Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3301 |
EN300-107047_1
|
|
Cc1cc(=O)[nH]cc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3302 |
EN300-245098_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@@H]5C(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3303 |
EN300-1602334_2
|
|
Cc1c(cn2c(n1)ncn2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3304 |
EN300-31147_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCNC(=O)C5CC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3305 |
EN300-314838_1
|
|
CCn1c(cnn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3306 |
EN300-341337_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C56CCOC5CCOC6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3307 |
EN300-21409_1
|
|
C#CCNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.1
|
7.1
± 0.1
|
3308 |
EN300-6762327_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(Cc5ccccn5)O |
−9.8
± 0.4
|
7.1
± 0.3
|
3309 |
EN300-378316_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCc5nnc6n5cc[nH]c6=O |
−9.8
± 0.3
|
7.1
± 0.2
|
3310 |
EN300-199481_2
|
|
CC1(CNC(=O)CN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.8
± 0.3
|
7.1
± 0.2
|
3311 |
EN300-2989643_2
|
|
Cn1c(cc(n1)OC)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3312 |
EN300-214552_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cc6c([nH]c(=O)[nH]6)nc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3313 |
EN300-1664603_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCc5ccn[nH]5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3314 |
EN300-34705_1
|
|
CS(=O)(=O)N1CCC(CC1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3315 |
EN300-1605226_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)CNC(=O)N6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3316 |
EN300-46832_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCC5CCOC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3317 |
EN300-817873_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(C5)COCCO6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3318 |
EN300-43047_3
|
|
CC(=O)NC(CC=C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.1
|
3319 |
EN300-160080_2
|
|
CS(=O)(=O)c1nnc(s1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3320 |
EN300-120414_1
|
|
CC1CN2CCN1CC2C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3321 |
EN300-7431964_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CN(C5)C(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3322 |
EN300-805037_2
|
|
Cn1c2cc(c(=O)[nH]c2cn1)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3323 |
EN300-137243_2
|
|
CN(C)c1ncc(o1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3324 |
EN300-217107_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCC5C(=O)N |
−9.8
± 0.2
|
7.1
± 0.1
|
3325 |
EN300-6739162_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC[C@@H]6[C@H](C5)OC(=O)N6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3326 |
EN300-62857_1
|
|
COCCS(=O)(=O)CCCO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.5
|
7.1
± 0.4
|
3327 |
EN300-10895_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)NCCC#N |
−9.8
± 0.4
|
7.1
± 0.3
|
3328 |
EN300-1718675_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnnn5C6CC6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3329 |
EN300-7352812_1
|
|
Cn1cc(cn1)OC2(CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3330 |
EN300-13489_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCN(CC5)C(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3331 |
EN300-7434114_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6(C5)C(CCCO6)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3332 |
EN300-245036_2
|
|
C[C@H]1[C@@H](CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3333 |
EN300-6335413_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5C[C@H]5C(=O)NCCO |
−9.8
± 0.4
|
7.1
± 0.3
|
3334 |
EN300-366852_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)c6[nH]nnn6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3335 |
EN300-100741_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5[nH]cnn5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3336 |
EN300-2983332_1
|
|
CC(C)C1CNC(=O)CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3337 |
EN300-117931_2
|
|
CC(C)(CC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3338 |
EN300-64536_3
|
|
COCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3339 |
EN300-222145_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@H]5CNC(=O)N5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3340 |
EN300-220194_2
|
|
CC(C(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)OC |
−9.7
± 0.2
|
7.1
± 0.2
|
3341 |
EN300-183001_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC#N |
−9.7
± 0.2
|
7.1
± 0.2
|
3342 |
EN300-633533_2
|
|
CS(=O)(=O)[C@@H]1C[C@]1(COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−9.7
± 0.3
|
7.1
± 0.3
|
3343 |
EN300-70487_1
|
|
Cc1[nH]c(nn1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3344 |
EN300-21200_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c(nccn5)C(=O)N |
−9.7
± 0.2
|
7.1
± 0.2
|
3345 |
EN300-120920_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OC5CCC(=O)NC5=O |
−9.7
± 0.2
|
7.1
± 0.2
|
3346 |
EN300-1709101_2
|
|
Cc1nc(nn1C)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3347 |
EN300-73582_2
|
|
CCS(=O)(=O)NCCOC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.3
|
3348 |
EN300-42591_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CNC(=O)NC5CC5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3349 |
EN300-104896_2
|
|
Cc1nnc(o1)CCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3350 |
