Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5401 |
EN300-136051_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC6(C5)CCOC6 |
−8.7
± 0.4
|
6.4
± 0.3
|
5402 |
EN300-95639_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C(C5)O)CO |
−8.7
± 0.2
|
6.4
± 0.2
|
5403 |
EN300-249421_4
|
|
CC(C1CCC(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.4
± 0.3
|
5404 |
EN300-6474647_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C(C5)CCNC6=O |
−8.7
± 0.2
|
6.4
± 0.1
|
5405 |
EN300-50194_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5cccn5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5406 |
EN300-299248_2
|
|
Cn1cnc(cc1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5407 |
EN300-233864_2
|
|
COc1cc([nH]n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5408 |
EN300-139403_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)C(F)(F)F |
−8.7
± 0.4
|
6.4
± 0.3
|
5409 |
EN300-121252_1
|
|
CN(C)C1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5410 |
EN300-65839_1
|
|
CCC(C(=O)N)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.2
|
6.4
± 0.2
|
5411 |
EN300-40947_4
|
|
CC(C)S(=O)(=O)C(C)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.4
|
6.4
± 0.3
|
5412 |
EN300-697456_1
|
|
CCS(=O)(=O)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.2
|
5413 |
EN300-152418_2
|
|
Cn1cncc1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5414 |
EN300-50654_2
|
|
CS(=O)(=O)CCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.4
± 0.2
|
5415 |
EN300-101796_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc(c5)OCCO |
−8.7
± 0.4
|
6.4
± 0.3
|
5416 |
EN300-307567_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)Cn6ccnn6 |
−8.7
± 0.3
|
6.4
± 0.2
|
5417 |
EN300-75420_1
|
|
COC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.1
|
5418 |
EN300-267855_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN6C[C@@H](C[C@H]6C5)O |
−8.7
± 0.4
|
6.4
± 0.3
|
5419 |
EN300-2009111_1
|
|
Cn1c(cc(n1)CO)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5420 |
EN300-68618_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cocn5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5421 |
EN300-259004_2
|
|
CC(=O)N1CC(C1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5422 |
EN300-7443835_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H]([C@H]([C@H]5O)O)CO |
−8.7
± 0.4
|
6.4
± 0.3
|
5423 |
EN300-51411_2
|
|
Cn1cc(cn1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5424 |
EN300-214094_2
|
|
CC(C)(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCO |
−8.7
± 0.3
|
6.4
± 0.2
|
5425 |
EN300-299387_2
|
|
COC1CS(=O)(=O)CC1NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.1
|
5426 |
EN300-94496_1
|
|
CN1CCN(CC1)C2CCN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.4
|
6.4
± 0.3
|
5427 |
EN300-86357_2
|
|
Cn1cc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5428 |
EN300-170678_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CN6CCCN5CC6 |
−8.7
± 0.3
|
6.4
± 0.2
|
5429 |
EN300-657222_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5C[C@@H]6COC[C@@H]6O5 |
−8.7
± 0.2
|
6.4
± 0.1
|
5430 |
EN300-104088_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)OCCO |
−8.7
± 0.3
|
6.4
± 0.2
|
5431 |
EN300-250126_4
|
|
CC(C)CC(C(=O)N)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.4
± 0.2
|
5432 |
EN300-1272704_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CCO[C@@H]5c6[nH]cnn6 |
−8.7
± 0.3
|
6.4
± 0.2
|
5433 |
EN300-85043_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccnc5OCCO |
−8.7
± 0.3
|
6.4
± 0.2
|
5434 |
EN300-204161_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccc[nH]c5=O |
−8.7
± 0.3
|
6.4
± 0.2
|
5435 |
EN300-176877_4
|
|
CN(C)C(=O)CCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.4
± 0.2
|
5436 |
EN300-100741_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5[nH]cnn5 |
−8.7
± 0.2
|
6.4
± 0.2
|
5437 |
EN300-69070_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)C(=O)N |
−8.7
± 0.2
|
6.4
± 0.1
|
5438 |
EN300-260418_2
|
|
Cn1c(nc(n1)C2CC2)CC(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.4
|
6.4
± 0.3
|
5439 |
EN300-16091_2
|
|
CCS(=O)(=O)N1CCCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.4
± 0.3
|
5440 |
EN300-702714_2
|
|
Cc1c(c(=O)cco1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.4
± 0.3
|
5441 |
EN300-252439_1
|
|
CC(C)NC(=O)C(C)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.3
|
6.4
± 0.2
|
5442 |
EN300-51801_2
|
|
CCCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−8.7
± 0.3
|
6.4
± 0.2
|
5443 |
EN300-6736515_1
|
|
CC(C1COCCO1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.1
|
5444 |
EN300-6488219_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@H]5N6CCOCC6 |
−8.7
± 0.4
|
6.4
± 0.3
|
5445 |
EN300-7355978_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6c(c(=O)[nH]cn6)[nH]n5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5446 |
EN300-24653_2
|
|
CNC(=O)C1CCN(CC1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.1
|
5447 |
EN300-119366_2
|
|
COCC1(CCN(CC1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.7
± 0.6
|
6.4
± 0.4
|
5448 |
EN300-7440263_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCn6c(ncn6)C5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5449 |
EN300-6501360_4
|
|
CN(C)C(=O)NCC(COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.7
± 0.3
|
6.4
± 0.2
|
5450 |
EN300-248895_1
|
|
CC1C(CCC(=O)N1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.4
± 0.2
|
5451 |
EN300-262008_4
|
|
CON1CCC(CC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.4
± 0.3
|
5452 |
EN300-28894_2
