Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5201 |
EN300-7456801_2
|
|
Cc1cc(n(n1)C)C(=O)NCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.4
± 0.2
|
5202 |
EN300-188585_2
|
|
CC1(CCS(=O)(=O)CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5203 |
EN300-97699_2
|
|
CC(CS(=O)(=O)C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5204 |
EN300-48680_1
|
|
CNC(=O)C1CCN(CC1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5205 |
EN300-297451_3
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−8.8
± 0.4
|
6.4
± 0.3
|
5206 |
EN300-69070_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)C(=O)N |
−8.8
± 0.4
|
6.4
± 0.3
|
5207 |
EN300-6739162_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@@H]6[C@H](C5)OC(=O)N6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5208 |
EN300-87527_2
|
|
CC[C@H](C)[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
5209 |
EN300-66975_2
|
|
CN(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
5210 |
EN300-121939_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN6C(C5)CCOC6=O |
−8.8
± 0.3
|
6.4
± 0.2
|
5211 |
EN300-124062_2
|
|
Cn1cnc(n1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5212 |
EN300-872798_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5c(nnn5)C6CC6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5213 |
EN300-170294_2
|
|
CC(CN(C(C)CO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.8
± 0.2
|
6.4
± 0.2
|
5214 |
EN300-310173_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H](CCO5)Cn6ccnc6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5215 |
EN300-6494693_2
|
|
CCn1c(ncn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5216 |
EN300-70541_2
|
|
CC(C(=O)N)N(CCOC)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5217 |
EN300-11144_1
|
|
CN(C)C(=O)CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5218 |
EN300-125100_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cccc(=O)[nH]5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5219 |
EN300-383891_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)Cc6[nH]nnn6 |
−8.8
± 0.4
|
6.4
± 0.3
|
5220 |
EN300-52193_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cn(nn5)CCO |
−8.8
± 0.3
|
6.4
± 0.2
|
5221 |
EN300-04073_2
|
|
CC(=O)NCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
5222 |
EN300-177398_1
|
|
CCN1CN(CC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5223 |
EN300-1697005_1
|
|
CCC(=O)N1CSC[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5224 |
EN300-114134_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCN5CCCS5(=O)=O |
−8.8
± 0.4
|
6.4
± 0.3
|
5225 |
EN300-215799_4
|
|
Cc1c(c(no1)CO)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5226 |
EN300-67191_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCN5CCCC5=O |
−8.8
± 0.3
|
6.4
± 0.2
|
5227 |
EN300-1703718_2
|
|
CC(=O)N1C[C@@H](C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.8
± 0.2
|
6.4
± 0.1
|
5228 |
EN300-36065_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCS(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
5229 |
EN300-94856_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CC(C5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
5230 |
EN300-6763072_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CS(=O)(=O)C56CC(C5)C6 |
−8.8
± 0.4
|
6.4
± 0.3
|
5231 |
EN300-29387_1
|
|
CC(CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.2
|
6.4
± 0.1
|
5232 |
EN300-186929_2
|
|
Cc1c(nc[nH]1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5233 |
EN300-298031_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC5(C6)CO |
−8.8
± 0.2
|
6.4
± 0.2
|
5234 |
EN300-206210_1
|
|
CCC[C@@H](C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5235 |
EN300-223198_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCCS(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.3
|
5236 |
EN300-386187_2
|
|
COC(=O)N[C@H]1CCN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5237 |
EN300-210907_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CCS(=O)(=O)CC5)O |
−8.8
± 0.2
|
6.4
± 0.2
|
5238 |
EN300-33657_4
|
|
CC(=O)N(C)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5239 |
EN300-226949_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5cnnc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5240 |
EN300-218219_2
|
|
CN(C)S(=O)(=O)CCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
5241 |
EN300-210246_1
|
|
CN(C)S(=O)(=O)N(C)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
5242 |
EN300-3074195_2
|
|
CNC(=O)[C@@H]1C[C@H](CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−8.8
± 0.4
|
6.4
± 0.3
|
5243 |
EN300-196962_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@H]5CO |
−8.8
± 0.3
|
6.4
± 0.2
|
5244 |
EN300-132817_2
|
|
COCCn1c(nnn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5245 |
EN300-210907_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCS(=O)(=O)CC5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
5246 |
EN300-244148_4
|
|
Cn1cc(c(n1)COC)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5247 |
EN300-109920_2
|
|
CC1COC(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.8
± 0.4
|
6.4
± 0.3
|
5248 |
EN300-6739173_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CN6CCC5C6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5249 |
EN300-111996_1
|
|
Cc1c(c(nc(=O)[nH]1)C)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5250 |
EN300-378722_4
|
|
CN1CCC(C1=O)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5251 |
EN300-159869_1
|
|
