Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4501 |
EN300-73861_2
|
|
CCC(c1[nH]nnn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4502 |
EN300-254121_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(c5cnc[nH]5)O |
−9.2
± 0.3
|
6.7
± 0.3
|
4503 |
EN300-248786_3
|
|
CN(C)C1(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4504 |
EN300-116313_4
|
|
CC(=O)N1CCOCC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4505 |
EN300-192809_3
|
|
Cn1cncc1C(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)N(C)C |
−9.2
± 0.5
|
6.7
± 0.4
|
4506 |
EN300-306495_3
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−9.2
± 0.3
|
6.7
± 0.2
|
4507 |
EN300-1425899_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@@H](C5)CS(=O)(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4508 |
EN300-1722713_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(C5)CC(=O)NC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4509 |
EN300-51961_4
|
|
CCC(C)C(=O)NCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4510 |
EN300-754601_2
|
|
COc1cc(nnc1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4511 |
EN300-199991_2
|
|
Cc1cc(=O)c(cn1C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4512 |
EN300-2723070_2
|
|
CN(C)C1COCC1OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4513 |
EN300-187055_1
|
|
CN1CC2CN(CCN2C1=O)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.2
|
6.7
± 0.2
|
4514 |
EN300-6763045_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCCNC6=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4515 |
EN300-223741_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)S(=O)(=O)N |
−9.2
± 0.2
|
6.7
± 0.2
|
4516 |
EN300-64297_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cncnc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4517 |
EN300-1706173_2
|
|
CC1(CS(=O)(=O)C1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4518 |
EN300-7501017_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5[C@@H]6[C@H]5C(=O)NC6 |
−9.2
± 0.2
|
6.7
± 0.1
|
4519 |
EN300-1265434_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C5CC5)C(=O)N |
−9.2
± 0.2
|
6.7
± 0.1
|
4520 |
EN300-6480251_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CN(C5)C(=O)C6CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4521 |
EN300-141645_2
|
|
CN(CCCO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4522 |
EN300-259060_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)(CC(=O)N)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4523 |
EN300-22884_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCNC(=O)C5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4524 |
EN300-246992_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCC(=O)NC5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4525 |
MAK-UNK-83e0a0b4-3
|
|
c1ccc2c(c1)cncc2N(CCNC3CNC3)C(=O)C4CCOc5c4cc(cc5)Cl |
−9.2
± 0.3
|
6.7
± 0.2
|
4526 |
EN300-158383_2
|
|
CN1CC(CC1=O)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4527 |
EN300-30615_2
|
|
CC(C)NC(=O)CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.1
|
4528 |
EN300-307190_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc6n5CCOC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4529 |
EN300-114134_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCCS5(=O)=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4530 |
EN300-1215712_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(COC5)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4531 |
EN300-103722_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5OCCC6 |
−9.2
± 0.2
|
6.7
± 0.2
|
4532 |
EN300-1448603_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCS(=O)(=O)C5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4533 |
EN300-224703_1
|
|
Cc1nnc(n1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4534 |
EN300-79921_2
|
|
CC(=O)NCCCN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4535 |
EN300-73582_4
|
|
CCS(=O)(=O)NCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.4
|
6.7
± 0.3
|
4536 |
EN300-25572_4
|
|
CC1CN(CCO1)C(=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4537 |
EN300-96886_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H](C[C@@H](C5)O)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4538 |
EN300-79180_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5CCOCC5)O |
−9.2
± 0.2
|
6.7
± 0.2
|
4539 |
EN300-223491_1
|
|
Cn1cnn(c1=O)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4540 |
EN300-252113_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)C6C5CCOC6 |
−9.2
± 0.6
|
6.7
± 0.4
|
4541 |
EN300-112872_1
|
|
CC(C)(C)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−9.2
± 0.3
|
6.7
± 0.2
|
4542 |
EN300-1699871_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CCS(=O)(=O)N5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4543 |
EN300-117839_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCS(=O)(=O)CC5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4544 |
EN300-176745_1
|
|
CC1CN(CC(S1(=O)=O)C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4545 |
EN300-68794_2
|
|
CS(=O)(=O)CCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.1
|
4546 |
EN300-6735902_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@@H]6CC[C@@H]6C(=O)N5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4547 |
EN300-1817278_1
|
|
C[C@@H](Cc1[nH]nnn1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4548 |
EN300-216032_2
|
|
CC1(COC1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4549 |
EN300-180906_1
|
|
Cc1nc(on1)C2(CCN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4550 |
