Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
401 |
EN300-6491117_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnco5 |
−11.8
± 0.2
|
8.6
± 0.2
|
402 |
EN300-92031_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5nc(no5)c6[nH]cnn6 |
−11.8
± 0.3
|
8.6
± 0.2
|
403 |
EN300-6482967_2
|
|
CNS(=O)(=O)CCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
8.6
± 0.2
|
404 |
EN300-205622_1
|
|
CS(=O)(=O)c1nccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.4
|
8.6
± 0.3
|
405 |
EN300-22245_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccon5 |
−11.8
± 0.2
|
8.6
± 0.1
|
406 |
VLA-UCB-50c39ae8-8
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC(=O)N5)Cl |
−11.8
± 0.2
|
8.6
± 0.1
|
407 |
EN300-52009_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCC5)O |
−11.8
± 0.3
|
8.6
± 0.2
|
408 |
EN300-39501_1
|
|
COCCS(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
8.6
± 0.3
|
409 |
EN300-315836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5[nH]ccn5 |
−11.8
± 0.1
|
8.6
± 0.1
|
410 |
EN300-36522_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)C5CC5 |
−11.8
± 0.2
|
8.6
± 0.2
|
411 |
EN300-174763_1
|
|
CCN(CC(=O)N)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
8.6
± 0.2
|
412 |
EN300-7456641_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(nn5)CCOC6 |
−11.8
± 0.3
|
8.6
± 0.2
|
413 |
EN300-207959_1
|
|
CC1(CCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
414 |
EN300-300020_3
|
|
CN1CCS(=O)(=O)CC1CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
8.6
± 0.3
|
415 |
EN300-219330_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCN5CCOCC5=O |
−11.8
± 0.3
|
8.6
± 0.2
|
416 |
EN300-190283_1
|
|
Cn1cncc1C(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.8
± 0.3
|
8.6
± 0.2
|
417 |
EN300-364679_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCn5cnnn5 |
−11.8
± 0.3
|
8.6
± 0.2
|
418 |
EN300-301925_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCOC5)C#N |
−11.8
± 0.3
|
8.6
± 0.2
|
419 |
EN300-125769_1
|
|
COCCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.2
|
8.6
± 0.2
|
420 |
EN300-95698_1
|
|
CC1CC(=O)NCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
421 |
EN300-157527_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)n6cnnc6 |
−11.8
± 0.2
|
8.6
± 0.2
|
422 |
EN300-201551_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5COCCN5CC(F)(F)F |
−11.8
± 0.3
|
8.6
± 0.2
|
423 |
EN300-116313_1
|
|
CC(=O)N1CCOCC1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
424 |
EN300-216978_4
|
|
Cn1nc(nn1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
425 |
EN300-1662365_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6ncnn6C5 |
−11.8
± 0.3
|
8.6
± 0.2
|
426 |
EN300-365398_2
|
|
Cn1c(nnn1)CCOC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
427 |
EN300-294602_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccsc5S(=O)(=O)N |
−11.8
± 0.3
|
8.6
± 0.2
|
428 |
EN300-05620_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCNC(=O)N |
−11.8
± 0.3
|
8.6
± 0.2
|
429 |
EN300-227310_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)OC |
−11.8
± 0.3
|
8.6
± 0.2
|
430 |
EN300-1724086_1
|
|
CC1CC(CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−11.8
± 0.1
|
8.6
± 0.1
|
431 |
EN300-7459768_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(C5)(C6(CCC6)O)O |
−11.8
± 0.3
|
8.6
± 0.2
|
432 |
EN300-7352438_1
|
|
COC[C@H]1C[C@@H]1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
433 |
EN300-69368_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)O |
−11.8
± 0.3
|
8.6
± 0.2
|
434 |
EN300-256762_1
|
|