CN(C1CCCNC1=O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5252 |
EN300-12204_1
|
|
CCCNC(=O)CN(C)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.4
|
6.4
± 0.3
|
5253 |
EN300-1215738_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCC5CCC(=O)NC5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5254 |
EN300-211482_1
|
|
CC(C(=O)NC)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.2
|
6.4
± 0.1
|
5255 |
EN300-748981_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCn6c5nnc6 |
−8.8
± 0.4
|
6.4
± 0.3
|
5256 |
EN300-135530_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cccnc5C(=O)N |
−8.8
± 0.4
|
6.4
± 0.3
|
5257 |
EN300-373476_2
|
|
CC1(CCCS1(=O)=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5258 |
EN300-1708882_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C[C@@H]5COC[C@H]5O |
−8.8
± 0.3
|
6.4
± 0.2
|
5259 |
EN300-196614_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCc5[nH]cnn5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5260 |
EN300-68794_4
|
|
CS(=O)(=O)CCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.2
|
6.4
± 0.2
|
5261 |
EN300-92447_2
|
|
CC1=NOC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5262 |
EN300-14437_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCS(=O)(=O)C5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5263 |
EN300-24102_2
|
|
Cn1cc(cc1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
5264 |
EN300-124365_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)N6CCOCC6 |
−8.8
± 0.6
|
6.4
± 0.4
|
5265 |
EN300-189729_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCO6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5266 |
EN300-6488374_1
|
|
Cn1cnc(n1)CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.1
|
5267 |
EN300-34309_1
|
|
CNC(=O)CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.2
|
6.4
± 0.1
|
5268 |
EN300-69049_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C6CCCC6O |
−8.8
± 0.4
|
6.4
± 0.3
|
5269 |
EN300-7473309_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]6CCCN6C(=O)N5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5270 |
EN300-1699492_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H]5COCCO5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5271 |
EN300-65253_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)Cc5ccc(cc5)O |
−8.8
± 0.3
|
6.4
± 0.2
|
5272 |
EN300-343474_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCNC5=O |
−8.8
± 0.4
|
6.4
± 0.3
|
5273 |
EN300-7355117_1
|
|
CN1CC2(C1)CCN(CC2CO)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.8
± 0.5
|
6.4
± 0.4
|
5274 |
EN300-318344_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ncco5 |
−8.8
± 0.1
|
6.4
± 0.1
|
5275 |
EN300-124062_1
|
|
Cn1cnc(n1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5276 |
EN300-31553_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCS(=O)(=O)N |
−8.8
± 0.3
|
6.4
± 0.2
|
5277 |
EN300-1704405_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)N6C5COCC6 |
−8.8
± 0.4
|
6.4
± 0.3
|
5278 |
EN300-08033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCS(=O)(=O)C5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5279 |
EN300-249856_1
|
|
CON1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5280 |
EN300-80083_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCCC(=O)N5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5281 |
EN300-342462_1
|
|
CN1CCC(CC1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5282 |
EN300-66126_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCCO |
−8.8
± 0.3
|
6.4
± 0.2
|
5283 |
EN300-6496334_2
|
|
CC1(CCS(=O)(=O)N1C)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5284 |
EN300-1704113_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)N5CC=CC5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5285 |
EN300-123416_4
|
|
CCCn1cc(nn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.4
|
6.4
± 0.3
|
5286 |
EN300-1608729_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H](C5)OCCO6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5287 |
EN300-6488851_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H]6[C@@H]5COC6)O |
−8.8
± 0.3
|
6.4
± 0.2
|
5288 |
EN300-170985_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5OCCCO5 |
−8.8
± 0.3
|
6.4
± 0.2
|
5289 |
EN300-1602334_1
|
|
Cc1c(cn2c(n1)ncn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5290 |
EN300-6745214_2
|
|
CON=C1CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5291 |
EN300-20668_2
|
|
COC(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.2
|
6.4
± 0.2
|
5292 |
EN300-151298_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(cnc5)n6ccnn6 |
−8.8
± 0.3
|
6.4
± 0.2
|
5293 |
EN300-332606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CCC(=O)O5 |
−8.8
± 0.2
|
6.4
± 0.1
|
5294 |
EN300-6760278_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC6C(O5)CCO6 |
−8.8
± 0.2
|
6.4
± 0.1
|
5295 |
EN300-1664105_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)n6cc(nn6)CO |
−8.8
± 0.3
|
6.4
± 0.2
|
5296 |
EN300-7356603_1
|
|
C[C@@H]([C@H](C)O)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5297 |
EN300-160159_1
|
|
CC(=O)N1CC(C1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.2
|
5298 |
EN300-34139_2
|
|
CCCNC(=O)CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.8
± 0.3
|
6.4
± 0.2
|
5299 |
EN300-7434791_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H](CO)O |
−8.8
± 0.3
|
6.4
± 0.3
|
5300 |
EN300-199449_2
|
|
CC1C(CCC(=O)N1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.8
± 0.2
|
6.4
± 0.1
|