Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4201 |
EN300-315737_4
|
|
CSCC[C@@H](C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.3
± 0.3
|
6.8
± 0.3
|
4202 |
EN300-365106_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)C(=O)N |
−9.3
± 0.2
|
6.8
± 0.2
|
4203 |
EN300-13890_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CSC5CCS(=O)(=O)C5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4204 |
EN300-47606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC(=O)NCC5CCS(=O)(=O)C5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4205 |
EN300-253462_4
|
|
CN(C)C(=O)[C@@H]1C[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4206 |
EN300-41473_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCOCC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4207 |
EN300-1266535_1
|
|
CC[C@H](C(=O)N(C)C)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4208 |
EN300-204364_2
|
|
CC[C@@H](CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4209 |
EN300-706065_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(C5(CCOCC5)O)(F)F |
−9.3
± 0.3
|
6.8
± 0.2
|
4210 |
EN300-31505_1
|
|
CCCC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4211 |
EN300-1699492_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@H]5COCCO5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4212 |
EN300-366855_1
|
|
Cn1ccnc1C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4213 |
EN300-1228556_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)Cn6ccnn6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4214 |
EN300-250458_2
|
|
Cn1c(ccn1)C(CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4215 |
EN300-222969_4
|
|
CN1CC(OC1=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4216 |
EN300-62448_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CNC(=O)C5CCC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4217 |
EN300-195072_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CN(CCO5)C(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4218 |
EN300-50009_2
|
|
COC(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4219 |
EN300-220527_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cc5[nH]ccn5 |
−9.3
± 0.6
|
6.8
± 0.4
|
4220 |
EN300-1688974_1
|
|
CC(CC(=O)N)N(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4221 |
EN300-60033_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COCC5CCCO5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4222 |
EN300-366974_2
|
|
CN(CCS(=O)(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4223 |
EN300-1091489_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@H]6[C@@H]5CC(C6)C(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4224 |
EN300-108171_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5COCCOC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4225 |
EN300-51889_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC(=O)N5CCC(CC5)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4226 |
EN300-62857_4
|
|
COCCS(=O)(=O)CCCOCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.5
|
6.8
± 0.3
|
4227 |
EN300-1717166_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC56CC(C6)O |
−9.3
± 0.1
|
6.8
± 0.1
|
4228 |
EN300-256096_2
|
|
CNC(=O)NCCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4229 |
EN300-79588_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCCS(=O)(=O)N |
−9.3
± 0.2
|
6.8
± 0.2
|
4230 |
EN300-1629199_2
|
|
Cc1c(c(nn1C)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−9.3
± 0.4
|
6.8
± 0.3
|
4231 |
EN300-248618_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CS(=O)(=O)C5CC5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4232 |
EN300-316386_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@H]5O |
−9.3
± 0.2
|
6.8
± 0.2
|
4233 |
EN300-69727_3
|
|
CC(C)(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)OC |
−9.3
± 0.3
|
6.8
± 0.2
|
4234 |
EN300-366299_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CCC(=O)NC[C@H]5C[C@@H](C5)O)cc1 |
−9.3
± 0.2
|
6.8
± 0.2
|
4235 |
EN300-07127_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5C(=O)N |
−9.3
± 0.2
|
6.8
± 0.1
|
4236 |
EN300-244744_2
|
|
Cn1ncc(n1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4237 |
EN300-267469_3
|
|
CS(=NC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(=O)C |
−9.3
± 0.3
|
6.8
± 0.2
|
4238 |
EN300-181938_3
|
|
CC(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(C=C)O |
−9.3
± 0.1
|
6.78
± 0.09
|
4239 |
EN300-6766477_2
|
|
CCN(CCC(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4240 |
EN300-69215_1
|
|
CN(C)C(=O)CCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4241 |
DAR-DIA-23e5a6a0-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CC5CC6(N5)COC6)Cl |
−9.3
± 0.2
|
6.8
± 0.2
|
4242 |
EN300-373791_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccnn5CC#N |
−9.3
± 0.3
|
6.8
± 0.2
|
4243 |
EN300-65978_2
|
|
Cn1cc(cn1)CN(C)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4244 |
EN300-18972_2
|
|
CC(=O)NCCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4245 |
EN300-6491795_2
|
|
CC1C2(CC(C2)(O1)CO)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4246 |
EN300-02067_2
|
|
CC(COC)NC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4247 |
EN300-55145_1
|
|
CC(CN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.2
|
6.8
± 0.2
|
4248 |
EN300-1694056_3
|
|
CC1(C(CC(=O)N1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.3
± 0.3
|
6.8
± 0.2
|
4249 |
EN300-298582_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC5CC(=O)NC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4250 |
EN300-105693_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(COC5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4251 |
