Rank |
Compound |
SMILES |
ΔG / kcal M-1 |
pIC50 |
301 |
EN300-125874_1
|
|
Cn1cnnc1N(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.8
± 0.2
|
302 |
EN300-1718836_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cc5nnc6n5CCOC6 |
−12.0
± 0.3
|
8.8
± 0.2
|
303 |
EN300-270710_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)N |
−12.0
± 0.3
|
8.8
± 0.2
|
304 |
VLA-UCB-34f3ed0c-9
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCc5c[nH]c(=O)o5 |
−12.0
± 0.3
|
8.8
± 0.2
|
305 |
EN300-248526_3
|
|
c1ccc(cc1)C(COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)(C(=O)N)O |
−12.0
± 0.4
|
8.8
± 0.3
|
306 |
EN300-21258_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCO |
−12.0
± 0.2
|
8.8
± 0.2
|
307 |
EN300-1627945_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)COC5CCCOC5 |
−12.0
± 0.2
|
8.8
± 0.1
|
308 |
EN300-1932780_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(C(F)F)O |
−12.0
± 0.2
|
8.8
± 0.1
|
309 |
EN300-93573_1
|
|
CN(C)C(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.0
± 0.2
|
8.8
± 0.2
|
310 |
EN300-149013_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)c5c([nH]nn5)Cl |
−12.0
± 0.2
|
8.7
± 0.2
|
311 |
EN300-6477724_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)[C@@H]5C[C@@H]5c6[nH]cnn6 |
−12.0
± 0.4
|
8.7
± 0.3
|
312 |
EN300-6489289_1
|
|
Cc1nnc2n1C(CC2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.0
± 0.3
|
8.7
± 0.2
|
313 |
EN300-62574_2
|
|
Cn1c(nnn1)COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.7
± 0.2
|
314 |
EN300-1074262_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cccn6c5cnn6 |
−12.0
± 0.3
|
8.7
± 0.2
|
315 |
EN300-658559_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CC5)n6ccnn6 |
−12.0
± 0.3
|
8.7
± 0.2
|
316 |
EN300-21221_1
|
|
Cc1ccn2c(n1)nc(n2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−12.0
± 0.2
|
8.7
± 0.2
|
317 |
EN300-370792_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N(CCO)c5cnccn5 |
−12.0
± 0.3
|
8.7
± 0.2
|
318 |
EN300-212266_1
|
|
CC(C)C(=O)N[C@@H](CO)C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−12.0
± 0.4
|
8.7
± 0.3
|
319 |
EN300-14767_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCN(C5)C(=O)N |
−12.0
± 0.2
|
8.7
± 0.2
|
320 |
EN300-20980_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cnnn5 |
−12.0
± 0.2
|
8.7
± 0.2
|
321 |
EN300-225560_1
|
|
CCn1c(cnn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.7
± 0.2
|
322 |
EN300-94945_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5CCNC5=O |
−12.0
± 0.2
|
8.7
± 0.2
|
323 |
EN300-7435929_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncc6c(n5)CCOC6 |
−12.0
± 0.3
|
8.7
± 0.2
|
324 |
EN300-45182_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCN5CCOC5=O |
−12.0
± 0.3
|
8.7
± 0.2
|
325 |
EN300-237561_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5c(=O)cccn5 |
−12.0
± 0.3
|
8.7
± 0.2
|
326 |
EN300-60514_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5cc(cn5)S(=O)(=O)N |
−12.0
± 0.4
|
8.7
± 0.3
|
327 |
EN300-7501017_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@@H]5[C@@H]6[C@H]5C(=O)NC6 |
−12.0
± 0.2
|
8.7
± 0.2
|
328 |
EN300-180069_1
|
|
Cn1c(c(cn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)S(=O)(=O)C |
−12.0
± 0.3
|
8.7
± 0.2
|
329 |
EN300-69811_1
|
|
Cn1cccc(c1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.7
± 0.2
|
330 |
EN300-28894_1
|
|
Cc1c(nn(c(=O)c1C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)C)C |
−12.0
± 0.2
|
8.7
± 0.2
|
331 |
EN300-207959_3
|
|
CC1(CCNC1=O)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.7
± 0.2
|
332 |
EN300-1248064_1
|
|
CC(C)(C(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)n5cnnn5 |
−12.0
± 0.3
|
8.7
± 0.2
|
333 |
DAR-DIA-5ff57136-12
|
|
c1ccc2c(c1)cncc2N(C#CC3CCCN3)C(=O)[C@@H]4CCOc5c4cc(cc5)Cl |
−12.0
± 0.2
|
8.7
