Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5101 |
EN300-254272_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)cc[nH]5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5102 |
EN300-82225_1
|
|
CC(CCO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.1
|
5103 |
EN300-7465386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCS(=O)(=O)C5)CO |
−8.9
± 0.4
|
6.5
± 0.3
|
5104 |
BEN-DND-c852c98b-7
|
|
c1cc2cncc(c2cc1C(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.89
± 0.06
|
6.48
± 0.04
|
5105 |
EN300-139050_2
|
|
CN(C)c1nc(on1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5106 |
EN300-6504714_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H]([C@H]5CO6)O |
−8.9
± 0.2
|
6.5
± 0.2
|
5107 |
EN300-7441080_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6cccn6c(=O)[nH]5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5108 |
EN300-55145_2
|
|
CC(CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.9
± 0.2
|
6.5
± 0.2
|
5109 |
EN300-95094_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CSC5 |
−8.9
± 0.1
|
6.5
± 0.1
|
5110 |
EN300-1700710_2
|
|
Cn1ccnc1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5111 |
EN300-122846_1
|
|
CNC(=O)C1CCCC1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5112 |
EN300-7436393_1
|
|
CCNC(=O)CCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5113 |
EN300-633533_1
|
|
CS(=O)(=O)[C@@H]1C[C@]1(CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−8.9
± 0.3
|
6.5
± 0.2
|
5114 |
EN300-781107_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(CO)O |
−8.9
± 0.4
|
6.5
± 0.3
|
5115 |
EN300-247184_1
|
|
CO[C@@H]1CN(C[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5116 |
EN300-51801_4
|
|
CCCC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−8.9
± 0.3
|
6.5
± 0.2
|
5117 |
EN300-1266316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCS(=O)(=O)N5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5118 |
EN300-317272_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CC6CCOC6 |
−8.9
± 0.2
|
6.5
± 0.2
|
5119 |
EN300-6491393_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H](C[C@H]5O)C#N |
−8.9
± 0.3
|
6.5
± 0.2
|
5120 |
EN300-73662_2
|
|
COC(=O)C[C@H](COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.9
± 0.4
|
6.5
± 0.3
|
5121 |
EN300-7434941_2
|
|
CC1(C[C@@H]([C@@H](CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O)C |
−8.9
± 0.3
|
6.5
± 0.2
|
5122 |
EN300-7459916_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC(=O)CO |
−8.9
± 0.2
|
6.5
± 0.1
|
5123 |
EN300-266552_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN(CC5)c6[nH]cnn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5124 |
EN300-81038_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)COC6 |
−8.9
± 0.2
|
6.5
± 0.2
|
5125 |
EN300-29970_1
|
|
CCS(=O)(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.4
|
6.5
± 0.3
|
5126 |
EN300-81730_1
|
|
CC[C@H](C)[C@@H](C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.3
|
5127 |
EN300-246260_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H](C[C@H]5C(=O)N)F |
−8.9
± 0.2
|
6.5
± 0.2
|
5128 |
EN300-6735024_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@]6(C5)C[C@@H](CNC6=O)O |
−8.9
± 0.5
|
6.5
± 0.3
|
5129 |
EN300-384234_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(c6cnn[nH]6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5130 |
EN300-7432415_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C6(CCC6)OC(=O)N5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5131 |
EN300-657153_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6(C5)CS(=O)(=O)C6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5132 |
EN300-155869_1
|
|
CCC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5133 |
EN300-6488851_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@H]6[C@@H]5COC6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5134 |
EN300-187369_1
|
|
CN1C[C@@H]2CN(C[C@@H]2C1)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5135 |
EN300-2009402_2
|
|
CC(C)(c1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.3
|
6.5
± 0.3
|
5136 |
EN300-6730698_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)N6CC(C6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5137 |
EN300-215968_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6CCOCC6 |
−8.9
± 0.4
|
6.5
± 0.3
|
5138 |
EN300-158082_2
|
|
CC1(CN(CC(O1)CO)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−8.9
± 0.4
|
6.5
± 0.3
|
5139 |
EN300-35642_3
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−8.9
± 0.5
|
6.5
± 0.3
|
5140 |
EN300-255496_2
|
|
CN1CCC(S1(=O)=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5141 |
EN300-657410_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CO)c5[nH]ccn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5142 |
EN300-761618_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)Nc5cccnn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5143 |
EN300-1630093_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5(CCOC5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5144 |
EN300-100689_2
|
|
CC(=O)N1CCOC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5145 |
DAR-DIA-0d514e7d-13
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccc(cc5)F |
−8.9
± 0.2
|
6.5
± 0.1
|
5146 |
EN300-183001_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC#N |
−8.9
± 0.2
|
6.5
± 0.2
|
5147 |
EN300-7427194_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@H](CC56CCC6)O)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5148 |
EN300-685077_2
|
|
COCCn1cccc(c1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5149 |
EN300-323327_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(n5)ccn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5150 |
