Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
3101 |
EN300-3451857_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCC(=O)NC5=O |
−9.9
± 0.3
|
7.2
± 0.2
|
3102 |
EN300-50009_4
|
|
COC(=O)NCC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
3103 |
EN300-65414_1
|
|
CC(=O)NC(C)(C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.9
± 0.3
|
7.2
± 0.2
|
3104 |
EN300-216968_1
|
|
CN1[C@H]2CCN(C[C@H]2NC1=O)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.9
± 0.2
|
7.2
± 0.2
|
3105 |
EN300-6526690_2
|
|
C[C@H](c1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−9.9
± 0.3
|
7.2
± 0.2
|
3106 |
EN300-92406_1
|
|
Cc1c([nH]c(=O)[nH]1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
3107 |
EN300-48902_3
|
|
CNC(=O)C1CCCN1C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
3108 |
EN300-306144_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(C5)(CO)CO |
−9.9
± 0.3
|
7.2
± 0.2
|
3109 |
EN300-70133_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)Nc5c(cnn5CCO)C#N |
−9.9
± 0.3
|
7.2
± 0.2
|
3110 |
EN300-95698_2
|
|
CC1CC(=O)NCC1C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.9
± 0.3
|
7.2
± 0.2
|
3111 |
EN300-94945_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5CCNC5=O |
−9.8
± 0.4
|
7.2
± 0.3
|
3112 |
EN300-117756_2
|
|
CCCCS(=O)(=O)NCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.4
|
7.2
± 0.3
|
3113 |
EN300-1071940_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)CC5(CCCOC5)O |
−9.8
± 0.3
|
7.2
± 0.2
|
3114 |
EN300-123614_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)C5(CC5)NC(=O)N |
−9.8
± 0.4
|
7.2
± 0.3
|
3115 |
EN300-117931_4
|
|
CC(C)(CC(=O)NCCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.2
|
7.2
± 0.2
|
3116 |
EN300-97697_2
|
|
CN(C1CC(C1)O)C(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3117 |
EN300-7550802_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]6C[C@H]5CN6C(=O)N |
−9.8
± 0.3
|
7.2
± 0.2
|
3118 |
EN300-219437_1
|
|
Cc1c(cnn1C)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3119 |
EN300-25572_1
|
|
CC1CN(CCO1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3120 |
EN300-77543_1
|
|
COc1ncc(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3121 |
EN300-1724771_3
|
|
CC(=O)N1CCN(CC1)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3122 |
EN300-202757_2
|
|
CC(CC(=O)N)C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.2
± 0.2
|
3123 |
EN300-155176_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CCCS5(=O)=O |
−9.8
± 0.3
|
7.2
± 0.2
|
3124 |
EN300-205486_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5cnccc5O |
−9.8
± 0.3
|
7.2
± 0.3
|
3125 |
EN300-128277_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(=O)NCC(F)F |
−9.8
± 0.3
|
7.2
± 0.2
|
3126 |
EN300-65115_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)O |
−9.8
± 0.3
|
7.2
± 0.2
|
3127 |
EN300-50194_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCCn5cccn5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3128 |
EN300-69368_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCOCC5)O |
−9.8
± 0.4
|
7.2
± 0.3
|
3129 |
EN300-139268_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C(=O)NCC(F)(F)F |
−9.8
± 0.2
|
7.2
± 0.2
|
3130 |
EN300-1718424_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(C5)CCC(=O)N6 |
−9.8
± 0.3
|
7.2
± 0.2
|
3131 |
EN300-204507_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(C5)(CO)F |
−9.8
± 0.2
|
7.2
± 0.2
|
3132 |
EN300-1709315_3
|
|
CC1(CCCNS1(=O)=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3133 |
EN300-14628_3
|
|
CN(CC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)C5CCS(=O)(=O)C5 |
−9.8
± 0.5
|
7.2
± 0.4
|
3134 |
EN300-383906_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CNC(=O)N5CCCC5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3135 |
EN300-224499_2
|
|
