Rank |
Microstate |
SMILES |
ΔG / kcal M-1 |
101 |
EN300-299215_1_1 |
|
C[C@H]1[C@H](OCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.9
± 0.3
|
102 |
EN300-245264_3_2 |
|
CC[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.9
± 0.3
|
103 |
EN300-31998_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]nn5 |
−12.9
± 0.2
|
104 |
EN300-176023_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6n(nn5)CCNC6=O |
−12.9
± 0.3
|
105 |
EN300-222120_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@](C5)(c6cnn[nH]6)O |
−12.9
± 0.3
|
106 |
EN300-13890_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS[C@@H]5CCS(=O)(=O)C5 |
−12.9
± 0.3
|
107 |
EN300-140837_1_1 |
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−12.9
± 0.3
|
108 |
EN300-6738732_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56COC[C@H]5C6(F)F |
−12.9
± 0.2
|
109 |
EN300-322100_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6n5ncc6 |
−12.9
± 0.2
|
110 |
EN300-203293_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@H]5CNC(=O)O5 |
−12.9
± 0.3
|
111 |
EN300-191904_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cnnn5 |
−12.9
± 0.2
|
112 |
EN300-60049_1_4 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H]5CN6CCC[C@H]6CO5 |
−12.8
± 0.4
|
113 |
EN300-12587_1_1 |
|
CC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.4
|
114 |
EN300-250593_3_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C[C@H]5CC(=O)N5 |
−12.8
± 0.2
|
115 |
EN300-746830_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6CCOC[C@H]6CO5 |
−12.8
± 0.2
|
116 |
EN300-261859_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]sn5 |
−12.8
± 0.2
|
117 |
EN300-304695_1_1 |
|
CN1CCCC[C@@H](C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.3
|
118 |
EN300-761220_1_1 |
|
CC(=O)N1CSC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.3
|
119 |
EN300-244909_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)CO |
−12.8
± 0.3
|
120 |
EN300-1273016_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCc6n5ncn6 |
−12.8
± 0.3
|
121 |
EN300-66976_1_1 |
|
Cn1ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.2
|
122 |
EN300-1719160_1_1 |
|
CCn1cnc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.2
|
123 |
EN300-1703711_1_1 |
|
COc1c(cnc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−12.8
± 0.3
|
124 |
EN300-173006_3_2 |
|
C[C@H](c1nnnn1C)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.3
|
125 |
EN300-315792_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCC(F)F |
−12.8
± 0.2
|
126 |
EN300-200426_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6n(n5)CCNC6=O |
−12.8
± 0.2
|
127 |
EN300-373476_1_1 |
|
C[C@@]1(CCCS1(=O)=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.4
|
128 |
EN300-261596_1_1 |
|
C=CCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.3
|
129 |
EN300-160277_1_1 |
|
COCCn1ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.8
± 0.2
|
130 |
EN300-24297_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csnn5 |
−12.7
± 0.2
|
131 |
EN300-141695_1_1 |
|
CN1CC[C@@H](C1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.4
|
132 |
EN300-217107_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@@H]5C(=O)N |
−12.7
± 0.3
|
133 |
EN300-42591_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)NC5CC5 |
−12.7
± 0.4
|
134 |
EN300-6764836_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC6[C@@H]([C@@H](C5O6)O)O |
−12.7
± 0.3
|
135 |
EN300-298552_1_4 |
|
CO[C@H]([C@H]1CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
136 |
EN300-198515_3_1 |
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.7
± 0.3
|
137 |
EN300-254854_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5N(=O)=O |
−12.7
± 0.2
|
138 |
EN300-1073320_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5(CCC5)O)O |
−12.7
± 0.3
|
139 |
EN300-304627_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H](CCO5)Cn6cccn6 |
−12.7
± 0.3
|
140 |
EN300-6735902_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@@H]6CC[C@@H]6C(=O)N5 |
−12.7
± 0.3
|
141 |
EN300-1715993_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5ccnn5 |
−12.7
± 0.3
|
142 |
EN300-7431629_1_2 |
|
Cc1nnc2n1CC[C@]2(C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.7
± 0.4
|
143 |
EN300-6474341_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCn6cnnc6C5 |
−12.7
± 0.3
|
144 |
EN300-364679_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cnnn5 |
−12.7
± 0.3
|
145 |
EN300-783124_1_3 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]([C@H]5CCOC5)F |
−12.7
± 0.3
|
146 |
EN300-116234_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCO5 |
−12.7
± 0.2
|
147 |
EN300-20496_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCO[C@@H]5CCOC5=O |
−12.7
± 0.2
|
148 |
EN300-42270_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnsn5 |
−12.7
± 0.2
|
149 |
EN300-7352736_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@@H]([C@@H](CO5)O)O |
−12.7
± 0.3
|
150 |
EN300-120119_1_1 |
|
CN([C@@H]1CCNC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
