Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4801 |
EN300-178515_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCC(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
4802 |
EN300-246058_1
|
|
Cc1c(nnn1c2cnn(c2)C)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.2
|
6.6
± 0.2
|
4803 |
EN300-45485_4
|
|
CS(=O)(=O)NCCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.4
|
6.6
± 0.3
|
4804 |
EN300-155362_4
|
|
CC1CC(=O)NC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.6
± 0.2
|
4805 |
EN300-256174_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCO)c5ccncn5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4806 |
EN300-7456562_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCC(=O)NC5=O |
−9.0
± 0.3
|
6.6
± 0.2
|
4807 |
EN300-321459_2
|
|
CN(C(=O)CC[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@H](C5)C(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
4808 |
EN300-184266_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CC(=O)N5 |
−9.0
± 0.2
|
6.6
± 0.2
|
4809 |
EN300-233951_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC(C5)O |
−9.0
± 0.2
|
6.6
± 0.1
|
4810 |
EN300-2969289_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5(CCCOC5)CO |
−9.0
± 0.2
|
6.6
± 0.2
|
4811 |
EN300-373446_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCO[C@@H](C5)[C@H](CO)O |
−9.0
± 0.3
|
6.6
± 0.3
|
4812 |
EN300-82386_1
|
|
CN(CC1CCS(=O)(=O)C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4813 |
EN300-77778_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCCS(=O)(=O)C5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4814 |
EN300-216063_4
|
|
CN(C)C(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.1
|
4815 |
EN300-266565_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)C(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
4816 |
EN300-257785_1
|
|
CC1(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
4817 |
EN300-208204_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CO)C(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
4818 |
EN300-42270_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnsn5 |
−9.0
± 0.2
|
6.6
± 0.2
|
4819 |
EN300-321558_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)CC(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
4820 |
EN300-233079_2
|
|
Cc1cnn(c1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.0
± 0.3
|
6.6
± 0.2
|
4821 |
EN300-206870_2
|
|
Cc1nnc(s1)COCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.2
|
6.6
± 0.1
|
4822 |
EN300-125409_2
|
|
CC(C(=O)N)N(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.1
|
4823 |
EN300-378343_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC=CC5CO |
−9.0
± 0.2
|
6.6
± 0.1
|
4824 |
EN300-59487_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)NC5 |
−9.0
± 0.2
|
6.6
± 0.1
|
4825 |
EN300-226949_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnnc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4826 |
EN300-262364_2
|
|
CC(CS(=O)(=O)N(C)C)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.2
|
4827 |
EN300-7427798_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6CS(=O)(=O)CC6C5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4828 |
EN300-342226_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnc[nH]5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4829 |
MAT-POS-f7918075-1
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.02
± 0.04
|
6.57
± 0.03
|
4830 |
EN300-250120_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5CCS(=O)(=O)CC5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4831 |
EN300-31145_3
|
|
CC(C)C(=O)N(C)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.2
|
4832 |
EN300-68875_1
|
|
CNS(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.6
± 0.2
|
4833 |
EN300-6491393_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H](C[C@H]5O)C#N |
−9.0
± 0.3
|
6.6
± 0.2
|
4834 |
EN300-95598_1
|
|
Cn1cc(cn1)S(=O)(=O)NCCO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.5
|
6.6
± 0.4
|
4835 |
EN300-59970_2
|
|
Cc1nc(on1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4836 |
EN300-36622_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5ccccc5=O |
−9.0
± 0.3
|
6.6
± 0.2
|
4837 |
EN300-12067_4
|
|
Cc1csc(=O)n1CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.4
|
6.6
± 0.3
|
4838 |
EN300-219802_1
|
|
Cn1cnc2c1c(cc(=O)[nH]2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.4
|
6.6
± 0.3
|
4839 |
EN300-84186_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)CO |
−9.0
± 0.4
|
6.6
± 0.3
|
4840 |
EN300-67478_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)NC(=O)N |
−9.0
± 0.4
|
6.6
± 0.3
|
4841 |
EN300-100963_1
|
|
Cn1cc(c(=O)cc1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.0
± 0.2
|
6.6
± 0.2
|
4842 |
EN300-128750_4
|
|
CC(=O)N(C)CCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.4
|
6.6
± 0.3
|
4843 |
EN300-113218_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CSC5CCOC5=O |
−9.0
± 0.3
|
6.6
± 0.2
|
4844 |
EN300-80813_1
|
|
Cn1c2c(nn1)CN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.2
|
6.6
± 0.1
|
4845 |
EN300-53918_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCN5CCOC5=O |
−9.0
± 0.4
|
6.6
± 0.3
|
4846 |
EN300-66800_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)c5ccc(cc5)O |
−9.0
± 0.3
|
6.6
± 0.2
|
4847 |
EN300-360157_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CCOC5)O |
−9.0
± 0.2
|
6.6
± 0.2
|
4848 |
EN300-250533_2
|
|
C[C@]1(C[C@@H](C1)NC(=O)CC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−9.0
± 0.3
|
6.6
± 0.2
|
4849 |
EN300-106988_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC5)C(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
