Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4901 |
EN300-74876_2
|
|
CC(=O)N1CC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4902 |
EN300-250767_1
|
|
CC1(CCC(=O)N1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.1
|
4903 |
EN300-1703093_2
|
|
C[C@@H](C1(CC1)O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4904 |
EN300-191904_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5cnnn5 |
−9.0
± 0.2
|
6.5
± 0.1
|
4905 |
EN300-133915_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5csc(=O)[nH]5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4906 |
EN300-251851_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5[nH]nnn5 |
−9.0
± 0.4
|
6.5
± 0.3
|
4907 |
EN300-86205_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5c(=O)[nH]cnc5O |
−9.0
± 0.3
|
6.5
± 0.2
|
4908 |
EN300-10334_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C56CCC(=O)N5CCS6 |
−9.0
± 0.3
|
6.5
± 0.2
|
4909 |
EN300-1720923_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C(C(=O)N)(F)F)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4910 |
EN300-56202_2
|
|
CC(=O)N1CSCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4911 |
EN300-78727_2
|
|
Cc1nc(no1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4912 |
EN300-1265432_1
|
|
Cn1ccnc1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4913 |
EN300-7466114_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@@H]6[C@H]5C(=O)OC6 |
−9.0
± 0.3
|
6.5
± 0.2
|
4914 |
EN300-697462_1
|
|
Cc1[nH]c(nn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4915 |
EN300-1707774_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)OC(=O)N |
−9.0
± 0.3
|
6.5
± 0.2
|
4916 |
EN300-7543383_2
|
|
CN1C(=O)C(CO1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4917 |
EN300-119385_1
|
|
CC(=O)N[C@@H](CCSC)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.5
± 0.2
|
4918 |
EN300-216968_2
|
|
CN1[C@H]2CCN(C[C@H]2NC1=O)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.3
|
6.5
± 0.2
|
4919 |
EN300-266299_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CC[C@@H](C5)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4920 |
EN300-298582_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CC(=O)NC5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4921 |
EN300-69727_4
|
|
CC(C)(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−9.0
± 0.4
|
6.5
± 0.3
|
4922 |
EN300-182084_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)c5cscn5 |
−9.0
± 0.4
|
6.5
± 0.3
|
4923 |
EN300-18610_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC(C5)C(=O)N |
−9.0
± 0.2
|
6.5
± 0.2
|
4924 |
EN300-309106_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn6cnnc6cn5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4925 |
EN300-62448_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)C5CCC5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4926 |
EN300-97938_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](C5)O)O |
−9.0
± 0.2
|
6.5
± 0.2
|
4927 |
EN300-2910941_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cc(nn5)C(F)(F)F |
−9.0
± 0.3
|
6.5
± 0.2
|
4928 |
DAR-DIA-6a508060-4
|
|
COc1cc(cc2c1OCCC2C(=O)Nc3cncc4c3cccc4)Cl |
−8.97
± 0.10
|
6.54
± 0.07
|
4929 |
EN300-244100_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5Cc6cncn6C5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4930 |
EN300-117756_1
|
|
CCCCS(=O)(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.5
|
6.5
± 0.4
|
4931 |
EN300-116092_1
|
|
CCS(=O)(=O)NCCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.4
|
6.5
± 0.3
|
4932 |
EN300-1968342_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(CF)O |
−9.0
± 0.2
|
6.5
± 0.1
|
4933 |
EN300-201164_4
|
|
CC(C)(C)C(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.0
± 0.4
|
6.5
± 0.3
|
4934 |
EN300-269419_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCNC(=O)N |
−9.0
± 0.2
|
6.5
± 0.1
|
4935 |
EN300-7445112_2
|
|
CC(C)(c1[nH]nnn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4936 |
EN300-211777_4
|
|
CC(=O)N1CCC[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.6
|
6.5
± 0.4
|
4937 |
EN300-75187_2
|
|
CC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(COC)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4938 |
EN300-170805_1
|
|
CC(=O)NC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4939 |
EN300-1301381_2
|
|
COCC1(CCCO1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4940 |
EN300-1272679_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5CC[C@@H](O5)CO |
−9.0
± 0.4
|
6.5
± 0.3
|
4941 |
EN300-1267258_2
|
|
CC1(CC(=O)NC1CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.0
± 0.3
|
6.5
± 0.2
|
4942 |
EN300-227044_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(CO)C#N |
−9.0
± 0.2
|
6.5
± 0.2
|
4943 |
EN300-75500_2
|
|
CC(COC)(C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.5
± 0.2
|
4944 |
EN300-106023_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(no5)C(=O)N |
−9.0
± 0.3
|
6.5
± 0.2
|
4945 |
EN300-80813_2
|
|
Cn1c2c(nn1)CN(CC2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.2
|
6.5
± 0.1
|
4946 |
EN300-6763836_2
|
|
C[C@H](c1[nH]cnn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.4
|
6.5
± 0.3
|
4947 |
EN300-315545_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5C(=O)N |
−9.0
± 0.3
|
6.5
± 0.2
|
4948 |
EN300-77778_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCS(=O)(=O)C5 |
−9.0
± 0.4
|
6.5
± 0.3
|
4949 |
EN300-45182_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCN5CCOC5=O |
−9.0
± 0.3
|
6.5
± 0.2
|
4950 |
EN300-132624_4
|
|
CCC(=O)CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.5
± 0.2
|
4951 |
EN300-6732769_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C6CC(=O)NC6=O |
