Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
901 |
EN300-74314_1
|
|
CCn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.2
± 0.2
|
902 |
EN300-5309123_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)Cn6cnnc6 |
−11.2
± 0.3
|
8.2
± 0.2
|
903 |
EN300-1265071_1
|
|
CN(Cc1c[nH]nn1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
904 |
EN300-246248_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCNC5=O |
−11.2
± 0.2
|
8.2
± 0.2
|
905 |
EN300-65050_2
|
|
CC(C)(CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.2
|
906 |
EN300-53395_1
|
|
CCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.2
|
907 |
EN300-43206_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCS5(=O)=O |
−11.2
± 0.3
|
8.2
± 0.2
|
908 |
EN300-52325_1
|
|
CCCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.2
|
909 |
EN300-19926_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC#N |
−11.2
± 0.2
|
8.2
± 0.1
|
910 |
EN300-54541_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)N5 |
−11.2
± 0.2
|
8.2
± 0.2
|
911 |
EN300-39101_3
|
|
CCOC(=O)N(C)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.3
|
912 |
EN300-248526_2
|
|
c1ccc(cc1)C(COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−11.2
± 0.3
|
8.2
± 0.2
|
913 |
EN300-98018_1
|
|
CC(=O)N1CCC(C1)(C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.2
± 0.2
|
914 |
EN300-761618_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)Nc5cccnn5 |
−11.2
± 0.3
|
8.2
± 0.2
|
915 |
EN300-194199_1
|
|
COCCn1cc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.2
± 0.2
|
916 |
EN300-189672_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(=O)[nH]c5 |
−11.2
± 0.2
|
8.2
± 0.2
|
917 |
EN300-169955_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C(CC(=O)N5)C(F)(F)F |
−11.2
± 0.3
|
8.2
± 0.2
|
918 |
EN300-128750_1
|
|
CC(=O)N(C)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.2
|
919 |
EN300-1717795_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H](C5)OCO6 |
−11.2
± 0.3
|
8.2
± 0.2
|
920 |
EN300-35789_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cccnc5=O |
−11.2
± 0.3
|
8.2
± 0.2
|
921 |
EN300-20668_1
|
|
COC(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
8.2
± 0.2
|
922 |
EN300-40947_1
|
|
CC(C)S(=O)(=O)C(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.2
± 0.2
|
923 |
EN300-6739879_1
|
|
CC1CCN(C2C1CNC2=O)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.2
± 0.3
|
8.2
± 0.3
|
924 |
EN300-05512_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NC5CCS(=O)(=O)C5 |
−11.2
± 0.3
|
8.2
± 0.2
|
925 |
EN300-53423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCOC5 |
−11.2
± 0.2
|
8.2
± 0.2
|
926 |
EN300-05277_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(=O)N5CCOCC5 |
−11.2
± 0.2
|
8.2
± 0.2
|
927 |
EN300-14767_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCN(C5)C(=O)N |
−11.2
± 0.3
|
8.2
± 0.2
|
928 |
EN300-79180_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5CCOCC5)O |
−11.2
± 0.3
|
8.2
± 0.2
|
929 |
EN300-220527_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]ccn5 |
−11.2
± 0.2
|
8.2
± 0.2
|
930 |
EN300-321703_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCOC5COC5 |
−11.2
± 0.3
|
8.2
± 0.2
|
931 |
NAU-LAT-b7d8c353-8
|
|
c1cc(c2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)CN |
−11.20
± 0.09
|
8.16
± 0.07
|
932 |
EN300-314455_3
|
|
CS(=O)(=O)N1CCC[C@@H](C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.7
|
8.2
± 0.5
|
933 |
EN300-1654606_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@@H]5F |
−11.2
± 0.1
|
8.2
± 0.1
|
934 |
EN300-24949_1
|
|
COC(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
8.2
± 0.2
|
935 |
EN300-1703143_3
|
|
CC(C)(C)c1nnn(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
8.2
± 0.3
|
936 |
EN300-6356960_3
|
|
Cn1cnnc1CCCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
8.2
± 0.3
|
937 |
EN300-76205_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−11.2
± 0.4
|
8.2
± 0.3
|
938 |
EN300-343474_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCNC5=O |
−11.2
± 0.3
|
8.2
± 0.2
|
939 |
EN300-36855_3
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5cnccn5 |
−11.2
± 0.3
|
8.2
± 0.2
|
940 |
EN300-258477_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.2
± 0.2
|
8.2
± 0.2
|
941 |
EN300-378828_3
|
|
C[C@@H]1[C@H]([C@H](C(=O)N1C)O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.4
|
8.1
± 0.3
|
942 |
EN300-7457159_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5cc(on5)C6(COC6)O |
−11.2
± 0.3
|
8.1
± 0.2
|
943 |
EN300-325738_1
|
|
CN1C(CCCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.2
|
944 |
VLA-UCB-34f3ed0c-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cc[nH]n5 |
−11.2
± 0.2
|
8.1
± 0.2
|
945 |
EN300-331941_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@H]5C(=O)N |
−11.2
± 0.2
|
8.1
± 0.2
|
946 |
EDJ-MED-e4b030d8-6
|
|
CCC[C@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl |
−11.2
± 0.1
|
8.15
± 0.08
|
947 |
EN300-244744_1
|
|
Cn1ncc(n1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.2
|
948 |
EN300-221518_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCCO |
−11.2
± 0.1
|
8.15
± 0.09
|
949 |
EN300-7352812_3
|
|
Cn1cc(cn1)OC2(CC2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.2
± 0.3
|
8.1
± 0.2
|
950 |
EN300-1726340_2
|
|
Cn1ccc(n1)n2cc(nc2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.2
± 0.3
|
8.1
± 0.2
|
951 |
