Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4601 |
EN300-7541885_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)c(=O)n6c(n5)CCC6 |
−9.1
± 0.5
|
6.7
± 0.4
|
4602 |
EN300-6763291_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6CC5C(C6O)O |
−9.1
± 0.2
|
6.7
± 0.1
|
4603 |
EN300-255795_2
|
|
CN1CC(NC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.7
± 0.2
|
4604 |
VLA-UCB-34f3ed0c-19
|
|
c1ccc2c(c1)cncc2N(C(=O)c3ccco3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−9.1
± 0.2
|
6.7
± 0.1
|
4605 |
EN300-107435_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCCS5(=O)=O |
−9.1
± 0.2
|
6.7
± 0.2
|
4606 |
EN300-316171_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(C(=O)N)O |
−9.1
± 0.3
|
6.7
± 0.2
|
4607 |
EN300-1248064_2
|
|
CC(C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−9.1
± 0.4
|
6.7
± 0.3
|
4608 |
EN300-72946_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5c(=O)n6ccccc6n5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4609 |
EN300-25791_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(CC5)C(=O)N |
−9.1
± 0.3
|
6.7
± 0.2
|
4610 |
EN300-7356603_2
|
|
C[C@@H]([C@H](C)O)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
4611 |
EN300-249899_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c6ncccn6cn5 |
−9.1
± 0.2
|
6.7
± 0.2
|
4612 |
EN300-144606_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cn[nH]c5S(=O)(=O)N |
−9.1
± 0.5
|
6.7
± 0.3
|
4613 |
EN300-114134_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCN5CCCS5(=O)=O |
−9.1
± 0.5
|
6.7
± 0.3
|
4614 |
EN300-96262_1
|
|
CC(C)(C)OC(=O)N[C@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
4615 |
EN300-85707_2
|
|
COCC1CN(CCO1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.7
± 0.2
|
4616 |
EN300-1448603_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CCS(=O)(=O)C5 |
−9.1
± 0.2
|
6.7
± 0.1
|
4617 |
EN300-77438_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(C5=O)C6CC6 |
−9.1
± 0.2
|
6.7
± 0.1
|
4618 |
EN300-7438451_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCn6c(nnn6)C5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4619 |
EN300-318169_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CC(=O)NC[C@H]5C[C@H](C5)O)cc1 |
−9.1
± 0.3
|
6.7
± 0.2
|
4620 |
EN300-124394_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C6COC6 |
−9.1
± 0.3
|
6.7
± 0.2
|
4621 |
EN300-218962_1
|
|
CCC(C(=O)N)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.7
± 0.1
|
4622 |
EN300-6746778_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5[nH]c(=O)ccn5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4623 |
EN300-71493_1
|
|
Cc1[nH]c(nn1)CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4624 |
EN300-248618_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)C5CC5 |
−9.1
± 0.4
|
6.7
± 0.3
|
4625 |
EN300-26031_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5CCC6 |
−9.1
± 0.3
|
6.7
± 0.2
|
4626 |
EN300-210933_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCN(C5)C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
4627 |
EN300-185729_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCc6c(nn[nH]6)C5 |
−9.1
± 0.5
|
6.6
± 0.4
|
4628 |
EN300-122849_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC5c6ncon6 |
−9.1
± 0.2
|
6.6
± 0.2
|
4629 |
EN300-44014_1
|
|
COCCn1cc(ccc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.4
|
6.6
± 0.3
|
4630 |
EN300-192893_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn6c(c5)ncn6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4631 |
EN300-157158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC=CCO |
−9.1
± 0.2
|
6.6
± 0.1
|
4632 |
EN300-104493_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CO)C5CCOC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4633 |
EN300-257949_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CC[C@H]5O |
−9.1
± 0.2
|
6.6
± 0.2
|
4634 |
EN300-1661020_1
|
|
Cc1nc(no1)N2CCN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4635 |
EN300-6758891_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6COCCN6C(=O)C5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4636 |
EN300-7442330_1
|
|
CN([C@@H]1COC[C@@H]1OC)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4637 |
EN300-2723070_3
|
|
CN(C)C1COCC1OCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4638 |
EN300-191187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C5CCCO5)C(=O)N |
−9.1
± 0.2
|
6.6
± 0.1
|
4639 |
EN300-248178_2
|
|
Cc1cn[nH]c1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4640 |
EN300-249222_2
|
|
CCC(C(=O)NC)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.2
|
4641 |
EN300-111863_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cnc(n5)C#N |
−9.1
± 0.3
|
6.6
± 0.2
|
4642 |
EN300-379046_1
|
|
CN(CCn1cnnc1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.1
|
4643 |
EN300-69811_2
|
|
Cn1cccc(c1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4644 |
EN300-68794_1
|
|
CS(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.2
|
4645 |
EN300-148515_2
|
|
Cn1c(nnn1)CN(C)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4646 |
EN300-107267_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC5CCCNC5=O |
−9.1
± 0.3
|
6.6
± 0.2
|
4647 |
EN300-332838_2
|
|
CN1C(COC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4648 |
EN300-6732376_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCCC5CO |
−9.1
± 0.2
|
6.6
± 0.2
|
4649 |
EN300-52167_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)Nc5ccn(n5)CC(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
4650 |
EN300-132523_4
|
|
CN(CCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−9.1
± 0.5
|
6.6
± 0.4
|
4651 |
