Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4401 |
EN300-6733282_1
|
|
CS(=O)(=O)CC1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4402 |
EN300-152705_4
|
|
C[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.2
± 0.4
|
6.7
± 0.3
|
4403 |
EN300-1703714_1
|
|
CN(CCCS(=O)(=O)C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.1
|
4404 |
EN300-1666341_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6c(cn[nH]6)C5CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4405 |
EN300-100830_2
|
|
CCS(=O)(=O)N(C)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.4
|
6.7
± 0.3
|
4406 |
EN300-04491_2
|
|
COCCN(CCOC)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.5
|
6.7
± 0.4
|
4407 |
EN300-120480_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nc5)S(=O)(=O)N |
−9.2
± 0.4
|
6.7
± 0.3
|
4408 |
EN300-195855_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(cn5)n6cncn6 |
−9.2
± 0.2
|
6.7
± 0.1
|
4409 |
EN300-11934_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CCCC5=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4410 |
EN300-59757_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCCNC5=O |
−9.2
± 0.2
|
6.7
± 0.2
|
4411 |
EN300-331687_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5CS(=O)(=O)C[C@H]5O |
−9.2
± 0.3
|
6.7
± 0.2
|
4412 |
EN300-76382_1
|
|
CCNC(=O)NC(C)(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.4
|
6.7
± 0.3
|
4413 |
EN300-62857_2
|
|
COCCS(=O)(=O)CCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.5
|
6.7
± 0.3
|
4414 |
EN300-211158_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(cc(c5)CO)CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4415 |
EN300-322603_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(C5)(CO)CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4416 |
EN300-42154_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS(=O)(=O)C5CCCC5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4417 |
EN300-245264_2
|
|
CCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnc(n5)C#N |
−9.2
± 0.4
|
6.7
± 0.3
|
4418 |
EN300-20496_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCOC5=O |
−9.2
± 0.1
|
6.7
± 0.1
|
4419 |
EN300-136785_1
|
|
Cn1c(nnn1)N2CCN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.4
|
6.7
± 0.3
|
4420 |
EN300-227021_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5[nH]cnn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4421 |
EN300-331687_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CS(=O)(=O)C[C@H]5O |
−9.2
± 0.3
|
6.7
± 0.2
|
4422 |
EN300-98143_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(cn[nH]5)F |
−9.2
± 0.3
|
6.7
± 0.2
|
4423 |
EN300-313062_2
|
|
CC(=O)N1CC2CC2(C1)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.4
|
6.7
± 0.3
|
4424 |
EN300-90531_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCC5C(=O)N |
−9.2
± 0.2
|
6.7
± 0.1
|
4425 |
EN300-219609_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCn5cnccc5=O |
−9.2
± 0.2
|
6.7
± 0.2
|
4426 |
EN300-307418_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6CC5(C6)C(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4427 |
EN300-252292_1
|
|
CCC1(COC1)Cn2cc(nn2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4428 |
EN300-6504697_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CC6(CC6)S(=O)(=O)N5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4429 |
EN300-13890_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CSC5CCS(=O)(=O)C5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4430 |
EN300-31147_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)C5CC5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4431 |
EN300-24014_2
|
|
CS(=O)(=O)N1CCCCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.6
|
6.7
± 0.4
|
4432 |
EN300-249222_1
|
|
CCC(C(=O)NC)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4433 |
EN300-253184_1
|
|
COC[C@@H]1C[C@@H](CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4434 |
EN300-253443_1
|
|
CCCN1CC(CC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4435 |
EN300-6734276_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC[C@H]6[C@@]5(COC6=O)CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4436 |
EN300-269863_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccnc6c5CC(=O)N6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4437 |
EN300-6491918_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)O)O |
−9.2
± 0.2
|
6.7
± 0.2
|
4438 |
EN300-300825_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCOCC5)CCO |
−9.2
± 0.2
|
6.7
± 0.2
|
4439 |
EN300-90142_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCCC(C5)C(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4440 |
EN300-7429986_1
|
|
CS(=O)(=O)C[C@H]1C[C@@H](C1)NC(=O)C[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4441 |
EN300-6488157_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc6n5cnn6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4442 |
EN300-1703560_2
|
|
C[C@@H](CS(=O)(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4443 |
EN300-129441_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc6n5ncn6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4444 |
EN300-261596_4
|
|
C=CCn1cc(nn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4445 |
EN300-1262640_2
|
|
CC(C)NC(=O)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4446 |
EN300-61086_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(C5CC5)C6CC(=O)NC6=O |
−9.2
± 0.2
|
6.7
± 0.1
|
4447 |
EN300-6477139_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CCS(=O)(=O)CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4448 |
EN300-342462_3
|
|
CN1CCC(CC1)NC(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4449 |
EN300-98429_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5c[nH]nn5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4450 |
