Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3701 |
EN300-187998_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC6(C5)CC(=O)NC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
3702 |
EN300-383824_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c([nH]c5=O)CCOC6 |
−9.6
± 0.4
|
7.0
± 0.3
|
3703 |
EN300-54922_1
|
|
CS(=O)(=O)N1CCCC(C1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
3704 |
EN300-1268020_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN(CC5)Cc6[nH]nnn6 |
−9.6
± 0.4
|
7.0
± 0.3
|
3705 |
EN300-92662_2
|
|
Cn1c(ccn1)CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.3
|
3706 |
EN300-305984_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cccn6c5nnn6 |
−9.6
± 0.3
|
7.0
± 0.2
|
3707 |
EN300-313267_1
|
|
CN1CCCC(C1=O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.1
|
3708 |
EN300-1266519_2
|
|
CC(C1CS(=O)(=O)C1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
3709 |
EN300-183231_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCCc5[nH]nnn5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3710 |
EN300-7355979_1
|
|
Cn1cnc2c(c1=O)[nH]nc2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.6
± 0.3
|
7.0
± 0.2
|
3711 |
EN300-6764836_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC6C(C(C5O6)O)O |
−9.6
± 0.2
|
7.0
± 0.1
|
3712 |
EN300-861925_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COC(CO)F |
−9.6
± 0.2
|
7.0
± 0.1
|
3713 |
EN300-210089_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5C6C5COC6 |
−9.6
± 0.2
|
7.0
± 0.1
|
3714 |
EN300-747207_2
|
|
CC(C)(CNC(=O)N)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.3
|
7.0
± 0.2
|
3715 |
EN300-185378_4
|
|
CC(COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.6
± 0.3
|
7.0
± 0.2
|
3716 |
EN300-1708899_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC[C@@H]5C[C@@H](CCO5)O |
−9.6
± 0.3
|
7.0
± 0.2
|
3717 |
BEN-DND-c852c98b-4
|
|
c1cc2cncc(c2cc1O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.56
± 0.05
|
6.97
± 0.04
|
3718 |
EN300-6736394_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C56CC(CCO5)OC6 |
−9.6
± 0.2
|
7.0
± 0.2
|
3719 |
EN300-70656_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCC5)O |
−9.6
± 0.3
|
7.0
± 0.2
|
3720 |
EN300-365650_1
|
|
C[C@@H](C1CN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.6
± 0.2
|
7.0
± 0.2
|
3721 |
EN300-1722713_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CC(=O)NC6 |
−9.6
± 0.3
|
7.0
± 0.2
|
3722 |
EN300-96159_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)Cc5[nH]cnn5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3723 |
EN300-255990_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn6c5ncc(c6)C#N |
−9.6
± 0.3
|
7.0
± 0.2
|
3724 |
EN300-316193_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]6COC(=O)[C@H]6C5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3725 |
EN300-7443527_1
|
|
CC(c1[nH]c(nn1)C(C)O)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
3726 |
EN300-1932780_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C(F)F)O |
−9.6
± 0.3
|
7.0
± 0.2
|
3727 |
EN300-6498726_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H](CO)CF |
−9.6
± 0.5
|
7.0
± 0.3
|
3728 |
EN300-11300_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5cc(=O)[nH]c(=O)[nH]5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3729 |
EN300-78135_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)NC5CC5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3730 |
EN300-304051_2
|
|
Cn1cc(nn1)CN(C)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
3731 |
EN300-51028_4
|
|
CC(C)S(=O)(=O)CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.6
± 0.4
|
7.0
± 0.3
|
3732 |
EN300-706065_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C5(CCOCC5)O)(F)F |
−9.6
± 0.4
|
7.0
± 0.3
|
3733 |
EN300-129710_2
|
|
