Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3801 |
EN300-7540542_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H](CCCO)CO |
−9.5
± 0.4
|
6.9
± 0.3
|
3802 |
EN300-35592_2
|
|
Cn1cc(cc1C(=O)N)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3803 |
EN300-132963_1
|
|
CN1C(CCC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3804 |
EN300-160080_4
|
|
CS(=O)(=O)c1nnc(s1)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3805 |
EN300-67791_2
|
|
CC(C)C1C(=O)NCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3806 |
EN300-657222_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5C[C@@H]6COC[C@@H]6O5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3807 |
EN300-649738_4
|
|
Cc1c(n(nn1)C)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3808 |
EN300-393121_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c(=O)[nH]ccn6n5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3809 |
EN300-219609_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCn5cnccc5=O |
−9.5
± 0.3
|
6.9
± 0.3
|
3810 |
EN300-123712_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccc(n5)n6cncn6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3811 |
EN300-49565_2
|
|
CS(=O)(=O)CCCNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3812 |
EN300-210254_2
|
|
C[C@@H](CN(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.2
|
6.9
± 0.1
|
3813 |
EN300-46832_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCC5CCOC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3814 |
EN300-137786_3
|
|
CC1CCCN(C1)C(=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3815 |
EN300-43090_2
|
|
Cc1nnc(o1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3816 |
EN300-150022_1
|
|
CC(=O)NCCN(C)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3817 |
EN300-342462_4
|
|
CN1CCC(CC1)NC(=O)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.7
|
6.9
± 0.5
|
3818 |
EN300-36622_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCn5ccccc5=O |
−9.5
± 0.3
|
6.9
± 0.2
|
3819 |
EN300-62192_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CC(=O)NC(=O)C5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3820 |
EN300-6746631_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5nnc6n5CCCC6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3821 |
EN300-62192_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)NC(=O)C5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3822 |
EN300-137243_1
|
|
CN(C)c1ncc(o1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3823 |
EN300-6744028_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC6CC5C(C6O)O |
−9.5
± 0.1
|
6.9
± 0.1
|
3824 |
EDJ-MED-e4b030d8-2
|
|
C[C@@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.51
± 0.05
|
6.93
± 0.04
|
3825 |
EN300-246501_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)C6CS(=O)(=O)C6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3826 |
EN300-155362_2
|
|
CC1CC(=O)NC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3827 |
EN300-6745581_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5nncn5C6CC6 |
−9.5
± 0.4
|
6.9
± 0.3
|
3828 |
EN300-188915_1
|
|
Cc1ccn(c(=O)c1)CC(C)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3829 |
BEN-DND-c852c98b-1
|
|
c1cc2cncc(c2cc1C#N)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.51
± 0.05
|
6.92
± 0.04
|
3830 |
EN300-264301_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC[C@@H]5CCC(=O)N5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3831 |
EN300-181492_2
|
|
C=CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.2
|
6.9
± 0.1
|
3832 |
EN300-1702911_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)NC(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
3833 |
EN300-14405_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6n(c5=O)CCS6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3834 |
EN300-256759_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCC(=O)NCC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3835 |
EN300-73620_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCS(=O)(=O)CC5 |
−9.5
± 0.5
|
6.9
± 0.3
|
3836 |
EN300-6759972_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC(CC5)NC(=O)N |
−9.5
± 0.2
|
6.9
± 0.2
|
3837 |
EN300-74314_2
|
|
CCn1c(=O)ccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3838 |
EN300-7444533_4
|
|
CC1CC(C(=O)O1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3839 |
EN300-7237143_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCc6c([nH]c(=O)[nH]6)C5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3840 |
EN300-56202_4
|
|
CC(=O)N1CSCC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3841 |
EN300-1724086_2
|
|
CC1CC(CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.5
± 0.2
|
6.9
± 0.1
|
3842 |
EN300-7435400_4
|
|
C[C@@H]1C[C@@H](CC(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.5
|
6.9
± 0.3
|
3843 |
EN300-1657635_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5COC[C@@H]5F |
−9.5
± 0.2
|
6.9
± 0.2
|
3844 |
EN300-370792_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N(CCO)c5cnccn5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3845 |
EN300-255496_4
|
|
CN1CCC(S1(=O)=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3846 |
EN300-237298_2
|
|
CS(=O)(=O)N1CC(C1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3847 |
EDJ-MED-28ec730d-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCOCC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3848 |
EN300-98143_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5c(cn[nH]5)F |
−9.5
± 0.3
|
6.9
± 0.2
|
3849 |
EN300-70092_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)C(=O)N |
−9.5
± 0.5
|
6.9
± 0.4
