8
± 0.2
|
546 |
EN300-1664865_1_1 |
|
Cn1c2c(nn1)CCC[C@@H]2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.8
± 0.3
|
547 |
EN300-1653482_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCn6c(nnn6)C5 |
−11.8
± 0.3
|
548 |
EN300-216978_4_1 |
|
Cn1nc(nn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
549 |
EN300-132157_1_2 |
|
C[C@]1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
550 |
EN300-365398_2_1 |
|
Cn1c(nnn1)CCOC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
551 |
EN300-132615_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)N |
−11.8
± 0.3
|
552 |
EN300-294602_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccsc5S(=O)(=O)N |
−11.8
± 0.3
|
553 |
EN300-05620_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCNC(=O)N |
−11.8
± 0.3
|
554 |
EN300-227310_1_1 |
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.8
± 0.3
|
555 |
EN300-861925_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@H](CO)F |
−11.8
± 0.3
|
556 |
EN300-332601_1_2 |
|
CC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.8
± 0.3
|
557 |
EN300-185378_3_1 |
|
C[C@@H](COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.8
± 0.3
|
558 |
EN300-7459768_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(C6(CCC6)O)O |
−11.8
± 0.3
|
559 |
EN300-7352438_1_1 |
|
COC[C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
560 |
EN300-6238494_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)[C@H]5COCCO5 |
−11.8
± 0.4
|
561 |
EN300-69368_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)O |
−11.8
± 0.3
|
562 |
EN300-7459545_3_1 |
|
CN(C)C[C@@](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−11.8
± 0.6
|
563 |
EN300-256762_1_1 |
|
Cc1c(c(=O)[nH]cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
564 |
EN300-95698_3_1 |
|
C[C@@H]1CC(=O)NC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.4
|
565 |
EN300-367589_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(=O)NCC56COC6 |
−11.8
± 0.3
|
566 |
EN300-247428_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CC6 |
−11.8
± 0.3
|
567 |
EN300-365993_1_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]6CS(=O)(=O)C[C@H]6C5 |
−11.8
± 0.4
|
568 |
EN300-173216_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC5CC5 |
−11.8
± 0.3
|
569 |
EN300-10402_1_1 |
|
CS(=O)(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
570 |
EN300-299215_3_1 |
|
C[C@H]1[C@H](OCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
571 |
EN300-92447_3_2 |
|
CC1=NO[C@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
572 |
EN300-7437385_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CN6CCC[C@H]6CO5 |
−11.8
± 0.3
|
573 |
EN300-736749_3_1 |
|
CC(=O)N1CSC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
574 |
EN300-125140_3_1 |
|
COCC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
575 |
EN300-41423_1_1 |
|
Cc1ccc(c(=O)n1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
576 |
EN300-210084_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCC(=O)N5 |
−11.8
± 0.3
|
577 |
EN300-805037_1_1 |
|
Cn1c2cc(c(=O)[nH]c2cn1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.7
± 0.3
|
578 |
EN300-219531_1_2 |
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.7
± 0.3
|
579 |
EN300-2008102_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5CN6CC(O5)CCC6=O |
−11.7
± 0.3
|
580 |
EN300-149224_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(cn5)C#N |
−11.7
± 0.2
|
581 |
EN300-59487_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC(=O)NC5 |
−11.7
± 0.3
|
582 |
EN300-51801_1_2 |
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.7
± 0.3
|
583 |
EN300-1726153_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccn6c5nnc6 |
−11.7
± 0.3
|
584 |
EN300-62574_3_1 |
|
Cn1c(nnn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
585 |
EN300-198633_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5CCCCNC5=O |
−11.7
± 0.3
|
586 |
EN300-146491_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCC(=O)N5 |
−11.7
± 0.2
|
587 |
EN300-151461_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)[C@@H]6CCOC6 |
−11.7
± 0.3
|
588 |
EN300-97697_1_1 |
|
CN(C1CC(C1)O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
589 |
EN300-222357_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCc5c[nH]nn5 |
−11.7
± 0.2
|
590 |
EN300-198240_1_2 |
|
Cn1cc(cn1)[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.7
± 0.3
|
591 |
EN300-6478631_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCCc6n5cnn6 |
−11.7
± 0.3
|
592 |
EN300-1644723_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@@H]6[C@@H]5COCC6 |
−11.7
± 0.3
|
593 |
EN300-3710141_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCCO5)C#N |
−11.7
± 0.2
|
594 |
EN300-84785_1_2 |
|
C[C@H](CC(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.2
|
595 |
EN300-84785_1_2 |
|
C[C@H](CC(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.2
|
596 |
EN300-195756_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCC(=O)N5 |
−11.7
± 0.2
|
597 |
EN300-1262640_1_1 |
|
CC(C)NC(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.2
|
598 |
EN300-6499531_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCCCCS5(=O)=O |
−11.7
± 0.2
|
599 |
EN300-6738887_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C6CCC5[C@H](CC[C@@H]6O)O |
−11.7
± 0.5
|
600 |
EN300-127197_1_1 |
|
COc1cc(on1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|