Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3401 |
EN300-297611_1
|
|
CC1CN(CCN1S(=O)(=O)C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3402 |
EN300-6487755_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]6C[C@@H](C5)[C@@H]([C@@H](C6)O)O |
−9.7
± 0.5
|
7.1
± 0.4
|
3403 |
EN300-49064_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5COC5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3404 |
EN300-107267_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCCNC5=O |
−9.7
± 0.2
|
7.1
± 0.1
|
3405 |
EN300-1258964_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)NC |
−9.7
± 0.2
|
7.1
± 0.2
|
3406 |
EN300-705381_3
|
|
COC[C@H]1C[C@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3407 |
EN300-103187_2
|
|
CCOCCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3408 |
EN300-373791_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccnn5CC#N |
−9.7
± 0.3
|
7.1
± 0.2
|
3409 |
EN300-367405_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)n6ccnn6 |
−9.7
± 0.2
|
7.1
± 0.1
|
3410 |
EN300-174561_2
|
|
Cn1cncc1CCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3411 |
EN300-7430501_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCn6c(cnn6)C5 |
−9.7
± 0.2
|
7.1
± 0.1
|
3412 |
EN300-57990_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5[nH]nnn5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3413 |
EN300-51028_3
|
|
CC(C)S(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3414 |
EN300-1608590_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nc(on5)N6CCOCC6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3415 |
EN300-189563_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCC5CS(=O)(=O)C5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3416 |
EN300-1273362_4
|
|
CC1(CN(C1=O)C)COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3417 |
ADA-UCB-dc2b944c-15
|
|
CC1(COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)C |
−9.7
± 0.1
|
7.07
± 0.09
|
3418 |
EN300-17381_1
|
|
CC(C(=O)N)O[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.07
± 0.08
|
3419 |
EN300-31185_4
|
|
CC(C)C(=O)NCCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
3420 |
EN300-158274_4
|
|
CC(=O)N1C[C@H](C[C@@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.4
|
7.1
± 0.3
|
3421 |
EN300-212266_3
|
|
CC(C)C(=O)N[C@@H](CO)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
3422 |
EN300-1663228_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@@H]5COC[C@@H]5CO |
−9.7
± 0.3
|
7.1
± 0.2
|
3423 |
EN300-6731226_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@]56CCO[C@H]5CC(=O)NC6 |
−9.7
± 0.4
|
7.1
± 0.3
|
3424 |
EN300-211777_3
|
|
CC(=O)N1CCC[C@@H]1C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3425 |
EN300-201180_1
|
|
CC1CCC(C(=O)N1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3426 |
EN300-191771_2
|
|
CS(=O)(=O)C1(CCC1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.5
|
7.1
± 0.4
|
3427 |
EN300-761746_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCc5c(=O)[nH]c(=O)[nH]n5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3428 |
EN300-124904_2
|
|
Cn1c(nnn1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3429 |
EN300-00903_2
|
|
Cc1ccnc2n1nc(n2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3430 |
EN300-135418_2
|
|
C=CCC(CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.1
± 0.1
|
3431 |
EN300-1988306_2
|
|
CS(=O)(=O)CCC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
3432 |
EN300-223061_2
|
|
CC(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)(CO)CO |
−9.7
± 0.3
|
7.1
± 0.2
|
3433 |
EN300-172020_1
|
|
Cn1cc(cn1)CC(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3434 |
EN300-154942_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5OCCO5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3435 |
EN300-221518_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCCO |
−9.7
± 0.2
|
7.1
± 0.2
|
3436 |
EN300-261210_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CCOC5)C#N |
−9.7
± 0.3
|
7.1
± 0.2
|
3437 |
EN300-220194_4
|
|
CC(C(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.7
± 0.3
|
7.1
± 0.2
|
3438 |
EN300-97699_3
|
|
CC(CS(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
3439 |
EN300-191114_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCCn5cccnc5=O |
−9.7
± 0.3
|
7.1
± 0.2
|
3440 |
EN300-75209_2
|
|
CC(CS(=O)(=O)C)N(C)C(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3441 |
EN300-02015_1
|
|
COCCNC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3442 |
EN300-205622_2
|
|
CS(=O)(=O)c1nccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.3
|
3443 |
EN300-04491_1
|
|
COCCN(CCOC)C(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.5
|
7.1
± 0.4
|
3444 |
EN300-7465104_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC(C5)(C6(CCC6)O)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3445 |
EN300-1087187_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CCC(=O)NC6C5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3446 |
EN300-6501360_2
|
|
CN(C)C(=O)NCC(COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.4
|
7.1
± 0.3
|
3447 |
EN300-17184_2
|
|
C=CCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3448 |
EN300-99064_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CC(=O)N(C5)c6c[nH]nc6 |
−9.7
± 0.4
|
7.1
± 0.3
|
3449 |
EN300-156212_2
|
|
Cn1c(nnn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3450 |
EN300-818706_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC6CC5C(=O)N6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3451 |
EN300-7444121_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@H](C56CCC6)O)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3452 |
