Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
601 |
EN300-373791_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnn5CC#N |
−11.5
± 0.2
|
8.4
± 0.1
|
602 |
EN300-343787_1
|
|
CN1[C@H](CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
603 |
EN300-195756_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CCC(=O)N5 |
−11.5
± 0.2
|
8.4
± 0.1
|
604 |
EN300-1666501_1
|
|
Cc1cc(n2c(n1)ncn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.5
± 0.3
|
8.4
± 0.2
|
605 |
EN300-248883_1
|
|
COCC1(CCOC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.3
|
606 |
EN300-1718428_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@]6(CCC[C@]6(C5)CO)CO |
−11.5
± 0.4
|
8.4
± 0.3
|
607 |
EN300-1608240_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(=O)N6C5COCC6 |
−11.5
± 0.3
|
8.4
± 0.2
|
608 |
EN300-6238494_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)C5COCCO5 |
−11.5
± 0.3
|
8.4
± 0.2
|
609 |
EN300-7461217_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C[C@H]([C@@H](C5)F)O |
−11.5
± 0.2
|
8.4
± 0.2
|
610 |
EN300-113218_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CSC5CCOC5=O |
−11.5
± 0.3
|
8.4
± 0.2
|
611 |
EN300-54891_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@@H]5CO |
−11.5
± 0.3
|
8.4
± 0.2
|
612 |
EN300-105693_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(COC5)CO |
−11.5
± 0.3
|
8.4
± 0.2
|
613 |
EN300-7463176_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5c(=O)[nH]cc6 |
−11.5
± 0.3
|
8.4
± 0.2
|
614 |
EN300-123489_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(CO)(F)F |
−11.5
± 0.2
|
8.4
± 0.2
|
615 |
EN300-52382_1
|
|
CN(C)C(=O)Cn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
616 |
EN300-6736413_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCNC5=O |
−11.5
± 0.1
|
8.39
± 0.10
|
617 |
VLA-UCB-50c39ae8-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−11.5
± 0.2
|
8.4
± 0.2
|
618 |
EN300-1273249_1
|
|
CO[C@@H]1COC[C@H]1n2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.5
± 0.4
|
8.4
± 0.3
|
619 |
EN300-152418_1
|
|
Cn1cncc1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
620 |
EN300-189563_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCC5CS(=O)(=O)C5 |
−11.5
± 0.3
|
8.4
± 0.2
|
621 |
EN300-61694_1
|
|
Cn1ncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.2
|
8.4
± 0.2
|
622 |
EN300-198240_1
|
|
Cn1cc(cn1)C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.5
± 0.3
|
8.4
± 0.2
|
623 |
EN300-68618_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cocn5 |
−11.5
± 0.2
|
8.4
± 0.1
|
624 |
DAR-DIA-5ff57136-18
|
|
c1ccc2c(c1)cncc2N(C(=O)[C@@H]3CCOc4c3cc(cc4)Cl)N=C=S |
−11.5
± 0.1
|
8.39
± 0.09
|
625 |
EN300-203402_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)[nH]c(=O)[nH]6 |
−11.5
± 0.3
|
8.4
± 0.2
|
626 |
EN300-297927_3
|
|
CC(C)(C)n1nc(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.4
|
8.4
± 0.3
|
627 |
EN300-120586_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCC(F)F |
−11.5
± 0.3
|
8.4
± 0.2
|
628 |
EN300-54417_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cccc(c5)O |
−11.5
± 0.3
|
8.4
± 0.2
|
629 |
EN300-651665_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6[C@H]5CCO6 |
−11.5
± 0.3
|
8.4
± 0.2
|
630 |
EN300-79180_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CCOCC5)O |
−11.5
± 0.3
|
8.4
± 0.3
|
631 |
EN300-98018_3
|
|
CC(=O)N1CCC(C1)(C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.2
|
8.4
± 0.2
|
632 |
EN300-74029_1
|
|
CC1CC(=O)NCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
633 |
EN300-171766_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5n[nH]c(=O)s5 |
−11.5
± 0.2
|