|
3850 |
EN300-1448674_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6c(ncn6)C5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3851 |
EN300-245061_4
|
|
Cc1c(cn(n1)C)CC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3852 |
EN300-13489_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCN(CC5)C(=O)N |
−9.5
± 0.4
|
6.9
± 0.3
|
3853 |
EN300-23792_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc(sc5)S(=O)(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
3854 |
EN300-6736515_2
|
|
CC(C1COCCO1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3855 |
EN300-256798_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCc6nnnn6CC5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3856 |
EN300-100467_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5ccnn5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3857 |
EN300-199449_1
|
|
CC1C(CCC(=O)N1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3858 |
EN300-1264816_1
|
|
CN1CCC(C1=O)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3859 |
EN300-7355737_1
|
|
Cn1cc(c(n1)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)N |
−9.5
± 0.3
|
6.9
± 0.2
|
3860 |
EN300-7353971_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H](CO)F |
−9.5
± 0.3
|
6.9
± 0.2
|
3861 |
EN300-36390_2
|
|
CCOC(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3862 |
EN300-97055_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(=O)[nH]ccn5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3863 |
EN300-18557_4
|
|
CC(=O)N1CCC(CC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3864 |
EN300-1601684_2
|
|
CC1(C(OCCO1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.5
± 0.5
|
6.9
± 0.3
|
3865 |
EN300-1651623_1
|
|
CN(CC(CF)O)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.2
|
6.9
± 0.2
|
3866 |
EN300-139629_1
|
|
CNC(=O)NC1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3867 |
EN300-262204_1
|
|
CS(=O)(=O)CC1(COC1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3868 |
EN300-6763072_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)C56CC(C5)C6 |
−9.5
± 0.5
|
6.9
± 0.3
|
3869 |
EN300-1238839_2
|
|
CS(=O)(=O)NCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.2
|
6.9
± 0.1
|
3870 |
EN300-36911_4
|
|
CNC(=O)NCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3871 |
EN300-6731334_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CCN(CC5)S(=O)(=O)C6 |
−9.5
± 0.4
|
6.9
± 0.3
|
3872 |
ALP-POS-d3acb8cc-4
|
|
C[C@@H]1C[C@H](c2cc(ccc2O1)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.48
± 0.06
|
6.91
± 0.04
|
3873 |
EN300-216674_1
|
|
COC[C@H](CO)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.3
|
3874 |
EN300-94945_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCNC5=O |
−9.5
± 0.3
|
6.9
± 0.3
|
3875 |
EN300-50657_1
|
|
Cc1nc(on1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3876 |
EN300-7435544_1
|
|
CC(C)(C1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3877 |
EN300-6497226_1
|
|
C[C@@H]1CN(C[C@H]1O)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3878 |
EN300-130644_1
|
|
CNC(=O)C1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3879 |
EN300-1273202_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCNC(=O)C(C5)(F)F |
−9.5
± 0.3
|
6.9
± 0.2
|
3880 |
EN300-50631_4
|
|
CN(C)S(=O)(=O)CCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3881 |
EN300-120562_1
|
|
CC1CN2CCN1C(C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.5
± 0.2
|
6.9
± 0.1
|
3882 |
EN300-204133_2
|
|
COC1(CCOCC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3883 |
EN300-651665_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@@H]6[C@H]5CCO6 |
−9.5
± 0.2
|
6.9
± 0.2
|
3884 |
EN300-6491682_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCc6c(nn[nH]6)C5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3885 |
EN300-214189_1
|
|
Cn1c(cnn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3886 |
EN300-243828_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnncc5O |
−9.5
± 0.4
|
6.9
± 0.3
|
3887 |
EN300-51735_2
|
|
CN(C)CCN1CC(CC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3888 |
DAR-DIA-0d514e7d-11
|
|
C[C@@H]1COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)C#N |
−9.5
± 0.2
|
6.9
± 0.1
|
3889 |
EN300-90142_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCC(C5)C(=O)N |
−9.5
± 0.2
|
6.9
± 0.1
|
3890 |
EN300-06654_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cn5cncn5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3891 |
EN300-1700143_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)c6ncon6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3892 |
EN300-154332_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC5CO |
−9.5
± 0.2
|
6.9
± 0.1
|
3893 |
EN300-1932013_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(CC(F)(F)F)O |
−9.5
± 0.4
|
6.9
± 0.3
|
3894 |
EN300-104493_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C5CCOC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3895 |
EN300-311920_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCS(=O)(=O)C5)F |
−9.5
± 0.3
|
6.9
± 0.2
|
3896 |
EN300-7385329_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5Cc6nccn6C5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3897 |
EN300-378316_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5nnc6n5cc[nH]c6=O |
−9.5
± 0.3
|
6.9
± 0.2
|
3898 |
EN300-217499_4
|
|
CC(C1CCOCC1)(C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3899 |
EN300-171752_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5CCOC5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3900 |
EN300-19342_2
|
|
CN(CCO)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|