CCc1[nH]c(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3136 |
EN300-6758671_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5C[C@@H](C[C@H]5O)O |
−9.8
± 0.3
|
7.2
± 0.2
|
3137 |
EN300-6478434_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC6(CC5)CNC(=O)C6O |
−9.8
± 0.3
|
7.2
± 0.2
|
3138 |
EN300-87536_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5CCCN5C(=O)N |
−9.8
± 0.3
|
7.2
± 0.2
|
3139 |
EN300-87528_1
|
|
CC(C)[C@@H](C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)NC(=O)N |
−9.8
± 0.3
|
7.2
± 0.2
|
3140 |
EN300-1178209_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCc5c[nH]nn5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3141 |
EN300-7435581_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCC5=NO[C@H]6[C@@H]5COC6 |
−9.8
± 0.3
|
7.2
± 0.2
|
3142 |
EN300-35592_3
|
|
Cn1cc(cc1C(=O)N)C(=O)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3143 |
EN300-7443667_1
|
|
CSCC(=O)N1CCN(CC1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.4
|
7.2
± 0.3
|
3144 |
EN300-69368_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOCC5)O |
−9.8
± 0.3
|
7.2
± 0.2
|
3145 |
EN300-160498_1
|
|
COc1c([nH]c(=O)[nH]c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3146 |
EN300-74306_2
|
|
CC(CCOC)(CNC(=O)CC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.3
|
7.2
± 0.2
|
3147 |
EN300-6472573_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC(=O)NC6(C5)CC6 |
−9.8
± 0.3
|
7.2
± 0.2
|
3148 |
EN300-118117_1
|
|
Cn1c(cccc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3149 |
EN300-247428_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cn(nn5)CC6CC6 |
−9.8
± 0.3
|
7.2
± 0.2
|
3150 |
EN300-316258_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)COCc5cc[nH]c(=O)c5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3151 |
EN300-250501_2
|
|
COCC1(CCOC1)NC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.4
|
7.2
± 0.3
|
3152 |
EN300-93074_1
|
|
CN(C(=O)C[C@@]1(c2c(ccc(c2)Cl)OCC1)C(=O)Nc3c4c(cnc3)cccc4)[C@H]5C[C@@H](C5)O |
−9.8
± 0.2
|
7.2
± 0.2
|
3153 |
EN300-12247_3
|
|
CC(C)(C)C(=O)NCC(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.3
|
7.2
± 0.2
|
3154 |
EN300-4698402_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)[C@@H]5C[C@H]5F |
−9.8
± 0.2
|
7.2
± 0.1
|
3155 |
EN300-316679_3
|
|
CCC[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O |
−9.8
± 0.4
|
7.2
± 0.3
|
3156 |
EN300-333677_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@@H]([C@@H](C5)CO)CO |
−9.8
± 0.3
|
7.2
± 0.3
|
3157 |
EN300-6746727_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5Cc6c([nH]c(=O)[nH]c6=O)C5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3158 |
EN300-31102_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCN(CC5)S(=O)(=O)N |
−9.8
± 0.3
|
7.2
± 0.3
|
3159 |
EN300-215852_2
|
|
CCn1nc(c(n1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C |
−9.8
± 0.3
|
7.2
± 0.2
|
3160 |
EN300-191915_2
|
|
C[C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3161 |
EN300-10729_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCNC(=O)N |
−9.8
± 0.3
|
7.2
± 0.2
|
3162 |
EN300-1260794_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NC5(CCSC5)CO |
−9.8
± 0.4
|
7.2
± 0.3
|
3163 |
EN300-260603_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCc5c[nH]c(=O)[nH]5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3164 |
EN300-392640_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@H]5C[C@H]([C@H](C5)O)O |
−9.8
± 0.4
|
7.2
± 0.3
|
3165 |
EN300-7003350_2
|
|
CCNC(=O)COC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.1
|
7.15
± 0.09
|
3166 |
EN300-261365_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CS(=O)(=O)C5 |
−9.8
± 0.3
|
7.2
± 0.2
|
3167 |
EN300-7355477_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CC6CC(C(CC6C5)O)O |
−9.8
± 0.2
|
7.2
± 0.1
|
3168 |
