Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4301 |
EN300-93474_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C[C@H](C=C5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4302 |
EN300-122656_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCSC5)O |
−9.3
± 0.4
|
6.8
± 0.3
|
4303 |
EN300-90531_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCCC5C(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4304 |
EN300-104896_1
|
|
Cc1nnc(o1)CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4305 |
EN300-68618_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cocn5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4306 |
EN300-97453_3
|
|
COCCCS(=O)(=O)NCCOCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4307 |
EN300-10414_2
|
|
CC1(CCS(=O)(=O)C1)NC(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4308 |
EN300-1428769_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC[C@@H]5[C@H](CO)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4309 |
EN300-28340_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC(=O)N5CCCC5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4310 |
EN300-19926_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC#N |
−9.3
± 0.2
|
6.8
± 0.1
|
4311 |
EN300-1268016_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC6C5CC(C6)C(=O)N |
−9.3
± 0.1
|
6.76
± 0.09
|
4312 |
EN300-6494693_4
|
|
CCn1c(ncn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4313 |
EN300-343103_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]c(=O)c6c(n5)CCOC6 |
−9.3
± 0.2
|
6.8
± 0.2
|
4314 |
EN300-112561_1
|
|
COCCCS(=O)(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4315 |
EN300-172020_2
|
|
Cn1cc(cn1)CC(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.3
± 0.4
|
6.8
± 0.3
|
4316 |
EN300-47657_3
|
|
CC(C(=O)N(C)C)NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4317 |
EN300-33398_4
|
|
CC(C)N1CC(CC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4318 |
DAR-DIA-0d514e7d-16
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccccc5F |
−9.3
± 0.2
|
6.8
± 0.2
|
4319 |
EN300-94408_2
|
|
CCC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4320 |
EN300-263601_2
|
|
COC[C@H]1C[C@H](CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.3
± 0.4
|
6.8
± 0.3
|
4321 |
EN300-180172_1
|
|
CC(Cn1ccccc1=O)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4322 |
EN300-131093_2
|
|
CC(C(=O)NCC(=O)C)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4323 |
EN300-746830_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5[C@H]6CCOC[C@H]6CO5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4324 |
EN300-111006_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccncn5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4325 |
EN300-115017_2
|
|
CC(C)[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4326 |
EN300-122866_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCSCC5C(=O)N |
−9.3
± 0.2
|
6.8
± 0.2
|
4327 |
EN300-7438176_2
|
|
CNC(=O)C[C@@H]1CN(C[C@H]1O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4328 |
EN300-51257_4
|
|
CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.3
± 0.2
|
6.8
± 0.2
|
4329 |
EN300-6734144_1
|
|
Cn1c2c(c(n1)CO)CN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.3
± 0.5
|
6.8
± 0.3
|
4330 |
EN300-139130_1
|
|
CC(CC1COCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4331 |
EN300-6486855_2
|
|
Cn1c(cnn1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.1
|
4332 |
EN300-307333_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCNC5=O |
−9.3
± 0.2
|
6.8
± 0.1
|
4333 |
EN300-6760290_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5[C@@H]6CC[C@H]([C@H]5CC[C@H]6O)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4334 |
EN300-79606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCCCNC(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4335 |
EN300-1721328_3
|
|
Cc1nnc(n1C)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4336 |
EN300-96933_2
|
|
CC(C)c1nnnn1CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4337 |
EN300-343787_4
|
|
CN1[C@H](CCC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4338 |
EN300-10673_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCO)C5CCS(=O)(=O)C5 |
−9.3
± 0.9
|
6.7
± 0.6
|
4339 |
EN300-107048_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CC5)CO |
−9.3
± 0.3
|
6.7
± 0.2
|
4340 |
EN300-1448558_1
|
|
CN(CC1(CC1)O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.7
± 0.3
|
4341 |
EN300-179091_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC(F)F |
−9.3
± 0.4
|
6.7
± 0.3
|
4342 |
EN300-2958082_2
|
|
C[C@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−9.3
± 0.3
|
6.7
± 0.2
|
4343 |
EN300-74856_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCS(=O)(=O)C5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4344 |
EN300-104746_4
|
|
CCC(C)(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.2
|
6.7
± 0.2
|
4345 |
EN300-6731821_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)nc[nH]5 |
−9.3
± 0.2
|
6.7
± 0.2
|
4346 |
EN300-7459545_1
|
|
CN(C)CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C(F)(F)F)O |
−9.3
± 0.2
|
6.7
± 0.2
|
4347 |
EN300-6491697_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5cccc(=O)[nH]5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4348 |
EN300-160080_1
|
|
CS(=O)(=O)c1nnc(s1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4349 |
BEN-DND-c852c98b-5
|
|
CS(=O)(=O)c1ccc2cncc(c2c1)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.26
± 0.08
|
6.74
± 0.06
|
4350 |
EN300-82453_1
|
|
CC(=O)N[C@@H](CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)N |
