Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1801 |
EN300-268198_1_2 |
|
C[C@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−10.9
± 0.3
|
1802 |
EN300-264301_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5CCC(=O)N5 |
−10.8
± 0.2
|
1803 |
EN300-373476_3_1 |
|
C[C@@]1(CCCS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
1804 |
EN300-142432_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)NC(=O)C6CC6 |
−10.8
± 0.3
|
1805 |
EN300-317555_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5=NCCO5 |
−10.8
± 0.2
|
1806 |
EN300-7494324_1_2 |
|
Cc1c(nc[nH]1)C[C@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.8
± 0.3
|
1807 |
EN300-77464_1_1 |
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.8
± 0.2
|
1808 |
EN300-114805_1_1 |
|
Cn1c(ccn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1809 |
EN300-114805_1_1 |
|
Cn1c(ccn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1810 |
EN300-246178_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn(c5)C[C@@H](CO)O |
−10.8
± 0.5
|
1811 |
EN300-51411_1_1 |
|
Cn1cc(cn1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1812 |
EN300-11300_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5cc(=O)[nH]c(=O)[nH]5 |
−10.8
± 0.3
|
1813 |
EN300-220536_1_1 |
|
CS(=O)(=O)C1(CCOCC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1814 |
EN300-6746918_1_1 |
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@](C5)(F)CO)cc1 |
−10.8
± 0.3
|
1815 |
EN300-217107_3_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@H]5C(=O)N |
−10.8
± 0.3
|
1816 |
EN300-80083_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCCC(=O)N5 |
−10.8
± 0.2
|
1817 |
EN300-305282_3_2 |
|
COC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.8
± 0.4
|
1818 |
EN300-47500_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCCCn5cccn5 |
−10.8
± 0.4
|
1819 |
EN300-106540_1_2 |
|
C[C@H](CC(=O)OC)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
1820 |
EN300-48886_1_1 |
|
CC(=O)N[C@@H]1CCCN(C1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1821 |
EN300-20284_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H](C5)O |
−10.8
± 0.3
|
1822 |
EN300-1664603_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5ccn[nH]5 |
−10.8
± 0.2
|
1823 |
EN300-51257_1_1 |
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.8
± 0.2
|
1824 |
EN300-861925_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H](CO)F |
−10.8
± 0.3
|
1825 |
EN300-364679_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5cnnn5 |
−10.8
± 0.2
|
1826 |
EN300-1608590_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nc(on5)N6CCOCC6 |
−10.8
± 0.4
|
1827 |
EN300-36522_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)C5CC5 |
−10.8
± 0.3
|
1828 |
EN300-393341_1_1 |
|
COc1cc(nc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−10.8
± 0.3
|
1829 |
EN300-64536_1_1 |
|
COCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.2
|
1830 |
EN300-256174_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5ccncn5 |
−10.8
± 0.4
|
1831 |
EN300-7355519_1_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C[C@@H]5C[C@H]6[C@@H](O5)CCO6 |
−10.8
± 0.3
|
1832 |
EN300-6499531_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCCCS5(=O)=O |
−10.8
± 0.3
|
1833 |
EN300-123205_3_1 |
|
CNS(=O)(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
1834 |
EN300-36495_2_1 |
|
CCOC(=O)NCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.2
|
1835 |
EN300-650518_3_1 |
|
CO[C@@H]1C[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1836 |
EN300-246992_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCC(=O)NC5 |
−10.8
± 0.3
|
1837 |
EN300-1706036_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5C(=O)NCCO5 |
−10.8
± 0.3
|
1838 |
EN300-62448_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)C5CCC5 |
−10.8
± 0.3
|
1839 |
EN300-6729572_1_2 |
|
C[C@H]([C@@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.8
± 0.3
|
1840 |
EN300-1272865_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@]6(CC[C@]6(C5)CO)CO |
−10.8
± 0.3
|
1841 |
EN300-180875_1_1 |
|
CN(C)C(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1842 |
EN300-11441_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cc(=O)[nH]c(=O)[nH]5 |
−10.8
± 0.3
|
1843 |
EN300-223491_3_1 |
|
Cn1cnn(c1=O)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.4
|
1844 |
EN300-365398_1_1 |
|
Cn1c(nnn1)CCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1845 |
EN300-6745453_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5Cc6nncn6C5 |
−10.8
± 0.3
|
1846 |
EN300-1653482_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCn6c(nnn6)C5 |
−10.8
± 0.3
|
1847 |
EN300-76841_3_1 |
|
C[C@@](COC)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−10.8
± 0.5
|
1848 |
EN300-98099_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cs5)S(=O)(=O)N |
−10.8
± 0.3
|
1849 |
EN300-306316_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5[nH]cnn5 |
−10.8
± 0.2
|
1850 |
EN300-120820_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cn[nH]c5=O |
−10.8
± 0.3