EN300-59043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(=O)Nc5c[nH]nc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4451 |
EN300-131051_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(ccn5)C(=O)N |
−9.2
± 0.2
|
6.7
± 0.2
|
4452 |
EN300-51411_3
|
|
Cn1cc(cn1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4453 |
EN300-117414_2
|
|
CC(CO)N(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.1
|
4454 |
EN300-1968342_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(CF)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4455 |
EN300-75674_4
|
|
Cc1c(non1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4456 |
EN300-658865_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc([nH]n5)CO |
−9.2
± 0.2
|
6.7
± 0.2
|
4457 |
EN300-212795_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC5CNC(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4458 |
EN300-114593_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5cccn6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4459 |
EN300-250767_2
|
|
CC1(CCC(=O)N1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4460 |
VLA-UCB-05e51b3f-13
|
|
c1ccc2c(c1)cncc2NC(=O)[C@]3(CCOc4c3cc(cc4)Cl)CCC5CCCCC5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4461 |
EN300-305701_1
|
|
Cn1cc(nc1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4462 |
EN300-76387_1
|
|
CC(Cc1[nH]nnn1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4463 |
EN300-905492_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)c6ncc(cn6)F |
−9.2
± 0.3
|
6.7
± 0.2
|
4464 |
EN300-657410_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)c5[nH]ccn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4465 |
EN300-182725_2
|
|
CC(C(C)S(=O)(=O)C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4466 |
EN300-1265946_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(CC5)C(=O)N |
−9.2
± 0.2
|
6.7
± 0.2
|
4467 |
EN300-7434941_1
|
|
CC1(C[C@@H]([C@@H](CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O)C |
−9.2
± 0.3
|
6.7
± 0.3
|
4468 |
EN300-399072_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H]5CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4469 |
EN300-864080_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−9.2
± 0.3
|
6.7
± 0.2
|
4470 |
EN300-90293_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCc6c([nH]nn6)C5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4471 |
EN300-87527_3
|
|
CC[C@H](C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.2
± 0.4
|
6.7
± 0.3
|
4472 |
EN300-1723663_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCN(C(=O)C5)CCO |
−9.2
± 0.3
|
6.7
± 0.2
|
4473 |
EN300-155823_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(CC#N)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4474 |
EN300-30419_2
|
|
CS(=O)(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.3
|
6.7
± 0.2
|
4475 |
EN300-332601_4
|
|
CCC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.2
± 0.3
|
6.7
± 0.2
|
4476 |
EN300-43282_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC5c6[nH]nnn6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4477 |
EN300-872798_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5c(nnn5)C6CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4478 |
EN300-299920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H]([C@H](C5)O)O)O |
−9.2
± 0.2
|
6.7
± 0.1
|
4479 |
BEN-DND-c852c98b-6
|
|
c1cc2cncc(c2cc1OC(F)F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.19
± 0.07
|
6.70
± 0.05
|
4480 |
ALP-POS-696356e4-1
|
|
c1cc2cncc(c2cc1F)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.19
± 0.05
|
6.70
± 0.03
|
4481 |
EN300-7500408_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCCOC5)CO |
−9.2
± 0.2
|
6.7
± 0.1
|
4482 |
EN300-10747_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CN5CSCC5=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4483 |
EN300-157158_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC=CCO |
−9.2
± 0.2
|
6.7
± 0.1
|
4484 |
EN300-133818_1
|
|
CS(=O)(=O)C1CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4485 |
EN300-205680_4
|
|
CN(C)CC1(CC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.3
|
4486 |
EN300-1264619_1
|
|
CN1C(CCC1=O)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4487 |
EN300-10170_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(CO)NC(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4488 |
EN300-127487_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(=O)NC5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4489 |
EN300-399606_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6n(n5)CCCC6O |
−9.2
± 0.3
|
6.7
± 0.2
|
4490 |
EN300-1721521_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)O)N6CCOCC6 |
−9.2
± 0.4
|
6.7
± 0.3
|
4491 |
EN300-266736_4
|
|
Cc1c(nc[nH]1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4492 |
EN300-1719401_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)c5[nH]cnn5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4493 |
EN300-51887_4
|
|
CNS(=O)(=O)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.2
|
4494 |
EN300-82038_1
|
|
CN(Cc1[nH]cnn1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4495 |
EN300-13287_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5ccc(=O)[nH]c5=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4496 |
EN300-318110_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(CC5)C(C(=O)N)F |
−9.2
± 0.3
|
6.7
± 0.2
|
4497 |
EN300-7549839_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn[nH]c5n6cnnn6 |
−9.2
± 0.2
|
6.7
± 0.1
|
4498 |
EN300-202922_4
|
|
CC(C(C)(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.2
± 0.2
|
6.7
± 0.1
|
4499 |
EN300-367405_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)n6ccnn6 |
−9.2
± 0.2
|
6.7
± 0.1
|
4500 |
EN300-304051_1
|
|
Cn1cc(nn1)CN(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.3
|