Cc1c(c(=O)[nH]cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
435 |
EN300-367589_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(=O)NCC56COC6 |
−11.8
± 0.3
|
8.6
± 0.3
|
436 |
EN300-247428_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)CC6CC6 |
−11.8
± 0.3
|
8.6
± 0.2
|
437 |
EN300-173006_2
|
|
CC(c1nnnn1C)OC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.2
|
8.6
± 0.2
|
438 |
EN300-173216_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)NCC5CC5 |
−11.8
± 0.3
|
8.6
± 0.2
|
439 |
EN300-299215_3
|
|
C[C@H]1[C@H](OCCO1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
440 |
EN300-27341_1
|
|
CS(=O)(=O)N1CCCC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
8.6
± 0.4
|
441 |
EN300-72211_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(C5CC5)O |
−11.8
± 0.2
|
8.6
± 0.1
|
442 |
EN300-211203_1
|
|
CC(C)C1(CC(=O)NC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
443 |
EN300-7437385_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CN6CCC[C@H]6CO5 |
−11.8
± 0.3
|
8.6
± 0.2
|
444 |
EN300-736749_3
|
|
CC(=O)N1CSC[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.3
|
8.6
± 0.2
|
445 |
EN300-125140_3
|
|
COCC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.8
± 0.3
|
8.6
± 0.2
|
446 |
EN300-41423_1
|
|
Cc1ccc(c(=O)n1C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.8
± 0.5
|
8.6
± 0.4
|
447 |
EN300-260816_3
|
|
CN1CCC(C1=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.6
± 0.2
|
448 |
EN300-178876_1
|
|
CC1(CCCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.4
|
8.6
± 0.3
|
449 |
EN300-132615_3
|
|
CC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)N |
−11.7
± 0.2
|
8.6
± 0.1
|
450 |
EN300-1726277_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(n5cccn5)F |
−11.7
± 0.2
|
8.6
± 0.2
|
451 |
EN300-805037_1
|
|
Cn1c2cc(c(=O)[nH]c2cn1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.7
± 0.3
|
8.6
± 0.2
|
452 |
EN300-149224_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc(cn5)C#N |
−11.7
± 0.2
|
8.6
± 0.2
|
453 |
EN300-1726153_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)c5cccn6c5nnc6 |
−11.7
± 0.3
|
8.6
± 0.2
|
454 |
EN300-62574_3
|
|
Cn1c(nnn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.6
± 0.2
|
455 |
EN300-146491_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCCC(=O)N5 |
−11.7
± 0.2
|
8.6
± 0.2
|
456 |
EN300-1301381_1
|
|
COCC1(CCCO1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.6
± 0.2
|
457 |
EN300-97697_1
|
|
CN(C1CC(C1)O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
458 |
EN300-6745453_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5Cc6nncn6C5 |
−11.7
± 0.3
|
8.5
± 0.2
|
459 |
EN300-222357_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCCc5c[nH]nn5 |
−11.7
± 0.2
|
8.5
± 0.2
|
460 |
EN300-313062_1
|
|
CC(=O)N1CC2CC2(C1)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.7
± 0.2
|
8.5
± 0.2
|
461 |
EN300-651307_3
|
|
CCC(C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cncn5 |
−11.7
± 0.3
|
8.5
± 0.2
|
462 |
EN300-1262640_1
|
|
CC(C)NC(=O)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.2
|
8.5
± 0.1
|
463 |
EN300-127197_1
|
|
COc1cc(on1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
464 |
EN300-83527_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6ncccn6n5 |
−11.7
± 0.2
|
8.5
± 0.2
|
465 |
EN300-370753_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC[C@H](C5)C(=O)N |
−11.7
± 0.4
|
8.5
± 0.3
|
466 |
EN300-205635_1
|
|
COC(=O)COCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.3
|
8.5
± 0.2
|
467 |
EN300-6745453_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5Cc6nncn6C5 |
