Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
701 |
EN300-266736_1
|
|
Cc1c(nc[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
702 |
EN300-6729572_1
|
|
CC(C1CC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.4
± 0.1
|
8.30
± 0.08
|
703 |
EN300-7435545_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CCO[C@@H]5C(=O)N |
−11.4
± 0.4
|
8.3
± 0.3
|
704 |
EN300-28571_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5n6cncn6 |
−11.4
± 0.3
|
8.3
± 0.2
|
705 |
EN300-197715_1
|
|
Cc1nnnn1CCCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
706 |
EN300-761220_3
|
|
CC(=O)N1CSC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
707 |
EN300-24297_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5csnn5 |
−11.4
± 0.3
|
8.3
± 0.2
|
708 |
EN300-332601_1
|
|
CCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.4
± 0.3
|
8.3
± 0.2
|
709 |
EN300-103031_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6c([nH]n5)CCOC6 |
−11.4
± 0.3
|
8.3
± 0.2
|
710 |
EN300-248352_1
|
|
Cn1c(cc(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
711 |
EN300-7461023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N(=O)=O |
−11.4
± 0.2
|
8.3
± 0.1
|
712 |
EN300-6743783_1
|
|
COC[C@H]1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
713 |
EN300-2007627_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(CC(C5)CO)CO |
−11.4
± 0.2
|
8.3
± 0.2
|
714 |
EN300-12929_1
|
|
Cc1cc(no1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
715 |
EN300-65050_3
|
|
CC(C)(CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.3
|
8.3
± 0.2
|
716 |
EN300-25986_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCn5cccn5 |
−11.4
± 0.3
|
8.3
± 0.2
|
717 |
EN300-05798_1
|
|
Cn1c(=O)ccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
718 |
EN300-151461_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CCOC6 |
−11.4
± 0.3
|
8.3
± 0.2
|
719 |
EN300-51801_1
|
|
CCCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−11.4
± 0.3
|
8.3
± 0.2
|
720 |
EN300-1600363_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5C[C@H]5C#N |
−11.4
± 0.2
|
8.3
± 0.2
|
721 |
EN300-755161_1
|
|
Cn1ncc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
722 |
EN300-7385329_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5Cc6nccn6C5 |
−11.4
± 0.2
|
8.3
± 0.2
|
723 |
EN300-59487_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)NC5 |
−11.4
± 0.2
|
8.3
± 0.2
|
724 |
EN300-6255179_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCn5cncn5 |
−11.4
± 0.2
|
8.3
± 0.1
|
725 |
EN300-152913_1
|
|
CN(C)c1nc(on1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
726 |
EN300-301690_3
|
|
CS(=O)(=O)N1CCC(C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
727 |
EN300-341337_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCOC5CCOC6 |
−11.4
± 0.2
|
8.3
± 0.2
|
728 |
EN300-185398_1
|
|
CC(C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(F)F)O |
−11.4
± 0.2
|
8.3
± 0.1
|
729 |
FRA-DIA-b66f7109-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@H]3CCOc4c3cc(cc4Cl)OC5CC(=O)N5 |
−11.4
± 0.2
|
8.3
± 0.2
|
730 |
EN300-137191_1
|
|
Cc1cc(n(c(=O)n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.4
± 0.3
|
8.3
± 0.2
|
731 |
EN300-206646_1
|
|
CS(=O)(=O)c1cncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
732 |
EN300-211779_3
|
|
CC(=O)N1CCC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
733 |
EN300-1239522_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−11.4
± 0.2
|
8.3
± 0.1
|
734 |
EN300-103638_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCCOC5=O |
−11.4
± 0.3
|
8.3
± 0.2
|
735 |
EN300-52193_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CCO |
−11.4
± 0.3
|
8.3
± 0.2
|
736 |
EN300-4293814_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CS(=O)(=O)CCO |
−11.4
± 0.5
|
8.3
± 0.4
|
737 |
EN300-10402_1
|
|
CS(=O)(=O)N1CCCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.5
|
8.3
± 0.4
|
738 |
EN300-1705754_3
|
|
CC1(CS(=O)(=O)C1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
739 |
EN300-128715_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)NCC(F)(F)F |
−11.4
± 0.3
|
8.3
± 0.2
|
740 |
EN300-6478631_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCc6n5cnn6 |
−11.4
± 0.3
|
8.3
± 0.2
|
741 |
EN300-331828_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCO[C@@H]5COC[C@H]5O |
−11.4
± 0.3
|
8.3
± 0.2
|
742 |
EN300-1697480_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6c(cnn6c5)C#N |
−11.4
± 0.3
|
8.3
± 0.2
|
743 |
EN300-138676_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CC(=O)N)CC(F)(F)F |
−11.4
± 0.3
|
8.3
± 0.2
|
744 |
EN300-7457159_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cc(on5)C6(COC6)O |
−11.4
± 0.3
|
8.3
± 0.2
|
745 |
EN300-6499531_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCCCS5(=O)=O |
−11.3
± 0.2
|
8.3
± 0.2
|
746 |
EN300-1715993_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCn5ccnn5 |
−11.3
± 0.2
|
8.3
± 0.2
|
747 |
EN300-364992_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC[C@H]5CC[C@H](O5)C(=O)N |
−11.3
± 0.3
|
8.3
± 0.2
|
748 |
EN300-246248_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CCNC5=O |
−11.3
± 0.2
|
8.3
± 0.1
|
749 |
EN300-365017_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C6(COC6)O |
−11.3
± 0.3
|
8.3
± 0.2
|
750 |
EN300-7435400_1
|
|
C[C@@H]1C[C@@H](CC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
