Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3901 |
EN300-99391_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)COC5CCOC5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3902 |
EN300-265898_1
|
|
COCc1nnc2n1CCN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3903 |
EN300-126412_2
|
|
CN(Cc1ncon1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3904 |
EN300-105081_2
|
|
Cn1cc(cc1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
3905 |
EN300-7355835_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCn6c(c(cn6)O)C5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3906 |
EN300-1073068_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5CCC(=O)NC5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3907 |
EN300-6474575_1
|
|
CNC(=O)N1CC(C1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3908 |
EN300-300519_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5csnn5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3909 |
EN300-252961_2
|
|
COCC1CC(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.2
|
6.9
± 0.2
|
3910 |
EN300-11714_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)Cn5ccccc5=O |
−9.5
± 0.3
|
6.9
± 0.2
|
3911 |
EN300-43972_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]cnn5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3912 |
EN300-2726690_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccc6c(n5)OCC(=O)N6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3913 |
EN300-25446_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnco5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3914 |
EN300-4726186_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CN5CCCNS5(=O)=O |
−9.5
± 0.6
|
6.9
± 0.4
|
3915 |
EN300-6494361_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CNC(=O)O6 |
−9.5
± 0.2
|
6.9
± 0.1
|
3916 |
EN300-1724997_1
|
|
CN1CCN(C(C1=O)CO)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3917 |
EN300-716163_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5Oc6c[nH]nc6 |
−9.5
± 0.4
|
6.9
± 0.3
|
3918 |
EN300-249475_2
|
|
CC(=O)NC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.2
|
6.9
± 0.2
|
3919 |
EN300-386296_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5COC[C@@H]5O |
−9.5
± 0.3
|
6.9
± 0.2
|
3920 |
EN300-31387_3
|
|
CS(=O)(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3921 |
EN300-05277_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCC(=O)N5CCOCC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3922 |
EN300-234362_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)n6cc(nn6)CO |
−9.5
± 0.3
|
6.9
± 0.2
|
3923 |
EN300-31562_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5c[nH]nc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3924 |
EN300-216104_2
|
|
CCn1c(nnn1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3925 |
EN300-1725234_1
|
|
Cn1c(ncn1)C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)OC |
−9.5
± 0.3
|
6.9
± 0.2
|
3926 |
EN300-41366_4
|
|
Cc1nc(n(n1)CCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.4
± 0.4
|
6.9
± 0.3
|
3927 |
EN300-1228556_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)Cn6ccnn6 |
−9.4
± 0.3
|
6.9
± 0.2
|
3928 |
EN300-186536_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCCCC5)n6cnnn6 |
−9.4
± 0.6
|
6.9
± 0.4
|
3929 |
EN300-219427_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6c(c(nn6)CO)C5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3930 |
EN300-817811_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cc(=O)[nH]cn5 |
−9.4
± 0.2
|
6.9
± 0.2
|
3931 |
EN300-36850_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCNC(=O)C5CC5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3932 |
EN300-52210_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CC(=O)N6 |
−9.4
± 0.2
|
6.9
± 0.1
|
3933 |
EN300-149224_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc(cn5)C#N |
−9.4
± 0.3
|
6.9
± 0.2
|
3934 |
EN300-69215_3
|
|
CN(C)C(=O)CCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.4
|
6.9
± 0.3
|
3935 |
EN300-1692359_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCC5CO)CO |
−9.4
± 0.2
|
6.9
± 0.1
|
3936 |
EN300-310888_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nnc6n5CCOCC6 |
−9.4
± 0.3
|
6.9
± 0.2
|
3937 |
EN300-1651623_2
|
|
CN(CC(CF)O)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.9
± 0.2
|
3938 |
EN300-221122_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(c6cnn[nH]6)O |
−9.4
± 0.4
|
6.9
± 0.3
|
3939 |
EN300-268198_4
|
|
CC(CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.4
± 0.2
|
6.9
± 0.1
|
3940 |
EN300-35843_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5[nH]c(=O)[nH]n5 |
−9.4
± 0.2
|
6.9
± 0.2
|
3941 |
EN300-300757_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5C[C@@H]([C@H]5n6cccn6)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3942 |
EN300-05754_4
|
|
CC(C(=O)N1CCOCC1)OCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3943 |
EN300-73620_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCS(=O)(=O)CC5 |
−9.4
± 0.4
|
6.9
± 0.3
|
3944 |
EN300-1212475_3
|
|
CC1(CC(=O)NCC1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.4
± 0.3
|
6.9
± 0.2
|
3945 |
EN300-159953_2
|
|
CN(C1CCN2CCOC1C2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.4
± 0.4
|
6.9
± 0.3
|
3946 |
EN300-268196_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CC5)N6CCOCC6 |
−9.4
± 0.5
|
6.9
± 0.3
|
3947 |
EN300-60440_2
|
|
CC(C)CNC(=O)CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.2
|
6.9
± 0.2
|
3948 |
EN300-25386_4
|
|
Cn1c(cc(=O)n(c1=O)C)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3949 |
EN300-2923949_2
|
|
c1ccc(cc1)C(C(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)O |