|
|
Cc1c(nn(c(=O)c1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C)C |
−8.7
± 0.3
|
6.4
± 0.3
|
5453 |
EN300-246808_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCCS5(=O)=O |
−8.7
± 0.2
|
6.4
± 0.1
|
5454 |
EN300-7494115_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c(=O)[nH]cnc6nc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5455 |
EN300-70522_4
|
|
CS(=O)(=O)CCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.5
|
6.4
± 0.3
|
5456 |
EN300-269802_1
|
|
CO[C@@H]1CS(=O)(=O)[C@@H]2[C@H]1CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.3
|
6.4
± 0.2
|
5457 |
EN300-132963_2
|
|
CN1C(CCC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5458 |
EN300-1268512_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5ccsc5S(=O)(=O)N |
−8.7
± 0.4
|
6.4
± 0.3
|
5459 |
EN300-371682_2
|
|
CN([C@@H]1COC[C@H]1O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.4
± 0.2
|
5460 |
EN300-143564_2
|
|
CN1C(=O)CSC1=CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5461 |
EN300-1719428_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5cc(cnc5)S(=O)(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
5462 |
EN300-2726690_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)OCC(=O)N6 |
−8.7
± 0.2
|
6.3
± 0.2
|
5463 |
EN300-2010267_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCC(=O)N6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5464 |
EN300-6480951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)C6CC(=O)NC6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5465 |
EN300-7353934_2
|
|
Cn1cnc(n1)CN(C)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.2
|
5466 |
EN300-761209_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnn(c5)CCO |
−8.7
± 0.3
|
6.3
± 0.2
|
5467 |
EN300-101373_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)CO |
−8.7
± 0.2
|
6.3
± 0.2
|
5468 |
EN300-237561_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5c(=O)cccn5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5469 |
EN300-69313_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H](C5)O |
−8.7
± 0.2
|
6.3
± 0.2
|
5470 |
EN300-1723991_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCN5CCCNC5=O |
−8.7
± 0.3
|
6.3
± 0.2
|
5471 |
EN300-305701_2
|
|
Cn1cc(nc1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5472 |
EN300-264318_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCOC(=O)N6 |
−8.7
± 0.3
|
6.3
± 0.3
|
5473 |
EN300-1264911_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(CF)O |
−8.7
± 0.3
|
6.3
± 0.2
|
5474 |
EN300-208191_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCOCC5 |
−8.7
± 0.4
|
6.3
± 0.3
|
5475 |
EN300-269863_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc6c5CC(=O)N6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5476 |
EN300-379020_1
|
|
Cn1ccn2c(nnc2c1=O)CO[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5477 |
EN300-259849_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CN5CCCCC(C5=O)O |
−8.7
± 0.3
|
6.3
± 0.2
|
5478 |
EN300-313438_1
|
|
Cn1c2c(cn1)c(ncn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.7
± 0.2
|
6.3
± 0.2
|
5479 |
EN300-1244816_4
|
|
Cc1nnnn1CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5480 |
EN300-379533_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)O |
−8.7
± 0.2
|
6.3
± 0.2
|
5481 |
EN300-2010267_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CCC(=O)N6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5482 |
EN300-1428805_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5Cc6cncn6C(=O)N5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5483 |
EN300-59757_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCCNC5=O |
−8.7
± 0.3
|
6.3
± 0.2
|
5484 |
EN300-743350_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6(C5)CCNC6=O |
−8.7
± 0.3
|
6.3
± 0.2
|
5485 |
EN300-152910_1
|
|
CN(CCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−8.7
± 0.3
|
6.3
± 0.2
|
5486 |
EN300-1664603_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5ccn[nH]5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5487 |
EN300-248895_2
|
|
CC1C(CCC(=O)N1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.2
|
6.3
± 0.1
|
5488 |
EN300-1703714_2
|
|
CN(CCCS(=O)(=O)C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.7
± 0.2
|
6.3
± 0.1
|
5489 |
EN300-7352736_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H]5C[C@@H]([C@@H](CO5)O)O |
−8.7
± 0.3
|
6.3
± 0.2
|
5490 |
EN300-12587_4
|
|
CC(=O)N1CCCC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5491 |
EN300-1723991_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCN5CCCNC5=O |
−8.7
± 0.3
|
6.3
± 0.2
|
5492 |
EN300-103284_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCC5)CC(=O)N |
−8.7
± 0.3
|
6.3
± 0.2
|
5493 |
EN300-325738_2
|
|
CN1C(CCCC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5494 |
EN300-233439_1
|
|
CN(C)CC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5495 |
EN300-134838_2
|
|
CC(CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)c5[nH]nnn5 |
−8.7
± 0.3
|
6.3
± 0.2
|
5496 |
EN300-342263_1
|
|
C[C@@H]1CN(CCS1(=O)=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.3
± 0.3
|
5497 |
EN300-102864_1
|
|
Cc1cc(cc(=O)n1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.7
± 0.3
|
6.3
± 0.2
|
5498 |
EN300-7492470_1
|
|
CN(C)Cc1cn(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.7
± 0.4
|
6.3
± 0.3
|
5499 |
EN300-7438138_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@H](C5)NC(=O)CO6 |
−8.7
± 0.3
|
6.3
± 0.2
|
5500 |
EN300-305294_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC(C6C5)O |
−8.7
± 0.1
|
6.33
± 0.09
|