Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
5001 |
EN300-39101_2
|
|
CCOC(=O)N(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.2
|
6.5
± 0.2
|
5002 |
EN300-6498351_1
|
|
Cc1c(n(cn1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.1
|
6.5
± 0.1
|
5003 |
EN300-66845_4
|
|
COC(=O)N1CCCC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5004 |
EN300-322272_1
|
|
CN(C)C[C@]12CN(C[C@H]1COC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.4
|
6.5
± 0.3
|
5005 |
EN300-172020_4
|
|
Cn1cc(cn1)CC(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.5
|
6.5
± 0.3
|
5006 |
EN300-7438176_1
|
|
CNC(=O)C[C@@H]1CN(C[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5007 |
EN300-6487680_2
|
|
Cc1nnn(n1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5008 |
EN300-52961_1
|
|
CC(C)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCN(CC5)C |
−8.9
± 0.4
|
6.5
± 0.3
|
5009 |
EN300-76843_2
|
|
CC(CCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−8.9
± 0.2
|
6.5
± 0.2
|
5010 |
EN300-154588_1
|
|
COCCOC1COCCC1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5011 |
EN300-31185_3
|
|
CC(C)C(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.5
|
6.5
± 0.3
|
5012 |
EN300-23226_2
|
|
CC(=O)N1CCC(CC1)NC(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5013 |
EN300-76574_1
|
|
CC(CS(=O)(=O)C)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5014 |
EN300-265003_1
|
|
Cn1cnnc1C2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5015 |
EN300-135123_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(cc5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5016 |
EN300-40225_4
|
|
Cc1c(cnn1CCO)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5017 |
EN300-1587757_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCNS5(=O)=O |
−8.9
± 0.4
|
6.5
± 0.3
|
5018 |
EN300-1718424_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC6(C5)CCC(=O)N6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5019 |
EN300-68740_4
|
|
CCCNC(=O)CCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5020 |
EN300-176135_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5nnc6n5nccc6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5021 |
EN300-313366_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CCN(C5)CC6 |
−8.9
± 0.4
|
6.5
± 0.3
|
5022 |
EN300-263056_1
|
|
COC[C@@H]1C[C@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5023 |
EN300-249086_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CC[C@@H](C5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5024 |
EN300-1698803_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]6CCNC(=O)[C@H]6C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5025 |
EN300-7437779_2
|
|
Cn1c(=O)c(c[nH]1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5026 |
EN300-297937_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5CCC(=O)N5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5027 |
EN300-370280_4
|
|
C[C@]1(CCC(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5028 |
EN300-1703559_2
|
|
C[C@H](CS(=O)(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5029 |
EN300-262136_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)N6CCC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5030 |
EN300-365017_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(on5)C6(COC6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5031 |
EN300-191187_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(C5CCCO5)C(=O)N |
−8.9
± 0.2
|
6.5
± 0.1
|
5032 |
EN300-216594_1
|
|
Cn1cncc1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5033 |
EN300-260621_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5ccc(=O)[nH]c5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5034 |
EN300-220013_4
|
|
CC1(CN(C1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−8.9
± 0.4
|
6.5
± 0.3
|
5035 |
EN300-298152_2
|
|
CS(=O)(=O)CC1(COC1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.3
|
5036 |
EN300-28571_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5n6cncn6 |
−8.9
± 0.4
|
6.5
± 0.3
|
5037 |
EN300-66679_2
|
|
CC1C(=O)NCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5038 |
EN300-651307_2
|
|
CCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5039 |
EN300-1719143_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)O)CC#N |
−8.9
± 0.3
|
6.5
± 0.3
|
5040 |
EN300-141695_2
|
|
CN1CCC(C1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5041 |
EN300-1703711_2
|
|
COc1c(cnc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−8.9
± 0.3
|
6.5
± 0.2
|
5042 |
EN300-298159_1
|
|
CN1CC(C1)CN(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5043 |
EN300-5638430_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CS(=O)(=O)C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5044 |
EN300-65540_2
|
|
Cc1nc2n(n1)CC(CC2)NC(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.2
|
6.5
± 0.1
|
5045 |
EN300-6477147_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]6[C@@H]5CC(=O)N6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5046 |
EN300-6739235_4
|
|
CN([C@H]1C[C@@H](C1)C(=O)NCCC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)C |
−8.9
± 0.4
|
6.5
± 0.3
|
5047 |
EN300-65978_1
|
|
Cn1cc(cn1)CN(C)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5048 |
EN300-82453_2
|
|
CC(=O)N[C@@H](CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)N |
−8.9
± 0.4
|
6.5
± 0.3
|
5049 |
EN300-50845_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(CO)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5050 |
EN300-310888_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5nnc6n5CCOCC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5051 |