−9.3
± 0.3
|
6.7
± 0.2
|
4351 |
EN300-00271_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.3
± 0.3
|
6.7
± 0.2
|
4352 |
EN300-79538_1
|
|
Cc1c(non1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.7
± 0.2
|
4353 |
EN300-249245_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(C(F)F)O |
−9.3
± 0.2
|
6.7
± 0.2
|
4354 |
EN300-66494_2
|
|
CNC(=O)NCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.7
± 0.2
|
4355 |
EN300-253443_2
|
|
CCCN1CC(CC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.7
± 0.2
|
4356 |
EN300-66432_2
|
|
CN(C)S(=O)(=O)CCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.7
± 0.2
|
4357 |
EN300-7493296_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H]5COC6 |
−9.3
± 0.3
|
6.7
± 0.2
|
4358 |
EN300-23226_1
|
|
CC(=O)N1CCC(CC1)NC(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4359 |
EN300-6474575_2
|
|
CNC(=O)N1CC(C1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.7
± 0.2
|
4360 |
EN300-82476_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cnc[nH]5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4361 |
EN300-45398_1
|
|
CC(C)C(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−9.2
± 0.4
|
6.7
± 0.3
|
4362 |
EN300-135130_1
|
|
CNC(=O)C(CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.2
|
6.7
± 0.2
|
4363 |
EN300-62808_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc[nH]5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4364 |
EN300-118760_4
|
|
CC(C1CC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4365 |
EN300-136870_1
|
|
CN(C)c1[nH]c(=O)cc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4366 |
EN300-6472847_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CN(C5)C(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4367 |
EN300-6739414_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6ccnn6CC(C5)CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4368 |
EN300-75402_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCN(C5)C(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4369 |
EN300-253681_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCN5CCNC5=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4370 |
EN300-59285_4
|
|
CC(C)(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4371 |
EN300-316386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@H]5O |
−9.2
± 0.2
|
6.7
± 0.2
|
4372 |
EN300-7183657_2
|
|
C[C@]1(C[C@@H](C1)C(=O)NC[C@@]2(c3c(ccc(c3)Cl)OCC2)C(=O)Nc4c5c(cnc4)cccc5)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4373 |
EN300-216978_2
|
|
Cn1nc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4374 |
EN300-80230_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ncccn5 |
−9.2
± 0.2
|
6.7
± 0.1
|
4375 |
EN300-225786_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5nnnn5C6CC6 |
−9.2
± 0.3
|
6.7
± 0.2
|
4376 |
EN300-181938_4
|
|
CC(CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−9.2
± 0.4
|
6.7
± 0.3
|
4377 |
EN300-7042784_2
|
|
C[C@H]([C@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.3
|
6.7
± 0.2
|
4378 |
EN300-1081256_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)OCC(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4379 |
EN300-331476_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5O |
−9.2
± 0.3
|
6.7
± 0.2
|
4380 |
EN300-312850_3
|
|
C[C@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N(C)C |
−9.2
± 0.4
|
6.7
± 0.3
|
4381 |
EN300-322332_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5ccc(nc5)C(=O)N |
−9.2
± 0.3
|
6.7
± 0.2
|
4382 |
EN300-2008102_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5CN6CC(O5)CCC6=O |
−9.2
± 0.3
|
6.7
± 0.2
|
4383 |
EN300-66930_1
|
|
CNC(=O)CCN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.2
± 0.4
|
6.7
± 0.3
|
4384 |
ADA-UCB-dc2b944c-11
|
|
c1ccc2c(c1)c(cnc2Br)NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.24
± 0.07
|
6.73
± 0.05
|
4385 |
EN300-22473_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5ccnc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4386 |
EN300-705381_2
|
|
COC[C@H]1C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4387 |
EN300-110321_2
|
|
CN(CCN1CCOC1=O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4388 |
EN300-217579_1
|
|
Cc1cc(=O)n(cn1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4389 |
EN300-6750919_2
|
|
CC(CCO)(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.2
± 0.2
|
6.7
± 0.2
|
4390 |
EN300-304135_4
|
|
CCC1(CCNC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.4
|
6.7
± 0.3
|
4391 |
EN300-708742_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC(=O)NC5=O |
−9.2
± 0.2
|
6.7
± 0.1
|
4392 |
EN300-697462_2
|
|
Cc1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4393 |
EN300-260284_1
|
|
Cn1c(c[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4394 |
EN300-91605_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCc5[nH]cnn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4395 |
EN300-133396_1
|
|
COC(=O)NC1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4396 |
EN300-19900_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnccn5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4397 |
EN300-7439985_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC6(CC5C6)CO |
−9.2
± 0.3
|
6.7
± 0.2
|
4398 |
EN300-1214633_2
|
|
CCN([C@@H]1COC[C@H]1O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.3
|
6.7
± 0.2
|
4399 |
EN300-28177_1
|
|
CC(C(=O)N1CCCC(C1)C(=O)N)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.2
± 0.2
|
6.7
± 0.2
|
4400 |
EN300-781107_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(CO)O |
−9.2
± 0.4
|
6.7
± 0.3
|