EN300-1722016_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)n6nccn6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4252 |
EN300-50631_3
|
|
CN(C)S(=O)(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4253 |
EN300-2009111_2
|
|
Cn1c(cc(n1)CO)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4254 |
EN300-6491117_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5cnco5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4255 |
EN300-312893_2
|
|
CN1C[C@H](CC1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4256 |
EN300-2008945_1
|
|
CC1(CN(CCN1S(=O)(=O)C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.3
± 0.3
|
6.8
± 0.2
|
4257 |
EN300-37123_2
|
|
Cn1cc(c(=O)[nH]c1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4258 |
EN300-1242134_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCNC(=O)C56CCC6 |
−9.3
± 0.4
|
6.8
± 0.3
|
4259 |
EN300-6492035_2
|
|
CN(C)CCN(CCO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4260 |
EN300-6731226_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56CCO[C@H]5CC(=O)NC6 |
−9.3
± 0.4
|
6.8
± 0.3
|
4261 |
EN300-6736851_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@H]6[C@@H]5C[C@@H]([C@@H]6O)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4262 |
EN300-70033_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC[C@H]5CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4263 |
EN300-245205_4
|
|
COc1nc(co1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4264 |
EN300-107823_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5ncnn5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4265 |
EN300-85043_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccnc5OCCO |
−9.3
± 0.4
|
6.8
± 0.3
|
4266 |
EN300-176877_2
|
|
CN(C)C(=O)CCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4267 |
EN300-76451_2
|
|
COC1COCCC1NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.1
|
4268 |
EN300-6504697_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC6(CC6)S(=O)(=O)N5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4269 |
EN300-306774_1
|
|
CC1(C(=O)NC(=O)N1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4270 |
EN300-1630093_2
|
|
CC(C)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5(CCOC5)O |
−9.3
± 0.4
|
6.8
± 0.3
|
4271 |
EN300-108407_2
|
|
CC(=O)N1CCC(C1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4272 |
EN300-82539_1
|
|
CCOC(=O)CC(CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.2
|
6.8
± 0.1
|
4273 |
EN300-99064_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)N(C5)c6c[nH]nc6 |
−9.3
± 0.2
|
6.8
± 0.2
|
4274 |
EN300-31210_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−9.3
± 0.4
|
6.8
± 0.3
|
4275 |
EN300-7436546_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)O)CC(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4276 |
EN300-6489289_2
|
|
Cc1nnc2n1C(CC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.3
± 0.2
|
6.8
± 0.1
|
4277 |
EN300-177118_4
|
|
CC1(CCC(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4278 |
EN300-96262_2
|
|
CC(C)(C)OC(=O)N[C@H](CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4279 |
EN300-20160_2
|
|
CC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.2
|
6.8
± 0.1
|
4280 |
EN300-702542_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC56CC(C5)(CO6)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4281 |
EN300-1301381_4
|
|
COCC1(CCCO1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4282 |
EN300-344563_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(c6[nH]nnn6)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4283 |
EN300-64247_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)N5CCOCC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4284 |
EN300-1721331_1
|
|
COC1(CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.3
± 0.4
|
6.8
± 0.3
|
4285 |
EN300-59386_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(s5)S(=O)(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4286 |
EN300-6745081_4
|
|
CC1(CCCCNC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4287 |
EN300-6746622_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)NC(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4288 |
EN300-215852_1
|
|
CCn1nc(c(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.3
± 0.2
|
6.8
± 0.2
|
4289 |
EN300-7434791_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H](CO)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4290 |
EN300-7443518_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6cncn6c(=O)[nH]5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4291 |
EN300-219531_4
|
|
CCCC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4292 |
EN300-349304_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]([C@H](C5)O)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4293 |
EN300-157882_2
|
|
COCCCN(CCO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4294 |
EN300-220536_2
|
|
CS(=O)(=O)C1(CCOCC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4295 |
EN300-254883_2
|
|
Cc1c(non1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4296 |
EN300-724820_1
|
|
C[C@@H]1CN(C[C@H]1CS(=O)(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4297 |
EN300-226425_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5ccc(=O)[nH]n5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4298 |
EN300-1091444_2
|
|
CN(C1COC1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4299 |
EN300-818709_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)Cc6[nH]nnn6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4300 |
EN300-263153_1
|
|
Cn1cc(nn1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|