−9.4
± 0.2
|
6.9
± 0.2
|
3950 |
EN300-396329_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@@H]5CO |
−9.4
± 0.2
|
6.9
± 0.2
|
3951 |
EN300-262008_3
|
|
CON1CCC(CC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3952 |
EN300-219531_2
|
|
CCCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3953 |
EN300-316171_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)(C(=O)N)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3954 |
MAT-POS-b3e365b9-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4)Cl |
−9.44
± 0.03
|
6.87
± 0.02
|
3955 |
EN300-306316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5[nH]cnn5 |
−9.4
± 0.2
|
6.9
± 0.1
|
3956 |
EN300-175300_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5nnc6n5CCC6 |
−9.4
± 0.3
|
6.9
± 0.2
|
3957 |
EN300-59478_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCCC(=O)N |
−9.4
± 0.4
|
6.9
± 0.3
|
3958 |
EN300-315854_4
|
|
CC1(CCNC(=O)C1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3959 |
EN300-248982_2
|
|
Cn1c(cc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−9.4
± 0.3
|
6.9
± 0.2
|
3960 |
EN300-266023_1
|
|
Cn1cc(nn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.2
|
6.9
± 0.2
|
3961 |
DAR-DIA-6a508060-3
|
|
c1ccc2c(c1)cncc2NC(=O)C3CCOc4c3cc(cc4)C#N |
−9.43
± 0.07
|
6.87
± 0.05
|
3962 |
EN300-266183_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CS(=O)(=O)C5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3963 |
EN300-761719_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@H](CO)O |
−9.4
± 0.3
|
6.9
± 0.3
|
3964 |
EN300-146174_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)CO |
−9.4
± 0.2
|
6.9
± 0.2
|
3965 |
EN300-861925_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC(CO)F |
−9.4
± 0.2
|
6.9
± 0.2
|
3966 |
EN300-185378_1
|
|
CC(CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.4
± 0.2
|
6.9
± 0.1
|
3967 |
EN300-08125_1
|
|
c1ccc(cc1)OCC(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3968 |
EN300-4207624_1
|
|
CC(C)C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.4
± 0.3
|
6.9
± 0.2
|
3969 |
EN300-72109_2
|
|
CC(C)(C)OC(=O)NC(CO)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.4
|
6.9
± 0.3
|
3970 |
EN300-306026_3
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CCNC(=O)[C@H]5C[C@H](C5)O)cc1 |
−9.4
± 0.3
|
6.9
± 0.2
|
3971 |
EN300-6481008_2
|
|
CO[C@@H]1COCC[C@H]1NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3972 |
EN300-83434_2
|
|
CC(C(C)S(=O)(=O)C)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.2
|
6.9
± 0.1
|
3973 |
EN300-6735421_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5(CN(C5)C6CC6)CO |
−9.4
± 0.4
|
6.9
± 0.3
|
3974 |
EN300-39476_2
|
|
Cc1c(cn(n1)CCO)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3975 |
EN300-7089802_2
|
|
C[C@@H]([C@@H](C)O)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.9
± 0.2
|
3976 |
EN300-81629_1
|
|
Cc1nncn1CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3977 |
EN300-259063_2
|
|
CC(=O)N1CCCC(C1)(CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3978 |
EN300-6488034_1
|
|
CC1(CN(CC(O1)CC(=O)N)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.4
± 0.4
|
6.9
± 0.3
|
3979 |
EN300-761220_2
|
|
CC(=O)N1CSC[C@@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3980 |
EN300-746830_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5[C@H]6CCOC[C@H]6CO5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3981 |
EN300-7413100_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)CCO |
−9.4
± 0.2
|
6.9
± 0.2
|
3982 |
EN300-1723254_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)N6CC(C6)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3983 |
EN300-1723498_2
|
|
CCc1c(non1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3984 |
EN300-79538_2
|
|
Cc1c(non1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.2
|
6.9
± 0.1
|
3985 |
EN300-225053_2
|
|
COc1cnc(nc1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3986 |
EN300-128463_2
|
|
CNC(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.9
± 0.2
|
3987 |
EN300-66494_1
|
|
CNC(=O)NCCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.3
|
6.9
± 0.2
|
3988 |
EN300-110134_1
|
|
Cn1c(c(cn1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.4
± 0.2
|
6.9
± 0.2
|
3989 |
EN300-1694031_1
|
|
Cc1c(nnn1C2CCOC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.4
± 0.2
|
6.9
± 0.1
|
3990 |
EN300-31845_2
|
|
COCCN1CC(CC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.4
± 0.3
|
6.9
± 0.2
|
3991 |
EN300-7455508_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC56CCC(C5)[C@@H]([C@@H]6O)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3992 |
EN300-6493972_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@]56C[C@H]5[C@@H](C6)O |
−9.4
± 0.2
|
6.9
± 0.1
|
3993 |
EN300-7471076_2
|
|
CC1C(CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.4
± 0.2
|
6.9
± 0.1
|
3994 |
EN300-31148_2
|
|
CCC(=O)NC(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.2
|
6.9
± 0.1
|
3995 |
EN300-188650_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCc5[nH]ccn5 |
−9.4
± 0.4
|
6.9
± 0.3
|
3996 |
EN300-366180_1
|
|
Cn1c(ccn1)C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)O |
−9.4
± 0.3
|
6.9
± 0.2
|
3997 |
EN300-862647_1
|
|
C[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C |
−9.4
± 0.2
|
6.9
± 0.2
|
3998 |
EN300-1627945_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CCCOC5 |
−9.4
± 0.2
|
6.9
± 0.1
|
3999 |
EN300-125769_4
|
|
COCCCOCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.4
± 0.4
|
6.9
± 0.3
|
4000 |
EN300-141809_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC56CCS(=O)(=O)CC6 |
−9.4
± 0.3
|
6.9
± 0.2
|