EN300-22880_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)N5CCCC(C5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
3351 |
EN300-141645_1
|
|
CN(CCCO)C(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.3
|
7.1
± 0.2
|
3352 |
EN300-16216_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
3353 |
EN300-92406_2
|
|
Cc1c([nH]c(=O)[nH]1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3354 |
EN300-237298_1
|
|
CS(=O)(=O)N1CC(C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3355 |
EN300-104592_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCC5CCC(=O)N5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3356 |
EN300-73102_2
|
|
CC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCOCC5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3357 |
EN300-301690_1
|
|
CS(=O)(=O)N1CCC(C1)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3358 |
EN300-2007564_2
|
|
CC1(C(CCS1(=O)=O)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.7
± 0.3
|
7.1
± 0.2
|
3359 |
EN300-94479_1
|
|
CC1CN(CCC1NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−9.7
± 0.3
|
7.1
± 0.2
|
3360 |
EN300-207451_1
|
|
CN(C)S(=O)(=O)C1CCCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3361 |
EN300-246486_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5coc(=O)[nH]5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3362 |
EN300-39504_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCS(=O)(=O)N |
−9.7
± 0.3
|
7.1
± 0.3
|
3363 |
EN300-211482_4
|
|
CC(C(=O)NC)OCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.1
± 0.1
|
3364 |
EN300-7436546_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]([C@@H](C5)O)CC(=O)N |
−9.7
± 0.4
|
7.1
± 0.3
|
3365 |
EN300-4293814_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)CCO |
−9.7
± 0.6
|
7.1
± 0.4
|
3366 |
EN300-734638_1
|
|
COc1cc(=O)[nH]cc1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3367 |
EN300-53656_1
|
|
CC(CNC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)CO |
−9.7
± 0.2
|
7.1
± 0.2
|
3368 |
EN300-121939_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCN6C(C5)CCOC6=O |
−9.7
± 0.2
|
7.1
± 0.2
|
3369 |
EN300-263392_1
|
|
CS(=O)(=O)Cc1nc(co1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3370 |
EN300-2853791_1
|
|
CN(C)C(=O)c1cn(nn1)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3371 |
DAR-DIA-0d514e7d-3
|
|
CC1(COc2ccc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)C |
−9.7
± 0.1
|
7.09
± 0.10
|
3372 |
DAR-DIA-23e5a6a0-6
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4CC5CCC6(N5)CCC6)Cl |
−9.7
± 0.3
|
7.1
± 0.2
|
3373 |
EN300-43090_1
|
|
Cc1nnc(o1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3374 |
EN300-30458_3
|
|
CN1CCC(CC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3375 |
EN300-85760_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCO5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3376 |
EN300-1700710_4
|
|
Cn1ccnc1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|
3377 |
EN300-139167_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC5COCCO5 |
−9.7
± 0.1
|
7.1
± 0.1
|
3378 |
EN300-92031_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCc5nc(no5)c6[nH]cnn6 |
−9.7
± 0.3
|
7.1
± 0.2
|
3379 |
EN300-134204_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CCCc5[nH]nnn5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3380 |
EN300-65115_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CC(C5)O |
−9.7
± 0.2
|
7.1
± 0.2
|
3381 |
EN300-1725538_2
|
|
Cn1cc(nc1)CC(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3382 |
EN300-33478_4
|
|
CCN1CC(CC1=O)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3383 |
EN300-307592_1
|
|
c1cc2c(c(cnc2)NC(=O)[C@]3(c4c(ccc(c4)Cl)OCC3)CC(=O)N[C@H]5C[C@@H](C5)O)cc1 |
−9.7
± 0.2
|
7.1
± 0.2
|
3384 |
DAR-DIA-23e5a6a0-3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(N5)COC6)Cl |
−9.7
± 0.2
|
7.1
± 0.2
|
3385 |
EN300-316196_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)[C@@H]6CC[C@H]6O |
−9.7
± 0.3
|
7.1
± 0.2
|
3386 |
DAR-DIA-0d514e7d-24
|
|
C[C@H]1COc2c(cc(cc2[C@@H]1C(=O)Nc3cncc4c3cccc4)Cl)CC(C)C |
−9.7
± 0.2
|
7.1
± 0.1
|
3387 |
EN300-300217_4
|
|
CC=CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.7
± 0.2
|
7.1
± 0.2
|
3388 |
EN300-716082_1
|
|
Cn1c(ccn1)C(CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.3
|
7.1
± 0.2
|
3389 |
EN300-180575_2
|
|
CC1CCS(=O)(=O)CCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3390 |
EN300-6734334_3
|
|
Cc1[nH]cc(c(=O)n1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3391 |
EN300-309106_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn6cnnc6cn5 |
−9.7
± 0.2
|
7.1
± 0.2
|
3392 |
EN300-210089_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5C6C5COC6 |
−9.7
± 0.2
|
7.1
± 0.1
|
3393 |
EN300-2977549_4
|
|
CNC(=O)COCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.7
± 0.2
|
7.1
± 0.1
|
3394 |
EN300-6494606_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(c(=O)[nH]c5=O)Cl |
−9.7
± 0.3
|
7.1
± 0.2
|
3395 |
EN300-249086_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@@H](C5)C(=O)N |
−9.7
± 0.3
|
7.1
± 0.2
|
3396 |
EN300-7121836_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cn[nH]c5F |
−9.7
± 0.3
|
7.1
± 0.2
|
3397 |
EN300-1725538_1
|
|
Cn1cc(nc1)CC(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.7
± 0.2
|
7.1
± 0.2
|
3398 |
EN300-7426520_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H]6CCOC(=O)[C@H]6C5 |
−9.7
± 0.4
|
7.1
± 0.3
|
3399 |
EN300-6732376_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCCC5CO |
−9.7
± 0.2
|
7.1
± 0.2
|
3400 |
EN300-217526_4
|
|
CCn1c(c(nn1)C)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.7
± 0.3
|
7.1
± 0.2
|