EN300-1590020_1
|
|
COc1cc[nH]c(=O)c1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4652 |
EN300-19709_2
|
|
CCC(CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.2
|
4653 |
EN300-115017_4
|
|
CC(C)[C@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.4
|
6.6
± 0.3
|
4654 |
EN300-107740_2
|
|
Cc1nnn(n1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4655 |
EN300-741822_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC[C@H]([C@H](C5)O)O |
−9.1
± 0.2
|
6.6
± 0.2
|
4656 |
EN300-6745081_2
|
|
CC1(CCCCNC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.5
|
6.6
± 0.3
|
4657 |
EN300-249421_2
|
|
CC(C1CCC(=O)N1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.3
|
4658 |
EDJ-MED-e4b030d8-10
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3c(c(cc4)Cl)Cl |
−9.1
± 0.1
|
6.63
± 0.07
|
4659 |
EN300-14752_2
|
|
CC(=O)N1CCCC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4660 |
EN300-6481008_1
|
|
CO[C@@H]1COCC[C@H]1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4661 |
EN300-31015_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCSCC(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
4662 |
EN300-254105_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC(CO)C5CCCOC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4663 |
EN300-378722_2
|
|
CN1CCC(C1=O)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4664 |
EN300-6479273_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(cc(=O)n6c5COCC6)O |
−9.1
± 0.4
|
6.6
± 0.3
|
4665 |
EN300-196870_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCCS(=O)(=O)C5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4666 |
EN300-105693_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(COC5)CO |
−9.1
± 0.3
|
6.6
± 0.2
|
4667 |
EN300-234971_1
|
|
CN(CC1COCCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4668 |
EN300-107048_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CC5)CO |
−9.1
± 0.3
|
6.6
± 0.2
|
4669 |
EN300-172481_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)(C(=O)N)O |
−9.1
± 0.3
|
6.6
± 0.2
|
4670 |
EN300-66679_1
|
|
CC1C(=O)NCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4671 |
EN300-23223_4
|
|
CNC(=O)CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
6.6
± 0.3
|
4672 |
EN300-65414_4
|
|
CC(=O)NC(C)(C)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.4
|
6.6
± 0.3
|
4673 |
EN300-92605_2
|
|
Cn1cc(cn1)C2=NOC(C2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.1
± 0.2
|
6.6
± 0.2
|
4674 |
EN300-96001_2
|
|
CC(C)(C)[C@@H](C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
4675 |
EN300-7432022_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCN(C5)S(=O)(=O)C6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4676 |
EN300-42819_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(=O)NC5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4677 |
EN300-6482296_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COC6C5COC6 |
−9.1
± 0.2
|
6.6
± 0.1
|
4678 |
EN300-1589101_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5c[nH]nc5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4679 |
EN300-7535791_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCC(CC5)(CO)CO |
−9.1
± 0.4
|
6.6
± 0.3
|
4680 |
EN300-135660_2
|
|
CC1(COC1)Cn2cc(nn2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4681 |
EN300-187253_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)N(C5)CC6CC6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4682 |
EN300-23129_1
|
|
CC(=O)NCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.6
± 0.2
|
4683 |
EN300-05841_3
|
|
CN(C1CCS(=O)(=O)C1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.5
|
6.6
± 0.4
|
4684 |
EN300-1704047_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5Cc6c(cn[nH]6)C5C(=O)N |
−9.1
± 0.2
|
6.6
± 0.2
|
4685 |
EN300-1258964_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−9.1
± 0.2
|
6.6
± 0.1
|
4686 |
EN300-155447_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5CCOC6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4687 |
EN300-126127_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(C6CC6)O |
−9.1
± 0.3
|
6.6
± 0.2
|
4688 |
EN300-37195_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NC5CCCCNC5=O |
−9.1
± 0.2
|
6.6
± 0.2
|
4689 |
EN300-7435892_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5C(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
4690 |
EN300-60049_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CN6CCCC6CO5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4691 |
EN300-171811_1
|
|
CC1(C(CS1(=O)=O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.1
± 0.3
|
6.6
± 0.2
|
4692 |
EN300-66930_2
|
|
CNC(=O)CCN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.2
|
4693 |
EN300-210110_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)C6CC6 |
−9.1
± 0.3
|
6.6
± 0.2
|
4694 |
EN300-257536_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)[nH]c(=O)[nH]5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4695 |
EN300-7440263_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCn6c(ncn6)C5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4696 |
EN300-125100_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cccc(=O)[nH]5 |
−9.1
± 0.3
|
6.6
± 0.2
|
4697 |
EN300-1702911_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)NC(=O)N |
−9.1
± 0.3
|
6.6
± 0.2
|
4698 |
EN300-306840_3
|
|
CC1(CN(C1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−9.1
± 0.4
|
6.6
± 0.3
|
4699 |
EN300-79022_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnn5 |
−9.1
± 0.2
|
6.6
± 0.2
|
4700 |
EN300-45328_2
|
|
CCNC(=O)CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.6
± 0.1
|