Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1601 |
EN300-13343_1_1 |
|
Cc1c(c(n2c(n1)ncn2)C)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.0
± 0.4
|
1602 |
EN300-59478_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCC(=O)N |
−11.0
± 0.3
|
1603 |
DAR-DIA-5ff57136-16_2
|
|
C[C@H](C#C)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.0
± 0.1
|
1604 |
EN300-244403_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CNC(=O)O5 |
−11.0
± 0.2
|
1605 |
EN300-658559_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)n6ccnn6 |
−11.0
± 0.3
|
1606 |
EN300-131572_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5cncc6 |
−11.0
± 0.3
|
1607 |
EN300-55072_2_1 |
|
C[C@@H](CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
1608 |
EN300-18074_4_1 |
|
CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.2
|
1609 |
EN300-220536_3_1 |
|
CS(=O)(=O)C1(CCOCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.4
|
1610 |
EN300-102901_3_1 |
|
CCC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−11.0
± 0.3
|
1611 |
EN300-207873_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)O |
−11.0
± 0.3
|
1612 |
EN300-6792206_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H](C5CCOCC5)O |
−11.0
± 0.3
|
1613 |
EN300-214800_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCN5CCNC5=O |
−11.0
± 0.3
|
1614 |
EN300-7444950_1_1 |
|
COc1cc(ncn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.0
± 0.3
|
1615 |
EN300-101443_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(COC5)O |
−11.0
± 0.3
|
1616 |
EN300-47657_1_2 |
|
C[C@H](C(=O)N(C)C)NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.0
± 0.3
|
1617 |
EN300-6743433_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)cnn6 |
−10.9
± 0.3
|
1618 |
EN300-159633_2_1 |
|
C[C@@](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.9
± 0.3
|
1619 |
EN300-2010317_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6C[C@@H]5[C@@H](C6)O |
−10.9
± 0.3
|
1620 |
EN300-214800_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCN5CCNC5=O |
−10.9
± 0.3
|
1621 |
EN300-263669_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56C[C@H]5COC6 |
−10.9
± 0.2
|
1622 |
EN300-270710_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)N |
−10.9
± 0.3
|
1623 |
EN300-120586_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(F)F |
−10.9
± 0.3
|
1624 |
EN300-75875_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnnc5 |
−10.9
± 0.2
|
1625 |
EN300-172640_3_2 |
|
C[C@H]1[C@@H](NC(=O)O1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1626 |
EN300-254840_1_1 |
|
C[C@@H]([C@@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.9
± 0.3
|
1627 |
EN300-53677_1_1 |
|
CS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.2
|
1628 |
EN300-185727_1_1 |
|
Cn1c2c(nn1)C[C@@H](CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−10.9
± 0.3
|
1629 |
EN300-127156_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(no5)C(=O)N |
−10.9
± 0.3
|
1630 |
EN300-98648_2_2 |
|
CN1CC[C@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
1631 |
EN300-98648_2_2 |
|
CN1CC[C@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
1632 |
EN300-366687_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCc6nncn6CC5 |
−10.9
± 0.3
|
1633 |
EN300-316193_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6COC(=O)[C@H]6C5 |
−10.9
± 0.3
|
1634 |
EN300-69727_1_1 |
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−10.9
± 0.3
|
1635 |
EN300-120436_1_1 |
|
Cn1cnn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1636 |
EN300-137784_1_1 |
|
CC1CCN(CC1)C(=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1637 |
EN300-378044_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC=CCO5 |
−10.9
± 0.3
|
1638 |
EN300-3044054_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5C6CC6 |
−10.9
± 0.3
|
1639 |
EN300-23318_2_2 |
|
C[C@H](C(=O)N[C@@H]1CCS(=O)(=O)C1)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1640 |
EN300-299806_1_1 |
|
CO[C@@]1(CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−10.9
± 0.4
|
1641 |
EN300-220676_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCCS(=O)(=O)C5 |
−10.9
± 0.3
|
1642 |
EN300-174603_3_1 |
|
CN(C(=O)CCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.9
± 0.3
|
1643 |
EN300-55109_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5CO |
−10.9
± 0.3
|
1644 |
EN300-88819_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c(on5)CCOC6 |
−10.9
± 0.2
|
1645 |
EN300-172640_3_3 |
|
C[C@@H]1[C@H](NC(=O)O1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1646 |
EN300-193399_3_1 |
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C5CC5 |
−10.9
± 0.3
|
1647 |
EN300-23318_3_3 |
|
C[C@@H](C(=O)N[C@H]1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|
1648 |
EN300-55072_1_1 |
|
C[C@@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
1649 |
EN300-6738732_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56COC[C@H]5C6(F)F |
−10.9
± 0.3
|
1650 |
EN300-80522_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC[C@@H]5CCOC5 |