EN300-1717596_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CNC(=O)[C@H]5C[C@@H](C5)n6cnnc6)cc1 |
−9.7
± 0.3
|
7.1
± 0.2
|
3453 |
EN300-386187_1
|
|
COC(=O)N[C@H]1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3454 |
EN300-7456801_1
|
|
Cc1cc(n(n1)C)C(=O)NCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.3
|
3455 |
EN300-7459540_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCCC5C(CO)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3456 |
EN300-151268_1
|
|
CC(C)NS(=O)(=O)NC(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.6
|
7.1
± 0.5
|
3457 |
EN300-1706173_1
|
|
CC1(CS(=O)(=O)C1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3458 |
EN300-52325_2
|
|
CCCS(=O)(=O)CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.5
|
7.1
± 0.4
|
3459 |
EN300-393300_2
|
|
CC(c1cn(nn1)C)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3460 |
EN300-317085_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5C[C@H]([C@@H](C5)F)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3461 |
EN300-21258_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCO |
−9.7
± 0.3
|
7.1
± 0.2
|
3462 |
EN300-212341_1
|
|
Cn1ccnc1COCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3463 |
EN300-317082_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5COC5 |
−9.7
± 0.2
|
7.1
± 0.1
|
3464 |
EN300-6473273_3
|
|
Cn1c(ccn1)C(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.2
|
7.1
± 0.2
|
3465 |
EN300-37077_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5ccn[nH]5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3466 |
EN300-6733137_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)n6cncn6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3467 |
EN300-05798_2
|
|
Cn1c(=O)ccc(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3468 |
EN300-257949_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@H]5O |
−9.7
± 0.2
|
7.1
± 0.2
|
3469 |
EN300-6497444_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5OCC(C6)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3470 |
DAR-DIA-0d514e7d-14
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)c5cccc(c5F)F |
−9.7
± 0.2
|
7.1
± 0.1
|
3471 |
EN300-7434398_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CC5)c6[nH]cnn6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3472 |
EN300-7443518_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6cncn6c(=O)[nH]5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3473 |
EN300-314274_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cncc6c5CCNC6=O |
−9.7
± 0.4
|
7.1
± 0.3
|
3474 |
EN300-304695_2
|
|
CN1CCCCC(C1=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3475 |
EN300-113112_4
|
|
Cn1cnnc1COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.3
|
3476 |
EN300-7438185_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6nncn6nc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3477 |
EN300-395954_2
|
|
CC12CN(CCN1C(=O)OC2)C(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3478 |
EN300-40947_2
|
|
CC(C)S(=O)(=O)C(C)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.4
|
7.1
± 0.3
|
3479 |
EN300-253187_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5COCO5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3480 |
EN300-866702_1
|
|
C=CCOC(=O)NCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3481 |
EN300-7427194_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@H](CC56CCC6)O)O |
−9.7
± 0.4
|
7.1
± 0.3
|
3482 |
EN300-42195_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(C5)CNC(=O)N |
−9.7
± 0.3
|
7.1
± 0.3
|
3483 |
EN300-325729_2
|
|
COCC1COCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3484 |
EN300-54837_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5C(=O)CCCC5=O |
−9.7
± 0.3
|
7.1
± 0.2
|
3485 |
MAK-UNK-8be7dca9-7
|
|
c1cc2cncc(c2cc1C(=O)O)NC(=O)C3CCOc4c3cc(cc4)Cl |
−9.68
± 0.08
|
7.05
± 0.06
|
3486 |
EN300-306026_2
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CNC(=O)[C@H]5C[C@H](C5)O)cc1 |
−9.7
± 0.2
|
7.0
± 0.1
|
3487 |
EN300-31102_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCN(CC5)S(=O)(=O)N |
−9.7
± 0.4
|
7.0
± 0.3
|
3488 |
EN300-269508_2
|
|
Cn1cc(c(n1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.7
± 0.3
|
7.0
± 0.2
|
3489 |
EN300-36731_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c(ccs5)n6cnnn6 |
−9.7
± 0.2
|
7.0
± 0.1
|
3490 |
EN300-257785_2
|
|
CC1(CN(C1)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.7
± 0.3
|
7.0
± 0.2
|
3491 |
EN300-6498351_3
|
|
Cc1c(n(cn1)C)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.0
± 0.1
|
3492 |
EN300-7438575_2
|
|
CC(C1=NO[C@H]2[C@@H]1COC2)NC(=O)CC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.7
± 0.2
|
7.0
± 0.2
|
3493 |
EN300-59478_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCC(=O)N |
−9.7
± 0.3
|
7.0
± 0.2
|
3494 |
EN300-11835_1
|
|
CC(C)CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−9.7
± 0.5
|
7.0
± 0.4
|
3495 |
DAR-DIA-23e5a6a0-2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(N5)CCC6)Cl |
−9.7
± 0.3
|
7.0
± 0.2
|
3496 |
EN300-222357_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCCc5c[nH]nn5 |
−9.7
± 0.4
|
7.0
± 0.3
|
3497 |
EN300-72272_1
|
|
CC(C(C)O)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.1
|
7.0
± 0.1
|
3498 |
EN300-316679_2
|
|
CCC[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.4
|
7.0
± 0.3
|
3499 |
EN300-152705_2
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.7
± 0.3
|
7.0
± 0.2
|
3500 |
EN300-1688983_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)N6C5CCC6 |
−9.7
± 0.3
|
7.0
± 0.2
|