Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
4101 |
EN300-174763_2
|
|
CCN(CC(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.8
± 0.3
|
4102 |
EN300-6764893_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)OCCO |
−9.4
± 0.4
|
6.8
± 0.3
|
4103 |
EN300-2010317_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6C[C@@H]5[C@@H](C6)O |
−9.4
± 0.2
|
6.8
± 0.2
|
4104 |
EN300-191771_3
|
|
CS(=O)(=O)C1(CCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.5
|
6.8
± 0.4
|
4105 |
EN300-30768_4
|
|
CC1CC1C(=O)NCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.2
|
6.8
± 0.2
|
4106 |
EN300-256513_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5(CC5)CC(=O)N |
−9.4
± 0.2
|
6.8
± 0.2
|
4107 |
EN300-6764893_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C5)OCCO |
−9.4
± 0.3
|
6.8
± 0.2
|
4108 |
EN300-266556_1
|
|
Cn1cnnc1N2CCN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.4
± 0.3
|
6.8
± 0.2
|
4109 |
EN300-6499479_2
|
|
C[C@@H](c1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.4
± 0.3
|
6.8
± 0.2
|
4110 |
EN300-35450_2
|
|
CC(C)N(CC(=O)N)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.8
± 0.2
|
4111 |
EN300-109060_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)C(=O)CC#N |
−9.4
± 0.3
|
6.8
± 0.2
|
4112 |
EN300-67573_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NC5CCOCC5 |
−9.4
± 0.5
|
6.8
± 0.4
|
4113 |
EN300-6356960_2
|
|
Cn1cnnc1CCCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.4
|
6.8
± 0.3
|
4114 |
EN300-04614_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc(=O)[nH]n5 |
−9.4
± 0.2
|
6.8
± 0.2
|
4115 |
EN300-814104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@H]6CC(=O)N[C@H]6C5 |
−9.4
± 0.3
|
6.8
± 0.2
|
4116 |
EN300-118760_2
|
|
CC(C1CC1)(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.4
± 0.4
|
6.8
± 0.3
|
4117 |
EN300-245265_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCn5cnc(n5)C#N |
−9.4
± 0.4
|
6.8
± 0.3
|
4118 |
EN300-7549621_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@H]5F |
−9.4
± 0.3
|
6.8
± 0.2
|
4119 |
EN300-1270171_2
|
|
CCC(CS(=O)(=O)C)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.8
± 0.2
|
4120 |
EN300-206282_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)C#N |
−9.4
± 0.3
|
6.8
± 0.2
|
4121 |
EN300-103722_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cnn6c5OCCC6 |
−9.4
± 0.3
|
6.8
± 0.2
|
4122 |
EN300-98214_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CCCC5=O |
−9.4
± 0.3
|
6.8
± 0.2
|
4123 |
EN300-74450_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]ccn5 |
−9.4
± 0.3
|
6.8
± 0.2
|
4124 |
EN300-237952_2
|
|
CCN1CC(CC1=O)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.8
± 0.2
|
4125 |
EN300-6974806_1
|
|
C[C@H]([C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.4
± 0.3
|
6.8
± 0.2
|
4126 |
EN300-7442191_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CN6CCC5CC6)O |
−9.4
± 0.4
|
6.8
± 0.3
|
4127 |
EN300-6735902_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5[C@@H]6CC[C@@H]6C(=O)N5 |
−9.4
± 0.3
|
6.8
± 0.3
|
4128 |
EN300-6737762_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCCNC5=O |
−9.4
± 0.2
|
6.8
± 0.2
|
4129 |
EN300-7444950_4
|
|
COc1cc(ncn1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.4
|
6.8
± 0.3
|
4130 |
EN300-52193_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CCO |
−9.4
± 0.3
|
6.8
± 0.2
|
4131 |
EN300-7432415_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5C6(CCC6)OC(=O)N5 |
−9.4
± 0.4
|
6.8
± 0.3
|
4132 |
EN300-6486576_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nnc(o5)N6CCOCC6 |
−9.4
± 0.4
|
6.8
± 0.3
|
4133 |
EN300-227021_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCc5[nH]cnn5 |
−9.4
± 0.3
|
6.8
± 0.2
|
4134 |
EN300-21200_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c(nccn5)C(=O)N |
−9.4
± 0.4
|
6.8
± 0.3
|
4135 |
EN300-7352812_2
|
|
Cn1cc(cn1)OC2(CC2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.4
± 0.4
|
6.8
± 0.3
|
4136 |
EN300-817968_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6CCCS(=O)(=O)[C@H]6C5 |
−9.4
± 0.4
|
6.8
± 0.3
|
4137 |
EN300-18064_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOCC5 |
−9.4
± 0.2
|
6.8
± 0.2
|
4138 |
EN300-115011_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOCC5)CO |
−9.4
± 0.2
|
6.8
± 0.2
|
4139 |
EN300-1709213_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)c6[nH]cnn6 |
−9.4
± 0.3
|
6.8
± 0.2
|
4140 |
DAR-DIA-0d514e7d-17
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cc(cc(c5)F)F |
−9.4
± 0.2
|
6.8
± 0.2
|
4141 |
EN300-256053_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)CO |
−9.4
± 0.1
|
6.81
± 0.10
|
4142 |
EN300-124365_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)N6CCOCC6 |
−9.4
± 0.4
|
6.8
± 0.3
|
4143 |
EN300-212142_1
|
|
Cn1ncc(n1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.2
|
6.8
± 0.1
|
4144 |
EN300-113507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)N |
−9.4
± 0.2
|
6.8
± 0.1
|
4145 |
EN300-70815_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5ccn(n5)CCO |
−9.4
± 0.2
|
6.8
± 0.2
|
4146 |
EN300-16772_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCO |
−9.4
± 0.2
|
6.8
± 0.2
|
4147 |
EN300-318258_3
|
|
CC(C)(CN1CCOCC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.5
|
6.8
± 0.3
|
4148 |
EN300-1709410_2
|
|
CC1CC(N1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.4
± 0.2
|
6.8
± 0.1
|
4149 |
EN300-6732933_1
|
|
Cn1c2c(c(n1)CO)CCN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.4
± 0.4
|
6.8
± 0.3
|
4150 |
EN300-122847_1
|
|