−10.9
± 0.3
|
1651 |
EN300-6763507_1_1 |
|
CO[C@@H]1C[C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−10.9
± 0.3
|
1652 |
EN300-203940_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5[nH]ccc6=O |
−10.9
± 0.2
|
1653 |
EN300-1644723_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@@H]6[C@@H]5COCC6 |
−10.9
± 0.2
|
1654 |
EN300-23214_3_1 |
|
CCCNC(=O)[C@@H](C)NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
1655 |
EN300-52325_3_1 |
|
CCCS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.5
|
1656 |
EN300-92472_1_1 |
|
Cn1c(ccn1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1657 |
EN300-172640_1_1 |
|
C[C@@H]1[C@@H](NC(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.2
|
1658 |
EN300-159633_1_2 |
|
C[C@](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.9
± 0.3
|
1659 |
EN300-85760_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCO5 |
−10.9
± 0.2
|
1660 |
EN300-77359_1_2 |
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCOC |
−10.9
± 0.3
|
1661 |
EN300-1273362_1_2 |
|
C[C@]1(CN(C1=O)C)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1662 |
EN300-201346_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COC(=O)N5 |
−10.9
± 0.3
|
1663 |
EN300-6498856_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC[C@H]5C(=O)NC(=O)N5 |
−10.9
± 0.3
|
1664 |
EN300-6759637_1_1 |
|
C[C@@H]1CN(C[C@H](O1)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1665 |
EN300-51350_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCc6nncn6C5 |
−10.9
± 0.3
|
1666 |
EN300-358956_1_1 |
|
Cc1cc(c(=O)[nH]c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−10.9
± 0.3
|
1667 |
EN300-75342_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5ccnc5 |
−10.9
± 0.4
|
1668 |
EN300-75342_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5ccnc5 |
−10.9
± 0.4
|
1669 |
EN300-36096_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCNC5=O |
−10.9
± 0.4
|
1670 |
EN300-160080_3_1 |
|
CS(=O)(=O)c1nnc(s1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1671 |
EN300-195924_3_1 |
|
C[C@@]1(CCC(=O)NC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1672 |
EN300-1253178_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CC5 |
−10.9
± 0.2
|
1673 |
EN300-1253178_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CC5 |
−10.9
± 0.2
|
1674 |
EN300-1258964_3_1 |
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−10.9
± 0.4
|
1675 |
EN300-79022_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnn5 |
−10.9
± 0.2
|
1676 |
EN300-250836_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5c[nH]nc5 |
−10.9
± 0.3
|
1677 |
EN300-35612_3_1 |
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)COC |
−10.9
± 0.3
|
1678 |
EN300-331941_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]5C(=O)N |
−10.9
± 0.3
|
1679 |
EN300-12440_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CC(=O)N(C5)C6CC6 |
−10.9
± 0.4
|
1680 |
EN300-360157_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@]5(CCOC5)O |
−10.9
± 0.3
|
1681 |
EN300-51257_3_1 |
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−10.9
± 0.3
|
1682 |
EN300-141628_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)S(=O)(=O)N |
−10.9
± 0.4
|
1683 |
EN300-302058_1_1 |
|
CON1CC[C@@H](C1=O)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1684 |
EN300-124918_3_1 |
|
Cn1c(=O)[nH]c(n1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1685 |
EN300-322332_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5ccc(nc5)C(=O)N |
−10.9
± 0.4
|
1686 |
EN300-55072_3_2 |
|
C[C@H](CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
1687 |
EN300-05754_3_1 |
|
C[C@@H](C(=O)N1CCOCC1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.5
|
1688 |
EN300-97904_1_1 |
|
CS(=O)(=O)CC1(CC1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|
1689 |
EN300-259849_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCC[C@H](C5=O)O |
−10.9
± 0.3
|
1690 |
EN300-139167_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5COCCO5 |
−10.9
± 0.3
|
1691 |
EN300-139167_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5COCCO5 |
−10.9
± 0.3
|
1692 |
EN300-139167_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5COCCO5 |
−10.9
± 0.3
|
1693 |
EN300-1696962_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCCn5cnnn5 |
−10.9
± 0.3
|
1694 |
EN300-71558_3_1 |
|
COC(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−10.9
± 0.3
|
1695 |
EN300-18928_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CSCN5C(=O)C6CC6 |
−10.9
± 0.3
|
1696 |
EN300-180532_1_2 |
|
C[C@H]1CN(CCS(=O)(=O)C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|
1697 |
EN300-159633_3_1 |
|
C[C@@](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−10.9
± 0.3
|
1698 |
EN300-33513_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CSCC(=O)N |
−10.9
± 0.3
|
1699 |
EN300-120119_2_1 |
|
CN([C@@H]1CCNC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.3
|
1700 |
EN300-174668_3_2 |
|
CO[C@]1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−10.9
± 0.4
|