8.4
± 0.1
|
634 |
EN300-149013_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c([nH]nn5)Cl |
−11.5
± 0.3
|
8.4
± 0.2
|
635 |
EN300-152337_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(=O)NCC5 |
−11.5
± 0.3
|
8.4
± 0.2
|
636 |
EN300-306316_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5[nH]cnn5 |
−11.5
± 0.3
|
8.4
± 0.2
|
637 |
EN300-72730_2
|
|
CC(C#N)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.5
± 0.2
|
8.4
± 0.1
|
638 |
EN300-77778_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCS(=O)(=O)C5 |
−11.5
± 0.2
|
8.4
± 0.2
|
639 |
EN300-1653482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6c(nnn6)C5 |
−11.5
± 0.2
|
8.4
± 0.2
|
640 |
EN300-658865_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc([nH]n5)CO |
−11.5
± 0.3
|
8.4
± 0.2
|
641 |
EN300-6760290_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5[C@@H]6CC[C@H]([C@H]5CC[C@H]6O)O |
−11.5
± 0.3
|
8.4
± 0.3
|
642 |
EN300-2008102_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CN6CC(O5)CCC6=O |
−11.5
± 0.2
|
8.4
± 0.2
|
643 |
EN300-1718364_3
|
|
CC1(CS(=O)(=O)C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
644 |
EN300-861925_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC(CO)F |
−11.5
± 0.2
|
8.4
± 0.2
|
645 |
EN300-198633_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCCNC5=O |
−11.5
± 0.2
|
8.4
± 0.2
|
646 |
EN300-249421_3
|
|
CC(C1CCC(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.2
|
8.4
± 0.1
|
647 |
EN300-66845_3
|
|
COC(=O)N1CCCC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.4
± 0.2
|
648 |
EN300-6487407_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC[C@@H]5[C@H](CC(=O)O5)O |
−11.5
± 0.3
|
8.4
± 0.2
|
649 |
EN300-185378_3
|
|
CC(COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.5
± 0.2
|
8.4
± 0.2
|
650 |
EN300-7537194_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6cnnc6c5 |
−11.5
± 0.2
|
8.4
± 0.2
|
651 |
EN300-191904_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cnnn5 |
−11.5
± 0.3
|
8.4
± 0.2
|
652 |
EN300-182665_1
|
|
Cc1nc(on1)[C@H]2C[C@@H](CN2C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−11.5
± 0.3
|
8.4
± 0.2
|
653 |
EN300-6473108_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6cccnn6n5 |
−11.5
± 0.2
|
8.4
± 0.2
|
654 |
EN300-149975_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)CO |
−11.5
± 0.2
|
8.4
± 0.2
|
655 |
EN300-343562_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]([C@H]5CO)CO |
−11.5
± 0.4
|
8.4
± 0.3
|
656 |
EN300-114082_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)C#N |
−11.5
± 0.2
|
8.4
± 0.2
|
657 |
EN300-10334_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCC(=O)N5CCS6 |
−11.5
± 0.3
|
8.4
± 0.2
|
658 |
EN300-132157_1
|
|
CC1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.2
|
8.4
± 0.2
|
659 |
EN300-6277108_3
|
|
COC(C1CCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.3
± 0.2
|
660 |
EN300-120436_3
|
|
Cn1cnn(c1=O)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.3
± 0.2
|
661 |
EN300-6487680_1
|
|
Cc1nnn(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.3
|
8.3
± 0.2
|
662 |
EN300-80083_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCCC(=O)N5 |
−11.5
± 0.3
|
8.3
± 0.2
|
663 |
EN300-40225_1
|
|
Cc1c(cnn1CCO)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.5
± 0.4
|
8.3
± 0.3
|
664 |
EN300-06654_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cncn5 |
−11.5
± 0.2
|
8.3
± 0.1
|
665 |
EN300-6491117_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnco5 |
−11.5
± 0.3
|
8.3
± 0.2
|
666 |
EN300-95507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)CO |
−11.5
± 0.2
|
8.3
± 0.2
|
