Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
1201 |
EN300-1654606_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@@H]5F |
−11.2
± 0.2
|
1202 |
EN300-1654606_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@@H]5F |
−11.2
± 0.2
|
1203 |
EN300-23214_2_2 |
|
CCCNC(=O)[C@H](C)NC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
1204 |
EN300-24949_1_1 |
|
COC(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
1205 |
EN300-1703143_3_1 |
|
CC(C)(C)c1nnn(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
1206 |
EN300-261210_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]5(CCOC5)C#N |
−11.2
± 0.4
|
1207 |
EN300-341337_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]56CCO[C@@H]5CCOC6 |
−11.2
± 0.3
|
1208 |
EN300-6356960_3_1 |
|
Cn1cnnc1CCCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
1209 |
EN300-76205_3_1 |
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−11.2
± 0.4
|
1210 |
EN300-36855_3_1 |
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5cnccn5 |
−11.2
± 0.3
|
1211 |
EN300-258477_1_1 |
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.2
± 0.2
|
1212 |
EN300-378828_3_1 |
|
C[C@@H]1[C@H]([C@H](C(=O)N1C)O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
1213 |
EN300-7457159_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5cc(on5)C6(COC6)O |
−11.2
± 0.3
|
1214 |
EN300-118760_3_1 |
|
C[C@@](C1CC1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.2
± 0.4
|
1215 |
VLA-UCB-34f3ed0c-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc[nH]n5 |
−11.2
± 0.2
|
1216 |
EN300-6729572_1_3 |
|
C[C@@H]([C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.2
± 0.2
|
1217 |
EN300-19515_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5 |
−11.2
± 0.2
|
1218 |
EN300-331941_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5C(=O)N |
−11.2
± 0.2
|
1219 |
EN300-100180_1_2 |
|
CC(=O)N1CC[C@H](C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
1220 |
EDJ-MED-e4b030d8-6_1
|
|
CCC[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−11.2
± 0.1
|
1221 |
JAG-UCB-706446eb-5_1
|
|
COCCN([C@@H]1CCCOC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1222 |
EN300-244744_1_1 |
|
Cn1ncc(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
1223 |
EN300-7444533_1_1 |
|
C[C@@H]1C[C@@H](C(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1224 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−11.2
± 0.2
|
1225 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−11.2
± 0.2
|
1226 |
EN300-221518_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−11.2
± 0.2
|
1227 |
EN300-7352812_3_1 |
|
Cn1cc(cn1)OC2(CC2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.2
± 0.3
|
1228 |
EN300-1726340_2_1 |
|
Cn1ccc(n1)n2cc(nc2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.2
± 0.3
|
1229 |
EN300-175186_3_1 |
|
C[C@@H](CO)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
1230 |
EN300-16582_1_2 |
|
CC(C)[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.2
± 0.3
|
1231 |
EDJ-MED-e4b030d8-4_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5COC5)Cl |
−11.2
± 0.2
|
1232 |
EN300-31184_3_2 |
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C(C)C |
−11.2
± 0.3
|
1233 |
EN300-116885_1_1 |
|
Cc1c(nc(c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.2
± 0.3
|
1234 |
EN300-22879_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCCC[C@H]5C(=O)N |
−11.2
± 0.4
|
1235 |
EN300-204936_3_1 |
|
Cn1c(cnn1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1236 |
EN300-248526_2_2 |
|
c1ccc(cc1)[C@](COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−11.2
± 0.4
|
1237 |
EN300-371682_1_1 |
|
CN([C@@H]1COC[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1238 |
EN300-30768_1_1 |
|
C[C@@H]1C[C@@H]1C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1239 |
EN300-140582_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5COCCN5CC(F)F |
−11.2
± 0.3
|
1240 |
EN300-18249_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N |
−11.2
± 0.2
|
1241 |
EN300-227218_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6CCC5C6 |
−11.2
± 0.4
|
1242 |
EN300-24419_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(ccs5)S(=O)(=O)N |
−11.2
± 0.3
|
1243 |
EN300-6495717_1_1 |
|
C[C@@H]1CC(CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(CO)CO |
−11.2
± 0.4
|
1244 |
EN300-220228_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6ccnn6c5O |
−11.2
± 0.3
|
1245 |
EN300-1721328_1_1 |
|
Cc1nnc(n1C)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1246 |
EN300-651307_3_2 |
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.2
± 0.4
|
1247 |
EN300-198240_1_1 |
|
Cn1cc(cn1)[C@@H](C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.2
± 0.3
|
1248 |
EN300-99391_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CO[C@@H]5CCOC5 |
−11.2
± 0.3
|
1249 |
EN300-1253122_3_1 |
|
CCN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
1250 |
EN300-1253122_3_1 |
|
CCN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
1251 |
EN300-62857_3_1 |