EN300-315198_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@@H]5CC(=O)N6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5052 |
EN300-7444106_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCc6nnnn6C5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5053 |
EN300-1086925_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5n6cccn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5054 |
EN300-19016_1
|
|
COCCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5055 |
EN300-1273019_2
|
|
CCc1[nH]c(=O)c(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5056 |
EN300-253571_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCc6nnnn6CC5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5057 |
EN300-102071_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc(c5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5058 |
EN300-7209468_1
|
|
CCC1(COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
5059 |
EN300-18569_4
|
|
CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−8.9
± 0.2
|
6.5
± 0.2
|
5060 |
EN300-6489289_4
|
|
Cc1nnc2n1C(CC2)C(=O)NCCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−8.9
± 0.4
|
6.5
± 0.3
|
5061 |
EN300-746852_2
|
|
CC1(COCCO1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5062 |
EN300-51335_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCS(=O)(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5063 |
EN300-1448558_2
|
|
CN(CC1(CC1)O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5064 |
EN300-190026_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C5CCCO5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5065 |
EN300-783124_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5CCOC5)F |
−8.9
± 0.2
|
6.5
± 0.2
|
5066 |
EN300-1719075_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(COC6)C(C5)(CO)F |
−8.9
± 0.2
|
6.5
± 0.2
|
5067 |
EN300-1609231_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC(C5)CO)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5068 |
EN300-131690_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)c6ncon6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5069 |
EN300-39476_4
|
|
Cc1c(cn(n1)CCO)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5070 |
EN300-343787_2
|
|
CN1[C@H](CCC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5071 |
EN300-118647_3
|
|
CN(C)C(=O)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5072 |
EN300-53677_4
|
|
CS(=O)(=O)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.5
|
6.5
± 0.3
|
5073 |
EN300-154156_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(=O)NC5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5074 |
EN300-6335413_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5C[C@H]5C(=O)NCCO |
−8.9
± 0.5
|
6.5
± 0.4
|
5075 |
EN300-301690_4
|
|
CS(=O)(=O)N1CCC(C1)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5076 |
EN300-110244_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCOCO5 |
−8.9
± 0.2
|
6.5
± 0.1
|
5077 |
EN300-120068_4
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−8.9
± 0.3
|
6.5
± 0.2
|
5078 |
EN300-7466231_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)[C@@H]([C@@H](CO6)O)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5079 |
EN300-1699797_2
|
|
Cc1[nH]c(nn1)[C@@H](CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5080 |
EN300-6501577_1
|
|
COC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
5081 |
EN300-248883_4
|
|
COCC1(CCOC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
5082 |
EN300-13287_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5ccc(=O)[nH]c5=O |
−8.9
± 0.3
|
6.5
± 0.2
|
5083 |
EN300-205779_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CCC(=O)N5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5084 |
EN300-6493123_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]6[C@@H]5CNC6=O |
−8.9
± 0.2
|
6.5
± 0.1
|
5085 |
EN300-1694056_4
|
|
CC1(C(CC(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−8.9
± 0.2
|
6.5
± 0.2
|
5086 |
EN300-91609_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC6C5C6 |
−8.9
± 0.2
|
6.5
± 0.1
|
5087 |
EN300-200699_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCOC5)O |
−8.9
± 0.1
|
6.5
± 0.1
|
5088 |
EN300-139897_1
|
|
CC(c1cn(nn1)C2CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5089 |
EN300-125884_2
|
|
CC[C@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
5090 |
EN300-1452069_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(CC5CCOCC5)O |
−8.9
± 0.3
|
6.5
± 0.2
|
5091 |
EN300-95507_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(on5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
5092 |
EN300-342082_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ncncn5 |
−8.9
± 0.2
|
6.5
± 0.2
|
5093 |
EN300-266460_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nc(co5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5094 |
EN300-6494859_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(OC5)Cn6cccn6 |
−8.9
± 0.3
|
6.5
± 0.2
|
5095 |
EN300-105110_2
|
|
Cc1cc(n[nH]1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5096 |
EN300-212381_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCCN(C5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
5097 |
EN300-36622_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCn5ccccc5=O |
−8.9
± 0.3
|
6.5
± 0.2
|
5098 |
EN300-260262_2
|
|
Cn1cc(nn1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
5099 |
EN300-169955_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5C(CC(=O)N5)C(F)(F)F |
−8.9
± 0.4
|
6.5
± 0.3
|
5100 |
EN300-123291_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CS(=O)(=O)C5 |
−8.9
± 0.3
|
6.5
± 0.3
|