COCC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.6
± 0.3
|
7.0
± 0.2
|
3734 |
EN300-260262_1
|
|
Cn1cc(nn1)CCNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.2
|
7.0
± 0.2
|
3735 |
EN300-1605433_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(C5)CCNC6=O |
−9.6
± 0.4
|
7.0
± 0.3
|
3736 |
EN300-62166_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCCC5CNC(=O)N |
−9.6
± 0.3
|
7.0
± 0.2
|
3737 |
EN300-204935_2
|
|
Cn1ncc(n1)C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3738 |
EN300-173536_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CCS5(=O)=O |
−9.6
± 0.2
|
7.0
± 0.2
|
3739 |
EN300-42591_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CNC(=O)NC5CC5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3740 |
EN300-42195_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC(C5)CNC(=O)N |
−9.6
± 0.2
|
7.0
± 0.2
|
3741 |
EN300-39005_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C(=O)OC |
−9.6
± 0.3
|
7.0
± 0.2
|
3742 |
EN300-1273172_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc(cn5)C(=O)N |
−9.6
± 0.3
|
7.0
± 0.2
|
3743 |
EN300-311920_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCS(=O)(=O)C5)F |
−9.6
± 0.2
|
7.0
± 0.2
|
3744 |
EN300-6277108_4
|
|
COC(C1CCCO1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.6
± 0.3
|
7.0
± 0.2
|
3745 |
EN300-118045_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnc([nH]c5=O)C6CC6 |
−9.5
± 0.4
|
7.0
± 0.3
|
3746 |
EN300-173020_2
|
|
CC(c1nnnn1C)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
7.0
± 0.1
|
3747 |
EN300-43972_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5[nH]cnn5 |
−9.5
± 0.2
|
7.0
± 0.1
|
3748 |
EN300-300020_1
|
|
CN1CCS(=O)(=O)CC1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
7.0
± 0.1
|
3749 |
EN300-02623_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5[nH]c(nn5)CCCO |
−9.5
± 0.3
|
7.0
± 0.2
|
3750 |
EN300-116885_2
|
|
Cc1c(nc(c(=O)[nH]1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.5
± 0.3
|
7.0
± 0.2
|
3751 |
EN300-717276_2
|
|
CCn1cc(nn1)CC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
7.0
± 0.2
|
3752 |
EN300-211403_1
|
|
CN(C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5(CC5)CO |
−9.5
± 0.4
|
7.0
± 0.3
|
3753 |
EN300-309457_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CN(C5)C6CCOC6 |
−9.5
± 0.3
|
7.0
± 0.2
|
3754 |
MAT-POS-8a69d52e-4
|
|
CC1COc2ccc(cc2C1C(=O)Nc3cncc4c3cccc4)Cl |
−9.54
± 0.05
|
6.95
± 0.04
|
3755 |
EN300-36931_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CCOCC5)C(=O)N |
−9.5
± 0.3
|
7.0
± 0.2
|
3756 |
EN300-310254_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5C(=O)NCC56CCOCC6 |
−9.5
± 0.4
|
7.0
± 0.3
|
3757 |
EN300-81629_2
|
|
Cc1nncn1CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
7.0
± 0.2
|
3758 |
EN300-31183_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)COC |
−9.5
± 0.3
|
7.0
± 0.2
|
3759 |
EN300-331828_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)O[C@@H]5COC[C@H]5O |
−9.5
± 0.2
|
7.0
± 0.1
|
3760 |
EN300-63781_1
|
|
Cc1c2c(c(=O)n(nc2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)C)no1 |
−9.5
± 0.3
|
7.0
± 0.2
|
3761 |
EN300-199359_3
|
|
CC(C)[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.3
|
7.0
± 0.2
|
3762 |
EN300-1073320_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C(C5(CCC5)O)O |
−9.5
± 0.4
|
7.0
± 0.3
|
3763 |
EN300-1296824_3
|
|
CC(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(COC)O |
−9.5
± 0.3
|
7.0
± 0.2
|
3764 |
EN300-341011_2
|
|
Cn1c2c(nn1)CCC(C2)NC(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.5
± 0.2
|
7.0
± 0.2
|
3765 |
EN300-04492_3
|
|
COCCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
7.0
± 0.2
|
3766 |
EN300-70064_4
|
|
CNC(=O)C1(CCC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.4
|
7.0
± 0.3
|
3767 |