|
COCCS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.5
|
1252 |
EN300-99983_2_1 |
|
CNC(=O)Cc1nc(on1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1253 |
EN300-206870_1_1 |
|
Cc1nnc(s1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1254 |
EN300-7438185_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6nncn6nc5 |
−11.2
± 0.3
|
1255 |
EN300-268198_1_1 |
|
C[C@@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−11.2
± 0.2
|
1256 |
EN300-60831_3_1 |
|
CS(=O)(=O)C1(CCCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.5
|
1257 |
EN300-7463161_1_1 |
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@H](C5)n6cnnc6)cc1 |
−11.2
± 0.3
|
1258 |
EN300-152337_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)NCC5 |
−11.2
± 0.3
|
1259 |
EN300-7355519_3_6 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@H]5C[C@@H]6[C@H](O5)CCO6 |
−11.2
± 0.3
|
1260 |
EN300-254836_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CC5CS6(=O)=O |
−11.2
± 0.4
|
1261 |
DAR-DIA-5ff57136-12_1
|
|
c1ccc2c(c1)cncc2N(C#C[C@@H]3CCCN3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−11.2
± 0.2
|
1262 |
EN300-98648_2_1 |
|
CN1CC[C@@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
1263 |
EN300-98648_2_1 |
|
CN1CC[C@@H](C1=O)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
1264 |
EN300-1718364_1_1 |
|
CC1(CS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1265 |
EN300-193399_1_1 |
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C5CC5 |
−11.2
± 0.5
|
1266 |
EN300-203306_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(C(=O)N)O |
−11.2
± 0.4
|
1267 |
EN300-199359_2_1 |
|
CC(C)[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.2
± 0.3
|
1268 |
EN300-83766_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC#CCO |
−11.2
± 0.2
|
1269 |
EN300-254137_1_1 |
|
C#C[C@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
1270 |
EN300-36158_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5COCCO5 |
−11.2
± 0.3
|
1271 |
EN300-6493972_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56C[C@H]5[C@@H](C6)O |
−11.2
± 0.2
|
1272 |
EN300-209316_3_1 |
|
Cn1c(ncn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
1273 |
EN300-129455_1_1 |
|
CCNC(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
1274 |
EN300-211158_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cc(c5)CO)CO |
−11.2
± 0.3
|
1275 |
EN300-195590_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@@H]5CCCNC(=O)C5 |
−11.2
± 0.3
|
1276 |
EN300-209532_2_1 |
|
CN(CCC(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
1277 |
EN300-6474220_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CCn5ccnn5)(F)F |
−11.1
± 0.3
|
1278 |
EN300-106432_1_1 |
|
C#CCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
1279 |
EN300-249804_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CCOC(=O)N5 |
−11.1
± 0.3
|
1280 |
EN300-7459916_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(=O)CO |
−11.1
± 0.3
|
1281 |
EN300-43939_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)CC(F)(F)F |
−11.1
± 0.2
|
1282 |
EN300-1589101_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5c[nH]nc5 |
−11.1
± 0.3
|
1283 |
EN300-314455_2_1 |
|
CS(=O)(=O)N1CCC[C@@H](C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
1284 |
EN300-67533_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H](C5CC5)O |
−11.1
± 0.3
|
1285 |
EN300-1968342_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H](CF)O |
−11.1
± 0.3
|
1286 |
EN300-1968342_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H](CF)O |
−11.1
± 0.3
|
1287 |
EN300-95698_1_4 |
|
C[C@H]1CC(=O)NC[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
1288 |
EN300-370967_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOC5=O |
−11.1
± 0.3
|
1289 |
EN300-370967_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOC5=O |
−11.1
± 0.3
|
1290 |
DAR-DIA-6a508060-5_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4C[C@H]5CC(=O)N5)Cl |
−11.1
± 0.2
|
1291 |
EN300-1239522_1_2 |
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−11.1
± 0.2
|
1292 |
EN300-6482296_1_7 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CO[C@H]6[C@H]5COC6 |
−11.1
± 0.2
|
1293 |
EN300-217494_4_4 |
|
C[C@]([C@H]1CCOC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.1
± 0.3
|
1294 |
EN300-305996_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5COC(=O)N5 |
−11.1
± 0.2
|
1295 |
EN300-13499_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCNC(=O)N |
−11.1
± 0.3
|
1296 |
EN300-159633_3_2 |
|
C[C@](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−11.1
± 0.3
|
1297 |
EN300-107267_2_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CO[C@@H]5CCCNC5=O |
−11.1
± 0.2
|
1298 |
EN300-7439284_4_1 |
|
COc1cn[nH]c1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.4
|
1299 |
EN300-90142_3_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5CCC[C@H](C5)C(=O)N |
−11.1
± 0.3
|
1300 |
EN300-269453_2_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCc6nnnn6C5 |
−11.1
± 0.3
|