−11.7
± 0.2
|
8.5
± 0.2
|
468 |
EN300-90142_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCC(C5)C(=O)N |
−11.7
± 0.3
|
8.5
± 0.2
|
469 |
EN300-107892_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(nn5)C6CC6 |
−11.7
± 0.3
|
8.5
± 0.2
|
470 |
EN300-1600517_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC(CO)F |
−11.7
± 0.2
|
8.5
± 0.2
|
471 |
EN300-151330_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)c6cccnc6 |
−11.7
± 0.2
|
8.5
± 0.1
|
472 |
EN300-248883_3
|
|
COCC1(CCOC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
473 |
EN300-250112_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5csc(n5)CO |
−11.7
± 0.2
|
8.5
± 0.2
|
474 |
EN300-246423_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CC5(CCC5)O |
−11.7
± 0.3
|
8.5
± 0.2
|
475 |
EN300-1644723_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5C6C5COCC6 |
−11.7
± 0.2
|
8.5
± 0.2
|
476 |
EN300-365398_4
|
|
Cn1c(nnn1)CCOCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.3
|
477 |
EN300-258702_1
|
|
Cn1ccc(n1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.1
|
478 |
EN300-90225_2
|
|
Cn1nc(nn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
479 |
EN300-93174_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(c5c[nH]c(=O)[nH]c5=O)(F)F |
−11.7
± 0.4
|
8.5
± 0.3
|
480 |
EN300-1448674_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCn6c(ncn6)C5 |
−11.7
± 0.2
|
8.5
± 0.2
|
481 |
EN300-17161_1
|
|
CCOC(=O)CCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.7
± 0.3
|
8.5
± 0.2
|
482 |
EN300-1073264_1
|
|
Cn1cc(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
483 |
EN300-332606_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CCC(=O)O5 |
−11.7
± 0.2
|
8.5
± 0.2
|
484 |
EN300-216673_3
|
|
Cn1c(cnn1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
485 |
EN300-217343_3
|
|
Cn1c2c(nn1)CCC(C2)C(=O)NCC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.7
± 0.3
|
8.5
± 0.2
|
486 |
EN300-1387104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCS5(=O)=O |
−11.7
± 0.3
|
8.5
± 0.2
|
487 |
EN300-210552_3
|
|
CC(=O)N1CCCC(C1)(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−11.7
± 0.4
|
8.5
± 0.3
|
488 |
EN300-185729_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6c(nn[nH]6)C5 |
−11.7
± 0.3
|
8.5
± 0.2
|
489 |
EN300-18928_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CSCN5C(=O)C6CC6 |
−11.7
± 0.3
|
8.5
± 0.3
|
490 |
EN300-51832_1
|
|
Cc1cnn(c1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
491 |
EN300-1138792_3
|
|
Cn1cnnc1CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.3
|
8.5
± 0.2
|
492 |
EN300-3710141_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCO5)C#N |
−11.7
± 0.2
|
8.5
± 0.1
|
493 |
EN300-131465_1
|
|
COc1cc(on1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
494 |
EN300-255795_1
|
|
CN1CC(NC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.2
|
8.5
± 0.2
|
495 |
EN300-136051_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC6(C5)CCOC6 |
−11.7
± 0.4
|
8.5
± 0.3
|
496 |
EN300-316196_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cn(nn5)[C@@H]6CC[C@H]6O |
−11.7
± 0.3
|
8.5
± 0.2
|
497 |
EN300-717276_3
|
|
CCn1cc(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.7
± 0.4
|
8.5
± 0.3
|
498 |
EN300-73772_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5[nH]c(=O)[nH]n5 |
−11.7
± 0.3
|
8.5
± 0.2
|
499 |
EN300-2690393_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(cnc5)n6cnnn6 |
−11.7
± 0.2
|
8.5
± 0.2
|
500 |
EN300-96159_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cc5[nH]cnn5 |
−11.7
± 0.3
|
8.5
± 0.2
|