4850 |
EN300-154158_1
|
|
COCC1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.0
± 0.4
|
6.6
± 0.3
|
4851 |
EN300-170720_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5OCCCO5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4852 |
EN300-267528_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)O)n6ccnn6 |
−9.0
± 0.5
|
6.6
± 0.3
|
4853 |
EN300-1705754_1
|
|
CC1(CS(=O)(=O)C1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4854 |
EN300-50561_2
|
|
Cc1nnc2n1CC(CC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.2
|
6.6
± 0.2
|
4855 |
EN300-266524_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)CC(CO)(F)F |
−9.0
± 0.5
|
6.6
± 0.3
|
4856 |
EN300-224741_2
|
|
CCC(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.0
± 0.3
|
6.6
± 0.2
|
4857 |
EN300-96037_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]([C@H](C5)O)O |
−9.0
± 0.3
|
6.6
± 0.2
|
4858 |
EN300-365106_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C(=O)N |
−9.0
± 0.2
|
6.6
± 0.2
|
4859 |
EN300-250836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5c[nH]nc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4860 |
EN300-70522_3
|
|
CS(=O)(=O)CCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.5
|
6.6
± 0.4
|
4861 |
EN300-7493922_2
|
|
Cn1cnc(n1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4862 |
EN300-862647_4
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.0
± 0.4
|
6.6
± 0.3
|
4863 |
EN300-2913619_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5Cc6nccn6C5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4864 |
EN300-40770_1
|
|
COCC(=O)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4865 |
EN300-132523_2
|
|
CN(CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−9.0
± 0.4
|
6.6
± 0.3
|
4866 |
EN300-267469_1
|
|
CS(=NC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(=O)C |
−9.0
± 0.3
|
6.6
± 0.2
|
4867 |
EN300-705381_4
|
|
COC[C@H]1C[C@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4868 |
EN300-1721027_1
|
|
Cn1c(ccn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4869 |
EN300-7442483_1
|
|
CN1[C@@H]2CN(C[C@@H]2OC1=O)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.0
± 0.3
|
6.6
± 0.2
|
4870 |
EN300-258753_1
|
|
CC1([C@H](CS1(=O)=O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.0
± 0.3
|
6.6
± 0.2
|
4871 |
EN300-107990_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cccnc5 |
−9.0
± 0.3
|
6.6
± 0.3
|
4872 |
EN300-7089802_4
|
|
C[C@@H]([C@@H](C)O)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.4
|
6.6
± 0.3
|
4873 |
EN300-60853_1
|
|
CC(C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.6
± 0.1
|
4874 |
EN300-52380_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cn(nn5)CC(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
4875 |
EN300-658355_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CCNC(=O)O6 |
−9.0
± 0.3
|
6.6
± 0.2
|
4876 |
VLA-UCB-1dbca3b4-15
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−8.99
± 0.04
|
6.55
± 0.03
|
4877 |
EN300-215799_2
|
|
Cc1c(c(no1)CO)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4878 |
EN300-205143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCCCS(=O)(=O)N |
−9.0
± 0.3
|
6.6
± 0.2
|
4879 |
EN300-1590388_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5cc(cn5)C#N |
−9.0
± 0.3
|
6.6
± 0.3
|
4880 |
EN300-6759637_2
|
|
C[C@@H]1CN(C[C@H](O1)CO)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4881 |
EN300-1608737_2
|
|
CN1C[C@@H](CC1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.6
± 0.2
|
4882 |
EN300-79588_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCCS(=O)(=O)N |
−9.0
± 0.2
|
6.5
± 0.2
|
4883 |
EN300-6743783_2
|
|
COC[C@H]1CN(CCO1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4884 |
EN300-50845_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(CO)O |
−9.0
± 0.3
|
6.5
± 0.2
|
4885 |
EN300-6494361_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CNC(=O)O6 |
−9.0
± 0.2
|
6.5
± 0.1
|
4886 |
EN300-254836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC5CS6(=O)=O |
−9.0
± 0.3
|
6.5
± 0.2
|
4887 |
EN300-128277_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)NCC(F)F |
−9.0
± 0.4
|
6.5
± 0.3
|
4888 |
EN300-82225_2
|
|
CC(CCO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.2
|
6.5
± 0.2
|
4889 |
EN300-315836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5[nH]ccn5 |
−9.0
± 0.2
|
6.5
± 0.1
|
4890 |
EN300-318284_3
|
|
CC(C)[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.0
± 0.3
|
6.5
± 0.2
|
4891 |
EN300-1709213_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC(C5)c6[nH]cnn6 |
−9.0
± 0.3
|
6.5
± 0.2
|
4892 |
EN300-58821_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C(=O)CO |
−9.0
± 0.4
|
6.5
± 0.3
|
4893 |
EN300-77520_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CCOCC5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4894 |
EN300-312850_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−9.0
± 0.4
|
6.5
± 0.3
|
4895 |
EN300-132963_4
|
|
CN1C(CCC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4896 |
EN300-47657_4
|
|
CC(C(=O)N(C)C)NC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.0
± 0.3
|
6.5
± 0.2
|
4897 |
EN300-7459964_2
|
|
Cn1c(cnn1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4898 |
EN300-223076_2
|
|
Cn1ncc(n1)CCCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.3
|
6.5
± 0.2
|
4899 |
EN300-191495_4
|
|
CS(=O)(=O)C1(CC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.0
± 0.4
|
6.5
± 0.3
|
4900 |
EN300-258477_4
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.0
± 0.3
|
6.5
± 0.3
|