EN300-238405_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)NCC5CC(=O)NC5 |
−9.8
± 0.2
|
7.2
± 0.1
|
3169 |
EN300-70033_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)N5CCC[C@H]5CO |
−9.8
± 0.3
|
7.2
± 0.2
|
3170 |
EN300-303519_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnn6c5OCC6 |
−9.8
± 0.2
|
7.2
± 0.2
|
3171 |
EN300-6733459_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C56CCCN5S(=O)(=O)CC6 |
−9.8
± 0.5
|
7.2
± 0.4
|
3172 |
EN300-42270_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)c5cnsn5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3173 |
EN300-299248_1
|
|
Cn1cnc(cc1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3174 |
EN300-266299_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N[C@@H]5CC[C@@H](C5)O |
−9.8
± 0.2
|
7.2
± 0.2
|
3175 |
EN300-13668_1
|
|
CN(CC(=O)NC1CC1)C(=O)CO[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.2
± 0.3
|
3176 |
EN300-223491_4
|
|
Cn1cnn(c1=O)CCC(=O)NCCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.4
|
7.2
± 0.3
|
3177 |
EN300-6478789_1
|
|
CC1C(=O)NC2(O1)CCN(CC2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−9.8
± 0.3
|
7.2
± 0.2
|
3178 |
EN300-1703015_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(=O)Nc5[nH]ccn5 |
−9.8
± 0.2
|
7.2
± 0.2
|
3179 |
EN300-657320_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCNC(=O)[C@@H]5CSCC(=O)N5 |
−9.8
± 0.4
|
7.2
± 0.3
|
3180 |
EN300-1702677_1
|
|
CN1CC2(CN(C2)C(=O)C[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6)C(C1=O)(F)F |
−9.8
± 0.3
|
7.2
± 0.2
|
3181 |
EN300-6494158_4
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCCOCC5CC(CO5)CO |
−9.8
± 0.2
|
7.2
± 0.1
|
3182 |
EN300-304662_3
|
|
Cc1nnc(o1)CCC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3183 |
EN300-205779_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCC(=O)NCCC5CCC(=O)N5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3184 |
EN300-200609_1
|
|
CS(=O)(=O)C1CCN(C1)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.6
|
7.1
± 0.5
|
3185 |
EN300-385132_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5[nH]c(nn5)C6CCOCC6 |
−9.8
± 0.3
|
7.1
± 0.2
|
3186 |
EN300-20233_2
|
|
COCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.1
|
3187 |
EN300-6974806_2
|
|
C[C@H]([C@@H](C(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)O)O |
−9.8
± 0.3
|
7.1
± 0.2
|
3188 |
EN300-103187_3
|
|
CCOCCNC(=O)COCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.4
|
7.1
± 0.3
|
3189 |
EN300-177118_2
|
|
CC1(CCC(=O)N1)C(=O)NC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3190 |
EN300-60514_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cc(cn5)S(=O)(=O)N |
−9.8
± 0.4
|
7.1
± 0.3
|
3191 |
EN300-43047_1
|
|
CC(=O)NC(CC=C)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.1
|
3192 |
EN300-48902_2
|
|
CNC(=O)C1CCCN1C(=O)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3193 |
EN300-2011083_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCC(=O)OCC5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3194 |
EN300-71125_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCn6cnnc6C5 |
−9.8
± 0.3
|
7.1
± 0.2
|
3195 |
EN300-220228_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5cnc6ccnn6c5O |
−9.8
± 0.3
|
7.1
± 0.2
|
3196 |
EN300-2007620_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCC(OCC5)CO |
−9.8
± 0.3
|
7.1
± 0.2
|
3197 |
EN300-64536_2
|
|
COCCC(=O)NC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−9.8
± 0.2
|
7.1
± 0.1
|
3198 |
EN300-122340_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C5(CCSCC5)O |
−9.8
± 0.5
|
7.1
± 0.4
|
3199 |
EN300-7543383_1
|
|
CN1C(=O)C(CO1)NC(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.2
|
7.1
± 0.2
|
3200 |
EN300-33553_1
|
|
Cc1c(c(=O)[nH]cn1)CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−9.8
± 0.3
|
7.1
± 0.2
|