Cn1ccc(n1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.8
± 0.2
|
4151 |
EN300-6491918_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)O)O |
−9.4
± 0.3
|
6.8
± 0.2
|
4152 |
EDJ-MED-e4b030d8-7
|
|
COc1cc(cc2c1OCC[C@H]2C(=O)Nc3cncc4c3cccc4)Cl |
−9.3
± 0.1
|
6.8
± 0.1
|
4153 |
EN300-173903_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCOC[C@H]5CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4154 |
EN300-1215738_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC5CCC(=O)NC5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4155 |
EN300-7459964_1
|
|
Cn1c(cnn1)CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4156 |
EN300-182913_4
|
|
CC(C)(C(=O)N)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4157 |
EN300-366050_2
|
|
CCC(Cn1cc(nn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4158 |
EN300-124063_2
|
|
Cn1c(ncn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4159 |
EN300-11300_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5cc(=O)[nH]c(=O)[nH]5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4160 |
EN300-6492197_2
|
|
CNC(=O)[C@H]1CCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4161 |
EN300-115058_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCC5)C(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4162 |
EN300-174561_4
|
|
Cn1cncc1CCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4163 |
EN300-731622_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5COCCO5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4164 |
EN300-227218_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCN6CCC5C6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4165 |
EN300-393148_4
|
|
CN1C(CCS1(=O)=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4166 |
EN300-23317_1
|
|
CC(C(=O)NCCOC)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4167 |
EN300-61694_2
|
|
Cn1ncc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4168 |
EN300-75807_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCS(=O)(=O)CC5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4169 |
EN300-7445890_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC6(C5)C(CC6O)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4170 |
EN300-294602_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5ccsc5S(=O)(=O)N |
−9.3
± 0.4
|
6.8
± 0.3
|
4171 |
EN300-23221_2
|
|
CC(C)NC(=O)CNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4172 |
EN300-210553_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)(C(=O)N)O |
−9.3
± 0.2
|
6.8
± 0.1
|
4173 |
EN300-624143_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CC56CC(C6)O |
−9.3
± 0.2
|
6.8
± 0.1
|
4174 |
EN300-392656_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5C[C@H]([C@H](C5)O)O |
−9.3
± 0.3
|
6.8
± 0.2
|
4175 |
EN300-36390_4
|
|
CCOC(=O)NCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4176 |
EN300-31077_2
|
|
Cn1c(ccn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4177 |
EN300-378044_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC=CCO5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4178 |
EN300-18564_3
|
|
CC(=O)NCCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.3
|
6.8
± 0.2
|
4179 |
EN300-81512_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4180 |
EN300-220676_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5CCCS(=O)(=O)C5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4181 |
EN300-18561_2
|
|
CC(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4182 |
EN300-1722017_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)n6nccn6 |
−9.3
± 0.4
|
6.8
± 0.3
|
4183 |
EN300-175186_1
|
|
CC(CO)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.1
|
4184 |
EN300-264308_2
|
|
C[C@H](c1cnnn1C)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.2
|
4185 |
EN300-114312_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCN5CCC5 |
−9.3
± 0.3
|
6.8
± 0.3
|
4186 |
EN300-133788_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCOC5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4187 |
EN300-88131_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H](C5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4188 |
EN300-1609249_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CS(=O)(=O)C6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4189 |
EN300-83691_4
|
|
Cc1c(nn[nH]1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4190 |
EN300-29387_2
|
|
CC(CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.2
|
4191 |
EN300-345656_4
|
|
C[C@@H]1C[C@@H](NC(=O)C1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.3
|
6.8
± 0.3
|
4192 |
EN300-268198_2
|
|
CC(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.3
± 0.3
|
6.8
± 0.2
|
4193 |
EN300-51832_4
|
|
Cc1cnn(c1)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4194 |
EN300-2010648_1
|
|
Cn1c(=O)c2c([nH]1)CN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.3
± 0.3
|
6.8
± 0.2
|
4195 |
EN300-30572_1
|
|
CS(=O)(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.4
|
6.8
± 0.3
|
4196 |
EN300-754601_1
|
|
COc1cc(nnc1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.3
± 0.2
|
6.8
± 0.2
|
4197 |
EN300-188650_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCc5[nH]ccn5 |
−9.3
± 0.4
|
6.8
± 0.3
|
4198 |
EN300-14458_1
|
|
CC(C(=O)N(C)C)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.3
± 0.2
|
6.8
± 0.1
|
4199 |
EN300-7549555_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5coc(n5)CO |
−9.3
± 0.3
|
6.8
± 0.2
|
4200 |
DAR-DIA-0d514e7d-12
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5ccc(cc5F)F |
−9.3
± 0.2
|
6.8
± 0.2
|