Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
501 |
EN300-218116_2
|
|
CC(CO)(CO)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.3
|
8.5
± 0.2
|
502 |
EN300-6735683_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](O[C@@H](C5)CO)CO |
−11.7
± 0.4
|
8.5
± 0.3
|
503 |
EN300-51736_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5cccc(c5)C(=O)N |
−11.7
± 0.3
|
8.5
± 0.3
|
504 |
EN300-122319_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(=O)[nH]c(=O)[nH]n5 |
−11.7
± 0.2
|
8.5
± 0.2
|
505 |
EN300-95094_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CSC5 |
−11.7
± 0.2
|
8.5
± 0.2
|
506 |
EN300-27341_3
|
|
CS(=O)(=O)N1CCCC(C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.4
|
8.5
± 0.3
|
507 |
EN300-3710141_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCO5)C#N |
−11.7
± 0.2
|
8.5
± 0.1
|
508 |
EN300-44821_1
|
|
C=CCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.2
|
8.5
± 0.1
|
509 |
EN300-71405_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccn[nH]5 |
−11.7
± 0.2
|
8.5
± 0.2
|
510 |
EN300-50514_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COc5ccc(cc5)CC(=O)N |
−11.7
± 0.3
|
8.5
± 0.2
|
511 |
EN300-321597_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CC[C@H](C5)O |
−11.7
± 0.3
|
8.5
± 0.2
|
512 |
EN300-111863_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cnc(n5)C#N |
−11.7
± 0.3
|
8.5
± 0.2
|
513 |
EN300-53591_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(CC5)NC(=O)N |
−11.6
± 0.3
|
8.5
± 0.2
|
514 |
EN300-107267_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOC5CCCNC5=O |
−11.6
± 0.2
|
8.5
± 0.2
|
515 |
EN300-226314_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(=O)C5CCS(=O)(=O)C5 |
−11.6
± 0.3
|
8.5
± 0.3
|
516 |
EN300-214800_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCNC5=O |
−11.6
± 0.3
|
8.5
± 0.2
|
517 |
EN300-114082_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)C#N |
−11.6
± 0.3
|
8.5
± 0.2
|
518 |
EN300-215465_1
|
|
CCn1ncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
519 |
EN300-6487755_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5C[C@H]6C[C@@H](C5)[C@@H]([C@@H](C6)O)O |
−11.6
± 0.5
|
8.5
± 0.3
|
520 |
EN300-151298_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cnc5)n6ccnn6 |
−11.6
± 0.3
|
8.5
± 0.2
|
521 |
EN300-1091448_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5(CO)CO |
−11.6
± 0.3
|
8.5
± 0.2
|
522 |
EN300-247951_3
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.6
± 0.2
|
8.5
± 0.2
|
523 |
EN300-257945_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5[C@H]6[C@@H]5COC6 |
−11.6
± 0.2
|
8.5
± 0.2
|
524 |
EN300-6488157_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccc6n5cnn6 |
−11.6
± 0.2
|
8.5
± 0.2
|
525 |
EN300-101197_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCc5[nH]cnn5 |
−11.6
± 0.2
|
8.5
± 0.2
|
526 |
EN300-222620_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cc(cnc5)O |
−11.6
± 0.4
|
8.5
± 0.3
|
527 |
EN300-7447185_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)NC(=O)[C@H]5C[C@]6(C5)NC(=O)OC6)cc1 |
−11.6
± 0.4
|
8.5
± 0.3
|
528 |
EN300-6277108_1
|
|
COC(C1CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.1
|
8.5
± 0.1
|
529 |
EN300-52380_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC(=O)N |
−11.6
± 0.3
|
8.5
± 0.2
|
530 |
EN300-128463_4
|
|
CNC(=O)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.6
± 0.3
|
8.5
± 0.2
|
531 |
EN300-7443878_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H](C5CCOCC5)O |
−11.6
± 0.2
|
8.5
± 0.2
|
532 |
EN300-7459545_3
|
|
CN(C)CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−11.6
± 0.4
|
8.5
± 0.3
|
533 |
EN300-124301_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5ccnn5 |