EN300-195590_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCCNC(=O)C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5151 |
EN300-88656_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCS5(=O)=O |
−8.9
± 0.3
|
6.5
± 0.2
|
5152 |
EN300-110012_2
|
|
CCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−8.9
± 0.5
|
6.5
± 0.4
|
5153 |
EN300-736749_4
|
|
CC(=O)N1CSC[C@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5154 |
EN300-185727_2
|
|
Cn1c2c(nn1)CC(CC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.2
|
6.5
± 0.1
|
5155 |
EN300-1264388_2
|
|
CN(CC1(CCOC1)O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5156 |
EN300-75402_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCN(C5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5157 |
EN300-1723511_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCC5)CO |
−8.9
± 0.2
|
6.5
± 0.1
|
5158 |
EN300-1604951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCNC(=O)C5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5159 |
EN300-299375_2
|
|
COCC1(CCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5160 |
EN300-304187_2
|
|
CC1(CC(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC)CO |
−8.9
± 0.2
|
6.5
± 0.1
|
5161 |
EN300-106070_1
|
|
CCOCCS(=O)(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.5
|
6.5
± 0.4
|
5162 |
EN300-1608737_1
|
|
CN1C[C@@H](CC1=O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5163 |
EN300-152337_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCC(=O)NCC5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5164 |
EN300-45384_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCN(CC5)C |
−8.9
± 0.3
|
6.5
± 0.2
|
5165 |
EN300-188316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(CO)C5CCOC5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5166 |
EN300-331941_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5C[C@H]5C(=O)N |
−8.9
± 0.4
|
6.5
± 0.3
|
5167 |
EN300-23417_2
|
|
COCCn1c(=O)ccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5168 |
EN300-152910_2
|
|
CN(CCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−8.9
± 0.2
|
6.5
± 0.2
|
5169 |
EN300-7442332_4
|
|
Cc1c(n(cn1)OC)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5170 |
EN300-6763395_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](CC6(C5)CC6)O)O |
−8.9
± 0.4
|
6.5
± 0.3
|
5171 |
EN300-760963_1
|
|
CC(C)[C@@H](C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.2
|
5172 |
EN300-6729744_2
|
|
COCC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(CO)O |
−8.9
± 0.5
|
6.5
± 0.4
|
5173 |
EN300-62449_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)C5CCC5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5174 |
EN300-158383_1
|
|
CN1CC(CC1=O)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5175 |
EN300-171481_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCC5)OCCO |
−8.9
± 0.3
|
6.5
± 0.2
|
5176 |
EN300-74167_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)C5CCOCC5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5177 |
EN300-49751_1
|
|
CC(=O)NCC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5178 |
EN300-68747_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCC5)C(=O)N |
−8.9
± 0.2
|
6.5
± 0.2
|
5179 |
EN300-755161_2
|
|
Cn1ncc(n1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5180 |
EN300-7444950_2
|
|
COc1cc(ncn1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5181 |
EN300-298552_2
|
|
COC(C1CCOC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5182 |
EN300-69556_4
|
|
Cc1ccc(=O)n(n1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5183 |
EN300-365965_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(C5)CS(=O)(=O)C6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5184 |
EN300-76707_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCCC5)C(=O)N |
−8.9
± 0.4
|
6.5
± 0.3
|
5185 |
EN300-370951_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CCCC6=O |
−8.9
± 0.3
|
6.5
± 0.2
|
5186 |
EN300-7460680_2
|
|
CC1([C@@H]([C@@H](CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O)C |
−8.9
± 0.3
|
6.5
± 0.2
|
5187 |
EN300-1273248_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5n6ccnn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5188 |
EN300-204239_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(=O)[nH]c(n5)C6CC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5189 |
EN300-246583_2
|
|
CC(CC(=O)NC)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.2
|
5190 |
EN300-7444121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](C56CCC6)O)O |
−8.9
± 0.4
|
6.5
± 0.3
|
5191 |
EN300-154912_2
|
|
COc1nccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5192 |
EN300-318110_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)C(C(=O)N)F |
−8.9
± 0.3
|
6.5
± 0.2
|
5193 |
EN300-127372_2
|
|
C=CCNC(=O)CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.4
± 0.1
|
5194 |
EN300-147887_1
|
|
Cn1c(cnn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.4
± 0.2
|
5195 |
EN300-264600_2
|
|
Cc1cc(=O)[nH]c(n1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.4
± 0.2
|
5196 |
EN300-176587_1
|
|
CC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.3
|
6.4
± 0.2
|
5197 |
EN300-1238839_4
|
|
CS(=O)(=O)NCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.4
± 0.2
|
5198 |
EN300-6487134_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC56CC(C5)C(=O)NC6 |
−8.9
± 0.4
|
6.4
± 0.3
|
5199 |
EN300-6497863_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OCCN(C)C |
−8.9
± 0.4
|
6.4
± 0.3
|
5200 |
EN300-1722226_2
|
|
CCN1CC(C1=O)(C)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.4
± 0.2
|