−9.0
± 0.2
|
6.5
± 0.1
|
4952 |
EN300-1452069_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(CC5CCOCC5)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4953 |
EN300-36158_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5COCCO5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4954 |
EN300-1717630_2
|
|
CC1(CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.0
± 0.2
|
6.5
± 0.2
|
4955 |
EN300-172870_1
|
|
COc1cncc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4956 |
EN300-378044_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC=CCO5 |
−9.0
± 0.2
|
6.5
± 0.1
|
4957 |
EN300-7427798_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC6CS(=O)(=O)CC6C5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4958 |
EN300-315198_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@@H]6[C@@H]5CC(=O)N6 |
−9.0
± 0.3
|
6.5
± 0.2
|
4959 |
EN300-100700_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H](NC(=O)C5)CO |
−9.0
± 0.3
|
6.5
± 0.2
|
4960 |
EN300-80855_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(C5CCOC5)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4961 |
EN300-7499295_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CCCO)CO |
−9.0
± 0.2
|
6.5
± 0.1
|
4962 |
EN300-7434620_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@H]6C[C@@H]5[C@@H]([C@@H]6O)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4963 |
EN300-207765_2
|
|
CN1C(CCC1=O)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4964 |
EN300-1267258_1
|
|
CC1(CC(=O)NC1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.0
± 0.2
|
6.5
± 0.2
|
4965 |
VLA-UCB-34f3ed0c-20
|
|
c1ccc2c(c1)cncc2N(C(=O)c3c[nH]cn3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−9.0
± 0.3
|
6.5
± 0.2
|
4966 |
EN300-381095_2
|
|
CC1(CCNC1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.2
|
4967 |
EN300-244659_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H](C[C@H]5CO)F |
−9.0
± 0.2
|
6.5
± 0.2
|
4968 |
EN300-1724771_1
|
|
CC(=O)N1CCN(CC1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.5
± 0.1
|
4969 |
EN300-36105_1
|
|
CNC(=O)CCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.5
± 0.2
|
4970 |
EN300-6496579_1
|
|
CC(C)CC(C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
4971 |
EN300-154201_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC5CO |
−8.9
± 0.2
|
6.5
± 0.1
|
4972 |
EN300-246486_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5coc(=O)[nH]5 |
−8.9
± 0.2
|
6.5
± 0.2
|
4973 |
EN300-1724771_2
|
|
CC(=O)N1CCN(CC1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.2
|
6.5
± 0.2
|
4974 |
EN300-215968_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)C6CCOCC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
4975 |
EN300-18292_1
|
|
CN1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
4976 |
EN300-122579_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCSCC5CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4977 |
EN300-7355534_1
|
|
CC[C@@H](C(=O)NCC)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
4978 |
EN300-307084_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC5CC6O |
−8.9
± 0.2
|
6.5
± 0.1
|
4979 |
EN300-244122_2
|
|
CC1(CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4980 |
EN300-1273016_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCc6n5ncn6 |
−8.9
± 0.4
|
6.5
± 0.3
|
4981 |
EN300-41549_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)CNC(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
4982 |
EN300-7472244_2
|
|
CO[C@@H]1C[C@H](N(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4983 |
EN300-71405_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5ccn[nH]5 |
−8.9
± 0.3
|
6.5
± 0.2
|
4984 |
EN300-66126_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCCO |
−8.9
± 0.3
|
6.5
± 0.2
|
4985 |
EN300-51411_4
|
|
Cn1cc(cn1)CCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.4
|
6.5
± 0.3
|
4986 |
EN300-191927_1
|
|
COCC(CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
4987 |
EN300-105482_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(COC5)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4988 |
EN300-6734454_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC56CC(C5)(OC6)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4989 |
EN300-7493255_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(OCC56CC6)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4990 |
EN300-226776_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(CO)O |
−8.9
± 0.4
|
6.5
± 0.3
|
4991 |
EN300-26953_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C(=O)N)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|
4992 |
EN300-97699_4
|
|
CC(CS(=O)(=O)C)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.4
|
6.5
± 0.3
|
4993 |
EN300-192482_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5[C@H]6[C@@H]5COC6 |
−8.9
± 0.3
|
6.5
± 0.2
|
4994 |
EN300-13668_3
|
|
CN(CC(=O)NC1CC1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.5
|
6.5
± 0.3
|
4995 |
EN300-195743_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H](CCO)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4996 |
EN300-175608_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CCF)CO |
−8.9
± 0.3
|
6.5
± 0.2
|
4997 |
EN300-366233_2
|
|
CCN(C(C)C(=O)NC)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−8.9
± 0.3
|
6.5
± 0.2
|
4998 |
EN300-72409_2
|
|
Cc1[nH]c(cn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−8.9
± 0.3
|
6.5
± 0.2
|
4999 |
EN300-313366_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C56CCN(C5)CC6 |
−8.9
± 0.3
|
6.5
± 0.3
|
5000 |
EN300-6739704_2
|
|
COC1(CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−8.9
± 0.3
|
6.5
± 0.2
|