151 |
EN300-99391_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CO[C@H]5CCOC5 |
−12.7
± 0.2
|
152 |
EN300-211777_1_1 |
|
CC(=O)N1CCC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
153 |
DAR-DIA-5ff57136-10_1
|
|
c1ccc2c(c1)cncc2N(C#CC#N)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−12.7
± 0.1
|
154 |
EN300-7463171_4_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCS(=O)(=O)CCO |
−12.7
± 0.8
|
155 |
EN300-23417_1_1 |
|
COCCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.4
|
156 |
EN300-222969_3_2 |
|
CN1C[C@H](OC1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.7
± 0.3
|
157 |
EN300-124555_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(nc5)n[nH]n6 |
−12.7
± 0.2
|
158 |
EN300-142240_1_1 |
|
Cn1c(cc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−12.7
± 0.3
|
159 |
EN300-198515_1_1 |
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−12.7
± 0.3
|
160 |
EN300-151423_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5(CCOCC5)O |
−12.6
± 0.2
|
161 |
EN300-300217_1_3 |
|
C/C=C\[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−12.6
± 0.3
|
162 |
EN300-1244816_3_1 |
|
Cc1nnnn1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
163 |
EN300-862094_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]5C(=O)N |
−12.6
± 0.3
|
164 |
EN300-1644723_1_5 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@@H]6[C@H]5COCC6 |
−12.6
± 0.2
|
165 |
EN300-6488240_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nncs5 |
−12.6
± 0.2
|
166 |
EN300-1425677_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@]5(CCCO5)CO |
−12.6
± 0.3
|
167 |
EN300-56202_1_1 |
|
CC(=O)N1CSC[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.4
|
168 |
EN300-123712_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc(n5)n6cncn6 |
−12.6
± 0.3
|
169 |
EN300-100467_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccnn5 |
−12.6
± 0.3
|
170 |
EN300-103144_4_1 |
|
CSCC[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−12.6
± 0.3
|
171 |
EN300-243828_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnncc5O |
−12.6
± 0.3
|
172 |
EN300-1248250_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C(=O)N |
−12.6
± 0.3
|
173 |
EN300-651307_1_1 |
|
CC[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−12.6
± 0.3
|
174 |
EN300-1262608_1_1 |
|
CCNC(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.6
± 0.2
|
175 |
EN300-36158_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5COCCO5 |
−12.6
± 0.3
|
176 |
EN300-20980_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnnn5 |
−12.6
± 0.2
|
177 |
EN300-170463_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCOC5 |
−12.6
± 0.3
|
178 |
EN300-100467_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccnn5 |
−12.6
± 0.2
|
179 |
EN300-175186_3_2 |
|
C[C@H](CO)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.6
± 0.3
|
180 |
EN300-191915_1_1 |
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.6
± 0.3
|
181 |
EN300-341337_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56CCO[C@@H]5CCOC6 |
−12.6
± 0.3
|
182 |
EN300-6505003_1_1 |
|
C[C@@H]1CC[C@@H](C(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
183 |
EN300-95698_1_3 |
|
C[C@@H]1CC(=O)NC[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.2
|
184 |
EN300-1072199_3_1 |
|
CO[C@@]1(CCCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.5
|
185 |
EN300-685077_1_1 |
|
COCCn1cccc(c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
186 |
EN300-315238_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H](O5)C(=O)N |
−12.6
± 0.3
|
187 |
EN300-90225_3_1 |
|
Cn1nc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.2
|
188 |
EN300-6744028_1_5 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC6CC5[C@@H]([C@H]6O)O |
−12.6
± 0.3
|
189 |
EN300-1600786_3_1 |
|
Cn1cc(nn1)CCOCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
190 |
EN300-1600786_3_1 |
|
Cn1cc(nn1)CCOCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.6
± 0.3
|
191 |
EN300-6499531_1_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCCCS5(=O)=O |
−12.5
± 0.4
|
192 |
FRA-DIA-13af2da5-2_1
|
|
CN(C)c1ccc(cc1)[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.5
± 0.2
|
193 |
EN300-1601684_1_2 |
|
CC1([C@H](OCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−12.5
± 0.3
|
194 |
EN300-102901_1_1 |
|
CCC[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−12.5
± 0.4
|
195 |
EN300-7431629_3_1 |
|
Cc1nnc2n1CC[C@@]2(C)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.5
± 0.3
|
196 |
EN300-702756_4_2 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CS(=O)(=O)CC(=O)N5 |
−12.5
± 0.2
|
197 |
EN300-640698_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc([nH]c5=O)C#N |
−12.5
± 0.3
|
198 |
EN300-102347_3_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(COC5)CO |
−12.5
± 0.2
|
199 |
EN300-149296_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncc(cn5)F |
−12.5
± 0.2
|
200 |
EN300-122340_1_1 |
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCSCC5)O |
−12.5
± 0.4
|