Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3201 |
EN300-1262608_2
|
|
CCNC(=O)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3202 |
EN300-741926_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC(C(C5)F)O |
−9.8
± 0.2
|
7.1
± 0.1
|
3203 |
EN300-93474_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N[C@H]5C[C@H](C=C5)CO |
−9.8
± 0.2
|
7.1
± 0.2
|
3204 |
EN300-1988306_1
|
|
CS(=O)(=O)CCC(=O)CO[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.4
|
7.1
± 0.3
|
3205 |
EN300-35642_1
|
|
CN(CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)S(=O)(=O)C |
−9.8
± 0.4
|
7.1
± 0.3
|
3206 |
EN300-237224_2
|
|
CN1CCC(CC1)OCC(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3207 |
EN300-307658_2
|
|
C=C[C@H](CO)NC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3208 |
EN300-650518_2
|
|
CO[C@@H]1C[C@H]1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.1
|
3209 |
EN300-60035_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CCCNC5=O |
−9.8
± 0.2
|
7.1
± 0.1
|
3210 |
EN300-1587691_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCNC(=O)C5CCO |
−9.8
± 0.4
|
7.1
± 0.3
|
3211 |
EN300-6486763_1
|
|
CC1C2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)OC(=O)N1 |
−9.8
± 0.2
|
7.1
± 0.2
|
3212 |
EN300-1717630_1
|
|
CC1(CCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
3213 |
EN300-107493_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5CCNC(=O)C5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3214 |
EN300-18064_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3215 |
EN300-305282_2
|
|
COCC(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−9.8
± 0.3
|
7.1
± 0.2
|
3216 |
EN300-6764450_1
|
|
CNC(=O)N1CCC(CC1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3217 |
EN300-1068239_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5cnon5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3218 |
EN300-259694_4
|
|
CCOC1(CCOC1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.4
|
7.1
± 0.3
|
3219 |
EN300-260603_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCc5c[nH]c(=O)[nH]5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3220 |
EN300-102347_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5(COC5)CO |
−9.8
± 0.2
|
7.1
± 0.2
|
3221 |
EN300-82616_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCCNC5=O |
−9.8
± 0.2
|
7.1
± 0.2
|
3222 |
EN300-260760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5cc(=O)[nH][nH]5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3223 |
EN300-7459540_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC5C(CO)O |
−9.8
± 0.5
|
7.1
± 0.4
|
3224 |
EN300-10729_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CCNC(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3225 |
EN300-321597_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5CC[C@H](C5)O |
−9.8
± 0.3
|
7.1
± 0.3
|
3226 |
DAR-DIA-23e5a6a0-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CCC6(N5)CCC6)Cl |
−9.8
± 0.3
|
7.1
± 0.2
|
3227 |
EN300-1722226_1
|
|
CCN1CC(C1=O)(C)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3228 |
EN300-7543132_1
|
|
CN(C)CCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3229 |
EN300-649738_1
|
|
Cc1c(n(nn1)C)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3230 |
EN300-6504697_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5CC6(CC6)S(=O)(=O)N5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3231 |
EN300-23129_2
|
|
CC(=O)NCCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3232 |
EN300-67050_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCS(=O)(=O)CC5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3233 |
EN300-246423_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CC5(CCC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3234 |
EN300-313438_2
|
|
Cn1c2c(cn1)c(ncn2)C(=O)NC[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3235 |
EN300-203293_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)OCC5CNC(=O)O5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3236 |
EN300-6746631_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5nnc6n5CCCC6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3237 |
EN300-247343_3
|
|
CC1(CC(C1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3238 |
EN300-71126_1
|
|
Cc1nnc2n1CCN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3239 |
EN300-36911_3
|
|
CNC(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3240 |
EN300-7494324_3
|
|
Cc1c(nc[nH]1)CC(C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3241 |
EN300-633533_4
|
|
CS(=O)(=O)[C@@H]1C[C@]1(COCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C#N |
−9.8
± 0.4
|
7.1
± 0.3
|
3242 |
EN300-171605_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCC5CS(=O)(=O)C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3243 |
EN300-173006_1
|
|
CC(c1nnnn1C)O[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3244 |
EN300-31186_3
|
|
CCC(=O)NCCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3245 |
EN300-370182_2
|
|
Cn1c(nnn1)CCCNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3246 |
EN300-217499_1
|
|
CC(C1CCOCC1)(C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.2
|
7.1
± 0.2
|
3247 |
EN300-1726073_2
|
|
Cn1c(cnn1)C(C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(F)F |
−9.8
± 0.3
|
7.1
± 0.2
|
3248 |
EN300-55744_1
|
|
CCCCC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3249 |
EN300-1708637_1
|
|
C[C@H](C1CN(CCO1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3250 |
EN300-360157_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCOC5)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3251 |
EN300-83434_1
|
|
CC(C(C)S(=O)(=O)C)NC(=O)C[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.1