667 |
EN300-6745081_3
|
|
CC1(CCCCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
8.3
± 0.3
|
668 |
EN300-7089802_3
|
|
C[C@@H]([C@@H](C)O)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.3
|
8.3
± 0.2
|
669 |
EN300-1664865_1
|
|
Cn1c2c(nn1)CCCC2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.4
± 0.3
|
8.3
± 0.2
|
670 |
EN300-7473354_3
|
|
Cc1ncn(n1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
8.3
± 0.3
|
671 |
EN300-129441_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc6n5ncn6 |
−11.4
± 0.2
|
8.3
± 0.2
|
672 |
EN300-98143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)F |
−11.4
± 0.2
|
8.3
± 0.2
|
673 |
EN300-262604_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnc(n5)C(=O)N |
−11.4
± 0.3
|
8.3
± 0.2
|
674 |
EN300-100916_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5nccn5 |
−11.4
± 0.3
|
8.3
± 0.2
|
675 |
EN300-37123_1
|
|
Cn1cc(c(=O)[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
676 |
EN300-6494158_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CC(CO5)CO |
−11.4
± 0.2
|
8.3
± 0.1
|
677 |
EN300-6491316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6cnnn6c5 |
−11.4
± 0.2
|
8.3
± 0.2
|
678 |
EN300-66845_1
|
|
COC(=O)N1CCCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
679 |
EN300-210084_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCC(=O)N5 |
−11.4
± 0.2
|
8.3
± 0.2
|
680 |
EN300-143449_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCN(=O)=O |
−11.4
± 0.2
|
8.3
± 0.2
|
681 |
EN300-50009_3
|
|
COC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.3
|
8.3
± 0.2
|
682 |
EN300-90225_4
|
|
Cn1nc(nn1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
683 |
EN300-10895_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)NCCC#N |
−11.4
± 0.2
|
8.3
± 0.2
|
684 |
EN300-123614_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)NC(=O)N |
−11.4
± 0.4
|
8.3
± 0.3
|
685 |
EN300-315963_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cnoc5 |
−11.4
± 0.3
|
8.3
± 0.2
|
686 |
EN300-103638_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCOC5=O |
−11.4
± 0.3
|
8.3
± 0.2
|
687 |
EN300-99983_1
|
|
CNC(=O)Cc1nc(on1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.4
|
8.3
± 0.3
|
688 |
EN300-1723214_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(c5)c(=O)[nH]c(=O)[nH]6 |
−11.4
± 0.4
|
8.3
± 0.3
|
689 |
EN300-10747_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CSCC5=O |
−11.4
± 0.3
|
8.3
± 0.2
|
690 |
EN300-188341_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cn5)O |
−11.4
± 0.3
|
8.3
± 0.2
|
691 |
EN300-225053_1
|
|
COc1cnc(nc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|
692 |
EN300-68747_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)C(=O)N |
−11.4
± 0.3
|
8.3
± 0.2
|
693 |
EN300-7355981_1
|
|
Cn1c2c(c(n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)nc[nH]c2=O |
−11.4
± 0.3
|
8.3
± 0.2
|
694 |
EN300-21303_3
|
|
CCOCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.4
± 0.2
|
8.3
± 0.2
|
695 |
EN300-42269_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnns5 |
−11.4
± 0.2
|
8.3
± 0.2
|
696 |
EN300-310398_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)S(=O)(=O)N |
−11.4
± 0.3
|
8.3
± 0.2
|
697 |
EN300-370967_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOC5=O |
−11.4
± 0.2
|
8.3
± 0.1
|
698 |
EN300-29520_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5nccc6 |
−11.4
± 0.2
|
8.3
± 0.2
|
699 |
EN300-333468_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5Cl)CCO |
−11.4
± 0.3
|
8.3
± 0.2
|
700 |
EN300-304135_3
|
|
CCC1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.4
± 0.2
|
8.3
± 0.2
|