± 0.1
|
334 |
EN300-143564_1
|
|
CN1C(=O)CSC1=CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.7
± 0.2
|
335 |
EN300-1178005_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(on5)C#N |
−12.0
± 0.2
|
8.7
± 0.2
|
336 |
VLA-UCB-34f3ed0c-21
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)C(=O)CCC5CC(=O)NC5 |
−12.0
± 0.3
|
8.7
± 0.2
|
337 |
EN300-64193_3
|
|
Cc1nnc(o1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.7
± 0.2
|
338 |
EN300-143449_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCCN(=O)=O |
−12.0
± 0.3
|
8.7
± 0.2
|
339 |
EN300-78753_3
|
|
CC1(COC1)C(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.3
|
8.7
± 0.2
|
340 |
EN300-120820_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5cn[nH]c5=O |
−12.0
± 0.2
|
8.7
± 0.2
|
341 |
EN300-113112_2
|
|
Cn1cnnc1COC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.2
|
8.7
± 0.2
|
342 |
EN300-94900_3
|
|
CS(=O)(=O)Cc1nc(on1)COCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−12.0
± 0.4
|
8.7
± 0.3
|
343 |
EN300-109540_3
|
|
CC(c1cn(nn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5)O |
−12.0
± 0.4
|
8.7
± 0.3
|
344 |
EN300-80230_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ncccn5 |
−11.9
± 0.1
|
8.7
± 0.1
|
345 |
EN300-1644723_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C6C5COCC6 |
−11.9
± 0.1
|
8.70
± 0.09
|
346 |
EN300-304135_1
|
|
CCC1(CCNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.7
± 0.2
|
347 |
EN300-133128_1
|
|
CN(C)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.3
|
8.7
± 0.2
|
348 |
EN300-123589_1
|
|
CC(C)(C)S(=O)(=O)CC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.2
|
8.7
± 0.2
|
349 |
EN300-7445396_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5Cc6c[nH]cc6S5(=O)=O |
−11.9
± 0.3
|
8.7
± 0.2
|
350 |
EN300-6478631_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCc6n5cnn6 |
−11.9
± 0.3
|
8.7
± 0.2
|
351 |
EN300-253571_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCc6nnnn6CC5 |
−11.9
± 0.3
|
8.7
± 0.2
|
352 |
EN300-261210_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCOC5)C#N |
−11.9
± 0.2
|
8.7
± 0.2
|
353 |
EN300-1932013_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C(CC(F)(F)F)O |
−11.9
± 0.3
|
8.7
± 0.2
|
354 |
EN300-10747_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CSCC5=O |
−11.9
± 0.2
|
8.7
± 0.2
|
355 |
EN300-1700760_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6(C5)CC(=O)N6 |
−11.9
± 0.3
|
8.7
± 0.2
|
356 |
EN300-17381_3
|
|
CC(C(=O)N)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.2
|
8.7
± 0.1
|
357 |
EN300-7432415_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5C6(CCC6)OC(=O)N5 |
−11.9
± 0.3
|
8.7
± 0.2
|
358 |
EN300-245265_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CCCn5cnc(n5)C#N |
−11.9
± 0.4
|
8.7
± 0.3
|
359 |
EN300-341337_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCOC5CCOC6 |
−11.9
± 0.2
|
8.7
± 0.2
|
360 |
EN300-20375_1
|
|
COCCOCC(=O)N[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.2
|
8.7
± 0.2
|
361 |
EN300-1719432_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)Cn5nc(nn5)C6CC6 |
−11.9
± 0.3
|
8.7
± 0.2
|
362 |
EN300-6733459_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C56CCCN5S(=O)(=O)CC6 |
−11.9
± 0.5
|
8.7
± 0.4
|
363 |
EN300-184266_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)[C@H]5CC(=O)N5 |
−11.9
± 0.3
|
8.7
± 0.2
|
364 |
EN300-150212_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc(n[nH]5)F |
−11.9
± 0.2
|
8.7
± 0.1
|
365 |
EN300-209048_1
|
|
CN1CCC(C1=O)N(C)C(=O)C[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.7
± 0.2
|
366 |
EN300-83864_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCC(CC5)S(=O)(=O)N |
−11.9
± 0.4
|
8.7
± 0.3
|
367 |
EN300-127197_3
|
|
COc1cc(on1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.4
|