EDJ-MED-e4b030d8-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5COC5)Cl |
−11.2
± 0.2
|
8.1
± 0.1
|
952 |
EN300-7464289_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(=O)OC)F |
−11.2
± 0.2
|
8.1
± 0.2
|
953 |
EN300-116885_1
|
|
Cc1c(nc(c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.2
± 0.3
|
8.1
± 0.2
|
954 |
EN300-204936_3
|
|
Cn1c(cnn1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
955 |
EN300-1258964_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−11.2
± 0.3
|
8.1
± 0.2
|
956 |
EN300-371682_1
|
|
CN([C@@H]1COC[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
957 |
EN300-140582_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5COCCN5CC(F)F |
−11.2
± 0.3
|
8.1
± 0.2
|
958 |
EN300-18249_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)N |
−11.2
± 0.2
|
8.1
± 0.2
|
959 |
EN300-227218_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6CCC5C6 |
−11.2
± 0.4
|
8.1
± 0.3
|
960 |
EN300-24419_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(ccs5)S(=O)(=O)N |
−11.2
± 0.3
|
8.1
± 0.2
|
961 |
EN300-305282_1
|
|
COCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.2
± 0.3
|
8.1
± 0.2
|
962 |
EN300-6495717_1
|
|
CC1CC(CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(CO)CO |
−11.2
± 0.4
|
8.1
± 0.3
|
963 |
EN300-220228_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6ccnn6c5O |
−11.2
± 0.3
|
8.1
± 0.2
|
964 |
EN300-169955_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5C(CC(=O)N5)C(F)(F)F |
−11.2
± 0.3
|
8.1
± 0.2
|
965 |
EN300-1721328_1
|
|
Cc1nnc(n1C)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
966 |
EN300-1253122_3
|
|
CCN(C)C(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
8.1
± 0.1
|
967 |
EN300-62857_3
|
|
COCCS(=O)(=O)CCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.5
|
8.1
± 0.3
|
968 |
EN300-99983_2
|
|
CNC(=O)Cc1nc(on1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
969 |
EN300-206870_1
|
|
Cc1nnc(s1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
970 |
EN300-7438185_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6nncn6nc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
971 |
EN300-60831_3
|
|
CS(=O)(=O)C1(CCCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.5
|
8.1
± 0.4
|
972 |
EN300-7463161_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@H](C5)n6cnnc6)cc1 |
−11.2
± 0.3
|
8.1
± 0.2
|
973 |
EN300-254836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CC5CS6(=O)=O |
−11.2
± 0.4
|
8.1
± 0.3
|
974 |
EN300-1718364_1
|
|
CC1(CS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
975 |
EN300-193399_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C5CC5 |
−11.2
± 0.5
|
8.1
± 0.3
|
976 |
EN300-39405_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−11.2
± 0.3
|
8.1
± 0.2
|
977 |
EN300-365993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6CS(=O)(=O)CC6C5 |
−11.2
± 0.4
|
8.1
± 0.3
|
978 |
EN300-203306_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)(C(=O)N)O |
−11.2
± 0.4
|
8.1
± 0.3
|
979 |
EN300-199359_2
|
|
CC(C)[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.2
± 0.3
|
8.1
± 0.2
|
980 |
EN300-83766_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC#CCO |
−11.2
± 0.2
|
8.1
± 0.1
|
981 |
JOH-SUS-a69c159d-6
|
|
c1ccc2c(c1)c(c(nc2F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−11.16
± 0.06
|
8.13
± 0.04
|
982 |
EN300-254137_1
|
|
C#C[C@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.1
|
983 |
EN300-6493972_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@]56C[C@H]5[C@@H](C6)O |
−11.2
± 0.2
|
8.1
± 0.2
|
984 |
EN300-310022_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(CN5c6ccncn6)O |
−11.2
± 0.4
|
8.1
± 0.3
|
985 |
EN300-209316_3
|
|
Cn1c(ncn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.3
|
8.1
± 0.2
|
986 |
EN300-129455_1
|
|
CCNC(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.3
|
8.1
± 0.2
|
987 |
EN300-211158_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cc(c5)CO)CO |
−11.2
± 0.3
|
8.1
± 0.2
|
988 |
EN300-249421_1
|
|
CC(C1CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.2
± 0.2
|
8.1
± 0.2
|
989 |
EN300-157541_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)CC5CO |
−11.2
± 0.5
|
8.1
± 0.3
|
990 |
EN300-209532_2
|
|
CN(CCC(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.2
± 0.2
|
8.1
± 0.2
|
991 |
EN300-6474220_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CCn5ccnn5)(F)F |
−11.1
± 0.3
|
8.1
± 0.2
|
992 |
EN300-106432_1
|
|
C#CCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.3
|
8.1
± 0.2
|
993 |
EN300-7459916_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC(=O)CO |
−11.1
± 0.3
|
8.1
± 0.2
|
994 |
EN300-43939_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)CC(F)(F)F |
−11.1
± 0.2
|
8.1
± 0.2
|
995 |
EN300-1589101_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5c[nH]nc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
996 |
EN300-314455_2
|
|
CS(=O)(=O)N1CCC[C@@H](C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.1
± 0.3
|
8.1
± 0.2
|
997 |
EN300-153257_1
|
|
CC(C)C(CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.2
|
998 |
EN300-101373_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)CO |
−11.1
± 0.2
|
8.1
± 0.2
|
999 |
EN300-175186_4
|
|
CC(CO)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.1
± 0.2
|
8.1
± 0.2
|
1000 |
EN300-370967_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCOC5=O |
−11.1
± 0.2
|
8.1
± 0.2
|