−11.6
± 0.3
|
8.5
± 0.2
|
534 |
EN300-78135_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NC5CC5 |
−11.6
± 0.2
|
8.5
± 0.2
|
535 |
EN300-60033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCC5CCCO5 |
−11.6
± 0.2
|
8.5
± 0.2
|
536 |
EN300-746311_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c6c5c(=O)[nH]cn6 |
−11.6
± 0.2
|
8.5
± 0.2
|
537 |
EN300-108236_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(nn5)CO |
−11.6
± 0.3
|
8.5
± 0.2
|
538 |
EN300-7444533_1
|
|
CC1CC(C(=O)O1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
539 |
EN300-102487_1
|
|
Cn1c(=O)c(c[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.5
± 0.2
|
540 |
EN300-300519_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5csnn5 |
−11.6
± 0.2
|
8.5
± 0.2
|
541 |
EN300-295132_1
|
|
Cn1cncc(c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.5
± 0.3
|
542 |
EN300-702615_1
|
|
CCc1nc(on1)COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.5
± 0.2
|
543 |
EN300-154942_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5OCCO5 |
−11.6
± 0.2
|
8.5
± 0.2
|
544 |
EN300-12139_1
|
|
CN(C)C(=O)CSCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.6
± 0.3
|
8.5
± 0.2
|
545 |
EN300-00904_1
|
|
Cc1cc(n2c(n1)nc(n2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)C |
−11.6
± 0.2
|
8.5
± 0.2
|
546 |
EN300-1726277_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(n5cccn5)F |
−11.6
± 0.2
|
8.5
± 0.2
|
547 |
EN300-51350_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nncn6C5 |
−11.6
± 0.2
|
8.5
± 0.2
|
548 |
EN300-108413_1
|
|
CC(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−11.6
± 0.2
|
8.5
± 0.2
|
549 |
EN300-122849_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5c6ncon6 |
−11.6
± 0.3
|
8.5
± 0.2
|
550 |
EN300-705386_1
|
|
COC[C@@H]1C[C@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.1
|
8.5
± 0.1
|
551 |
EN300-132157_2
|
|
CC1(CC(=O)NC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
552 |
EN300-1301381_3
|
|
COCC1(CCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.5
± 0.2
|
553 |
EN300-1439991_1
|
|
Cn1nc(c(n1)Br)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.5
± 0.2
|
554 |
EN300-105693_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(COC5)CO |
−11.6
± 0.3
|
8.5
± 0.2
|
555 |
EN300-761746_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5c(=O)[nH]c(=O)[nH]n5 |
−11.6
± 0.3
|
8.5
± 0.2
|
556 |
VLA-UCB-34f3ed0c-1
|
|
C=C(C#N)C(=O)N(c1cncc2c1cccc2)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.6
± 0.2
|
8.5
± 0.1
|
557 |
EN300-7434209_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cncc6c5[nH]c(=O)[nH]6 |
−11.6
± 0.3
|
8.5
± 0.2
|
558 |
EN300-245264_1
|
|
CCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−11.6
± 0.2
|
8.5
± 0.2
|
559 |
EN300-1664865_3
|
|
Cn1c2c(nn1)CCCC2C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.6
± 0.4
|
8.5
± 0.3
|
560 |
DAR-DIA-5ff57136-17
|
|
c1ccc2c(c1)cncc2N(CC#CBr)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.6
± 0.2
|
8.5
± 0.1
|
561 |
EN300-6736394_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CC(CCO5)OC6 |
−11.6
± 0.3
|
8.5
± 0.2
|
562 |
EN300-7456948_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5cccnn5 |
−11.6
± 0.3
|
8.5
± 0.2
|
563 |
EN300-6738887_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C6CCC5C(CCC6O)O |
−11.6
± 0.3
|
8.5
± 0.2
|
564 |
EN300-223187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c6c(nn5)CCCC6 |
−11.6
± 0.3
|
8.4
± 0.2
|
565 |
EN300-87536_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5CCCN5C(=O)N |
−11.6
± 0.3
|
8.4
± 0.2
|
566 |
EN300-199991_1
|
|
Cc1cc(=O)c(cn1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