EN300-204338_2
|
|
COC[C@@H](CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4551 |
EN300-170721_2
|
|
CN1CCC(CC1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4552 |
EN300-749499_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5(CCOCC5)O)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4553 |
EN300-188324_2
|
|
CC1C(CCO1)(CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.2
|
6.7
± 0.1
|
4554 |
EN300-138170_1
|
|
CC1CCN(C1)C(=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4555 |
EN300-3143295_2
|
|
Cn1cnnc1[C@@H]2CC[C@@H]2C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.4
|
6.7
± 0.3
|
4556 |
EN300-7494324_2
|
|
Cc1c(nc[nH]1)CC(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.2
|
6.7
± 0.2
|
4557 |
EN300-295132_2
|
|
Cn1cncc(c1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4558 |
EN300-6503811_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@H](Cc5cnc[nH]5)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4559 |
EN300-91354_2
|
|
CNC(=O)Cn1cnc(n1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4560 |
EN300-76843_1
|
|
CC(CCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.2
|
6.7
± 0.1
|
4561 |
EN300-6733147_1
|
|
CC1CCNC(=O)C1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4562 |
EN300-2913619_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5Cc6nccn6C5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4563 |
EN300-24419_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5c(ccs5)S(=O)(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4564 |
EN300-70656_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CCC5)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4565 |
EN300-367351_2
|
|
Cn1c(cnn1)C2(CN(C2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4566 |
EN300-7444635_1
|
|
Cn1c(ncn1)CN(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4567 |
EN300-6478631_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCc6n5cnn6 |
−9.2
± 0.2
|
6.7
± 0.2
|
4568 |
EN300-205680_1
|
|
CN(C)CC1(CC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4569 |
EN300-1387104_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCS5(=O)=O |
−9.2
± 0.4
|
6.7
± 0.3
|
4570 |
EN300-379052_1
|
|
C[C@H](Cc1cn(nn1)C)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4571 |
EN300-26973_2
|
|
Cc1nc(nn1c2[nH]cnn2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4572 |
EN300-331993_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)Nc5[nH]ccn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4573 |
EN300-7438227_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCC5)CCS(=O)(=O)N |
−9.2
± 0.5
|
6.7
± 0.4
|
4574 |
EN300-99287_2
|
|
CS(=O)(=O)CC1(CC1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4575 |
EN300-261986_2
|
|
CS(=O)(=O)N1CCC(C1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4576 |
EN300-313197_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cc(c(=O)[nH]c5=O)C#N |
−9.2
± 0.3
|
6.7
± 0.2
|
4577 |
EN300-1083988_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)C(C5)(F)F |
−9.2
± 0.3
|
6.7
± 0.2
|
4578 |
EN300-209532_1
|
|
CN(CCC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4579 |
EN300-267089_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@@H](CC[C@H]5CO)CO |
−9.2
± 0.4
|
6.7
± 0.3
|
4580 |
EN300-7356782_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)CC5C(=O)N |
−9.2
± 0.2
|
6.7
± 0.2
|
4581 |
EN300-6732589_2
|
|
CN1CCC(CC1)(C2(CC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−9.2
± 0.5
|
6.7
± 0.4
|
4582 |
EN300-77656_2
|
|
COCC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.1
± 0.2
|
6.7
± 0.2
|
4583 |
EN300-249979_2
|
|
CCNC(=O)C(C)(C)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
4584 |
EN300-7356782_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)CC5C(=O)N |
−9.1
± 0.4
|
6.7
± 0.3
|
4585 |
EN300-218962_2
|
|
CCC(C(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.2
|
6.7
± 0.2
|
4586 |
EN300-22884_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)N5CCNC(=O)C5 |
−9.1
± 0.2
|
6.7
± 0.2
|
4587 |
EN300-1708620_3
|
|
CN(C)CCSCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
4588 |
EN300-234971_2
|
|
CN(CC1COCCO1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.2
|
6.7
± 0.2
|
4589 |
EN300-105829_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOC5)CCO |
−9.1
± 0.2
|
6.7
± 0.1
|
4590 |
MAK-UNK-8be7dca9-2
|
|
c1cc2c(cc1CC(=O)N)cncc2NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.14
± 0.09
|
6.66
± 0.06
|
4591 |
EN300-92664_4
|
|
COCCn1c(ccn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4592 |
EN300-204419_2
|
|
C[C@@H](CO)N(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.1
± 0.3
|
6.7
± 0.2
|
4593 |
EN300-312004_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5nnc6n5CCOCC6 |
−9.1
± 0.3
|
6.7
± 0.2
|
4594 |
EN300-243465_2
|
|
Cn1c(cc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)F |
−9.1
± 0.2
|
6.7
± 0.2
|
4595 |
EN300-299532_4
|
|
CC(C)(C(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.1
± 0.3
|
6.7
± 0.2
|
4596 |
EN300-210104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cnc(n5)C#N |
−9.1
± 0.3
|
6.7
± 0.2
|
4597 |
EN300-247827_1
|
|
COCC1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.1
± 0.2
|
6.7
± 0.2
|
4598 |
EN300-108670_2
|
|
Cn1c(ncn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.1
± 0.3
|
6.7
± 0.2
|
4599 |
EN300-129424_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCC5O |
−9.1
± 0.1
|
6.7
± 0.1
|
4600 |
EN300-39785_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccn[nH]5 |
−9.1
± 0.2
|
6.7
± 0.1
|