|
1851 |
EN300-125769_3_1 |
|
COCCCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
1852 |
EN300-198540_3_2 |
|
Cn1cc(cn1)[C@H](C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.8
± 0.4
|
1853 |
EN300-1968342_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H](CF)O |
−10.8
± 0.4
|
1854 |
EN300-1968342_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H](CF)O |
−10.8
± 0.4
|
1855 |
EN300-263153_3_1 |
|
Cn1cc(nn1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1856 |
EN300-139167_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5COCCO5 |
−10.8
± 0.2
|
1857 |
EN300-139167_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5COCCO5 |
−10.8
± 0.2
|
1858 |
EN300-139167_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@H]5COCCO5 |
−10.8
± 0.2
|
1859 |
EN300-252683_1_1 |
|
CO[C@@H]1COC[C@@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1860 |
EN300-196140_1_2 |
|
C[C@]1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)NC |
−10.8
± 0.3
|
1861 |
EN300-1709410_1_2 |
|
C[C@H]1C[C@@H](N1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.8
± 0.3
|
1862 |
EN300-246248_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC[C@@H]5CCNC5=O |
−10.8
± 0.3
|
1863 |
EN300-325738_3_1 |
|
CN1[C@@H](CCCC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1864 |
EN300-1644723_1_6 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H]6[C@H]5COCC6 |
−10.8
± 0.3
|
1865 |
EN300-202757_1_2 |
|
C[C@H](CC(=O)N)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
1866 |
EN300-2958082_1_1 |
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.8
± 0.3
|
1867 |
EN300-315792_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)COCC(F)F |
−10.8
± 0.3
|
1868 |
EN300-05512_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N[C@@H]5CCS(=O)(=O)C5 |
−10.8
± 0.4
|
1869 |
EN300-7385389_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C(F)(F)F |
−10.8
± 0.3
|
1870 |
EN300-6486855_1_1 |
|
Cn1c(cnn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1871 |
EN300-6486855_1_1 |
|
Cn1c(cnn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1872 |
EN300-205047_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(c[nH]5)S(=O)(=O)CC6 |
−10.8
± 0.3
|
1873 |
EN300-132613_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(scn5)S(=O)(=O)N |
−10.8
± 0.2
|
1874 |
EN300-1587757_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCNS5(=O)=O |
−10.8
± 0.3
|
1875 |
EN300-40153_1_1 |
|
CN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.3
|
1876 |
EN300-1588617_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@@H]5C#N |
−10.8
± 0.2
|
1877 |
DAR-DIA-0d514e7d-28_1
|
|
C[C@H]1COc2ccc(cc2[C@]1(C)C(=O)Nc3cncc4c3cccc4)Cl |
−10.81
± 0.10
|
1878 |
EN300-3710141_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@]5(CCCO5)C#N |
−10.8
± 0.3
|
1879 |
EN300-332838_1_1 |
|
CN1[C@@H](COC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.2
|
1880 |
EN300-191495_1_1 |
|
CS(=O)(=O)C1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1881 |
EN300-7540875_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6ncnn6c5 |
−10.8
± 0.2
|
1882 |
EN300-370967_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCOC5=O |
−10.8
± 0.3
|
1883 |
EN300-370967_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCOC5=O |
−10.8
± 0.3
|
1884 |
EN300-1789253_2_1 |
|
Cn1cc(nn1)c2cc(no2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.8
± 0.2
|
1885 |
EN300-221518_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCO |
−10.8
± 0.2
|
1886 |
EN300-221518_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCO |
−10.8
± 0.2
|
1887 |
EN300-221518_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCO |
−10.8
± 0.2
|
1888 |
EN300-7423123_1_1 |
|
Cc1nc(n(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−10.8
± 0.3
|
1889 |
DAR-DIA-5ff57136-9_1
|
|
COC(=O)/C=C/C(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−10.8
± 0.3
|
1890 |
EN300-342226_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnc[nH]5 |
−10.8
± 0.3
|
1891 |
EN300-144970_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)CO |
−10.8
± 0.3
|
1892 |
EN300-144970_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H](C5)CO |
−10.8
± 0.3
|
1893 |
EN300-263392_2_1 |
|
CS(=O)(=O)Cc1nc(co1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.8
± 0.3
|
1894 |
EN300-6494158_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5C[C@@H](CO5)CO |
−10.8
± 0.4
|
1895 |
EN300-1425677_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]5(CCCO5)CO |
−10.8
± 0.4
|
1896 |
EN300-30687_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc(c5)OCC(=O)N |
−10.8
± 0.3
|
1897 |
EN300-6764836_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC6[C@@H]([C@@H](C5O6)O)O |
−10.8
± 0.4
|
1898 |
EN300-1988306_3_1 |
|
CS(=O)(=O)CCC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.8
± 0.4
|
1899 |
EN300-46832_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC[C@@H]5CCOC5 |
−10.8
± 0.3
|
1900 |
EN300-1718836_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5nnc6n5CCOC6 |
−10.8
± 0.3
|