8.7
± 0.3
|
368 |
EN300-258477_3
|
|
C[C@@H](C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4)OC |
−11.9
± 0.3
|
8.7
± 0.2
|
369 |
EN300-1719432_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)Cn5nc(nn5)C6CC6 |
−11.9
± 0.3
|
8.7
± 0.2
|
370 |
EN300-211482_3
|
|
CC(C(=O)NC)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.2
|
8.7
± 0.1
|
371 |
EN300-393121_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5cc6c(=O)[nH]ccn6n5 |
−11.9
± 0.3
|
8.7
± 0.2
|
372 |
EN300-70431_1
|
|
COc1c(c(ncn1)OC)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.7
± 0.2
|
373 |
EN300-6494474_1
|
|
Cn1cnnc1CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.7
± 0.2
|
374 |
EN300-6744028_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CC6CC5C(C6O)O |
−11.9
± 0.1
|
8.7
± 0.1
|
375 |
EN300-171766_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCc5n[nH]c(=O)s5 |
−11.9
± 0.3
|
8.7
± 0.2
|
376 |
EN300-270422_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5C[C@H](C[C@@H](C5)F)O |
−11.9
± 0.3
|
8.7
± 0.2
|
377 |
EN300-97758_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CCF |
−11.9
± 0.2
|
8.7
± 0.2
|
378 |
EN300-123416_1
|
|
CCCn1cc(nn1)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.7
± 0.2
|
379 |
EN300-1789253_1
|
|
Cn1cc(nn1)c2cc(no2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.9
± 0.2
|
8.7
± 0.2
|
380 |
EN300-261210_2
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CNC(=O)C5(CCOC5)C#N |
−11.9
± 0.2
|
8.7
± 0.2
|
381 |
EN300-25960_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5(CCCC5)O |
−11.9
± 0.3
|
8.7
± 0.2
|
382 |
EN300-21009_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)C5CCCO5 |
−11.9
± 0.1
|
8.7
± 0.1
|
383 |
EN300-7444950_3
|
|
COc1cc(ncn1)CC(=O)NCC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.6
± 0.2
|
384 |
EN300-92684_1
|
|
Cc1c(cn(n1)C)C2=NOC(C2)C(=O)N[C@]3(CCOc4c3cc(cc4)Cl)C(=O)Nc5cncc6c5cccc6 |
−11.9
± 0.3
|
8.6
± 0.2
|
385 |
EN300-254121_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)C(c5cnc[nH]5)O |
−11.9
± 0.4
|
8.6
± 0.3
|
386 |
EN300-172179_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)CN5CCOC5=O |
−11.9
± 0.3
|
8.6
± 0.2
|
387 |
EN300-1138792_1
|
|
Cn1cnnc1CCC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.6
± 0.2
|
388 |
EN300-131093_3
|
|
CC(C(=O)NCC(=O)C)OCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.3
|
8.6
± 0.2
|
389 |
EN300-7463171_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCCS(=O)(=O)CCO |
−11.9
± 0.8
|
8.6
± 0.6
|
390 |
EN300-300088_2
|
|
CCn1cc(nn1)CNC(=O)CC[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.6
± 0.2
|
391 |
EN300-6759972_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CC(=O)N5CCCC(CC5)NC(=O)N |
−11.9
± 0.3
|
8.6
± 0.2
|
392 |
EN300-307008_1
|
|
CN1C(CNC1=O)C(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.2
|
8.6
± 0.2
|
393 |
EN300-126104_1
|
|
Cc1cccn(c1=O)CC(=O)N[C@]2(CCOc3c2cc(cc3)Cl)C(=O)Nc4cncc5c4cccc5 |
−11.9
± 0.3
|
8.6
± 0.2
|
394 |
EN300-188217_3
|
|
CC(C)(CS(=O)(=O)C)C(=O)NCC[C@]1(CCOc2c1cc(cc2)Cl)C(=O)Nc3cncc4c3cccc4 |
−11.9
± 0.4
|
8.6
± 0.3
|
395 |
EN300-7433864_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c[nH]c(=O)n(c5=O)C6CC6 |
−11.9
± 0.4
|
8.6
± 0.3
|
396 |
EN300-192893_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccn6c(c5)ncn6 |
−11.9
± 0.2
|
8.6
± 0.2
|
397 |
EN300-188174_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5ccc6c(n5)[nH]c(=O)o6 |
−11.9
± 0.3
|
8.6
± 0.2
|
398 |
EN300-249899_1
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)NC(=O)c5c6ncccn6cn5 |
−11.9
± 0.2
|
8.6
± 0.2
|
399 |
EN300-77092_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCOCC5OCCO5 |
−11.8
± 0.3
|
8.6
± 0.2
|
400 |
EN300-256583_3
|
|
c1ccc2c(c1)cncc2NC(=O)[C@@]3(CCOc4c3cc(cc4)Cl)CCNC(=O)CC5CS(=O)(=O)C5 |
−11.8
± 0.3
|
8.6
± 0.2
|