EN300-318305_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6(C5)CS(=O)(=O)C6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3768 |
EN300-182084_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)c5cscn5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3769 |
EN300-1081277_3
|
|
CNC(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3770 |
EN300-296237_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(CO)C(F)(F)F |
−9.5
± 0.3
|
6.9
± 0.2
|
3771 |
EN300-1699100_2
|
|
CN(c1[nH]cnn1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3772 |
EN300-322100_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnc6n5ncc6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3773 |
EN300-18074_1
|
|
CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.2
|
6.9
± 0.1
|
3774 |
EN300-116234_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@H]5CCCO5 |
−9.5
± 0.4
|
6.9
± 0.3
|
3775 |
EN300-151423_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCOCC5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3776 |
EN300-6478526_2
|
|
CNC(=O)N1CCC(CC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3777 |
EN300-67191_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCN5CCCC5=O |
−9.5
± 0.3
|
6.9
± 0.2
|
3778 |
EN300-6735421_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5(CN(C5)C6CC6)CO |
−9.5
± 0.5
|
6.9
± 0.4
|
3779 |
EN300-155498_4
|
|
CC(=C)[C@H](CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.2
|
6.9
± 0.2
|
3780 |
EN300-59487_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CC(=O)NC5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3781 |
EN300-378828_1
|
|
C[C@@H]1[C@H]([C@H](C(=O)N1C)O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3782 |
EN300-6487134_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC56CC(C5)C(=O)NC6 |
−9.5
± 0.4
|
6.9
± 0.3
|
3783 |
EN300-7433071_1
|
|
CN(C)C1(CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.5
± 0.5
|
6.9
± 0.3
|
3784 |
EN300-131943_2
|
|
COc1cc(ncn1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3785 |
EN300-7438088_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@@H]6CS(=O)(=O)C[C@@H]6C5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3786 |
EN300-172485_2
|
|
Cc1nnc(n1C)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3787 |
EN300-1722017_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CC5)n6nccn6 |
−9.5
± 0.3
|
6.9
± 0.2
|
3788 |
EN300-130825_2
|
|
CN1[C@@H](CCC1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3789 |
EN300-12204_2
|
|
CCCNC(=O)CN(C)C(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.4
|
6.9
± 0.3
|
3790 |
EN300-761719_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@H](CO)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3791 |
EN300-7535922_1
|
|
CN(C)c1ccc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.2
|
6.9
± 0.1
|
3792 |
EN300-312662_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5[nH]c(nn5)CO |
−9.5
± 0.3
|
6.9
± 0.2
|
3793 |
EN300-68225_2
|
|
CC(C)(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.5
± 0.2
|
6.9
± 0.2
|
3794 |
EN300-260642_2
|
|
Cc1c(c(=O)[nH][nH]1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3795 |
EN300-318341_2
|
|
CN(C1CS(=O)(=O)C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3796 |
EN300-55072_4
|
|
CC(CO)C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.5
± 0.3
|
6.9
± 0.2
|
3797 |
EN300-113234_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)OC5 |
−9.5
± 0.2
|
6.9
± 0.2
|
3798 |
EN300-176587_2
|
|
CC1(CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.5
± 0.3
|
6.9
± 0.2
|
3799 |
EN300-239233_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCn5c(=O)cccn5 |
−9.5
± 0.3
|
6.9
± 0.2
|
3800 |
EN300-6763470_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC(C(=O)N)C(F)(F)F |
−9.5
± 0.2
|
6.9
± 0.1
|