567 |
EN300-182124_3
|
|
COC1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
568 |
EN300-188356_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOC5)F |
−11.6
± 0.2
|
8.4
± 0.2
|
569 |
EN300-114133_1
|
|
CCC(=O)N1CCC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.4
± 0.3
|
570 |
EN300-220676_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5CCCS(=O)(=O)C5 |
−11.6
± 0.3
|
8.4
± 0.2
|
571 |
EN300-120282_3
|
|
Cn1cc(nn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
572 |
EN300-2983057_1
|
|
Cn1c(c(cn1)C#N)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.2
|
573 |
EN300-69070_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)C(=O)N |
−11.6
± 0.3
|
8.4
± 0.2
|
574 |
EN300-92447_1
|
|
CC1=NOC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.1
|
575 |
EN300-219531_1
|
|
CCCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.6
± 0.2
|
8.4
± 0.1
|
576 |
EN300-175425_1
|
|
CCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−11.6
± 0.2
|
8.4
± 0.2
|
577 |
EN300-316258_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COCc5cc[nH]c(=O)c5 |
−11.6
± 0.3
|
8.4
± 0.2
|
578 |
EN300-38979_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccnc5 |
−11.6
± 0.2
|
8.4
± 0.1
|
579 |
EN300-131799_1
|
|
Cc1nc2nccc(n2n1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.6
± 0.2
|
8.4
± 0.2
|
580 |
EN300-6729747_1
|
|
Cc1nnc2n1CC(C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.6
± 0.3
|
8.4
± 0.2
|
581 |
EN300-124384_1
|
|
Cn1c2c(cn1)c(c(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−11.6
± 0.3
|
8.4
± 0.2
|
582 |
EN300-216673_2
|
|
Cn1c(cnn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.2
|
583 |
EN300-20233_1
|
|
COCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.6
± 0.2
|
8.4
± 0.1
|
584 |
EN300-1267109_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cn[nH]5)C#N |
−11.6
± 0.3
|
8.4
± 0.2
|
585 |
EN300-6745081_1
|
|
CC1(CCCCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.4
± 0.3
|
586 |
EN300-148421_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)O |
−11.6
± 0.3
|
8.4
± 0.2
|
587 |
EN300-23318_3
|
|
CC(C(=O)NC1CCS(=O)(=O)C1)OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.4
|
8.4
± 0.3
|
588 |
EN300-343562_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]([C@H]5CO)CO |
−11.6
± 0.5
|
8.4
± 0.4
|
589 |
EN300-7437385_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CN6CCC[C@H]6CO5 |
−11.6
± 0.5
|
8.4
± 0.4
|
590 |
EN300-108236_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)CO |
−11.6
± 0.2
|
8.4
± 0.2
|
591 |
EN300-1590388_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(cn5)C#N |
−11.6
± 0.3
|
8.4
± 0.2
|
592 |
EN300-702714_1
|
|
Cc1c(c(=O)cco1)OCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
593 |
EN300-142957_1
|
|
Cn1cc(c(n1)OC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.2
|
8.4
± 0.2
|
594 |
EN300-255422_1
|
|
Cc1cn(nc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−11.6
± 0.2
|
8.4
± 0.2
|
595 |
EN300-156318_1
|
|
COc1cc[nH]c(=O)c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.6
± 0.3
|
8.4
± 0.2
|
596 |
EN300-366931_1
|
|
COc1cnnc(c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.6
± 0.4
|
8.4
± 0.3
|
597 |
VLA-UCB-50c39ae8-6
|
|
c1ccc2c(c1)cncc2N(C(=O)CCl)C(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−11.6
± 0.2
|
8.4
± 0.2
|
598 |
EN300-181492_1
|
|
C=CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−11.5
± 0.2
|
8.4
± 0.2
|
599 |
EN300-14458_3
|
|
CC(C(=O)N(C)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.5
± 0.2
|
8.4
± 0.2
|
600 |
EN300-4254263_1
|
|
Cn1ccn2c1c(cn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.5
± 0.2
|
8.4
± 0.2
|