751 |
EN300-100689_3
|
|
CC(=O)N1CCOC(C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.3
± 0.2
|
752 |
EN300-107048_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CC5)CO |
−11.3
± 0.2
|
8.3
± 0.2
|
753 |
EN300-1655797_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@@H](C5)O)F |
−11.3
± 0.3
|
8.3
± 0.2
|
754 |
EN300-303908_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@]6(C[C@H]6C5)O |
−11.3
± 0.2
|
8.3
± 0.2
|
755 |
EN300-83558_1
|
|
Cc1ccnn1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.3
± 0.2
|
756 |
EN300-85853_1
|
|
Cc1cc(=O)c(c[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
757 |
EN300-247951_1
|
|
C[C@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.3
± 0.2
|
8.3
± 0.2
|
758 |
EN300-221022_1
|
|
CCCN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.3
|
8.3
± 0.2
|
759 |
EN300-6487680_3
|
|
Cc1nnn(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
760 |
EN300-146174_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)CO |
−11.3
± 0.3
|
8.3
± 0.2
|
761 |
EN300-863933_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C(=O)C |
−11.3
± 0.2
|
8.3
± 0.2
|
762 |
EN300-191495_2
|
|
CS(=O)(=O)C1(CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.7
|
8.3
± 0.5
|
763 |
EN300-185727_1
|
|
Cn1c2c(nn1)CC(CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.3
± 0.3
|
8.3
± 0.2
|
764 |
EN300-7465954_1
|
|
COc1c(=O)ccoc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.3
± 0.2
|
765 |
EN300-1073533_1
|
|
COC1(CC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−11.3
± 0.3
|
8.3
± 0.2
|
766 |
EN300-6482296_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COC6C5COC6 |
−11.3
± 0.1
|
8.25
± 0.10
|
767 |
EN300-269453_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCc6nnnn6C5 |
−11.3
± 0.2
|
8.3
± 0.2
|
768 |
EN300-84785_1
|
|
CC(CC(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.2
|
8.2
± 0.1
|
769 |
EN300-11195_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCC5 |
−11.3
± 0.2
|
8.2
± 0.2
|
770 |
EN300-182758_1
|
|
Cc1nc(no1)Cn2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.3
± 0.2
|
8.2
± 0.2
|
771 |
EN300-7549555_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5coc(n5)CO |
−11.3
± 0.2
|
8.2
± 0.2
|
772 |
EN300-128463_1
|
|
CNC(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.3
± 0.3
|
8.2
± 0.2
|
773 |
EN300-872798_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5c(nnn5)C6CC6 |
−11.3
± 0.5
|
8.2
± 0.4
|
774 |
EN300-171766_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5n[nH]c(=O)s5 |
−11.3
± 0.3
|
8.2
± 0.2
|
775 |
EN300-1265948_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)N5CCS(=O)(=O)CC5 |
−11.3
± 0.3
|
8.2
± 0.2
|
776 |
EN300-82179_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC(=O)N |
−11.3
± 0.2
|
8.2
± 0.1
|
777 |
EN300-783124_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5CCOC5)F |
−11.3
± 0.2
|
8.2
± 0.1
|
778 |
MAK-UNK-8be7dca9-6
|
|
c1cc(c2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl)CN |
−11.31
± 0.09
|
8.24
± 0.07
|
779 |
EN300-19515_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCC(=O)N5 |
−11.3
± 0.3
|
8.2
± 0.2
|
780 |
EN300-77006_1
|
|
Cc1nc(on1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
781 |
EN300-132615_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)N |
−11.3
± 0.2
|
8.2
± 0.2
|
782 |
EN300-74089_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)C#N |
−11.3
± 0.4
|
8.2
± 0.3
|
783 |
EN300-246747_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CC(=O)NC5 |
−11.3
± 0.2
|
8.2
± 0.2
|
784 |
EN300-295905_1
|
|
CC1CN(CC(O1)C(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.2
± 0.2
|
785 |
EN300-66845_2
|
|
COC(=O)N1CCCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
786 |
EN300-175506_1
|
|
Cc1c(c(nc(=O)[nH]1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
787 |
EN300-7456499_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCS(=O)(=O)CCCO |
−11.3
± 0.4
|
8.2
± 0.3
|
788 |
EN300-251867_1
|
|
COCCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
789 |
EN300-39504_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCS(=O)(=O)N |
−11.3
± 0.6
|
8.2
± 0.4
|
790 |
EN300-217343_2
|
|
Cn1c2c(nn1)CCC(C2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.3
± 0.3
|
8.2
± 0.2
|
791 |
EN300-307084_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CC5CC6O |
−11.3
± 0.2
|
8.2
± 0.1
|
792 |
EN300-181938_1
|
|
CC(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−11.3
± 0.2
|
8.2
± 0.1
|
793 |
EN300-113112_3
|
|
Cn1cnnc1COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
794 |
EN300-95698_3
|
|
CC1CC(=O)NCC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.2
|
8.2
± 0.2
|
795 |
EN300-97055_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]ccn5 |
−11.3
± 0.3
|
8.2
± 0.2
|
796 |
EN300-396748_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc(c5)CO |
−11.3
± 0.3
|
8.2
± 0.2
|
797 |
EN300-214800_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCNC5=O |
−11.3
± 0.3
|
8.2
± 0.2
|
798 |
EN300-27268_1
|
|
Cc1nc(on1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|
799 |
EN300-6487134_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC56CC(C5)C(=O)NC6 |
−11.3
± 0.4
|
8.2
± 0.3
|
800 |
EN300-180532_1
|
|
CC1CN(CCS(=O)(=O)C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.3
± 0.3
|
8.2
± 0.2
|