|
3252 |
EN300-120920_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOC5CCC(=O)NC5=O |
−9.8
± 0.2
|
7.1
± 0.2
|
3253 |
EN300-172481_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(C(=O)N)O |
−9.8
± 0.5
|
7.1
± 0.3
|
3254 |
EN300-100830_3
|
|
CCS(=O)(=O)N(C)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.4
|
7.1
± 0.3
|
3255 |
EN300-83827_1
|
|
CS(=O)(=O)C1CSCCN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3256 |
EN300-7445396_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5Cc6c[nH]cc6S5(=O)=O |
−9.8
± 0.4
|
7.1
± 0.3
|
3257 |
EN300-6477724_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5C[C@@H]5c6[nH]cnn6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3258 |
EN300-61898_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc(nn5)n6ccnc6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3259 |
EN300-75030_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5CCC(=O)N5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3260 |
EN300-378373_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COC5CC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3261 |
EN300-6478054_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOCC(C5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
3262 |
EN300-370280_1
|
|
C[C@]1(CCC(=O)N1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3263 |
EN300-53395_3
|
|
CCS(=O)(=O)CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3264 |
EN300-263085_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)n6cnnn6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3265 |
EN300-383664_1
|
|
Cn1cc(ncc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3266 |
EN300-246178_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cnn(c5)CC(CO)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3267 |
EN300-65839_2
|
|
CCC(C(=O)N)OC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.2
|
3268 |
EN300-226314_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC(=O)C5CCS(=O)(=O)C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3269 |
EN300-6729572_4
|
|
CC(C1CC1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.8
± 0.1
|
7.13
± 0.10
|
3270 |
EN300-396329_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC[C@@H]5C[C@@H]5CO |
−9.8
± 0.3
|
7.1
± 0.2
|
3271 |
EN300-256513_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5(CC5)CC(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3272 |
EN300-30859_1
|
|
Cn1cnnc1CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3273 |
EN300-6505003_4
|
|
CC1CCC(C(=O)N1)C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3274 |
EN300-385267_1
|
|
COC1(CCS(=O)(=O)C1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3275 |
EN300-62074_3
|
|
CC(=O)NC(CCOC)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3276 |
EN300-104891_1
|
|
CNC(=O)c1cccc(n1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3277 |
EN300-321558_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCOC(C5)CC(=O)N |
−9.8
± 0.4
|
7.1
± 0.3
|
3278 |
EN300-1251424_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5ccn(n5)CC#N |
−9.8
± 0.3
|
7.1
± 0.2
|
3279 |
EN300-176877_3
|
|
CN(C)C(=O)CCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.1
± 0.2
|
3280 |
EN300-31210_4
|
|
CC(C(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NS(=O)(=O)C |
−9.8
± 0.4
|
7.1
± 0.3
|
3281 |
EN300-89418_2
|
|
CC(CO)(C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3282 |
EN300-244909_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOCC5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
3283 |
EN300-73102_1
|
|
CC(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)C5CCOCC5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3284 |
EN300-69708_1
|
|
Cc1c(c(=O)n2c([nH]1)ccn2)CC(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.4
|
7.1
± 0.3
|
3285 |
EN300-364992_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC[C@H]5CC[C@H](O5)C(=O)N |
−9.8
± 0.4
|
7.1
± 0.3
|
3286 |
EN300-39826_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nc6ncccn6n5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3287 |
JAG-UCB-706446eb-1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC(F)(F)F |
−9.8
± 0.2
|
7.1
± 0.2
|
3288 |
EN300-307336_1
|
|
CC1(CC(CN1C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O)CO |
−9.8
± 0.4
|
7.1
± 0.3
|
3289 |
EN300-104746_1
|
|
CCC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.2
|
7.1
± 0.2
|
3290 |
DAR-DIA-23e5a6a0-4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@H]3CCOc4c3cc(cc4OC5CC6(CC6)CN5)Cl |
−9.8
± 0.3
|
7.1
± 0.2
|
3291 |
EN300-182725_3
|
|
CC(C(C)S(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.2
|
3292 |
EN300-08259_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)COCC(=O)NCCCN5CCCC5=O |
−9.8
± 0.4
|
7.1
± 0.3
|
3293 |
EN300-114894_1
|
|
CC1(OCCO1)CNC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3294 |
EN300-151411_1
|
|
CCn1c(c(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.8
± 0.3
|
7.1
± 0.2
|
3295 |
EN300-201551_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5COCCN5CC(F)(F)F |
−9.8
± 0.4
|
7.1
± 0.3
|
3296 |
EN300-705386_4
|
|
COC[C@@H]1C[C@H]1C(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3297 |
EN300-1697763_2
|
|
C[C@]1(CCCN1C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C(=O)N |
−9.8
± 0.3
|
7.1
± 0.2
|
3298 |
EN300-386200_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NC5CC[C@H]([C@H](CC5)O)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3299 |
EN300-12440_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC(=O)N(C5)C6CC6 |
−9.8
± 0.2
|
7.1
± 0.2
|
3300 |
EN300-42154_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)CS(=O)(=O)C5CCCC5 |
−9.8
± 0.4
|
7.1
± 0.3
|